International journal of clinical and experimental medicine最新文献_第7页

A clinical study on the role of psychosomatic therapy in evaluation and treatment of patients with chronic obstructive pulmonary disease complicated with anxiety-depression disorder. 关于心身疗法在评估和治疗慢性阻塞性肺病并发焦虑抑郁症患者中的作用的临床研究。

IF 0.1

International journal of clinical and experimental medicine Pub Date : 2015-09-15 eCollection Date: 2015-01-01

Qing Chen, Chi Wu, Yang Gao, Lijuan Chen, Yuejian Liu

{"title":"A clinical study on the role of psychosomatic therapy in evaluation and treatment of patients with chronic obstructive pulmonary disease complicated with anxiety-depression disorder.","authors":"Qing Chen, Chi Wu, Yang Gao, Lijuan Chen, Yuejian Liu","doi":"","DOIUrl":"","url":null,"abstract":"This study aimed to evaluate the effect of psychotic therapy on patients with chronic obstructive pulmonary disease (COPD) complicated with anxiety-depression disorder by Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), COPD Assessment Test (CAT) and modified British Medical research Council (mMRC). Thirty-five patients with COPD were evaluated by pulmonary physicians with CAT and mMRC. They were further evaluated with HAMD and HAMA by psychologists and diagnosed and grouped into group B and D according to the Global initiative for chronic Obstructive Lung Disease (GOLD) version 2014. Patients were given psychotic therapy and followed up for at least 1 month. Comparison and analysis were performed with clinical data before and after treatment. Fourteen patients were subscribed into B group, while 21 patients were subscribed into D group, accounting for 40% and 60% respectively. After psychotic therapy, the HAMA and MAMD score of patients in both groups improved significantly (P<0.05). The CAT and Mmrc score of 8 patients in B group improved as A, while 10 patients in D group improved as B. The longest follow-up was 12 months. Symptoms were significantly alleviated after combined respiratory and psychotic therapy. COPD complicated with anxiety-depression is of high prevalence. The psychosomatic problems usually aggravate respiratory symptoms. Make better use of the evaluation methods such as HAMA, HAMA, CAT, mMRC may facilitate the treatment for patients. ","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 9","pages":"16613-9"},"PeriodicalIF":0.1,"publicationDate":"2015-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Galectin-3 mediates the effect of PDGF on pulmonary arterial hypertension. Galectin-3 介导了 PDGF 对肺动脉高压的影响。

IF 0.2

International journal of clinical and experimental medicine Pub Date : 2015-09-15 eCollection Date: 2015-01-01

Shaomei Guo, Ziming Feng

{"title":"Galectin-3 mediates the effect of PDGF on pulmonary arterial hypertension.","authors":"Shaomei Guo, Ziming Feng","doi":"","DOIUrl":"","url":null,"abstract":"Aims: The present study aimed to perform in vitro experiments to investigate whether Galectin-3 (Gal-3) mediates the effect of platelet-derived growth factor (PDGF) on pulmonary arterial smooth muscle cells (PASMC) proliferation, apoptosis and migration, and to reveal the mechanism of how Gal-3 functions in the pathogenesis of pulmonary arterial hypertension (PAH).Methods: Pulmonary arterial smooth muscle cells (PASMC) were treated with various concentration of PDGF for indicated times, and the expression of Gal-3 was analyzed by western blotting. Gal-3 siRNA was transfected into the PASMC to knock down endogenous Gal-3. MTT assay was performed to examine cell proliferation. Transwell-migration assay was used to determine cell migration ability. Cell apoptosis rate was determined by flow cytometric analysis.Results: The result showed that the expression of Gal-3 protein was induced by PDGF in a dose- and a time-dependent manner. PDGF contributes to the progression of PAH by inducing cell proliferation and migration, as well as inhibiting cell apoptosis of PASMC. However, these effects of PDGF on PASMC were attenuated by Gal-3 knockdown.Conclusion: The present study provided potential evidence about the role of Gal-3 in the pathophysiological mechanisms of PAH. This study firstly demonstrated that Gal-3 could be induced by PDGF in PASMC, and mediates the effect of PDGF on PASMC proliferation, apoptosis and migration, thus contributing to the pathogenesis of PAH.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 9","pages":"15302-7"},"PeriodicalIF":0.2,"publicationDate":"2015-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knockdown of CIP2A sensitizes ovarian cancer cells to cisplatin: an in vitro study. 敲除 CIP2A 可使卵巢癌细胞对顺铂敏感：一项体外研究。

IF 0.1

International journal of clinical and experimental medicine Pub Date : 2015-09-15 eCollection Date: 2015-01-01

Xiaoli Zhang, Bin Xu, Chuanying Sun, Liming Wang, Xia Miao

{"title":"Knockdown of CIP2A sensitizes ovarian cancer cells to cisplatin: an in vitro study.","authors":"Xiaoli Zhang, Bin Xu, Chuanying Sun, Liming Wang, Xia Miao","doi":"","DOIUrl":"","url":null,"abstract":"Background: CIP2A is a recently characterized oncoprotein which involves in the progression of several human malignancies. CIP2A is overexpressed in human ovarian cancer and regulates cell proliferation and apoptosis. This study was performed to investigate the role of CIP2A in ovarian cancer (OC) chemoresistance.Methods: Using DDP-resistant SKOV3 cells (SKOV3(DDP)), we first determined the effect of CIP2A silencing by siRNA-mediated knockdown of CIP2A on chemosensitivity in vitro; we then determined the effect of pCDNA3.1-mediated overexpression of CIP2A on chemosensitivity in SKOV3 cells in vitro. To elucidate the molecular mechanisms underlying CIP2A-mediated chemoresistance, the activities of AKT signaling molecules associated with CIP2A were analyzed.Results: Knockdown of endogenous CIP2A in SKOV3(DDP) cells resulted in the reduction in cell growth and increase in the chemosensitivity of SKOV3(DDP) cells to DDP in vitro, which may be caused by CIP2A-induced AKT activity inhibition. Notably, CIP2A overexpression could significantly decrease the sensitivities of SKOV3 cells to cisplatin, which might be ascribed to CIP2A-induced activation of the AKT pathway.Conclusions: Taken together, the results suggest that CIP2A contributes to cisplatin resistance in OC. Thus, CIP2A is a potential therapeutic target for OC.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 9","pages":"16941-7"},"PeriodicalIF":0.1,"publicationDate":"2015-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognosis of patients with coronary artery disease treated in different therapy units at department of cardiology: a retrospective cohort study. 在心脏科不同治疗单元接受治疗的冠心病患者的预后：一项回顾性队列研究。

IF 0.1

International journal of clinical and experimental medicine Pub Date : 2015-09-15 eCollection Date: 2015-01-01

Cong Fu, Yuyu Yao, Xin Wang, Chaojun Yu, Genshan Ma

{"title":"Prognosis of patients with coronary artery disease treated in different therapy units at department of cardiology: a retrospective cohort study.","authors":"Cong Fu, Yuyu Yao, Xin Wang, Chaojun Yu, Genshan Ma","doi":"","DOIUrl":"","url":null,"abstract":"Background: Coronary artery disease (CAD) is a major health problem in global. Benefit from different care unit for various type of CAD is remaining unknown. We investigate if coronary care unit (CCU) reduces the incidence of major adverse cardiovascular events (MACEs).Method: 806 CAD patients including stable angina (SA) and acute coronary syndrome (ACS) who treated in department of cardiology were involved in the study as two groups. Each group involved two subgroups according to the therapy unit including CCU and normal unit. 12-48 months follow-up was carried out. The primary end point was all cause mortality.Results: For SA, death from any cause occurred in 1.0% of the patients in the normal group (1 of 108), as compared with 5.1% in the CCU group (3 of 59) (hazard ratio [HR], 0.164; 95% confidence interval [CI], 0.017 to 1.580; P=0.118). Kaplan-Meier survival analysis showed that there were no significant differences between the two subgroups with respect to the risk of death (P=0.074), revascularization (P=0.660), stroke (P=0.497), heart failure (P=0.658) and hemorrhage (P=0.096). For ACS, death occurred in 1.9% of the patients in the normal subgroup (5 of 267), as compared with 1.3% in the CCU subgroup (5 of 372) (HR, 1.403; 95% CI, 0.406-4.846; P=0.593). Kaplan-Meier survival analysis showed that there were no significant differences between the two subgroups with respect to the risk of death (P=0.591), revascularization (P=0.996), stroke (P=0.425), heart failure (P=0.625).Conclusion: CAD patients treated in CCU obtain little benefits compared with normal.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 9","pages":"15657-65"},"PeriodicalIF":0.1,"publicationDate":"2015-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overexpression of RACK1 inhibits collagen synthesis in keloid fibroblasts via inhibition of transforming growth factor-β1/Smad signaling pathway. 通过抑制转化生长因子-β1/Smad 信号通路，过表达 RACK1 可抑制瘢痕疙瘩成纤维细胞中胶原蛋白的合成。

IF 0.2

International journal of clinical and experimental medicine Pub Date : 2015-09-15 eCollection Date: 2015-01-01

Ping Zhou, Lina Shi, Qing Li, Di Lu

引用次数: 0

Environmental tobacco smoke and pancreatic cancer: a case-control study. 环境烟草烟雾与胰腺癌：一项病例对照研究。

IF 0.1

International journal of clinical and experimental medicine Pub Date : 2015-09-15 eCollection Date: 2015-01-01

Yi Ding, Chundong Yu, Zenggang Han, Sunyu Xu, Dacheng Li, Xiao Meng, Dong Chen

{"title":"Environmental tobacco smoke and pancreatic cancer: a case-control study.","authors":"Yi Ding, Chundong Yu, Zenggang Han, Sunyu Xu, Dacheng Li, Xiao Meng, Dong Chen","doi":"","DOIUrl":"","url":null,"abstract":"Background: It has been conformed that active smoking is an established risk factor for pancreatic cancer, but the role of environmental tobacco smok (passive smoking) in pancreatic cancer remains unclear. We intended to study the relationship between passive smoking and pancreatic cancer.Methods: From Oct. 1991 to Sep. 2014, A hospital-based case-control study on pancreatic cancer was conducted from the inpatient of five hospitals. 1076 cases pancreatic cancer patients. History of exposure to environmental tobacco smoke was assessed through questionnaires. Relative risks (RR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models.Results: During 23 years of follow-up (1991-2014), 1076 patients were diagnosed with pancreatic cancer (686 men and 390 women). Compared to paternal smoking (RR, 0.97; 95% CI, 0.77-1.21; P = 0.084), maternal smoking significantly increased the risk of pancreatic cancer (R, 1.56; 95% CI, 1.13-1.98; P = 0.018). Although the risk associated with maternal smoking remained elevated compared to the never smokers (RR, 1.49; 95% CI, 1.07-2.27), there was no statistical significance.Conclusions: The positive association with maternal smoking suggests that environmental tobacco smoke, potentially in utero or in early life, may be associated with pancreatic cancer.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 9","pages":"16729-32"},"PeriodicalIF":0.1,"publicationDate":"2015-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of anxiety level on circadian rhythm of blood pressure in hypertensive patients. 焦虑水平对高血压患者血压昼夜节律的影响。

IF 0.1

International journal of clinical and experimental medicine Pub Date : 2015-09-15 eCollection Date: 2015-01-01

Mehmet Emre Özpelit, Ebru Özpelit, Nazile Bilgin Doğan, Nihat Pekel, Ferhat Ozyurtlu, Akar Yılmaz, Serkan Saygı, İstemihan Tengiz, Ertugrul Ercan

{"title":"Impact of anxiety level on circadian rhythm of blood pressure in hypertensive patients.","authors":"Mehmet Emre Özpelit, Ebru Özpelit, Nazile Bilgin Doğan, Nihat Pekel, Ferhat Ozyurtlu, Akar Yılmaz, Serkan Saygı, İstemihan Tengiz, Ertugrul Ercan","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Considering the high prevalence rates and growing incidences of hypertension (HT) and anxiety disorders in the modern world, a full understanding of anxiety's relationship to HT is crucial. In this study we aimed to investigate the effects of anxiety level on circadian rhythm of blood pressure (BP) in hypertensive patients.Material and method: This cross-sectional study included 160 previously diagnosed essential hypertensive patients (80 female, 80 male, mean age: 55.3±15.1 years). All participants underwent 24 h ambulatory blood pressure monitoring (ABPM) and filled State-Trait Anxiety Inventory (STAI) (trait) Questionnaire. The study population was divided into 2 groups according to their STAI scores; an anxiety group (n=97; STAI ≥45) and a control group (n=63; STAI<44). Clinical characteristics, laboratory findings and ABPM measurements were compared between the groups.Results: There was no significant difference between the groups for ABPM parameters except morning blood pressure surge (MBPS). Anxiety group had a significantly higher MBPS compared to control group (14.4±17.0 vs 9.1±11.9 mmHg, P:0.03). Multivariate analysis showed that duration of HT and STAI score were the only independent predictors of MBPS.Conclusion: Patients' anxiety level is associated with MBPS which is an independent risk factor for cardiovascular complications. Assessment and control of anxiety seems to be worthy in effective treatment of hypertension.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 9","pages":"16252-8"},"PeriodicalIF":0.1,"publicationDate":"2015-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apigenin attenuates diabetes-associated cognitive decline in rats via suppressing oxidative stress and nitric oxide synthase pathway. 芹菜素通过抑制氧化应激和一氧化氮合酶途径减轻糖尿病导致的大鼠认知能力下降

IF 0.1

International journal of clinical and experimental medicine Pub Date : 2015-09-15 eCollection Date: 2015-01-01

Xiao-Yuan Mao, Jing Yu, Zhao-Qian Liu, Hong-Hao Zhou

{"title":"Apigenin attenuates diabetes-associated cognitive decline in rats via suppressing oxidative stress and nitric oxide synthase pathway.","authors":"Xiao-Yuan Mao, Jing Yu, Zhao-Qian Liu, Hong-Hao Zhou","doi":"","DOIUrl":"","url":null,"abstract":"Our present investigation aimed to determine the neuroprotection of apigenin (API) against diabetes-associated cognitive decline (DACD) a diabetic rat model and exploring its potential mechanism. Diabetic rat model was induced by intraperitoneal injection of streptozotocin. All experiment animals treated with vehicle or API by doses of 10, 20 and 40 mg/kg for seven weeks. Firstly, the body weight and blood glucose levels were detected. We used Morris water maze test to evaluate learning and memory function. The oxidative indicators (malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH)), cNOS, iNOS, caspase-3 and caspase-9 were measured in cerebral cortex and hippocampus using corresponding commercial kits. API can increase body weight, reduce the blood glucose levels, and improve the cognitive function in rats induced by diabetes. API decrease the MDA content, and increase SOD activity and GSH level of diabetic animals in the cerebral cortex and hippocampus of diabetic rats. Meanwhile, constitutive nitric oxide synthase (cNOS), inducible nitric oxide synthase (iNOS), caspase-3/9 were markedly exhibited in the cerebral cortex and hippocampus of diabetic rats. In summary, our current work discloses that API attenuates DACD in rats via suppressing oxidative stress, nitric oxide and apoptotic cascades synthase pathway. ","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 9","pages":"15506-13"},"PeriodicalIF":0.1,"publicationDate":"2015-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive and prognostic molecular markers for cholangiocarcinoma in Han Chinese population. 汉族人群胆管癌的预测和预后分子标记物

IF 0.1

International journal of clinical and experimental medicine Pub Date : 2015-08-15 eCollection Date: 2015-01-01

Lingqin Meng, Zhong Tian, Yong Wang, Yuan Liu, Jingang Liu

{"title":"Predictive and prognostic molecular markers for cholangiocarcinoma in Han Chinese population.","authors":"Lingqin Meng, Zhong Tian, Yong Wang, Yuan Liu, Jingang Liu","doi":"","DOIUrl":"","url":null,"abstract":"Cholangiocarcinoma (CCA) is the most common malignant heterogeneous polygenetic carcinoma with a high incidence in Asia. Most patients would die within 1 year after diagnosis and the 5 year survival rate is less than 10-20% worldwide. Single nucleotide polymorphisms (SNPs) in genes regulate telomere maintenance, mitosis, and inflammation, and may help predict individual susceptibility to certain drugs, environmental factor, and risks to particular diseases. The gene-gene interaction and the regulation of SNPs have not been assessed extensively in CCA. According to our previous study, the GRB2-associated-binding protein (Gab1) gene rs3805246 (X(2) =5.015, P=0.025, OR=0.531, 95% CI 0.304-0.928) and epidermal growth factor receptor (EGFR) gene rs2007000 (X(2) =7.934, P=0.005, OR=2.148, 95% CI 1.255-3.675) presented significant difference between CCA patients and controls. This study conducted a population-based analysis using 225 CCA cases (153 biliary tract cancer patients and 72 gall bladder cancer patients) to assess the association between SNPs and progression of CCA patients, including the overall survival and the prognosis analysis. Results showed that an increased susceptibility of BTC was significantly associated with SNP loci distribution frequency in EGFR rs2107000 (X(2) =7.934, P=0.005, OR=2.148, 95% CI 1.255-3.675). Furthermore, multivariate factor regression analysis represented cholelithiasis medical history of BTC patients can be an effective evaluation criteria of BTC susceptibility in early stage. This study also assessed the relationship between these genotypic polymorphisms and clinicopathologic data, including tumor differentiation stage and overall survival. This is the first study identifying that EGFR polymorphisms are associated with BTC and EGFR rs2017000 polymorphisms may be an important survival predictor in BTC patients. ","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 8","pages":"13680-9"},"PeriodicalIF":0.1,"publicationDate":"2015-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mixed epithelial and stromal tumor of the kidney: a rare case report and review of the literatures. 肾上皮和间质混合瘤:罕见病例报告及文献复习。

IF 0.1

International journal of clinical and experimental medicine Pub Date : 2015-08-15 DOI: 10.14740/jmc1797w

Cheng Yang, Jianzhong Wang, Hexi Du, Mingwei Chen, Xia Zhu, Jun Zhou, Z. Hao, Haoqiang Shi, Li Zhang, C. Liang

{"title":"Mixed epithelial and stromal tumor of the kidney: a rare case report and review of the literatures.","authors":"Cheng Yang, Jianzhong Wang, Hexi Du, Mingwei Chen, Xia Zhu, Jun Zhou, Z. Hao, Haoqiang Shi, Li Zhang, C. Liang","doi":"10.14740/jmc1797w","DOIUrl":"https://doi.org/10.14740/jmc1797w","url":null,"abstract":"Mixed epithelial and stromal tumor of the kidney (MESTK) is a rare complex renal neoplasm composed of a mixture of cystic and solid components. Until date only few cases of MESTK have been reported. We present here a rare case of MESTK that was diagnosed in a 56-year-old female. The patients were referred to our hospital due to a mass on the right kidney identified incidentally in a routine physical examination. A pre-operative diagnosis of cystic renal cell carcinoma was made and a right radical nephrectomy was carried out. Macroscopically, a cystic tumor was noticed in the upper portion of the right kidney. Various-sized cysts accompanied by multiple cysts and few solid areas were observed. Immunohistochemically, various epithelial markers as well as stromal markers were identified. Taken together with all the immunohistochemical results and morphological pattern of the tumor, a diagnosis of MESTK was made. MESTK is relatively rare and generally benign. However, it is difficult to distinguish between benign or malignant tumors according to the current radiological method. Therefore a complete resection of the tumor by partial or radical nephrectomy is suggested.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 8 1","pages":"14180-3"},"PeriodicalIF":0.1,"publicationDate":"2015-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67236604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3