发布求助
文献互助 智能选刊 最新文献

Alkaloids: Chemistry and Biology最新文献

筛选
英文 中文
Pyrrolizidine Alkaloids. Pyrrolizidine生物碱。
Alkaloids: Chemistry and Biology Pub Date : 2018-01-01 Epub Date: 2018-07-06 DOI: 10.1016/bs.alkal.2018.03.001
Joaquín Tamariz, Eleuterio Burgueño-Tapia, Miguel A Vázquez, Francisco Delgado
{"title":"Pyrrolizidine Alkaloids.","authors":"Joaquín Tamariz,&nbsp;Eleuterio Burgueño-Tapia,&nbsp;Miguel A Vázquez,&nbsp;Francisco Delgado","doi":"10.1016/bs.alkal.2018.03.001","DOIUrl":"https://doi.org/10.1016/bs.alkal.2018.03.001","url":null,"abstract":"<p><p>Naturally occurring pyrrolizidine alkaloids (PAs) are isolated from plants and other sources. The interest of the scientific community in these compounds owes itself to their high toxicity and biological activity, as well as to the challenge of synthesizing their pyrrolizidine scaffold. This review encompasses a wide range of topics found in the literature from 1995 to date, including the occurrence, biosynthesis, toxicity (hepatotoxicity, genotoxicity, and tumorigenicity), biological activity, and pharmacological properties (glycosidase inhibitory activity) of these secondary metabolites. Particular attention is given to the chemistry of PAs, addressing general strategies for formal and total syntheses via amino-based substrates, pyrroles, and pyrrolidine-based derivatives.</p>","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":"80 ","pages":"1-314"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.alkal.2018.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40532752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Benzoxazole Alkaloids: Occurrence, Chemistry, and Biology. 苯并恶唑类生物碱:发生、化学和生物学。
Alkaloids: Chemistry and Biology Pub Date : 2018-01-01 DOI: 10.1016/bs.alkal.2017.12.002
Sitaram Pal, Bhanu Manjunath, Sujit Ghorai, Swarnendu Sasmal
{"title":"Benzoxazole Alkaloids: Occurrence, Chemistry, and Biology.","authors":"Sitaram Pal,&nbsp;Bhanu Manjunath,&nbsp;Sujit Ghorai,&nbsp;Swarnendu Sasmal","doi":"10.1016/bs.alkal.2017.12.002","DOIUrl":"https://doi.org/10.1016/bs.alkal.2017.12.002","url":null,"abstract":"<p><p>Benzoxazole alkaloids exhibit a diverse array of structures and interesting biological activities. In spite of the extensive research done on the synthesis and biology, till date there is no concise update on this class of alkaloids. This chapter summarizes the literature on benzoxazole alkaloids till March 2017, which covers their isolation, characterization, possible biosynthetic origins, biological activities, and major synthetic approaches. These alkaloids have been broadly classified in the context of their sources, namely (i) fungal origin, (ii) marine origin, and (iii) plant origin.</p>","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":"79 ","pages":"71-137"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.alkal.2017.12.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35842516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Moschamine-Related Indole Alkaloids. 与莫沙明相关的吲哚生物碱。
Alkaloids: Chemistry and Biology Pub Date : 2018-01-01 DOI: 10.1016/bs.alkal.2017.12.004
Chengfeng Xia, Xiaogang Tong
{"title":"Moschamine-Related Indole Alkaloids.","authors":"Chengfeng Xia,&nbsp;Xiaogang Tong","doi":"10.1016/bs.alkal.2017.12.004","DOIUrl":"https://doi.org/10.1016/bs.alkal.2017.12.004","url":null,"abstract":"<p><p>Moschamine-related alkaloids originate mainly from feruloylserotonin by cyclization or dimerization. This review provides a comprehensive overview on the achievements in the field of moschamine-related alkaloids. In the isolation part, a detailed structural characterization of moschamine-related alkaloids is followed by their spectral data. Besides the well-known antioxidative activities, other screened biological properties are also outlined. Since their isolation, different protocols have been developed to synthesize these alkaloids. The synthetic part is organized according to the different synthetic methodologies for the formation of key structural elements.</p>","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":"79 ","pages":"139-189"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.alkal.2017.12.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35842513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preface. 前言。
Alkaloids: Chemistry and Biology Pub Date : 2018-01-01 DOI: 10.1016/S1099-4831(18)30022-1
Hans-Joachim Knölker
{"title":"Preface.","authors":"Hans-Joachim Knölker","doi":"10.1016/S1099-4831(18)30022-1","DOIUrl":"https://doi.org/10.1016/S1099-4831(18)30022-1","url":null,"abstract":"","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":"80 ","pages":"ix"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1099-4831(18)30022-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40531743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alkaloid Synthesis Using Organocatalysts. 利用有机催化剂合成生物碱。
Alkaloids: Chemistry and Biology Pub Date : 2018-01-01 Epub Date: 2018-02-01 DOI: 10.1016/bs.alkal.2017.12.001
Hayato Ishikawa, Shinya Shiomi
{"title":"Alkaloid Synthesis Using Organocatalysts.","authors":"Hayato Ishikawa,&nbsp;Shinya Shiomi","doi":"10.1016/bs.alkal.2017.12.001","DOIUrl":"https://doi.org/10.1016/bs.alkal.2017.12.001","url":null,"abstract":"<p><p>This chapter covers the literature since the advent, in the 21st century, of total syntheses of alkaloids using enantio- or diastereoselective organocatalytic reactions to construct the alkaloid scaffolds. The details of these alkaloid syntheses are described separately for each basic skeleton, including indole, indoline, oxindole, and piperidine alkaloids.</p>","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":"79 ","pages":"1-70"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.alkal.2017.12.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35842512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Preface. 前言。
Alkaloids: Chemistry and Biology Pub Date : 2018-01-01 DOI: 10.1016/S1099-4831(18)30008-7
Hans-Joachim Knölker
{"title":"Preface.","authors":"Hans-Joachim Knölker","doi":"10.1016/S1099-4831(18)30008-7","DOIUrl":"https://doi.org/10.1016/S1099-4831(18)30008-7","url":null,"abstract":"","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":"79 ","pages":"ix"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1099-4831(18)30008-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35842518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Rigidins: Isolation, Bioactivity, and Total Synthesis-Novel Pyrrolo[2,3-d]Pyrimidine Analogues Using Multicomponent Reactions. 刚性蛋白:分离、生物活性和全合成——新型吡咯[2,3-d]嘧啶类似物的多组分反应。
Alkaloids: Chemistry and Biology Pub Date : 2018-01-01 Epub Date: 2018-02-06 DOI: 10.1016/bs.alkal.2017.12.003
Aletta E van der Westhuyzen, Liliya V Frolova, Alexander Kornienko, Willem A L van Otterlo
{"title":"The Rigidins: Isolation, Bioactivity, and Total Synthesis-Novel Pyrrolo[2,3-d]Pyrimidine Analogues Using Multicomponent Reactions.","authors":"Aletta E van der Westhuyzen,&nbsp;Liliya V Frolova,&nbsp;Alexander Kornienko,&nbsp;Willem A L van Otterlo","doi":"10.1016/bs.alkal.2017.12.003","DOIUrl":"https://doi.org/10.1016/bs.alkal.2017.12.003","url":null,"abstract":"<p><p>Rigidins (2-6) are pyrrolopyrimidine alkaloids isolated from marine tunicates. Since their isolation, refinement of their total syntheses, and biochemical evaluation, interest toward this pyrrolo[2,3-d]pyrimidine scaffold as a medicinal candidate has been triggered. The derivatization of these natural products has led to the discovery of a novel range of 7-deazahypoxanthines, which exhibit extremely potent anticancer activity in human cancer cell lines. A major breakthrough toward the synthesis of rigidin and various rigidin analogues has been the application of multicomponent reactions (MCRs). The rapid assembly of molecular diversity and flexibility displayed by MCRs makes it an attractive strategy for the preparation of rigidin-inspired small molecules. Furthermore, a number of rigidin-like 7-deazaxanthine compounds have been reported in the literature and the popularity of implementing MCRs to construct these 7-deazaxanthines is highlighted here. It is our hope that the synthetic methods described in this chapter will result in the further generation of rigidin-inspired compounds that will move on from being \"hits\" into \"leads\" in the medicinal chemistry drug discovery pipeline and potentially into anticancer therapeutics.</p>","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":"79 ","pages":"191-220"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.alkal.2017.12.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35842517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Galbulimima Alkaloids. Galbulimima生物碱。
Alkaloids: Chemistry and Biology Pub Date : 2017-01-01 Epub Date: 2017-06-22 DOI: 10.1016/bs.alkal.2017.05.001
Uwe Rinner
{"title":"Galbulimima Alkaloids.","authors":"Uwe Rinner","doi":"10.1016/bs.alkal.2017.05.001","DOIUrl":"https://doi.org/10.1016/bs.alkal.2017.05.001","url":null,"abstract":"<p><p>This chapter provides a comprehensive overview of recent achievements in the area of Galbulimima alkaloids. Following a discussion of the isolation of Galbulimima alkaloids and structural features of members of this fascinating family of secondary metabolites, biological properties of selected compounds are briefly discussed. Furthermore, the proposed biosynthetic routes toward Galbulimima alkaloids are outlined. The main section of the chapter is devoted to a detailed discussion and comparison of all total syntheses of Galbulimima alkaloids published to date.</p>","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":" ","pages":"109-166"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.alkal.2017.05.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35297329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Acridone Alkaloids. 吖啶酮生物碱。
Alkaloids: Chemistry and Biology Pub Date : 2017-01-01 Epub Date: 2017-07-12 DOI: 10.1016/bs.alkal.2017.06.001
Joseph P Michael
{"title":"Acridone Alkaloids.","authors":"Joseph P Michael","doi":"10.1016/bs.alkal.2017.06.001","DOIUrl":"https://doi.org/10.1016/bs.alkal.2017.06.001","url":null,"abstract":"<p><p>There have been substantial developments in the chemistry and biology of the acridone alkaloids in the 16years since the topic was last reviewed in this series of monographs (2000). The present survey covers the literature from mid-1999 to 2016. A brief overview of the biosynthesis of acridone alkaloids is followed by details of the occurrence and characterization of known alkaloids from new sources, and of novel alkaloids. The classes covered include simple acridone alkaloids, C-prenylacridones, furo[3,2-b]- and furo[2,3-c]acridones, pyrano[3,2-b]- and pyrano[2,3-c]acridones, and dimeric alkaloids containing acridone moieties. Syntheses of acridone alkaloids and certain analogs reported during the review period are comprehensively covered. The final section summarizes aspects of their bioactivity, including cytotoxicity and anticancer activity, antimicrobial and antiparasitic properties, and enzyme inhibition. The chapter concludes with a brief description of important bioactive synthetic analogs.</p>","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":" ","pages":"1-108"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.alkal.2017.06.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35343270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Total Synthesis of Lundurine and Related Alkaloids: Synthetic Approaches and Strategies. 环嘌呤及相关生物碱的全合成:合成方法与策略。
Alkaloids: Chemistry and Biology Pub Date : 2017-01-01 Epub Date: 2017-02-28 DOI: 10.1016/bs.alkal.2017.01.001
Shigeru Arai, Masaya Nakajima, Atsushi Nishida
{"title":"Total Synthesis of Lundurine and Related Alkaloids: Synthetic Approaches and Strategies.","authors":"Shigeru Arai,&nbsp;Masaya Nakajima,&nbsp;Atsushi Nishida","doi":"10.1016/bs.alkal.2017.01.001","DOIUrl":"https://doi.org/10.1016/bs.alkal.2017.01.001","url":null,"abstract":"<p><p>This review focuses on the total synthesis of lundurines A-C. Their main structural feature is a unique cyclopropa[b]indole core that has been found only in these alkaloids. In addition to this characteristic structure, the biological activity makes them as attractive synthetic targets. However, almost two decades passed from their isolation and structural determination in 1995 to their first total synthesis. The first part of this review summarizes the synthetic approaches to the tri- and tetracyclic ring systems of lundurine as well as an inter- and intramolecular cyclopropanation strategy that gives the cyclopropa[b]indole core. The second part presents a detailed description of four total syntheses that were reported from 2014 to 2016. In addition, the asymmetric total synthesis of the related alkaloids grandilodine C and lapidilectine B is described.</p>","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":" ","pages":"167-204"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.alkal.2017.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35297331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信