Proceedings of the Shevchenko Scientific Society. Medical Sciences最新文献

{"title":"COMORBIDITY AND ITS IMPACT ON THE COURSE OF GOUT AND COVID-19","authors":"S. Smiyan, O. Makhovska","doi":"10.25040/ntsh2022.01.14","DOIUrl":"https://doi.org/10.25040/ntsh2022.01.14","url":null,"abstract":"Introduction. Comorbid diseases signifi cantly exacerbate gout burden, represent an even more elevated risk of hospitalization and mortality rates owing to the coronavirus disease 2019 (COVID-19) than gout itself. Objectives. To evaluate the infl uence of the modifi ed Rheumatic Disease Comorbidity Index (mRDCI) on the clinical course of gout and COVID-19. Methods. Using data from 136 male participants with gout, we distributed the cohort according to values of the mRDCI as follows: 0 – without comorbidities, 1-2 – low comorbidity index (CI), 3-4 – moderate CI and ≥5 – high CI. “Treat-to-target” approach for gout, the association of mRDCI with the clinical course of gout, lipid metabolism, and severity of COVID-19 were analyzed. Results. According to mRDCI scores, almost every second gout patient (45.6%) had moderate CI, every fi fth (19.1%) – high CI, and 14.7% – low CI. Greater mRDCI was associated with the higher severity of COVID-19 (p=0.003), limited physical functioning (r=0.5, p<0.001), higher body mass index (r=0.63, p<0.001), hyperuricemia (r=0.37, p<0.001), increased low–density lipoprotein cholesterol (LDL–C) (r=0.38, p<0.001), higher gout activity (r=0.4, p<0.001), more frequent acute fl ares in the preceding year (r=0.39, p<0.001), number of tophi (r=0.31, p<0.001), longer duration of gout (r=0.34, p<0.001), reduced glomerular fi ltration rate (r =–0.39, p<0.001), and daily excretion of uric acid (UA) (r=–0.28, p=0.001). The target level of serum UA was achieved in 22.1%. The majority of patients were not controlled for LDL-C (83.7%), blood pressure (75.5%), and glucose (69.44%) in the cohort with dyslipidemia, hypertension, and diabetes respectively. Conclusion. The high prevalence of comorbidities in gout patients was associated with the severity of COVID-19. We have established the following three patterns of comorbidity predictors: anthropometric, disease-related, and dysmetabolic. The management of gout requires a multidisciplinary approach.","PeriodicalId":140699,"journal":{"name":"Proceedings of the Shevchenko Scientific Society. Medical Sciences","volume":"2017 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125648031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BIOLOGICAL AGE ESTIMATION BASED ON HEART RATE VARIABILITY: A PILOT STUDY","authors":"Oleksiy Bashkirtsev, Vitaliy Sagan, V. Gaevska, O. Zimba","doi":"10.25040/ntsh2021.02.21","DOIUrl":"https://doi.org/10.25040/ntsh2021.02.21","url":null,"abstract":"Introduction. Biomarkers of biological age (BA) are essential for anti-aging research and practice because of their prediction of life expectancy, detection of premature aging, and estimation of anti-ageing programs' effectiveness. The purpose of this study is a clinical validation of the method of biological age estimation based on the analysis of heart rate variability (HRV), artificial intelligence technologies, and biometric monitoring. Methods. In 51 patients who received wellness and rehabilitation services in the medical center \"Edem Medical\", biological age was determined based on the analysis of HRV and machine learning algorithms. A comparison was made between the proposed method and other known methods of biological age estimation. Biological age estimation by physicians which is based on the Frailty Index was chosen as a reference method. The second method was DNA methylation age (DNAm PhenoAge). This method predicts biological age based on nine parameters of blood (albumin, creatinine, glucose, C-reactive protein, lymphocytes [%], mean corpuscular volume [MCV], red cell distribution width [RDW], alkaline phosphatase, WBC count). Using the «leave one out» technique, an additional algorithm was created for approximating biological age in view of blood test parameters and ECG signals as input data. Morning HRV assessment was performed on empty stomach and after 10-minute rest in horizontal position. ECG was recorded using Mawi Vital multisensor device. The following statistical tests were used to reveal associations between different methods of biological age estimation: 1. bivariate correlation, 2. mean absolute error (MAE), 3. qualitative binary age estimation. Results. All tested methods of BA evaluation were strongly correlated with the reference method (physician-determined age). HRV based approach was superior in comparison with other methods. In 9 out of 10 cases, the qualitative binary age assessment using HRV coincided with the reference method. The HRV method was the most accurate for biological age estimation (3.62 vs 12.62) based on MAE. Conclusion. The method based on HRV is an affordable and convenient approach to biological age estimation. This method offers opportunities for early stratification of individuals at risk of accelerated aging. It combines well with the paradigm of 3 P medicine which is based on Prevention, Prediction, and Personalized approach to each patient","PeriodicalId":140699,"journal":{"name":"Proceedings of the Shevchenko Scientific Society. Medical Sciences","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117312450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ARTIFICIAL INTELLIGENCE AND NEXT GENERATION PATHOLOGY: TOWARDS PERSONALIZED MEDICINE","authors":"Oleksandr Dudin, O. Mintser, O. Sulaieva","doi":"10.25040/ntsh2021.02.07","DOIUrl":"https://doi.org/10.25040/ntsh2021.02.07","url":null,"abstract":"Introduction. Over the past few decades, thanks to advances in algorithm development, the introduction of available computing power, and the management of large data sets, machine learning methods have become active in various fields of life. Among them, deep learning possesses a special place, which is used in many spheres of health care and is an integral part and prerequisite for the development of digital pathology. Objectives. The purpose of the review was to gather the data on existing image analysis technologies and machine learning tools developed for the whole-slide digital images in pathology. Methods: Analysis of the literature on machine learning methods used in pathology, staps of automated image analysis, types of neural networks, their application and capabilities in digital pathology was performed. Results. To date, a wide range of deep learning strategies have been developed, which are actively used in digital pathology, and demonstrated excellent diagnostic accuracy. In addition to diagnostic solutions, the integration of artificial intelligence into the practice of pathomorphological laboratory provides new tools for assessing the prognosis and prediction of sensitivity to different treatments. Conclusions: The synergy of artificial intelligence and digital pathology is a key tool to improve the accuracy of diagnostics, prognostication and personalized medicine facilitation","PeriodicalId":140699,"journal":{"name":"Proceedings of the Shevchenko Scientific Society. Medical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133339145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ENDOTHELIAL DYSFUNCTION UNDER EXPERIMENTAL SUBARACHNOID HEMORRHAGE. POSSIBLE WAYS OF PHARMACOCORRECTION","authors":"O. Polkovnikov, S. Pavlov, I. Belenichev, N. Matolinets","doi":"10.25040/ntsh2021.02.08","DOIUrl":"https://doi.org/10.25040/ntsh2021.02.08","url":null,"abstract":"Purpose of the article: to study the effect of acelysine and nimodipine on certain endothelial dysfunction indicators and to evaluate their therapeutic efficacy after subarachnoid hemorrhage in rats. Materials and Methods: an experimental study was carried out using 50 Wistar rats of both sexes. Spontaneous subarachnoid hemorrhage was modeled in animals. Three groups of animals were identified: a control group, a group of animals received a standard therapeutic dose of acelysine, and a group received a standard therapeutic dose of nimotop. Each group included 15 animals. There were also 5 intact animals. The animals were withdrawn from the experiment on days 4 and 7 after the motor and exploratory activity determination. Motor and exploratory activity determination was carried out following SAH with the “Open Field” technique. Determination of biochemical markers of endothelial dysfunction was performed in a rat brain homogenate. Results and discussion. It was found that modeling of subarachnoid hemorrhage (SAH) led to the oxidative stress development development and the product of oxidative modification of proteins (nitrotyrosine (Ntz) on the 4th and especially on the 7th day of the experiment) increase in the brain tissues. Starting from the 4th day, we registered a compensatory increase in the activity of NO-synthase (NOS) - by 56%, followed by a decrease in its activity on the 7th day, by more than 33% against the intact group of animals. It was registered a compensatory increase in VEGF-A in rats with SAH modeling on the 4th day of the experiment and its further decrease on the 7th day. The established pathobiochemical changes in the brain tissue were accompanied by the cognitive deficit development in experimental animals, especially on the 7th day of the SAH. SAH led to a significant decrease in the total activity of animals by 2.63 times, a decrease in the distance traveled by animals by 1.89 times, the number of freezes increased by 1.86 times and the immobility of animals increased when moving from the periphery to the center and immobility in the center of the arena (anxiety, fear, disorientation), as well as a decrease in the distance traveled and the speed of movement in illuminated center of the arena 2 and 2.6 times, respectively. Experimental therapy with acelysine 15 mg/kg led to the normalization of biochemical indicators of endothelial dysfunction: concentration of nitrotyrosine, starting from the 4th day of the experiment, increased eNOS activity and VEGF-A concentration (by 75% and 64% on 7th day). The administration of namidopine led to less pronounced effects, statistically significant changes occurred only in relation to the VEGF-A concentration. Administration of namidopine resulted in only a slight increase in VEGF-A concentration. Acelysine and nimotope significantly increased the total activity of rats on the 7th day after SAH by 76.3% and 48.8%, respectively. In animals treated with acelysine, anxiety and fear decreas","PeriodicalId":140699,"journal":{"name":"Proceedings of the Shevchenko Scientific Society. Medical Sciences","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133746330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CANCER AND COVID-19. A COMBAT STRATEGY","authors":"N. Lukavetskyy, N. Volod'ko","doi":"10.25040/ntsh2021.02.01","DOIUrl":"https://doi.org/10.25040/ntsh2021.02.01","url":null,"abstract":"Strict quarantine measures and the unpreparedness of the medical industry have exacerbated public health problems on all continents. The number of patients with advanced stages of cancer has increased at the end of the year. Several approaches could mitigate the negative effects of Covid-19 on screening programs. International oncology organization «European Society of Medical Oncology» (ESMO) has launched a section COVID 19 on its website. We believe that some aspects of the ESMO recommendations should be widely presented. The feasibility of vaccinating cancer patients against COVID-19 is undeniable","PeriodicalId":140699,"journal":{"name":"Proceedings of the Shevchenko Scientific Society. Medical Sciences","volume":"83 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126186679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OUTCOMES OF CONGENITAL HEART DISEASE IN NEWBORNS AT LVIV REGIONAL CLINICAL HOSPITAL, LVIV, UKRAINE","authors":"Y. Sharhorodska, O. Shkolnyk, Olena Rachkevych, Halyna Makukch","doi":"10.25040/ntsh2021.02.16","DOIUrl":"https://doi.org/10.25040/ntsh2021.02.16","url":null,"abstract":"Introduction. Congenital abnormalities are the most common medical and social problems and the primary cause of fetal loss and children’s disability in the World, and particularly in Ukraine. In Ukraine, about 5 thousand children with congenital heart disease (CHD) are born every year. Up to date, information on the future of patients who received medical care for CHD was not systematized and often remains unavailable. The aim of the study: To perform a survey of women who gave birth to children with CHD and collect information about distant health outcomes. Methods. The medical history files of 170 children born with CHD in Lviv Regional Clinical Hospital, Lviv, Ukraine between 2011-2015 were selected. The criterion for inclusion in the group was a clinical diagnosis ''Congenital malformations of the circulatory system'' based on International Classification of Diseases-10 (Q20 - Q28). Results. According to the medical history files analysed in our study, among 170 children born with CHD, heart defects were detected at the prenatal stage in 67 patients (39.4%). Urgent surgical intervention was performed in 32 (18.6%) children.","PeriodicalId":140699,"journal":{"name":"Proceedings of the Shevchenko Scientific Society. Medical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129581269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RESEARCH OF CANCER CASES AMONG LONG-LIVED WOMEN IN LVIV REGION (UKRAINE) DURING 1991–2019 YEARS","authors":"N. Kitsera, Y. Shparyk, O. Tril, Z. Dvulit","doi":"10.25040/ntsh2021.02.18","DOIUrl":"https://doi.org/10.25040/ntsh2021.02.18","url":null,"abstract":"Cancer is the second leading cause of death worldwide. Aim of our study was to describe the spectrum of cancer among longlivers women in Lviv region (Ukraine) from database during 1991-2019. Material and methods. We studied 444 longlivers women aged 90+ who were diagnosed of cancer, treated and followed-up. Results. 104 women (23%) were diagnosed cancer to stage I, II -142 (32%), III -71 (10%), IV -57 (13%):other malignant neoplasms of skin (38.29%), breast (9.46%), colon (6.98%) and pancreas (4.95%) cancer. Diagnosis was confirmed cytology -169 (38.1%), histology-139 (31.3%). CT and MRI were used in rare cases in older women – 11(2.5%). Half of the women (227 or 51.13%) lived beyond 1 year after diagnosis. The rest is from 1 to 13 years. The relationship between life expectancy after diagnosis of cancer and type of treatment is weak (Сramer ratio ; Pearson's criterion ). Detected that the relationship between life expectancy after diagnosis and the age of patients at the time of oncologic diagnosis is weak too (Сramer ratio ; Pearson's criterion ). The relationship between life expectancy after diagnosis and stage of cancer is strong (Сramer ratio ; Pearson's criterion ). Conclusion. Aggressive anticancer treatments are less commonly used in cancer patients aged 90+, which may be one of the reasons for poorer survival due to comorbidities and natural causes. Life expectancy has relationship on the stage of the cancer, but does not have relationship on the age of the long-lived women and the type of treatment.","PeriodicalId":140699,"journal":{"name":"Proceedings of the Shevchenko Scientific Society. Medical Sciences","volume":"129 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124648453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ADVANCES IN SCIENCE EDITING AND COMMUNICATION (PART 3)","authors":"U. Telishevska, O. Telishevska","doi":"10.25040/ntsh2021.02.04","DOIUrl":"https://doi.org/10.25040/ntsh2021.02.04","url":null,"abstract":"In the second half of 2021, 2 webinars and a meeting of the editorial team of the journal “Proceedings of the Shevchenko Scientific Society. Medical Sciences ” took place online. These events took place as a continuation of a specially designed program of lectures and masterclasses in English to improve the writing skills of modern high-quality scientific publications. These events were held with the support of Danylo Halytsky Lviv National Medical University, the Shevchenko Scientific Society, the Western Scientific Centre of the National Academy of Sciences of Ukraine, the Ministry of Education and Science of Ukraine, and the Council of Scientific Editors of Ukraine. Registered participants had the opportunity to view online broadcasts and recordings of the events at “Рroceedings of the Shevchenko Scientific Society. Medical Sciences” journal Facebook page and Youtube channel (https://www.youtube.com/channel/UC40L7KlZ5UU4hrMj_--yqHw). Each registered participant received a certificate with a certain number of points of continuous professional development","PeriodicalId":140699,"journal":{"name":"Proceedings of the Shevchenko Scientific Society. Medical Sciences","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115062670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"APPRECIATION TO THE EDITORIAL BOARD, AUTHORS, REVIEWERS, AND THE EDITORIAL STAFF FOR THEIR CONTRIBUTIONS TO THE \"PROCEEDINGS OF THE SHEVCHENKO SCIENTIFIC SOCIETY\" FOR THE YEARS 2020-2021","authors":"Oksana Zayachkivska, M. Kovalska, V. Lonchyna","doi":"10.25040/ntsh2021.02.02","DOIUrl":"https://doi.org/10.25040/ntsh2021.02.02","url":null,"abstract":"Dear Reader! We express our sincere appreciation to all the authors, reviewers, members of the editorial board, and the editorial staff for their tireless contributions during these difficult years 2020-2021. The preparation of each issue of \"The Proceedings of the Shevchenko Scientific Society: Medical Sciences” ensures its continuing development. The Journal is accepted by the Content Selection & Advisory Board of Scopus to the international indexing Scopus; to the international catalog of journals Ulrichsweb & Ulrichs; and to the Norsk Center for Forsknings data. As an open-access journal that undergoes peer review, the Editors have received multiple manuscripts from multiple countries. Information from the website shows that we had readers in 134 countries.","PeriodicalId":140699,"journal":{"name":"Proceedings of the Shevchenko Scientific Society. Medical Sciences","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125020389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INTEGRATIVE PHYSIOLOGY AS A TOOL FOR MEDICAL EDUCATION TRANSFORMATION","authors":"Yaryna Pohoretska, I. Kovalchuk, I. Muzyka, Iryna Stryiska, Maryanna Savytska, Oksana Zayachkivska","doi":"10.25040/ntsh2021.02.24","DOIUrl":"https://doi.org/10.25040/ntsh2021.02.24","url":null,"abstract":"Given the rapid progress of modern science, integrative physiology holds a key place in medical education, as it studies patterns of human body functioning in terms of individual characteristics, epigenetic factors and endogenous effects on cellular mechanisms. Drawing on five years of experience in teaching physiology at Danylo Halytsky Lviv National Medical University, we highlight the importance of implementing applied integrative physiology in the training of future doctors. We present interpretation of physiological phenomena, adaptive mechanisms and compensation resources in the human body. The introduction of methods for assessing human functions in real time based on high-precision registration of individual functional characteristics and adaptive physiological mechanisms with high diagnostic value, allows future doctors to develop clinical competencies in modern principles of medical science, personalized medicine, and preventive healthcare strategies","PeriodicalId":140699,"journal":{"name":"Proceedings of the Shevchenko Scientific Society. Medical Sciences","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128377574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}