Lens and eye toxicity research最新文献_第6页

Transmission of the normal and cataractous lenses. 正常晶状体和白内障晶状体的透射。

Lens and eye toxicity research Pub Date : 1991-01-01

A Bielski, T Robaczewski, J Wolnikowski, L Bieganowski

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IR spectra of lens crystallins. 透镜晶体的红外光谱。

Lens and eye toxicity research Pub Date : 1991-01-01

J Rózyczka, A Gutsze

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Rapid enhancement of "MIP" 26kDa protein phosphorylation by RF-36 nucleic acid binding protein in lens cells. RF-36核酸结合蛋白快速增强晶状体细胞“MIP”26kDa蛋白磷酸化。

Lens and eye toxicity research Pub Date : 1991-01-01

J H Chen, T C Tong, L Zhang

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Inhibition of bovine lens glutathione S-transferases by hematin, bilirubin, and bromosulfophthalein. 血红素、胆红素和溴磺酞对牛晶状体谷胱甘肽s -转移酶的抑制作用。

Lens and eye toxicity research Pub Date : 1991-01-01

H Ahmad, S V Singh, Y C Awasthi

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Measurements of proton relaxation time T2 on cattle eyes lenses. 牛眼晶状体质子弛豫时间T2的测量。

Lens and eye toxicity research Pub Date : 1991-01-01

A Gutsze, D Deninger, R Olechnowicz, J A Bodurka

{"title":"Measurements of proton relaxation time T2 on cattle eyes lenses.","authors":"A Gutsze, D Deninger, R Olechnowicz, J A Bodurka","doi":"","DOIUrl":"","url":null,"abstract":"A simple two phase model does not explain the temperature dependence of T1 relaxation time in lenses as biological systems. Therefore, a distribution of correlation times of water particles has to be assumed by a certain distribution of the water protein binding energy. As a consequence, from the temperature dependence of T1 relaxation time, the activation energy of water molecules in the lens cannot be evaluated directly without the knowledge of the distribution width. This problem can be solved by T2 measurements in lenses. From the slope of T2 as a function of temperature, mean activation energy can be calculated independently on the distribution width. Measurements were performed on lenses originating from 5-7 years old cows, 2-year old bull-calfs and a 12-year old bull in the temperature range -30 to +105 degrees C. It could be demonstrated that about 80% of water behaves as liquid-like water with an activation energy 14 +/- 4 kJ/mol corresponding to the value of free water. The remaining water (about 20%) is bound to the protein with an activation energy of 20 +/- 5 kJ/mol. At 42 degrees C the protein denaturation process starts in the eye lens and will be completed by 70 degrees C, yielding a protein bound-water complex.","PeriodicalId":17964,"journal":{"name":"Lens and eye toxicity research","volume":"8 2-3","pages":"155-62"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12820508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Elemental profiles in Emory mouse lens. Emory小鼠镜头的元素轮廓。

Lens and eye toxicity research Pub Date : 1991-01-01

M Bagchi, K Emanuel

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Components of light scattered by eye lens. 由眼晶状体散射的光的组成部分。

Lens and eye toxicity research Pub Date : 1991-01-01

M Pyskir, B Grzegorzewski, A Gutsze

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Structure/function relationship between optics and biochemistry of the lens. 光学与透镜生物化学的结构/功能关系。

Lens and eye toxicity research Pub Date : 1991-01-01

B K Pierscionek, R C Augusteyn

{"title":"Structure/function relationship between optics and biochemistry of the lens.","authors":"B K Pierscionek, R C Augusteyn","doi":"","DOIUrl":"","url":null,"abstract":"The lens is an important element in the optical system of the eye. It has a gradient of refractive index for purposes of aberration control and in order to provide the ocular system with sufficient power. The lens also contains unique structural proteins. Although much work has been done to characterize the lens proteins, a structure/function relationship between these entities and the optics of the normal lens had not been previously considered. To investigate if such a relationship exists, biochemical and optical investigations were carried out under the common theme of development and aging. Investigations of distribution patterns of the three protein classes and measurements of the refractive index gradient were made on bovine and human lenses over wide age ranges. The results of these studies were compared. Although there was no direct evidence of a link between a single protein class and the index gradient, there are hints from interspecies comparison, that the level of LMW proteins may determine the magnitude of the refractive index. It is also possible that the insoluble fraction, which bears the greatest relationship in trend to the refractive index gradient, may represent proteins (largely pounds-crystallins) which have been structurally altered in situ in order for the lens to maintain viable optical function under the conditions of continual growth and aging.","PeriodicalId":17964,"journal":{"name":"Lens and eye toxicity research","volume":"8 2-3","pages":"229-43"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13070534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationships between human cataracts and environmental radiant energy. Cataract formation, light scattering and fluorescence. 人类白内障与环境辐射能的关系。白内障的形成、光散射和荧光。

Lens and eye toxicity research Pub Date : 1991-01-01

S Zigman, G Sutliff, M Rounds

{"title":"Relationships between human cataracts and environmental radiant energy. Cataract formation, light scattering and fluorescence.","authors":"S Zigman, G Sutliff, M Rounds","doi":"","DOIUrl":"","url":null,"abstract":"This preliminary report has two parts. The first is based upon data obtained from a group of cataract patients in southern Florida (USA) with the object of relating the types of cataracts removed to their personal background and their protein biochemistry. Intra-capsular cataract surgery patients at the Venice Eye Clinic (Florida) were interviewed, and their extracted lenses were classified. The parameters were: age, place of residency, occupation, medical and family history and indoor/outdoor activity. Subcapsular cataracts were found mainly in the youngest patients and in those who were in Florida the least. Mixed cataracts predominated in the oldest patients, while non-nuclear cataracts were associated most with outdoor activity. Water-insoluble protein was elevated in nuclei of lenses with nuclear opacities. Soluble proteins in the nuclei of nuclear cataracts had increased levels of voided (heavy) protein, beta-crystallins, and less than 20 Kd peptides. The above changes were enhanced in brunescent cataracts. In lenses with cortical opacities, only increased size heterogeneity in the beta-crystallin region was observed. The second part of this report is based upon direct measurements of the optical properties of freshly extracted intra-capsular cataracts obtained in Rochester, New York (USA). The purpose was to attempt to learn the relative contributions that absorption, scattering, and fluorescence make toward obscuring vision. A general conclusion is that the shorter wavelengths of radiant energy in environmental lighting influence the above-stated optical properties the most, and thus appear to be the major contributors to obscured vision.","PeriodicalId":17964,"journal":{"name":"Lens and eye toxicity research","volume":"8 2-3","pages":"259-80"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13070537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proceedings of an international conference on The Lens: Physical and Biochemical Properties. Bydgoszcz, Poland, August 6-9, 1990. 透镜:物理和生化性质国际会议论文集。1990年8月6日至9日，波兰比得哥什。

Lens and eye toxicity research Pub Date : 1991-01-01

引用次数: 0