Immuno-Analyse & Biologie Specialisee最新文献_第8页

The Role of APOE and NF-κB in Alzheimer’s Disease APOE和NF-κB在阿尔茨海默病中的作用

Immuno-Analyse & Biologie Specialisee Pub Date : 2021-10-28 DOI: 10.3390/immuno1040027

D. A. Davies

引用次数: 4

Recent Advances in Understanding the Role of TIGIT+ Follicular Helper T Cells in IgG4-Related Disease TIGIT+滤泡辅助性T细胞在igg4相关疾病中的作用研究进展

Immuno-Analyse & Biologie Specialisee Pub Date : 2021-10-26 DOI: 10.3390/immuno1040026

M. Akiyama, Y. Kaneko

{"title":"Recent Advances in Understanding the Role of TIGIT+ Follicular Helper T Cells in IgG4-Related Disease","authors":"M. Akiyama, Y. Kaneko","doi":"10.3390/immuno1040026","DOIUrl":"https://doi.org/10.3390/immuno1040026","url":null,"abstract":"IgG4-related disease (IgG4-RD) is a fibro-inflammatory disease characterized by elevated serum IgG4 levels and massive infiltration of IgG4+plasma cells. Although storiform fibrosis, obliterative phlebitis and IgG4+plasma cell infiltration are well described pathological features in this disease, the excessive formation of tertiary lymphoid organs (TLOs), particularly in the early phase of the disease lesions, has gained much attention. TLOs of IgG4-RD are orchestrated by specific immune cell subsets including follicular helper T cells (Tfh), CD20+ B cells, and CD21+ follicular dendritic cells (FDCs). Tfh is the key player of this disease because recent studies have suggested the pathological role of this immune cell subset in formation of TLOs, helping IgG4+plasma cell differentiation, inducing storiform fibrosis by secreting interleukin-4, and activating cytotoxic T cells by secreting interleukin-21. We have recently identified a new Tfh subset which expresses T cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT). TIGIT+Tfh efficiently produces interleukin-21 through OX40 signal, and the increase in peripheral TIGIT+Tfh cells reflects disease activity in IgG4-RD. TIGIT is important to mediate the retention and positioning of TIGIT+Tfh within TLOs through interaction with CD155 expressed on CD21+ FDCs. In this review, we summarize and discuss recent progress in understanding the pathogenesis of IgG4-RD, focusing on TIGIT+Tfh.","PeriodicalId":55599,"journal":{"name":"Immuno-Analyse & Biologie Specialisee","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84943189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Immune Responses Are Differentially Regulated by Root, Stem, Leaf, and Flower Extracts of Female and Male CBD Hemp (Cannabis sativa L.) Plants 雌雄CBD大麻(Cannabis sativa L.)根、茎、叶和花提取物对免疫反应的差异调节植物

Immuno-Analyse & Biologie Specialisee Pub Date : 2021-10-22 DOI: 10.3390/immuno1040025

Laura G. A. Esposito, E. Overbaugh, J. Xiong, Thirumurugan Rathinasabapathy, S. Komarnytsky, D. D. da Silva, D. Esposito

{"title":"Immune Responses Are Differentially Regulated by Root, Stem, Leaf, and Flower Extracts of Female and Male CBD Hemp (Cannabis sativa L.) Plants","authors":"Laura G. A. Esposito, E. Overbaugh, J. Xiong, Thirumurugan Rathinasabapathy, S. Komarnytsky, D. D. da Silva, D. Esposito","doi":"10.3390/immuno1040025","DOIUrl":"https://doi.org/10.3390/immuno1040025","url":null,"abstract":"Industrial hemp (Cannabis sativa L.) has many applications, including the production of textiles, agricultural extracts, nutritional products, and botanicals enriched with cannabinoids and full-spectrum terpenes naturally present in the plant. In this study, the dynamics of distribution and accumulation of 10 main cannabinoids in hemp were quantified. Hemp bioactive compounds were evaluated for anti-inflammatory activity in lipopolysaccharide-induced RAW 264.7 macrophage cells. While all tissues of hemp showed moderate anti-inflammatory properties, female flowers demonstrated the highest activity. CBD showed the strongest anti-inflammatory activity with suppression of nitric oxide production at 2 μg/mL and the reduced expressions of the pro-inflammatory genes COX-2, IL-6, and TNF-α at as low as 2 ng/mL. The topical hemp inflorescences (1–50 μg/mL) and CBD alone (20–200 ng/mL) also improved mitochondrial respiration. These data contribute to the future development of agricultural and plant management techniques to produce hemp with specific metabolite profiles to selectively support immune health.","PeriodicalId":55599,"journal":{"name":"Immuno-Analyse & Biologie Specialisee","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91320611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Lymphocyte-to-Monocyte Ratio as a Marker for Endoscopic Activity in Ulcerative Colitis 淋巴细胞/单核细胞比值作为溃疡性结肠炎内镜下活动的标志

Immuno-Analyse & Biologie Specialisee Pub Date : 2021-10-03 DOI: 10.3390/immuno1040024

Natsuki Ishida, Satoru Takahashi, Y. Asai, Takahiro Miyazu, Satoshi Tamura, Shinya Tani, M. Yamade, M. Iwaizumi, Yasushi Hamaya, S. Osawa, T. Furuta, K. Sugimoto

{"title":"Lymphocyte-to-Monocyte Ratio as a Marker for Endoscopic Activity in Ulcerative Colitis","authors":"Natsuki Ishida, Satoru Takahashi, Y. Asai, Takahiro Miyazu, Satoshi Tamura, Shinya Tani, M. Yamade, M. Iwaizumi, Yasushi Hamaya, S. Osawa, T. Furuta, K. Sugimoto","doi":"10.3390/immuno1040024","DOIUrl":"https://doi.org/10.3390/immuno1040024","url":null,"abstract":"Leukocyte subtypes can be used to evaluate the severity of ulcerative colitis (UC). In this study, we examined the relationship between the lymphocyte-to-monocyte ratio (LMR) and the Mayo endoscopic score (MES) in assessing endoscopic activity in UC. Eighty-nine samples of leukocyte subtypes and biomarkers, including fecal calprotectin (FC), the fecal immunochemical occult blood test (FIT), and C-reactive protein (CRP), from 71 patients with UC were retrospectively investigated, along with the MES. The MES was significantly correlated with the LMR, FC, the FIT, and CRP. There were significant differences in the LMR, FC, the FIT, and CRP between groups with an MES < 1 and >2 (p = 0.001, p = 0.003, p < 0.001, and p < 0.001, respectively). In the receiver operating characteristic (ROC) analysis for predicting mucosal healing (MES 0 or 1), the areas under the curve (AUCs) for the LMR, FC, the FIT, and CRP, were 0.712, 0.860, 0.908, and 0.796, respectively. In the analysis of patients without immunomodulators, the correlation of the MES with the LMR and CRP was significant. The LMR can be used to assess endoscopic activity in UC, particularly in patients without immunomodulators.","PeriodicalId":55599,"journal":{"name":"Immuno-Analyse & Biologie Specialisee","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88222595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Ischaemic Stroke in Infective Endocarditis: Pathophysiology and Clinical Outcomes in Patients Treated with Reperfusion Therapy 感染性心内膜炎并发急性缺血性卒中:再灌注治疗患者的病理生理学和临床结果

Immuno-Analyse & Biologie Specialisee Pub Date : 2021-09-24 DOI: 10.3390/immuno1040023

Rohan Maheshwari, D. Wardman, D. Cordato, S. Bhaskar

引用次数: 6

Thimet Oligopeptidase—A Classical Enzyme with New Function and New Form 硫寡肽酶——具有新功能和新形态的经典酶

Immuno-Analyse & Biologie Specialisee Pub Date : 2021-09-23 DOI: 10.3390/immuno1040022

Yu Liu, J. Sigman, L. Bruce, A. Wolfson

引用次数: 1

Role of KIR Receptor in NK Regulation during Viral Infections 病毒感染过程中KIR受体在NK调控中的作用

Immuno-Analyse & Biologie Specialisee Pub Date : 2021-09-06 DOI: 10.3390/immuno1030021

S. Rizzo, Giovanna Schiuma, S. Beltrami, V. Gentili, R. Rizzo, D. Bortolotti

引用次数: 5

Cannabinoid Type-2 Receptor Agonist, JWH133 May Be a Possible Candidate for Targeting Infection, Inflammation, and Immunity in COVID-19 大麻素2型受体激动剂JWH133可能是靶向COVID-19感染，炎症和免疫的可能候选物

Immuno-Analyse & Biologie Specialisee Pub Date : 2021-08-30 DOI: 10.3390/immuno1030020

N. Jha, Charu Sharma, M. Meeran, S. Jha, V. Dwivedi, P. Gupta, A. Dey, K. Kesari, S. Ojha

{"title":"Cannabinoid Type-2 Receptor Agonist, JWH133 May Be a Possible Candidate for Targeting Infection, Inflammation, and Immunity in COVID-19","authors":"N. Jha, Charu Sharma, M. Meeran, S. Jha, V. Dwivedi, P. Gupta, A. Dey, K. Kesari, S. Ojha","doi":"10.3390/immuno1030020","DOIUrl":"https://doi.org/10.3390/immuno1030020","url":null,"abstract":"The COVID-19 pandemic, caused by SARS-CoV-2, is a deadly disease affecting millions due to the non-availability of drugs and vaccines. The majority of COVID-19 drugs have been repurposed based on antiviral, immunomodulatory, and antibiotic potential. The pathogenesis and advanced complications with infection involve the immune-inflammatory cascade. Therefore, a therapeutic strategy could reduce infectivity, inflammation, and immune modulation. In recent years, modulating the endocannabinoid system, particularly activation of the cannabinoid type 2 (CB2) receptor is a promising therapeutic target for modulation of immune-inflammatory responses. JWH133, a selective, full functional agonist of the CB2 receptor, has been extensively studied for its potent anti-inflammatory, antiviral, and immunomodulatory properties. JWH133 modulates numerous signaling pathways and inhibits inflammatory mediators, including cytokines, chemokines, adhesion molecules, prostanoids, and eicosanoids. In this study, we propose that JWH133 could be a promising candidate for targeting infection, immunity, and inflammation in COVID-19, due to its pharmacological and molecular mechanisms in numerous preclinical efficacy and safety studies, along with its immunomodulatory, anti-inflammatory, organoprotective, and antiviral properties. Thus, JWH133 should be investigated in preclinical and clinical studies for its potential as an agent or adjuvant with other agents for its effect on viremia, infectivity, immune modulation, resolution of inflammation, reduction in severity, and progression of complications in COVID-19. JWH133 is devoid of psychotropic effects due to CB2 receptor selectivity, has negligible toxicity, good bioavailability and druggable properties, including pharmacokinetic and physicochemical effects. We believe that JWH133 could be a promising drug and may inspire further studies for an evidence-based approach against COVID-19.","PeriodicalId":55599,"journal":{"name":"Immuno-Analyse & Biologie Specialisee","volume":"AES-7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84488684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age-Associated Characteristics of CD4+ T-Cell Composition in Patients with Atherosclerosis 动脉粥样硬化患者CD4+ t细胞组成的年龄相关特征

Immuno-Analyse & Biologie Specialisee Pub Date : 2021-08-27 DOI: 10.3390/immuno1030019

A. Filatova, A. Potekhina, T. Arefieva

{"title":"Age-Associated Characteristics of CD4+ T-Cell Composition in Patients with Atherosclerosis","authors":"A. Filatova, A. Potekhina, T. Arefieva","doi":"10.3390/immuno1030019","DOIUrl":"https://doi.org/10.3390/immuno1030019","url":null,"abstract":"Background. We aimed to analyze the contents of the main CD4+ T-cell subsets in patients with atherosclerosis (AS) depending on age. Methods. Male patients with coronary and/or carotid AS, who are non-smokers, and who are receiving statins were divided into three age groups (I—<55 y.o. (n = 23), II—55–64 y.o. (n = 42), III—≥65 y.o. (n = 46)). Leukocyte phenotyping was performed by direct immunofluorescence and flow cytometry. For intracellular cytokine detection, blood mononuclear cells were pre-activated with phorbol 12-myristate 13-acetate and ionomycin in the presence of an intracellular vesicle transport blocker monensin. Results. The groups did not differ in traditional CVD risk factors and AS severity. The content of CD4+ T-cells was lower in group III and II than in group I. The content of CD4+CD25high Treg was lower in group III than in groups I and II. No differences in the quantities of the primed CD39+CD45RA− and CD278high Treg, CD4+INFγ+ Th1, CD4+IL17+ Th17, and CD4+IL17+INFγ+ Th1/17 were observed. There were negative correlations between the values of CD4+ T-cells, CD4+CD45RA+ T-cells, CD4+CD25high Treg, CD4+CD25highCD45RA+ Treg, and age. Conclusion. In patients with AS, the age-related depletion of naive CD4+ T-cells also extends to the regulatory compartment. This phenomenon should be considered when studying the impact of the immune cells on the progression of AS.","PeriodicalId":55599,"journal":{"name":"Immuno-Analyse & Biologie Specialisee","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80540922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Eosinophil Count as Predictive Biomarker of Immune-Related Adverse Events (irAEs) in Immune Checkpoint Inhibitors (ICIs) Therapies in Oncological Patients 嗜酸性粒细胞计数作为肿瘤患者免疫检查点抑制剂(ICIs)治疗中免疫相关不良事件(irAEs)的预测性生物标志物

Immuno-Analyse & Biologie Specialisee Pub Date : 2021-08-17 DOI: 10.3390/immuno1030017

E. Giommoni, Roberta Giorgione, A. Paderi, E. Pellegrini, E. Gambale, A. Marini, A. Antonuzzo, R. Marconcini, G. Roviello, M. Matucci-Cerinic, David Capaccioli, S. Pillozzi, L. Antonuzzo

{"title":"Eosinophil Count as Predictive Biomarker of Immune-Related Adverse Events (irAEs) in Immune Checkpoint Inhibitors (ICIs) Therapies in Oncological Patients","authors":"E. Giommoni, Roberta Giorgione, A. Paderi, E. Pellegrini, E. Gambale, A. Marini, A. Antonuzzo, R. Marconcini, G. Roviello, M. Matucci-Cerinic, David Capaccioli, S. Pillozzi, L. Antonuzzo","doi":"10.3390/immuno1030017","DOIUrl":"https://doi.org/10.3390/immuno1030017","url":null,"abstract":"Background: To date, no biomarkers are effective in predicting the risk of developing immune-related adverse events (irAEs) in patients treated with immune checkpoint inhibitors (ICIs). This study aims to evaluate the association between basal absolute eosinophil count (AEC) and irAEs during treatment with ICIs for solid tumors. Methods: We retrospectively evaluated 168 patients with metastatic melanoma (mM), renal cell carcinoma (mRCC), and non-small cell lung cancer (mNSCLC) receiving ICIs at our medical oncology unit. By combining baseline AEC with other clinical factors, we developed a mathematical model for predicting the risk of irAEs, which we validated in an external cohort of patients. Results: Median baseline AEC was 135/µL and patients were stratified into two groups accordingly; patients with high baseline AEC (>135/µL) were more likely to experience toxicity (p = 0.043) and have a better objective response rate (ORR) (p = 0.003). By constructing a covariance analysis model, it emerged that basal AEC correlated with the risk of irAEs (p < 0.01). Finally, we validated the proposed model in an independent cohort of 43 patients. Conclusions: Baseline AEC could be a predictive biomarker of ICI-related toxicity, as well as of response to treatment. The use of a mathematical model able to predict the risk of developing irAEs could be useful for clinicians for monitoring patients receiving ICIs.","PeriodicalId":55599,"journal":{"name":"Immuno-Analyse & Biologie Specialisee","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91015293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9