EHP toxicogenomics : journal of the National Institute of Environmental Health Sciences最新文献_第2页

Liver library. Creating a microarray for hepatotoxicants. 肝库。制造肝毒物微阵列。

EHP toxicogenomics : journal of the National Institute of Environmental Health Sciences Pub Date : 2003-01-01 DOI: 10.1289/ehp.111t-a26

Victoria McGovern

引用次数: 0

Monitoring estrogenic effects. A genomics approach. 监测雌激素效应。基因组学方法。

EHP toxicogenomics : journal of the National Institute of Environmental Health Sciences Pub Date : 2003-01-01 DOI: 10.1289/ehp.111t-a27

Mary Eubanks

引用次数: 0

Toxicogenomics. An emerging discipline. Toxicogenomics。新兴学科。

EHP toxicogenomics : journal of the National Institute of Environmental Health Sciences Pub Date : 2003-01-01 DOI: 10.1289/ehp.111t-a20

Charles W Schmidt

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The human proteome organization (HUPO) and environmental health. 人类蛋白质组组织(HUPO)与环境健康。

EHP toxicogenomics : journal of the National Institute of Environmental Health Sciences Pub Date : 2003-01-01

B Alex Merrick

{"title":"The human proteome organization (HUPO) and environmental health.","authors":"B Alex Merrick","doi":"","DOIUrl":"","url":null,"abstract":"The Human Proteome Organization, or HUPO, was formed to promote research and large-scale analysis of the human proteome. By consolidating national proteome organizations into an international body, HUPO will coordinate international initiatives, biological resources, protocols, standards and data for studying the human proteome. HUPO has identified five key areas to advance study of the human proteome, specifically in bioinformatics, new technologies, the plasma proteome, cell models, and a public antibody initiative. Consideration of three major issue areas may help develop HUPO's strategy for human proteome study. First is the need to distinguish the value of high throughput platforms from discovery platforms in proteomics. Second is the importance for international planning on integrating both transcriptome and proteome data and databases. Last is that effects of the environment from chemical, physical, and biological exposures alter the expression and structure of the proteome, which become manifest in long-term adverse health effects and disease. Environmental health research stands to greatly benefit from the shared resources, data, and vision of the HUPO organization as a valuable resource in exploiting knowledge of the human proteome toward improving public health.","PeriodicalId":84641,"journal":{"name":"EHP toxicogenomics : journal of the National Institute of Environmental Health Sciences","volume":"111 1T","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22374942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene expression profiles associated with inflammation, fibrosis, and cholestasis in mouse liver after griseofulvin. 灰黄霉素后小鼠肝脏炎症、纤维化和胆汁淤积相关的基因表达谱。

EHP toxicogenomics : journal of the National Institute of Environmental Health Sciences Pub Date : 2003-01-01

Timothy W Gant, Petra R Baus, Bruce Clothier, Joan Riley, Reginald Davies, David J Judah, Richard E Edwards, Elisabeth George, Peter Greaves, Andrew G Smith

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引用次数: 0

Gene expression profiles associated with inflammation, fibrosis, and cholestasis in mouse liver after griseofulvin. 灰黄霉素后小鼠肝脏炎症、纤维化和胆汁淤积相关的基因表达谱。

EHP toxicogenomics : journal of the National Institute of Environmental Health Sciences Pub Date : 2002-11-18 DOI: 10.1289/TXG.5849

T. Gant, Petra R Baus, B. Clothier, J. Riley, R. Davies, D. Judah, R. Edwards, E. George, P. Greaves, Andrew G Smith

{"title":"Gene expression profiles associated with inflammation, fibrosis, and cholestasis in mouse liver after griseofulvin.","authors":"T. Gant, Petra R Baus, B. Clothier, J. Riley, R. Davies, D. Judah, R. Edwards, E. George, P. Greaves, Andrew G Smith","doi":"10.1289/TXG.5849","DOIUrl":"https://doi.org/10.1289/TXG.5849","url":null,"abstract":"Erythropoietic protoporphyria patients can develop cholestasis, severe hepatic damage, fibrosis, and cirrhosis. We modeled this hepatic pathology in C57BL/6J and BALB/c mice using griseofulvin and analyzed 3,127 genes for alteration of expression in the liver before and during the onset of protoporphyria, cholestasis, inflammation, and hepatic fibrosis. The two mouse strains developed different levels of pathologic damage in response to the griseofulvin. Characteristic gene expression profiles could be associated with griseofulvin-induced gene expression, disruption of lipid metabolism, and the pathologic states of inflammation, early fibrosis, and cholestasis. Additionally, some genes individually indicated an alteration of homeostasis. or pathologic state; for example, fibroblast proliferation was potentially indicated by increased calcyclin (SA100a6) expression. Changes in cytochrome P450 (Cyp) gene expression were particularly pronounced, with increased expression of the Cyp2a, Cyp2b, and Cyp3a families. Decreased Cyp4a10 and Cyp4a14 expression was observed that could be associated with early pathologic change. A potential decrease in bile acid and steroid biosynthesis was indicated by the decreased expression of Cyp7b1 and Hsd3b4, respectively. DNA damage was indicated by induction of GADD45. This study illustrates how transcriptional programs can be associated with different stimuli in the same experiment. The time course of change in the gene expression profile compared with changes in pathology and clinical chemistry shows the potential of this approach for modeling causative, predictive, and adaptive changes in gene expression during pathologic change.","PeriodicalId":84641,"journal":{"name":"EHP toxicogenomics : journal of the National Institute of Environmental Health Sciences","volume":"111 1T 1","pages":"37-43"},"PeriodicalIF":0.0,"publicationDate":"2002-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66643041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5