Frontiers in gastroenterology (Lausanne, Switzerland)最新文献

{"title":"Impact of nucleos(t)ide analogues on the risk of hepatocellular carcinoma in chronic hepatitis B patients: a time-dependent Cox regression analysis.","authors":"Makoto Moriyama, Ryosuke Tateishi, Mizuki Nishibatake Kinoshita, Tsuyoshi Fukumoto, Tomoharu Yamada, Taijiro Wake, Ryo Nakagomi, Takuma Nakatsuka, Tatsuya Minami, Masaya Sato, Mitsuhiro Fujishiro, Kazuhiko Koike","doi":"10.3389/fgstr.2025.1585760","DOIUrl":"https://doi.org/10.3389/fgstr.2025.1585760","url":null,"abstract":"<p><strong>Background and aims: </strong>The preventive effect of nucleos(t)ide analog (NA) use on HCC development in patients with chronic hepatitis B (CHB) is controversial due to the difficulty of conducting randomized controlled trials.</p><p><strong>Approach and results: </strong>In this single-center, retrospective study, NA-naïve CHB patients without a history of HCC were enrolled and followed-up from the first visit on or after January 2000 to December 2020. Patients were categorized into the NA group, including those who started NA after study enrollment, and the non-NA group, including patients who were never administered NA during the follow-up period. After propensity score matching (PSM) to balance the confounding factors, we applied a multivariable time-dependent Cox proportional regression analysis with the initiation of NA as a time-dependent covariate. We further performed a subgroup analysis according to the presence or absence of cirrhosis. The baseline characteristics of 212 pairs of patients retrieved by PSM were comparable. During the mean follow-up of 12.9 and 6.8 years in the NA and non-NA groups, respectively, 25 and 28 patients developed HCC, respectively. Multivariable analysis with time-dependent covariates showed that NA did not affect HCC risk (HR, 0.68; 95% CI, 0.36-1.31; <i>p</i> = 0.25) after adjusting for other risk factors, including age, sex, and HBV viral load. Subgroup analysis showed that NA use significantly reduced the risk of HCC in cirrhotic patients (HR, 0.26; 95% CI, 0.08-0.85; <i>p</i> = 0.03).</p><p><strong>Conclusions: </strong>The preventive effect of NA on hepatocarcinogenesis may be limited to cirrhotic patients.</p>","PeriodicalId":73085,"journal":{"name":"Frontiers in gastroenterology (Lausanne, Switzerland)","volume":"4 ","pages":"1585760"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malaria and malnutrition in tribal areas of India: implications for paediatric health.","authors":"Anil Kumar Verma, Suyesh Shrivastava, Nishant Saxena","doi":"10.3389/fgstr.2025.1526806","DOIUrl":"https://doi.org/10.3389/fgstr.2025.1526806","url":null,"abstract":"<p><p>Malaria and malnutrition (undernutrition) are associated with poor health and poverty. Undernutrition affects children's general development, particularly the formation of a healthy immune system. Malaria parasites infect and propagate within vulnerable populations, causing anemia, fever, and, if ignored, death. Furthermore, frequent exposure to malaria and intestinal infections alters gut flora, exacerbating malnutrition caused by poor digestion and malabsorption of ingested food. In India, Tribal people are trapped in a vicious cycle of hunger and infectious diseases, such as malaria, due to inadequate diet, unsanitary practices, water quality, sanitation, attitude, and lack of access to healthcare facilities. Therefore, an integrated approach that caters to the nutritional and malaria-specific needs of the tribal population is required to eliminate malaria from tribal areas of India. This mini-review discusses the problems and probable solutions for the control and elimination of malaria in the tribal areas in India.</p>","PeriodicalId":73085,"journal":{"name":"Frontiers in gastroenterology (Lausanne, Switzerland)","volume":"4 ","pages":"1526806"},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endometriosis presenting as a rectal stricture in a patient with ulcerative colitis and primary sclerosing cholangitis: a case report.","authors":"Daniel Chorley, Ibrahim Mian, Deloshaan Subhaharan, Pradeep Kakkadasam Ramaswamy","doi":"10.3389/fgstr.2025.1584899","DOIUrl":"https://doi.org/10.3389/fgstr.2025.1584899","url":null,"abstract":"<p><p>Patients with ulcerative colitis (UC) are at an increased risk of colorectal cancer (CRC), which is compounded in the presence of other risk factors such as primary sclerosing cholangitis (PSC) and stricture. We report a middle-aged lady who developed a rectal stricture on the background of ulcerative colitis and primary sclerosing cholangitis. Although initial endoscopic biopsies showed no dysplasia, the patient proceeded with a total colectomy due to the concern for an underlying malignancy. Histology of the rectal specimens revealed endometriosis at the site of the stricture. This case emphasises the importance of evaluating the risk factor profile for malignancy in patients with ulcerative colitis while also highlighting the need to consider alternative aetiologies for rectal strictures.</p>","PeriodicalId":73085,"journal":{"name":"Frontiers in gastroenterology (Lausanne, Switzerland)","volume":"4 ","pages":"1584899"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: jaundice in the young: the complexity of rare diseases beyond cholangiopathies.","authors":"Simone Guglielmo, Francesca Pasin, Marta Biolo, Claudia Mescoli, Stefania Vio, Luca Fabris, Paolo Simioni","doi":"10.3389/fgstr.2025.1579928","DOIUrl":"https://doi.org/10.3389/fgstr.2025.1579928","url":null,"abstract":"<p><p>Jaundice is a common presentation of diseases of the biliary tree, which differential diagnosis can be challenging, in particular when associated to pancreas involvement. In this respect, autoimmune pancreatitis (AIP), a rare form of chronic pancreatitis, shares clinical presentations with pancreatic cancer, such as biliary obstruction and pancreatic mass. AIP is categorized into two subtypes, type 1, associated with elevated serum IgG4 levels and systemic involvement, including the biliary system, and type 2, which is not linked to IgG4 and can be associated with inflammatory bowel disease (IBD). Early recognition is critical as both subtypes respond well to corticosteroid therapy, potentially avoiding unnecessary surgical interventions. Here we discuss the case of a 29-year-old African man with no significant medical history, who presented with skin-scleral jaundice, pale stools, dark urine, and mild weight loss. Laboratory results showed elevated liver and pancreatic enzymes, and imaging revealed bile duct dilation and pancreatic enlargement, raising suspicion of AIP. Serum IgG4 levels were normal, and fecal calprotectin was elevated, suggesting possible IBD. Corticosteroid therapy was initiated, leading to rapid remission of jaundice. One year later, the patient developed gastrointestinal symptoms, mostly abdominal pain and diarrhea, which led to the endoscopic diagnosis of Crohn's disease. This association further supported the diagnosis of type 2 AIP. The patient subsequently developed a recurrent jaundice due to autoimmune hemolytic anemia (AHIA), a very rare complication of AIP, supported by a positive Coombs test. Once again, corticosteroids resulted in a complete clinical response. This case illustrates the diagnostic challenges of jaundice caused by pancreato-biliary diseases and the wide range of related immunological disorders, i.e. IBD and AHIA, which may influence the clinical presentation. Prompt recognition of the disease enables us to start timely corticosteroid therapy, which confirmed the diagnosis avoiding unnecessary surgery.</p>","PeriodicalId":73085,"journal":{"name":"Frontiers in gastroenterology (Lausanne, Switzerland)","volume":"4 ","pages":"1579928"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of trastuzumab deruxtecan in gastrointestinal malignancies: a systemic review and meta-analysis.","authors":"Ali Hussain, Qamar Iqbal, Sangeetha Isaac, Faisal Shariff, Ezza Tariq, Hassan Awais, Nayan Mainkar, Heidi Lynn Reis, Aakriti Arora, Akshay Deotare, Azka Tasleem, Srijan Valasapalli, Munizay Paracha, Maya Hashmi, Hamdi Battah, Mahvish Muzaffar","doi":"10.3389/fgstr.2025.1559934","DOIUrl":"https://doi.org/10.3389/fgstr.2025.1559934","url":null,"abstract":"<p><strong>Background: </strong>Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) that is effective in treating gastrointestinal (GI) cancers. However, the significant variability in its reported efficacy and safety profiles is likely due to differences in trial designs, patient populations, and clinical settings. This systematic review and meta-analysis aimed to consolidate current evidence on the efficacy and safety of T-DXd in human epidermal growth factor receptor 2 (HER2)-positive GI malignancies.</p><p><strong>Methods: </strong>We conducted a systematic review and meta-analysis following the Preferred Reporting Items for Systemic Reviews and Meta-Analysis guidelines (PRISMA), utilizing the Medline, Embase, Cochrane Central, and ClinicalTrials.gov databases. Out of 5,594 articles reviewed, 10 studies were ultimately included after both primary and secondary screenings, providing data on the outcomes and safety of T-DXd in HER2-positive GI malignancies. The National Institute of Health quality assessment tool was employed to evaluate the quality of the studies. Pooled analyses were performed using the 'meta' package (Schwarzer et al., R programming language), and proportions with 95% confidence intervals (CIs) were calculated.</p><p><strong>Results: </strong>We identified 653 patients treated with T-DXd for HER2-positive GI malignancies in 10 studies. The median age of the patients was 64.5 years (27-85) and 53% were male. The median follow-up duration was 5.9 months (0.5-30.5). The median overall survival and progression-free survival were 11.15 (1.4-20.8) and 5.6 months (2.6-8.7), respectively. The pooled objective response rate (ORR) was 36.9% (95% CI:31.5%-42.5%, I² = 41%, n = 589), with partial response and complete response rates of 35.2% (95% CI:31.1%-39.5%, I² = 0%, n = 516) and 1.3% (95% CI: 0.0%-4.7%, I² = 73%, n = 516), respectively. The median duration of response (DoR) was 7 months (0.7-22.3). Reported adverse events included anemia, febrile neutropenia, thrombocytopenia, diarrhea, nausea, interstitial lung disease/pneumonitis, heart failure, and hepatitis. For the 5.4 mg/kg dose, grade 3/4 adverse events were reported in 67 patients. For the 6.4 mg/kg dose, 146 grade 3/4 adverse events were reported.</p><p><strong>Conclusions: </strong>This meta-analysis supports the efficacy of T-DXd in patients with HER2-positive GI malignancies with a moderate ORR, even in patients who have experienced disease progression after multiple lines of therapy. Overall, T-DXd is well-tolerated, with limited severe adverse events. These findings validate existing research and underscore the need for further clinical trials, particularly in earlier lines of treatment.</p>","PeriodicalId":73085,"journal":{"name":"Frontiers in gastroenterology (Lausanne, Switzerland)","volume":"4 ","pages":"1559934"},"PeriodicalIF":0.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical challenges in diagnosing idiopathic mesenteric phlebosclerotic colitis: two case reports and an up-to-date literature review.","authors":"MingYan Shang, Liang Yin, Zhangzhu Li, Jie Gan, Jing Wang","doi":"10.3389/fgstr.2025.1549662","DOIUrl":"https://doi.org/10.3389/fgstr.2025.1549662","url":null,"abstract":"<p><p>Idiopathic mesenteric phlebosclerotic colitis (IMP) is a rare ischemic colitis primarily affecting the right colon, characterized by mesenteric venous sclerosis and calcification. Its etiology remains unclear, but prolonged use of traditional Chinese herbal medicines, particularly those containing gardeniae fructus, has been suggested as one of several contributing factors, alongside metabolic disorders and potential genetic predispositions. This case report highlights two cases of IMP linked to herbal medicine use, providing insights into its pathogenesis, diagnosis, and management. Both patients were diagnosed with IMP based on CT imaging and histopathology. Management involved discontinuation of herbal treatments, dietary modifications, and controlling metabolic conditions. Both patients had stable outcomes with no disease progression upon follow-up. This case report underscores the importance of considering IMP in patients with unexplained ischemic colitis, particularly those with a history of long-term herbal medicine use. Early intervention, including discontinuation of herbal remedies and management of metabolic factors, is crucial for preventing disease progression. Further research is needed to better understand the pathophysiology of IMP and its relationship with herbal medicine.</p>","PeriodicalId":73085,"journal":{"name":"Frontiers in gastroenterology (Lausanne, Switzerland)","volume":"4 ","pages":"1549662"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors of metabolic-associated fatty liver disease in sub-Saharan Africa: a systematic review and meta-analysis.","authors":"Emmanuel M Sindato, Violet Dismas Kajogoo, Gloria Ngajilo, Wondwossen Amogne Degu, Zahid Khan, Gideon Mlawa","doi":"10.3389/fgstr.2025.1506032","DOIUrl":"https://doi.org/10.3389/fgstr.2025.1506032","url":null,"abstract":"<p><strong>Background: </strong>Sub-Saharan Africa (SSA) is undergoing an epidemiological transition with a steady rise in non-communicable diseases. Among these diseases, metabolic dysfunction-associated fatty liver disease (MAFLD) has emerged as a rapidly increasing public health burden, but is inaccurately documented. We characterized the MAFLD prevalence and identified associated risk factors among adults in SSA.</p><p><strong>Methods: </strong>We searched PubMed/Medline, Cochrane, Embase, Web of Science, Google Scholar, and African Journals Online for studies looking into the prevalence of and the risk factors for MAFLD in SSA. Studies from 1990 in the English language were included, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used for reporting. The quality of the studies was assessed using the Newcastle-Ottawa Scale. A random-effects model was used to estimate the prevalence and the risk factors with 95% confidence intervals (CIs). Meta-regression was used for the subgroup analyses to account for heterogeneity. Stata version 17 software was used for the analysis. This study was registered with PROSPERO (registration no. CRD42024506067).</p><p><strong>Results: </strong>A total of 538 studies were identified, with 22 included in the analysis. The overall prevalence of MAFLD was 29·21% (95%CI = 22.09-36.88, <i>p</i> < 0.05). Regionally, the results were: West, 34.36%; South, 26.92%; and East, 24.56%. The prevalence of MAFLD among people living with HIV was 13.02%, with diabetes was 37.06%, with hypertension was 36.75%, and with a body mass index above 25 kg/m² was 46.05%. The prevalence was higher in women than in men (27.13% <i>vs</i>. 23.01%), as shown in studies conducted from 2000 onwards compared with those conducted between 2009 and 2019 (30.23% <i>vs</i>. 28.4%) and in studies with small sample sizes <500 than in studies with large sample sizes >500 (32.42% <i>vs</i>. 12.17%).</p><p><strong>Interpretation: </strong>MAFLD is highly prevalent in SSA, with a steady increasing magnitude. The significant risk factors included diabetes, hypertension, obesity, and female sex. This study underscores the emerging need of clinicians in SSA to screen MAFLD among patients at high risk and to instigate tailored care.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/, identifier CRD42024506067.</p>","PeriodicalId":73085,"journal":{"name":"Frontiers in gastroenterology (Lausanne, Switzerland)","volume":"4 ","pages":"1506032"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric bezoar: a simple and innovative lithotripsy method-a case report and review of the literature.","authors":"Xudong Yan","doi":"10.3389/fgstr.2025.1527031","DOIUrl":"https://doi.org/10.3389/fgstr.2025.1527031","url":null,"abstract":"<p><p>Gastrointestinal bezoars result from the ingestion of indigestible materials and are classified by their consistency. This material is commonly located in the stomach. Human bezoars may be formed by non-digestible plant fibers (phytobezoars), persimmons (diospyrobezoar), hair (trichobezoar), long-acting medications (pharmacobezoar), milk and mucus components (lactobezoar), or other various substances. This condition may be asymptomatic, or it may cause symptoms such as stomachache, ulcers, bleeding, perforation, gastric outlet obstruction, and mechanical intestinal obstruction. We herein report a simple and innovative lithotripsy method using Zebra Guidewire, and review the pathogenesis, clinical manifestations, and treatment of bezoars.</p>","PeriodicalId":73085,"journal":{"name":"Frontiers in gastroenterology (Lausanne, Switzerland)","volume":"4 ","pages":"1527031"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Insights into multiple cases of Pseudomyxoma peritonei.","authors":"HanJie Chu, XiaoBiao Song","doi":"10.3389/fgstr.2025.1529423","DOIUrl":"https://doi.org/10.3389/fgstr.2025.1529423","url":null,"abstract":"<p><p>As a rare peritoneal malignant tumor, Pseudomyxoma peritonei (PMP) is a challenge in the field of surgery and oncology due to its complex pathological mechanism and difficult clinical management. Although the comprehensive treatment regimen centered on cell reduction (CRS) combined with intraperitoneal hyperthermic chemotherapy (HIPEC) has significantly improved the prognosis of patients, postoperative recurrence is still common, and repeated recurrence cases are particularly rare, and its clinical characteristics and treatment strategies need to be further explored. In this paper, the clinicopathological features, recurrence patterns and treatment difficulties of PMP were systematically analyzed by reviewing an elderly patient with three relapses and operation and combining with the data of four cases with different disease course. Through multi-case discussion and literature review, this study aims to provide clinicians with a more comprehensive understanding of the disease, optimize individualized treatment decisions, and provide references for further exploration of the molecular mechanism and novel therapeutic targets of PMP.</p>","PeriodicalId":73085,"journal":{"name":"Frontiers in gastroenterology (Lausanne, Switzerland)","volume":"4 ","pages":"1529423"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for mortality in patients with primary biliary cholangitis: a nomogram to predict 5-year survival.","authors":"Yaxing Liu, Muyu Gao, Bin Li, Long Liu, Yao Liu, Ying Feng, Xiaojing Wang, Xianbo Wang, Guiqin Zhou","doi":"10.3389/fgstr.2025.1534145","DOIUrl":"https://doi.org/10.3389/fgstr.2025.1534145","url":null,"abstract":"<p><strong>Aim: </strong>The issue of transplant-free survival rate (OS) among patients with primary biliary cholangitis (PBC) remains a persistent concern. In predicting the long-term OS of PBC patients, given the complexity and population specificity of models such as the GLOBE and UK-PBC, our objective is to calculate and assess the risk factors for mortality and 5-year OS among PBC patients based on routine clinical data, ultimately facilitating its clinical application.</p><p><strong>Methods: </strong>This study enrolled 315 patients with PBC from Beijing Ditan Hospital and randomly divided them into a training cohort (n = 189) and a validation cohort (n = 126). Through Cox regression analyses, we identified risk predictors of mortality to develop a 5-year survival nomogram for PBC. The model was evaluated with Receiver Operating Characteristic (ROC) curves, calibration curves, Decision Curve Analysis (DCA).Kaplan-Meier (KM) curves compared OS across risk groups. Additionally, correlations among the indicators were analyzed.</p><p><strong>Results: </strong>Ultimately, we established a nomogram incorporating Age, NLR, and TBIL. The Area Under the ROC Curve(AUC-ROC) values for the training and validation groups were 0.7251 and 0.7721, respectively, indicating solid consistency and outperforming the GLOBE model. Calibration and DCA curves further underscored the clinical utility of our model.KM curves revealed the model could differentiate OS across risk levels in subgroup. Additionally, a significant correlation between NLR and TBIL (P=0.0021) was observed, potentially impacting patient prognosis.</p><p><strong>Conclusion: </strong>We have constructed a well-performing prognostic model based on Age, NLR, and TBIL. This model shows good discrimination, consistency, and clinical use. It helps identifying high-risk patients, enabling more frequent follow-ups and tailored interventions, potentially enhancing prognosis and clinical outcomes.</p>","PeriodicalId":73085,"journal":{"name":"Frontiers in gastroenterology (Lausanne, Switzerland)","volume":"4 ","pages":"1534145"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}