Annals of Pediatric Endocrinology & Metabolism最新文献_第8页

Congenital hyperinsulinism due to NEUROD1 gene mutation. 神经原1基因突变所致先天性高胰岛素血症。

IF 3.3

Annals of Pediatric Endocrinology & Metabolism Pub Date : 2025-10-01 Epub Date: 2025-10-31 DOI: 10.6065/apem.2550310.155

In Kim, Chong Kun Cheon

引用次数: 0

Incidence rate and characteristics of newly diagnosed type 1 diabetes in a Vietnamese tertiary pediatric center: challenges in early detection. 越南第三儿科中心新诊断1型糖尿病的发病率和特点：早期发现的挑战

IF 3.3

Annals of Pediatric Endocrinology & Metabolism Pub Date : 2025-10-01 Epub Date: 2025-05-07 DOI: 10.6065/apem.2448282.141

Ngoc Can Thi Bich, Son Do Tien, Khanh Nguyen Ngoc, Dien Tran Minh, Bach Le Xuan, Xuan Bui Thi, Huong Bui Thi, Linh Tran Thi Thuy, Hoa Do Thi, Huong Nguyen Thi Thu, Thao Bui Phuong, Dung Vu Chi

{"title":"Incidence rate and characteristics of newly diagnosed type 1 diabetes in a Vietnamese tertiary pediatric center: challenges in early detection.","authors":"Ngoc Can Thi Bich, Son Do Tien, Khanh Nguyen Ngoc, Dien Tran Minh, Bach Le Xuan, Xuan Bui Thi, Huong Bui Thi, Linh Tran Thi Thuy, Hoa Do Thi, Huong Nguyen Thi Thu, Thao Bui Phuong, Dung Vu Chi","doi":"10.6065/apem.2448282.141","DOIUrl":"10.6065/apem.2448282.141","url":null,"abstract":"Purpose: This study aims to estimate the incidence and examine the clinical and laboratory characteristics of newly diagnosed type 1 diabetes (T1D) in Vietnamese children at a tertiary referral pediatric hospital.Methods: A retrospective cross-sectional analysis was conducted on 64 children newly diagnosed with T1D at Vietnam National Children's Hospital in 2023. Data on the children were analyzed, including demographics, family history, symptoms, anthropometric measurements, hemoglobin A1c levels, and pancreatic islet autoantibodies.Results: The average age at diagnosis was 9.1±3.7 years, with a male predominance (53.1%). The incidence rate of T1D in these northern Vietnamese children was 0.77 per 100,000 children. Diabetic ketoacidosis (DKA) was present in 57.8% of children at diagnosis, and 75% tested positive for autoantibodies. The Red River Delta reported the highest proportion of children with T1D (43.5%), but the incidence rate was highest in Hanoi, the capital city (0.91 per 100,000 children).Conclusion: This study underscores the considerable diagnostic delays in T1D in a tertiary pediatric center in Vietnam, with a high prevalence of DKA. The results highlight the need for an enhanced network of satellite hospitals to enable early diagnosis and treatment for patients.","PeriodicalId":44915,"journal":{"name":"Annals of Pediatric Endocrinology & Metabolism","volume":" ","pages":"250-259"},"PeriodicalIF":3.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12597153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ChatGPT: how to use it and the pitfalls/cautions in academia. ChatGPT：如何使用它以及学术界的陷阱/注意事项。

IF 3.3

Annals of Pediatric Endocrinology & Metabolism Pub Date : 2025-10-01 Epub Date: 2025-10-31 DOI: 10.6065/apem.2550028.014

Jeong-Moo Lee

{"title":"ChatGPT: how to use it and the pitfalls/cautions in academia.","authors":"Jeong-Moo Lee","doi":"10.6065/apem.2550028.014","DOIUrl":"10.6065/apem.2550028.014","url":null,"abstract":"The integration of large language models (LLMs) in academic research has transformed traditional research methodologies. This review investigates the current state, applications, and limitations of LLMs, particularly ChatGPT, in medical and scientific research. I performed a systematic review of recent literature and LLM development reports in artificial intelligence-assisted research tools, including commercial LLM services (GPT-4o, Claude 3, Gemini Pro) and specialized research platforms (Genspark, Scispace). I evaluated their performance, applications, and limitations across stages of the research process. Recent advancements in LLMs shows potential for improving research efficiency, particularly in literature review, data analysis, and manuscript preparation. Performance comparison revealed varying strengths: GPT-4o and o1 outperformed in the overall area, Claude 3 in writing and coding, and Gemini Pro in multimodal processing. Therefore, it is important to choose and use each model wisely according to its advantages. However, hallucination risks, inherent biases, plagiarism concerns, and privacy issues are concerns in LLMs. The emergence of Retrieval-Augmented Generation models and specialized research tools has improved accuracy and current information access. LLMs offer effective support for research productivity, but they should serve as complementary tools rather than primary research drivers. The successful application of these tools depends on a thorough understanding of their limitations, strict adherence to ethical guidelines, and preservation of researcher autonomy.","PeriodicalId":44915,"journal":{"name":"Annals of Pediatric Endocrinology & Metabolism","volume":"30 5","pages":"229-241"},"PeriodicalIF":3.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12597148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145483341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of high-normal thyroid-stimulating hormone levels with metabolic syndrome and abdominal obesity in euthyroid adolescents: insights from the Korea National Health and Nutrition Examination Survey. 高正常促甲状腺激素水平与正常甲状腺青少年代谢综合征和腹部肥胖的关系：来自韩国国家健康和营养检查调查的见解

IF 3.3

Annals of Pediatric Endocrinology & Metabolism Pub Date : 2025-10-01 Epub Date: 2025-10-31 DOI: 10.6065/apem.2448324.162

Jung Heo, Hyunjyung Oh, Kyungdo Han, Min-Kyung Lee

{"title":"Association of high-normal thyroid-stimulating hormone levels with metabolic syndrome and abdominal obesity in euthyroid adolescents: insights from the Korea National Health and Nutrition Examination Survey.","authors":"Jung Heo, Hyunjyung Oh, Kyungdo Han, Min-Kyung Lee","doi":"10.6065/apem.2448324.162","DOIUrl":"10.6065/apem.2448324.162","url":null,"abstract":"Purpose: Metabolic syndrome (MetS) is increasingly prevalent among adolescents, and thyroid-stimulating hormone (TSH) levels influence metabolic health. This study investigates whether TSH levels are associated with MetS and its components in euthyroid adolescents.Methods: We used data from the Korean National Health and Nutrition Examination Survey between 2013 and 2015. The study included 940 euthyroid adolescents aged 10-18 years, who were divided into 2 groups: high-normal TSH group (top 25% of euthyroid TSH levels) and nonhigh TSH group (remaining 75%). We analyzed the association between high-normal TSH levels and MetS and its components.Results: TSH quartiles were related to MetS (P for trend=0.006). The prevalence of MetS was 3.5% in the high-normal TSH group and 1.9% in the nonhigh group (P=0.1929). Abdominal obesity was more prevalent in the high-normal TSH than in the nonhigh TSH group (16.2% vs. 9.6%, P=0.0153). Other MetS components were more prevalent in the high-normal TSH group, but the difference was not significant. High-normal TSH was significantly associated with abdominal obesity (adjusted odds ratio, 1.975; 95% confidence interval, 1.104-3.531, P=0.0218).Conclusion: In euthyroid adolescents, a significant trend was observed between TSH quartile and MetS. Specifically, high-normal TSH levels showed a significant association with abdominal obesity, a key component of MetS.","PeriodicalId":44915,"journal":{"name":"Annals of Pediatric Endocrinology & Metabolism","volume":"30 5","pages":"260-267"},"PeriodicalIF":3.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12597154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145483318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on "Incidence rate and characteristics of newly diagnosed type 1 diabetes in a Vietnamese tertiary pediatric center: challenges in early detection". 评论“越南三级儿科中心新诊断的1型糖尿病的发病率和特点：早期发现的挑战”。

IF 3.3

Annals of Pediatric Endocrinology & Metabolism Pub Date : 2025-10-01 Epub Date: 2025-10-31 DOI: 10.6065/apem.2524141edi05

Young Suk Shim

引用次数: 0

The role of continuous glucose monitoring in improving glycemic control in adolescents with type 1 diabetes. 持续血糖监测在改善青少年1型糖尿病患者血糖控制中的作用

IF 3.3

Annals of Pediatric Endocrinology & Metabolism Pub Date : 2025-10-01 Epub Date: 2025-10-31 DOI: 10.6065/apem.2550006.003

Minkyu Seo, Kyu Hyun Park, Ji Won Park, EunJeong Kim, Do Young Shin, Eungu Kang, Hyo-Kyoung Nam, Young-Jun Rhie, Kee-Hyoung Lee

{"title":"The role of continuous glucose monitoring in improving glycemic control in adolescents with type 1 diabetes.","authors":"Minkyu Seo, Kyu Hyun Park, Ji Won Park, EunJeong Kim, Do Young Shin, Eungu Kang, Hyo-Kyoung Nam, Young-Jun Rhie, Kee-Hyoung Lee","doi":"10.6065/apem.2550006.003","DOIUrl":"10.6065/apem.2550006.003","url":null,"abstract":"Purpose: Continuous glucose monitoring (CGM) technology offers real-time glucose feedback and has shown potential to improve glycemic control. This retrospective study evaluated the effect of CGM on glycemic outcomes in Korean children and adolescents with type 1 diabetes mellitus (T1DM) in a real-world setting.Methods: We included 66 participants divided into a CGM group (n=22) and a self-monitoring blood glucose (SMBG) group (n=44). We compared changes in hemoglobin A1c (HbA1c) of the 2 groups over 1 year and observed changes in CGM activation time, mean glucose, glucose management indicator (GMI), coefficient of variation (CV), time in range (TIR), and hypoglycemia.Results: The CGM group had a mean age of 16.63 years and time from diagnosis to the initiation of study of 4.19 years, while those of the SMBG group were 17.85 years and 5.19 years, respectively. In the CGM group, mean HbA1c decreased from 8.68% at baseline to 7.92% at 12 months (P=0.011), whereas HbA1c increased from 8.46% to 8.93% in the SMBG group (P<0.001). The changes in HbA1c at 1 year between the CGM and SMBG groups were significantly different (-0.76%±1.39% vs. 0.47%±1.38%, P=0.001). CGM activation time decreased slightly (89.09% to 79.24%, P=0.093), and there were no significant changes in TIR, mean glucose, GMI, CV, or hypoglycemia over time.Conclusion: CGM use in Korean children and adolescents with T1DM significantly improves HbA1c levels over 12 months compared to SMBG. The implementation of CGM may provide valuable benefits in glycemic control and potentially reduce the risk of diabetes-related complications.","PeriodicalId":44915,"journal":{"name":"Annals of Pediatric Endocrinology & Metabolism","volume":"30 5","pages":"268-274"},"PeriodicalIF":3.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12597149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145483360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Type 2 diabetes in children and adolescents: key considerations based on the 2025 Korea Diabetes Association clinical practice guidelines for diabetes management. 儿童和青少年2型糖尿病：基于2025年韩国糖尿病协会糖尿病管理临床实践指南的关键考虑

IF 3.3

Annals of Pediatric Endocrinology & Metabolism Pub Date : 2025-10-01 Epub Date: 2025-10-31 DOI: 10.6065/apem.2550270.135

Jieun Lee, Sung Eun Kim, Yong Hee Hong

引用次数: 0

Is the triptorelin stimulation test comparable to the gonadorelin stimulation test in diagnosing central precocious puberty in boys? 在诊断男孩中枢性性性早熟方面，雷公干扰素刺激试验与促性腺激素刺激试验是否具有可比性？

IF 3.3

Annals of Pediatric Endocrinology & Metabolism Pub Date : 2025-10-01 Epub Date: 2025-10-31 DOI: 10.6065/apem.2550018.009

Jeong Ho Seo, Myoung Jin Yoo, Kyeongmi Lee, Jinjoo Choi, Yunsoo Choe, Seung Yang

引用次数: 0

Commentary on "Predictive factors of permanent versus transient congenital hypothyroidism: a pragmatic cohort study". “永久性与暂时性先天性甲状腺功能减退症的预测因素：一项实用队列研究”评论。

IF 3.3

Annals of Pediatric Endocrinology & Metabolism Pub Date : 2025-08-01 Epub Date: 2025-08-31 DOI: 10.6065/apem.2550268.134

Zainab Ayesha, Fatima Zahid, Syed Hassan Ali

引用次数: 0

Association of obesity and adrenal androgen levels with bone age progression in boys with premature adrenarche. 肥胖和肾上腺雄激素水平与早熟男孩骨龄进展的关系。

IF 3.3

Annals of Pediatric Endocrinology & Metabolism Pub Date : 2025-08-01 Epub Date: 2025-08-31 DOI: 10.6065/apem.2448248.124

Kyeongmi Lee, Jinjoo Choi, Yunsoo Choe, Seung Yang

{"title":"Association of obesity and adrenal androgen levels with bone age progression in boys with premature adrenarche.","authors":"Kyeongmi Lee, Jinjoo Choi, Yunsoo Choe, Seung Yang","doi":"10.6065/apem.2448248.124","DOIUrl":"10.6065/apem.2448248.124","url":null,"abstract":"Purpose: Both premature adrenarche (PA) and obesity are closely linked to increases in bone age (BA). However, the mechanisms underlying these associations are unclear as research data, particularly in boys, are lacking. Therefore, our aim in this study was to test for an association between obesity and BA progression in boys with PA and to assess the role of adrenal androgen in the mediation of any identified association.Methods: We retrospectively analyzed data from medical records of prepubertal boys with PA. Participants were categorized into 2 groups based on the difference between their BA and chronological age (CA), BA-CA≥1 and BA-CA<1.Results: Among 67 boys having a mean age of 8.3±0.7 years, the 27 boys in the BA-CA≥1 group had significantly higher body mass index (BMI) z-scores (1.7±0.9 vs. 1.0±1.3, P=0.022) and dehydroepiandrosterone sulfate (DHEA-S) z-scores (1.7±1.3 μg/dL vs. 1.1±0.7 μg/dL, P=0.020), than the 40 boys in the BA-CA<1 group. Multivariate regression analyses revealed a significant association between BMI z-score and BA progression for the BA-CA≥1 group, even after adjusting for DHEA-S z-score, odds ratio=1.605 with P=0.048. Mediation analyses indicated that the direct effect of BMI z-score on BA-CA was statistically significant, β=0.2190 with P=0.039; however, the indirect effect of BMI z-score on BA-CA through DHEA-S z-score was not significant.Conclusion: In boys with PA, higher DHEA-S z-scores and BMI z-scores were associated with BA-CA. However, DHEA-S did not mediate the relationship between obesity and BA progression. Our data suggested that in boys with obesity and PA, the rapid progression of skeletal maturation is primarily the result of a direct impact of obesity on BA and not due to an increase in adrenal androgen levels.","PeriodicalId":44915,"journal":{"name":"Annals of Pediatric Endocrinology & Metabolism","volume":"30 4","pages":"175-181"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12415281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145013423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0