EJC Skin Cancer最新文献

{"title":"Validation of a prognostic microRNA signature in early-stage melanoma across NanoString and RNA-sequencing platforms","authors":"Ryan Van Laar ,&nbsp;Lauren Coombs ,&nbsp;Christopher Love ,&nbsp;Chris Barnes ,&nbsp;Luke Bookallil ,&nbsp;Catherine Uzzel ,&nbsp;Mirette Saad ,&nbsp;Ingrid Winship ,&nbsp;Peter Kaub ,&nbsp;Anthony Langren","doi":"10.1016/j.ejcskn.2026.101127","DOIUrl":"10.1016/j.ejcskn.2026.101127","url":null,"abstract":"<div><h3>Background</h3><div>Most patients with early-stage invasive melanoma have excellent outcomes, yet a minority experience disease progression and melanoma-specific death. Identifying these high-risk patients at diagnosis remains a significant clinical challenge. We previously validated the MEL12 microRNA signature as a prognostic biomarker in plasma samples. Here, we evaluate whether this signature retains its prognostic value when measured in formalin-fixed paraffin-embedded (FFPE) tumour tissue and assess its performance across two microRNA expression profiling platforms.</div></div><div><h3>Methods</h3><div>We conducted a retrospective analysis of 277 stage I–II melanoma patients with up to 15-year survival data, stratified into training (n = 179) and independent validation (n = 98) cohorts. MicroRNA expression profiling was performed using both NanoString and RNA-sequencing platforms. A principal component-based Cox regression model was developed using leave-one-out cross-validation in the training cohort, with frozen model parameters applied to the validation cohort. The primary endpoint was melanoma-specific survival (MSS), with overall survival (OS) as secondary endpoint.</div></div><div><h3>Results</h3><div>In the training cohort, the MEL12 score showed strong prognostic performance for MSS (C-index=0.82, HR=5.32 per SD, p &lt; 0.001) and OS (C-index=0.73, HR=2.90 per SD, p &lt; 0.001). These findings were confirmed in independent validation for both MSS (C-index=0.77, HR=3.34, p = 0.002) and OS (C-index=0.63, HR=1.28, p = 0.17). High-risk patients experienced significantly worse 15-year MSS in both cohorts (training HR=9.61, p &lt; 0.001; validation HR=8.40, p &lt; 0.001). In multivariable analysis adjusting for clinicopathologic variables, the MEL12 score remained independently associated with MSS and platform analysis revealed no significant interaction between MEL12 score and measurement platform.</div></div><div><h3>Conclusions</h3><div>The MEL12 microRNA signature represents a potentially valuable prognostic biomarker for identifying early-stage melanoma patients at high risk of poor outcomes, maintaining consistent performance when measured in FFPE tissue across different expression profiling platforms. These results support further investigation into integrating genomic risk stratification with traditional histopathologic assessment.</div></div>","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 101127"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147537852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of newly diagnosed primary melanoma: a retrospective multicenter study before and four years after the COVID-19 pandemic onset","authors":"E. Pennacchioli ,&nbsp;L. Nespoli ,&nbsp;D. Piazzalunga ,&nbsp;V. Caliendo ,&nbsp;P. Rossi ,&nbsp;M. Clementi ,&nbsp;M. Mascherini ,&nbsp;F. Cananzi ,&nbsp;S. Asero ,&nbsp;C. Caracò ,&nbsp;P. Carcoforo ,&nbsp;P. Del Fiore ,&nbsp;C. Trevisol ,&nbsp;F. Cavallin ,&nbsp;A. Buja ,&nbsp;P. Gallina ,&nbsp;M. Rastrelli","doi":"10.1016/j.ejcskn.2026.100806","DOIUrl":"10.1016/j.ejcskn.2026.100806","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100806"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence-based smartphone app for skin cancer detection: a prospective diagnostic accuracy study","authors":"J. Kips ,&nbsp;J. Papeleu ,&nbsp;A. Shen ,&nbsp;S. Mylle ,&nbsp;E. Genouw ,&nbsp;I. Hoorens ,&nbsp;E. Verhaeghe ,&nbsp;L. Brochez","doi":"10.1016/j.ejcskn.2026.100798","DOIUrl":"10.1016/j.ejcskn.2026.100798","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100798"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and dermatoscopic assessment of the probability of developing skin melanoma in the population of the Republic of Belarus","authors":"A. Prakoshyn ,&nbsp;A. Zhukavets","doi":"10.1016/j.ejcskn.2026.100805","DOIUrl":"10.1016/j.ejcskn.2026.100805","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100805"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection patterns, reasons for consultation, and sex differences in melanoma prognosis among young adults: a 30-year retrospective cohort study","authors":"B. Rodríguez-Sánchez,&nbsp;J. Martín-Nieto González,&nbsp;M. de la Puente-Alonso,&nbsp;L.Á. Zamarro-Díaz,&nbsp;D. de Ramón-Rueda,&nbsp;A. Fuentes-Bellas,&nbsp;R. Horcajo-Ortega,&nbsp;V. Robles-Almazán,&nbsp;A. Bergaz-Alonso,&nbsp;L. Jiménez-Briones,&nbsp;M. Córdoba García-Rayo,&nbsp;P. García-Piqueras,&nbsp;E. Rodríguez-Lomba,&nbsp;P. de la Cueva-Dobao,&nbsp;J.A. Avilés-Izquierdo","doi":"10.1016/j.ejcskn.2026.100823","DOIUrl":"10.1016/j.ejcskn.2026.100823","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100823"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological trends of pediatric melanoma: A 35-year single-center experience with 82 patients","authors":"C. Barbieri ,&nbsp;E. Tolomio ,&nbsp;B.M. Scoppio ,&nbsp;G. Spadola ,&nbsp;S. Mercurio ,&nbsp;R. Patuzzo ,&nbsp;G. Gallino ,&nbsp;I. Mattavelli ,&nbsp;D. Cortese ,&nbsp;B. Taglione ,&nbsp;B. Valeri ,&nbsp;M. Cossa ,&nbsp;A. Maurichi ,&nbsp;M. Santinami","doi":"10.1016/j.ejcskn.2026.100829","DOIUrl":"10.1016/j.ejcskn.2026.100829","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100829"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lethal myositis with predominant involvement of the cardiac and respiratory muscles during checkpoint inhibitor monotherapy for metastatic malignant melanoma","authors":"J.N. Kern ,&nbsp;K.-C. Klespe ,&nbsp;I. von Wasielewski","doi":"10.1016/j.ejcskn.2026.100853","DOIUrl":"10.1016/j.ejcskn.2026.100853","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100853"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality trends of melanoma in Germany from 2001 to 2020","authors":"L. Nanz,&nbsp;C. Garbe,&nbsp;U. Leiter","doi":"10.1016/j.ejcskn.2026.100864","DOIUrl":"10.1016/j.ejcskn.2026.100864","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100864"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of Lentigo Maligna presenting as repigmentation of hair in a scalp that previously underwent radiotherapy for tinea capitis","authors":"M. Kelly,&nbsp;R. Miller","doi":"10.1016/j.ejcskn.2026.100787","DOIUrl":"10.1016/j.ejcskn.2026.100787","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100787"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of melanoma arising in a long-standing intradermal nevus.","authors":"D. Kakulashvili","doi":"10.1016/j.ejcskn.2026.100788","DOIUrl":"10.1016/j.ejcskn.2026.100788","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100788"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}