European journal of cancer. Part B, Oral oncology最新文献_第5页

Human papillomavirus in oral premalignant lesions 人乳头瘤病毒在口腔癌前病变中的作用

European journal of cancer. Part B, Oral oncology Pub Date : 1996-07-01 DOI: 10.1016/0964-1955(96)00011-5

H. Nielsen , B. Norrild , P. Vedtofte , F. Prætorius , J. Reibel , P. Holmstrup

{"title":"Human papillomavirus in oral premalignant lesions","authors":"H. Nielsen , B. Norrild , P. Vedtofte , F. Prætorius , J. Reibel , P. Holmstrup","doi":"10.1016/0964-1955(96)00011-5","DOIUrl":"10.1016/0964-1955(96)00011-5","url":null,"abstract":"<div><p>The aetiology of oral premalignant lesions is generally accepted to be multifactorial. Tobacco and alcohol are established as important cofactors in malignant development in the oral cavity, but in addition microorganisms, such as human papillomavirus (HPV), have gained much interest over the past decade. For many years, HPV has been accepted as an important cofactor in the development of cervical cancer, originating from a mucous membrane with similarities to the oral mucosa. 49 patients with oral premalignant lesions and 20 control patients with normal oral mucosa and no history of HPV infection were examined for the presence of HPV by immune histochemical staining using the peroxidase anti-peroxidase technique (PAP), DNA-DNA <em>in situ</em> hybridisation (ISH), and polymerase chain reaction (PCR) analysed by Southern blot hybridisation with an HPV 16 specific probe. The investigations revealed that HPV was found in 62.5% of the verrucous leucoplakias, 50.0% of the erythroplakias, 45.5% of the homogeneous leucoplakias, 33.3% of erythroleucoplakias and in 12.5% of the nodular leucoplakias. An overall HPV detection rate in the examined premalignant lesions was 40.8% and no patients in the control sample were positive. Concerning oral cancer development, it seems likely that HPV may be a cofactor, as 100% of patients who developed oral cancers within 4–12 years were all positive for HPV, one being positive for HPV 16.</p></div>","PeriodicalId":77118,"journal":{"name":"European journal of cancer. Part B, Oral oncology","volume":"32 4","pages":"Pages 264-270"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0964-1955(96)00011-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19748038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 83

The significance of epidermal growth factor receptor and matrix metalloproteinase-3 in squamous cell carcinoma of the oral cavity 表皮生长因子受体和基质金属蛋白酶-3在口腔鳞状细胞癌中的意义

European journal of cancer. Part B, Oral oncology Pub Date : 1996-07-01 DOI: 10.1016/0964-1955(96)00016-4

J. Kusukawa , H. Harada , I. Shima , Y. Sasaguri , T. Kameyama , M. Morimatsu

{"title":"The significance of epidermal growth factor receptor and matrix metalloproteinase-3 in squamous cell carcinoma of the oral cavity","authors":"J. Kusukawa , H. Harada , I. Shima , Y. Sasaguri , T. Kameyama , M. Morimatsu","doi":"10.1016/0964-1955(96)00016-4","DOIUrl":"10.1016/0964-1955(96)00016-4","url":null,"abstract":"<div><p>Surgical specimens from 65 patients with squamous cell carcinoma (SCC) of the oral cavity were examined immunohistochemically. The clinicopathological significance of the expression of epidermal growth factor receptor (EGFR) and matrix metalloproteinase-3 (MMP-3) was assessed. Among the 65 tumours, 20 (30.8%) and 37 (56.9%) tested positively for EGFR and MMP-3, respectively. A positive correlation between the expression of EGFR and MMP-3 was found. The expression of EGFR in oral SCCs was associated with an advanced T stage of the primary tumour, an advanced pathological stage, and a high incidence of neck metastasis. In addition, MMP-3 was primarily expressed at the advancing front of cancer with a diffuse invasive mode. Thus, overexpression of MMP-3 was associated with an advanced pathological stage, a diffuse invasive mode, and a high incidence of neck metastasis. The analysis of MMP-3 expression is useful to evaluate the pathological status of tumours. Because EGFR-overexpressed tumour should produce larger amounts of MMP-3 <em>in vivo</em>, a close examination of oral SCC for expression of EGFR and MMP-3 should be helpful to predict their malignant potential.</p></div>","PeriodicalId":77118,"journal":{"name":"European journal of cancer. Part B, Oral oncology","volume":"32 4","pages":"Pages 217-221"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0964-1955(96)00016-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19748749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 73

p53 overexpression in head and neck squamous cell carcinoma: Review of the literature 头颈部鳞状细胞癌中p53过表达:文献综述

European journal of cancer. Part B, Oral oncology Pub Date : 1996-05-01 DOI: 10.1016/0964-1955(95)00095-X

H. Raybaud-Diogène , B. Tétu , R. Morency , A. Fortin , R.A. Monteil

{"title":"p53 overexpression in head and neck squamous cell carcinoma: Review of the literature","authors":"H. Raybaud-Diogène , B. Tétu , R. Morency , A. Fortin , R.A. Monteil","doi":"10.1016/0964-1955(95)00095-X","DOIUrl":"10.1016/0964-1955(95)00095-X","url":null,"abstract":"<div><p>As a tumour suppressor gene, the inactivation of p53 induces the development of numerous human cancers. Mutations of p53 have been implicated in the pathogenesis of head and neck squamous cell carcinoma (HN-SCC) at a high incidence. In premalignant lesions and <em>in situ</em> carcinomas, p53 overexpression is not exclusively restricted to neoplastic cells, but frequently affects the normal appearing keratinocytes adjacent to p53 positive neoplasms or present in dysplastic areas. These results suggest that as contributors to the early phases of HN-SCC development, p53 alterations may be excellent biomarkers that indicate the predisposition of a particular oral cavity premalignant lesion toward malignancy. In most cases, the p53 overexpression status of a tumour metastasis is identical to that of a primary tumour, indicating that a p53 mutation precedes metastatic spread. In patients with multiple primary tumours, multiple foci of p53 overexpression are observed in epithelia distant from the tumour. So the expression of p53 in normal epithelium would indicate an increased risk for transformation to second or third primary cancers. Distinct p53 mutations in different primary tumours of the same patient indicate that these cancers arise as independent events; these results support the existence of multifocal polyclonal processes. Regardless of the aforementioned results that support p53 as a valid tumour biomarker, most studies have shown no relationship between the expression of p53 and clinical and histopathological parameters. The role played by p53 mutations in the progression and vital prognosis of HN-SCC has not yet been demonstrated.</p></div>","PeriodicalId":77118,"journal":{"name":"European journal of cancer. Part B, Oral oncology","volume":"32 3","pages":"Pages 143-149"},"PeriodicalIF":0.0,"publicationDate":"1996-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0964-1955(95)00095-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19735426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 143

Nuclear morphometry in experimental oral mucosal carcinogenesis 实验性口腔黏膜癌变的核形态测定

European journal of cancer. Part B, Oral oncology Pub Date : 1996-05-01 DOI: 10.1016/0964-1955(95)00086-0

A.M. Rich, P.C. Reade

引用次数: 7

The dental problems of patients with head and neck cancer treated with CHART 应用图表治疗头颈癌患者的牙病

European journal of cancer. Part B, Oral oncology Pub Date : 1996-05-01 DOI: 10.1016/0964-1955(95)00083-6

D.E. Roos , S. Dische , M.I. Saunders

{"title":"The dental problems of patients with head and neck cancer treated with CHART","authors":"D.E. Roos , S. Dische , M.I. Saunders","doi":"10.1016/0964-1955(95)00083-6","DOIUrl":"10.1016/0964-1955(95)00083-6","url":null,"abstract":"<div><p>Between 1985 and 1990, 99 head and neck cancer patients were treated at Mount Vernon Centre for Cancer Treatment in a CHART pilot study. The aims of this retrospective review were to obtain baseline data for this population on their pretreatment dental status and to determine the extent to which our conservative policy of teeth preservation is being realised. This is of particular interest because of the believed sparing of late normal tissue effects by CHART compared with conventional fractionation. Prior to treatment, 40% of patients were edentulous, and prophylactic dental clearance was avoided in 59% of the remaining (dentate) patients. Following radiotherapy, only 21% of dentate patients subsequently lost all their remaining teeth. The proportion of patients with full or partial upper dentures increased from 61% pretreatment to 76% post-treatment; the corresponding increase in lower dentures was 46% to 66%. However, actual usage of dentures decreased somewhat. There was only one documented case of (minor) osteo-radionecrosis of the mandible which resolved with conservative care. The greater use in our patients of prophylactic measures, in particular, chlorhexidine and fluoride mouthwashes seemed indicated.</p></div>","PeriodicalId":77118,"journal":{"name":"European journal of cancer. Part B, Oral oncology","volume":"32 3","pages":"Pages 176-181"},"PeriodicalIF":0.0,"publicationDate":"1996-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0964-1955(95)00083-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19734644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Investigation of chromosome 9q22.3-q31 DNA marker loss in odontogenic keratocysts 牙源性角化囊肿9q22.3-q31染色体DNA标记缺失的研究

European journal of cancer. Part B, Oral oncology Pub Date : 1996-05-01 DOI: 10.1016/0964-1955(95)00053-4

N.J. Lench , A.S. High , A.F. Markham , W.J. Hume , P.A. Robinson

引用次数: 67

Cell kinetics of pleomorphic adenomas of the parotid gland 腮腺多形性腺瘤的细胞动力学

European journal of cancer. Part B, Oral oncology Pub Date : 1996-05-01 DOI: 10.1016/0964-1955(95)00090-9

L. Matturri , A.M. Lavezzi , B. Biondo , M. Mantovani

引用次数: 13

Non-Hodgkin's lymphoma of the tongue: a case report 舌非霍奇金淋巴瘤1例

European journal of cancer. Part B, Oral oncology Pub Date : 1996-05-01 DOI: 10.1016/0964-1955(95)00061-5

A. Piattelli , L. Di Alberti , L. Artese

引用次数: 24

Pathology illustrated, 4th Edition, 1995 病理学图解，1995年第4版

European journal of cancer. Part B, Oral oncology Pub Date : 1996-05-01 DOI: 10.1016/0964-1955(96)83451-8

R.A. Cawson

引用次数: 0

Oral health care for those with HIV infection and other special needs 为感染艾滋病毒及有其他特殊需要人士提供口腔保健服务

European journal of cancer. Part B, Oral oncology Pub Date : 1996-05-01 DOI: 10.1016/0964-1955(96)83452-X

J. Epstein

引用次数: 3