Neurophysiology最新文献

{"title":"Effects of Galarmin and Cobra Venom on the Morphofunctional State of the Substantia Nigra in a Rat Model of Parkinson’s Disease","authors":"M. Danielyan, K. V. Кarapetyan, K. Nebogova, O. H. Nazaryan, V. P. Khachatryan","doi":"10.1007/s11062-021-09909-1","DOIUrl":"https://doi.org/10.1007/s11062-021-09909-1","url":null,"abstract":"","PeriodicalId":19141,"journal":{"name":"Neurophysiology","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83367339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analgesic Action of Invasive Carboxytherapy: Mechanisms and Applications","authors":"N. Seredynska, S. Drogovoz, E. G. Shchokina, L. B. Ivantsyk, Yurii Stoletov, A. Shtroblya, I. Kireyev","doi":"10.1007/s11062-021-09913-5","DOIUrl":"https://doi.org/10.1007/s11062-021-09913-5","url":null,"abstract":"","PeriodicalId":19141,"journal":{"name":"Neurophysiology","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75564197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Acute Ethanol Intoxication on Local Field Potentials in the Rat Lateral Septum","authors":"O. Chaikovska, I. Rokunets, O. Dovhan, O. V. Vlasenko","doi":"10.1007/s11062-021-09910-8","DOIUrl":"https://doi.org/10.1007/s11062-021-09910-8","url":null,"abstract":"","PeriodicalId":19141,"journal":{"name":"Neurophysiology","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86717461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulatory Effects of Stevia Rebaudiana on NADPH Oxidase-Related Manifestations of Oxidative Stress in Diabetic Rats with Spinal Cord Injury","authors":"K. Simonyan, V. Chavushyan, L. Avetisyan, R. Simonyan, A. Isoyan, G. Simonyan, L. Hovhannisyan, M. Simonyan","doi":"10.1007/s11062-021-09908-2","DOIUrl":"https://doi.org/10.1007/s11062-021-09908-2","url":null,"abstract":"","PeriodicalId":19141,"journal":{"name":"Neurophysiology","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88073731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrahippocampal Injections of Ghrelin and Aerobic Physical Exercise: Effects on Learning and Passive Avoidance Memory in Rats","authors":"M. Farzin, P. Babaei, M. Rostampour","doi":"10.1007/s11062-021-09912-6","DOIUrl":"https://doi.org/10.1007/s11062-021-09912-6","url":null,"abstract":"","PeriodicalId":19141,"journal":{"name":"Neurophysiology","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82624762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Levels of the Biomarkers Associated with Astrocytosis, Neurodegeneration, and Demyelination: Neurological Benefits of Citicoline Treatment of Patients with Ischemic Stroke and Atrial Fibrillation.","authors":"O V Kuryata, Yu S Kushnir, V S Nedzvetsky, V V Korsa, A A Tykhomyrov","doi":"10.1007/s11062-021-09907-3","DOIUrl":"10.1007/s11062-021-09907-3","url":null,"abstract":"<p><p>Ischemic stroke is a main complication of atrial fibrillation (cardiac arrhythmia). The aim of our study was to estimate the effects of citicoline (CDP-choline) therapy on the levels of circulating neurospecific protein markers in serum of the patients with ischemic stroke and atrial fibrillation. Fiftyfour patients (mean age 76 years) treated with citicoline in a dose of 2.0 g daily intravenously for 12 to 14 days in addition to basic treatment formed the examined group. Thirty-two patients (mean age 68.5 years) obtained only standard therapy and formed the control group. Serum levels of neuronal and glial protein markers, including glial fibrillary acidic protein (GFAP), a neurofilament light subunit (NF-L), myelin basic protein (MBP), and ionized calcium-binding adaptor molecule 1 (Iba1), were measured in patients of both groups before and after treatment; an immunoblotting technique followed by densitometry analysis were used. Supplementary citicoline treatment provided significant reductions of the levels of GFAP (33%, <i>P</i> = 0.034), NF-L (27%, <i>P</i> = 0.019), and MBP (32%, <i>P</i> = 0.018), as compared to the initial values, while there were no marked changes in the studied parameters in the control group. The results obtained allow us to hypothesize that therapeutic benefit of citicoline in patients with ischemic stroke and atrial fibrillation can be mediated through increasing neuronal viability, protecting against axonal injury, decreasing the level of reactive astrogliosis, preventing deficiencies in the blood-brain integrity, and reducing the intensity of demyelination. However, citicoline administration exerted no effect on the blood content of microglial marker Iba-1, thus possibly preserving an important functional significance of microglia, which is needed to resolve local inflammation and clear cellular debris, and also provide protective factors to reduce cell injury in the ischemic brain. The obtained results indicate that serum levels of neurospecific biomarkers are significant and clinically relevant indices of the efficiency of treatment of the above-mentioned pathologies and can be used for further investigations of the stroke pathophysiology and molecular mechanisms of nootropic-mediated neuroprotection.</p>","PeriodicalId":19141,"journal":{"name":"Neurophysiology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39782670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial 1.","authors":"","doi":"10.1007/s11062-022-09926-8","DOIUrl":"https://doi.org/10.1007/s11062-022-09926-8","url":null,"abstract":"","PeriodicalId":19141,"journal":{"name":"Neurophysiology","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40392821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central Serotonergic Trophic Support of the Retina: Its Impairment in Retinitis Pigmentosa (in an Animal Model and in Clinics)","authors":"A. Mekhtiev, U. S. Ismailova","doi":"10.1007/s11062-021-09911-7","DOIUrl":"https://doi.org/10.1007/s11062-021-09911-7","url":null,"abstract":"","PeriodicalId":19141,"journal":{"name":"Neurophysiology","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76832979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethical Responsibilities of the Authors","authors":"","doi":"10.1007/s11062-021-09906-4","DOIUrl":"https://doi.org/10.1007/s11062-021-09906-4","url":null,"abstract":"","PeriodicalId":19141,"journal":{"name":"Neurophysiology","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80602942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viktor S. Gurfinkel (1922–2020)","authors":"","doi":"10.1007/s11062-021-09915-3","DOIUrl":"https://doi.org/10.1007/s11062-021-09915-3","url":null,"abstract":"","PeriodicalId":19141,"journal":{"name":"Neurophysiology","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79479510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}