发布求助
文献互助 智能选刊 最新文献

Advances in Testosterone Action最新文献

筛选
英文 中文
Influence of Testosterone on Body and Testicular Development in Zebu Cattle in the Tropical Climate 睾酮对热带气候条件下泽布牛身体和睾丸发育的影响
Advances in Testosterone Action Pub Date : 2018-11-21 DOI: 10.5772/INTECHOPEN.76706
M. G. Chacur, A. Arikawa, E. Oba, C. D. Souza, LuisRoberto Gabriel Filho
{"title":"Influence of Testosterone on Body and Testicular Development in Zebu Cattle in the Tropical Climate","authors":"M. G. Chacur, A. Arikawa, E. Oba, C. D. Souza, LuisRoberto Gabriel Filho","doi":"10.5772/INTECHOPEN.76706","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.76706","url":null,"abstract":"The Brahman cattle is mainly used for breeding and the meat industry. The present chapter had the objective of evaluating the physical and testicular development, and the serum testosterone level of 8–18 months old male Brahman cattle on grazing weight gain - ing performance tests. In Bos indicus , puberty usually occurs between the ages of 16 and 18 months. Variables such age, weight, and scrotal circumference were equally important in the estimation of sexual maturity in male Bos indicus. An increase in serum testosterone level occurred between 12 and 14 months of age, followed by testicular and body growth. An elevation in testosterone levels is an indicator that an acceleration in physical and tes ticular growth is approaching. The variables body weight and scrotal circumference which are important in the estimation of sexual maturity are dependent on testosterone levels in zebu cattle according to literature. It is recommended to calculate body mass index and tes - ticular volume to follow male growth due to the high correlation between these variables.","PeriodicalId":178043,"journal":{"name":"Advances in Testosterone Action","volume":"243 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115603003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Effects of Dehydroepiandrosterone (DHEA) Supplementation to Improve Ovarian Response and IVF Outcomes on Women with Poor Ovarian Response 补充脱氢表雄酮(DHEA)对改善卵巢反应差的女性卵巢反应和体外受精结果的影响
Advances in Testosterone Action Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.79320
J. F. Macedo, M. Oliveira, O. Martins
{"title":"Effects of Dehydroepiandrosterone (DHEA) Supplementation to Improve Ovarian Response and IVF Outcomes on Women with Poor Ovarian Response","authors":"J. F. Macedo, M. Oliveira, O. Martins","doi":"10.5772/INTECHOPEN.79320","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.79320","url":null,"abstract":"There is still no clear consensus on the poor responder (PR) definition, however, the European Society of Human Reproduction and Embryology (ESHRE) suggested, in 2011, the Bologna criteria, which includes, for a poor ovarian response definition, at least two of the following three characteristics: age > 40 years, the number of oocytes previously recovered equal to or less than three, and low ovarian reserve tests score. It is noticed that, despite the use of different effective ovulation stimulation protocols, clinical pregnancy rates remain low in PR. In recent years, however, many authors, including Casson et al., reported the beneficial of DHEA supplementation on ovarian response in this group. Dehydroepiandrosterone (DHEA), a precursor of estradiol (E2) and testosterone (T), orig- inates from the reticularis adrenal zone and from ovarian theca cell. In this chapter, we intend to demonstrate the potential benefits of DHEA supplementation in women with poor response in IVF outcomes.","PeriodicalId":178043,"journal":{"name":"Advances in Testosterone Action","volume":"104 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122565172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Morphological Bases of Human Leydig Cell Dysfunction 人间质细胞功能障碍的形态学基础
Advances in Testosterone Action Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.79201
M. Miguel, P. Gónzalez‐Peramato, M. Nistal
{"title":"Morphological Bases of Human Leydig Cell Dysfunction","authors":"M. Miguel, P. Gónzalez‐Peramato, M. Nistal","doi":"10.5772/INTECHOPEN.79201","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.79201","url":null,"abstract":"In this chapter, we describe the histophysiology of human Leydig cells, their cytologi- cal characteristics, their differentiation processes, and the physiopathological processes occurring at various times throughout life. We first focus on the normal development of fetal Leydig cells as well as the pathologies of fetal Leydig cells that can affect num bers or hyperplasic processes (e.g., hypogonadotropic hypogonadism, cryptorchidism, congenital Leydig cell hyperplasia secondary to diabetes, and isoimmunization). Next, we explain the changes occurring at puberty with the onset and differentiation of adult Leydig cells and the pathophysiology of delayed puberty. We then describe the histophysiology of adult Leydig cells and the most frequent pathologies (e.g., hypogo- nadotropic hypogonadism, testicular dysgenesia, mild androgen insensitivity syndrome, 5-α-reductase defect, and Klinefelter syndrome). Finally, we discuss the morphological changes of these cells in the elderly.","PeriodicalId":178043,"journal":{"name":"Advances in Testosterone Action","volume":"230 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116170911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The Biological Role of Androgen Receptor in Prostate Cancer Progression 雄激素受体在前列腺癌进展中的生物学作用
Advances in Testosterone Action Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.76360
Ken-ichi Takayama
{"title":"The Biological Role of Androgen Receptor in Prostate Cancer Progression","authors":"Ken-ichi Takayama","doi":"10.5772/INTECHOPEN.76360","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.76360","url":null,"abstract":"Prostate cancer is the most commonly diagnosed cancer in men all over the world. Localized cancers in the early stages can be well managed by surgical or radiation therapy. Metastatic prostate cancer is treated with androgen deprivation therapy because androgen signaling is essential to the prostate tumor growth and anti-apoptotic ability. However, resistance develops quickly in the clinical course and leads to castration-resis- tant prostate cancer (CRPC). Androgen receptor (AR) functions as a nuclear receptor to facilitate ligand-dependent transcriptional activation in the nucleus. AR interacts with several tissue-specific transcription factors such as forkhead box protein A1 (FOXA1) and regulates epigenetic status by recruiting epigenetic factors. In addition, AR transcriptional activity is modulated by interacting directly or indirectly with non-coding RNAs such as long non-coding RNAs (lncRNAs) and micro RNAs (miRNAs). Notably, enhanced AR signaling in CRPC has been documented in several studies; however, which of these factors are important for the biological function it remains poorly understood. Here, I review our current knowledge of the mechanistic roles of AR involved in prostate cancer progression and discuss the importance of the prostate cancer-associated signals.","PeriodicalId":178043,"journal":{"name":"Advances in Testosterone Action","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128197604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信