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Global, regional and national burden of pancreatitis in children and adolescents, 1990-2021: a systematic analysis for the global burden of disease study 2021. 1990-2021年全球、区域和国家儿童和青少年胰腺炎负担:对2021年全球疾病负担研究的系统分析
Annals of medicine Pub Date : 2025-12-01 Epub Date: 2025-05-06 DOI: 10.1080/07853890.2025.2499699
Derong Lin, Yue Li, Jingya Fang, Xiaohua Xie, Bin Zhang, Xiaolin Ye, Yiheng Huang, Xiaowen Zhang, Aiguo Xue
{"title":"Global, regional and national burden of pancreatitis in children and adolescents, 1990-2021: a systematic analysis for the global burden of disease study 2021.","authors":"Derong Lin, Yue Li, Jingya Fang, Xiaohua Xie, Bin Zhang, Xiaolin Ye, Yiheng Huang, Xiaowen Zhang, Aiguo Xue","doi":"10.1080/07853890.2025.2499699","DOIUrl":"https://doi.org/10.1080/07853890.2025.2499699","url":null,"abstract":"<p><strong>Background: </strong>Pancreatitis poses a significant global health burden, disproportionately affecting children and adolescents. This study uses the global burden of disease (GBD) 2021 dataset to evaluate pancreatitis epidemiology in this demographic, focusing on disparities by age, sex, and region.</p><p><strong>Objective: </strong>To assess global trends in pediatric pancreatitis, identify risk factors, and forecast disease burden to 2035.</p><p><strong>Methods: </strong>We analysed GBD 2021 data on deaths and disability-adjusted life years (DALYs) for pancreatitis in individuals under 20. The socio-demographic index (SDI) assessed the link between societal development and health outcomes. Bayesian age-period-cohort (BAPC) modelling and Poisson's linear models were applied to project future burdens and estimate annual percentage changes (EAPCs) in age-standardized rates.</p><p><strong>Results: </strong>In 2021, pancreatitis caused 1120.09 deaths in children and adolescents, comprising 2% of all pancreatitis-related deaths. Age-standardized death rate (ASDR) and DALYs rate declined from 1990 to 2021 (EAPC -0.92 and -0.86, respectively). Low-middle SDI regions, notably Andean and Central Latin America and Eastern Europe, faced the highest burden. Alcohol was a leading risk factor, accounting for 3.51% of related deaths, and males had higher death and DALYs rate.</p><p><strong>Conclusions: </strong>Despite declining pancreatitis-related mortality and DALYs, the disease remains a challenge, particularly in low-middle SDI regions. Alcohol consumption is a key risk factor, underscoring the need for targeted public health interventions. Gender-, age-, and region-specific strategies are essential to mitigate pancreatitis impact in children and adolescents.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2499699"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fibrinogen/albumin ratio is associated with first-ever cardiovascular events in patients with peritoneal dialysis. 纤维蛋白原/白蛋白比率与腹膜透析患者首次心血管事件相关
Annals of medicine Pub Date : 2025-12-01 Epub Date: 2025-04-30 DOI: 10.1080/07853890.2025.2499025
Qiqi Yan, Guiling Liu, Ruifeng Wang, Dandan Li, Deguang Wang
{"title":"Fibrinogen/albumin ratio is associated with first-ever cardiovascular events in patients with peritoneal dialysis.","authors":"Qiqi Yan, Guiling Liu, Ruifeng Wang, Dandan Li, Deguang Wang","doi":"10.1080/07853890.2025.2499025","DOIUrl":"https://doi.org/10.1080/07853890.2025.2499025","url":null,"abstract":"<p><strong>Objective: </strong>The fibrinogen/albumin ratio (FAR) is a novel inflammatory indicator, which has been associated with cardiovascular disease. However, the relationship between FAR and cardiovascular event (CVE) in patients with peritoneal dialysis (PD) remains unclear. This study aims to clarify the relationship between FAR and first-ever CVE in patients with PD.</p><p><strong>Methods: </strong>A total of 278 patients were enrolled between January 2012 and June 2021. They were defined as the high FAR group and the low FAR group based on the median FAR value (0.107). The primary outcome was the occurrence of first-ever CVE. Kaplan-Meier's curves and Cox regression analysis were used to analyse the relationship between FAR and first-ever CVE in patients with PD. Forest plots were employed to depict the relationship between FAR and first-ever CVE in each subgroup.</p><p><strong>Results: </strong>The average follow-up period was 40.26 ± 28.27 months. A total of 101 (36.3%) patients developed first-ever CVE. Kaplan-Meier's analysis showed that there was a higher risk of first-ever CVE (<i>p</i> = .002) in the high FAR group. Multivariate Cox regression analysis showed that FAR ≥ 0.107 and age were independently associated with the risk of first-ever CVE in patients with PD. Receiver operating characteristic (ROC) analysis showed that FAR had a greater predicting value on the first-ever CVE.</p><p><strong>Conclusions: </strong>High levels of FAR are independently associated with an increased risk of first-ever CVE in patients with PD.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2499025"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of using app-based interventions on quality of life among breast cancer patients: a systematic review with meta-analysis. 使用基于app的干预措施对乳腺癌患者生活质量的影响:一项带有meta分析的系统综述。
Annals of medicine Pub Date : 2025-12-01 Epub Date: 2025-05-06 DOI: 10.1080/07853890.2025.2499027
Lv Tian, Yixuan Wen, Tao Li, Chuanwang Liu, Jun Fan
{"title":"Effects of using app-based interventions on quality of life among breast cancer patients: a systematic review with meta-analysis.","authors":"Lv Tian, Yixuan Wen, Tao Li, Chuanwang Liu, Jun Fan","doi":"10.1080/07853890.2025.2499027","DOIUrl":"https://doi.org/10.1080/07853890.2025.2499027","url":null,"abstract":"<p><strong>Background: </strong>Application-based interventions have gradually emerged as potential tools for improving the health status of cancer patients. However, the conclusions of existing studies on the effectiveness of app-based intervention in managing breast cancer symptoms vary.</p><p><strong>Methods: </strong>This study systematically searched the PubMed, Web of Science, Scopus, Cochrane Library, and EMBASE databases from the inception of each database to October 25, 2024. Two researchers independently screened studies, extracted data, and evaluated the quality using the Cochrane Risk of Bias Tool. Data analysis was performed using RevMan 5.3 software, and the effect size was expressed as the standardized mean difference (SMD).</p><p><strong>Results: </strong>Of 16 included randomized controlled trials, meta-analysis results indicated that, compared to usual care, app-based interventions significantly improved breast cancer patients' quality of life (14 studies, SMD = 0.84, 95%CI = 0.48 - 1.19, <i>p</i> < 0.00005, I<sup>2</sup> = 90%, GRADE = low), and positively alleviated physical pain and anxiety (5 studies, SMD = - 0.60, 95%CI = -0.92 to -0.29, <i>p</i> = 0.0002, I<sup>2</sup>= 56%, GRADE = very low; 3 studies, SMD = -0.75, 95% CI = -1.40 to -0.09, <i>p</i> = 0.03, I<sup>2</sup>= 86%, GRADE = very low). However, no statistically significant differences were observed in improving fatigue (3 studies, SMD = 0.18, 95%CI = - 0.05 - 0.42, <i>p</i> = 0.13, I<sup>2</sup> = 0%) and depression (2 studies, SMD = -0.65, 95%CI = - 2.12 - 0.82, <i>p</i> = 0.38, I<sup>2</sup> = 96%).</p><p><strong>Conclusion: </strong>Application-based interventions can significantly improve the quality of life of breast cancer patients, effectively relieve pain, and reduce anxiety.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2499027"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Network characteristics of comorbid symptoms in alcohol use disorder. 酒精使用障碍共病症状的网络特征
Annals of medicine Pub Date : 2025-12-01 Epub Date: 2025-01-13 DOI: 10.1080/07853890.2024.2446691
Xin Yu, Wen Zhang, Can Wang, Guolin Mi, Xiuzhe Chen, Yanhu Wang, Xu Chen
{"title":"Network characteristics of comorbid symptoms in alcohol use disorder.","authors":"Xin Yu, Wen Zhang, Can Wang, Guolin Mi, Xiuzhe Chen, Yanhu Wang, Xu Chen","doi":"10.1080/07853890.2024.2446691","DOIUrl":"10.1080/07853890.2024.2446691","url":null,"abstract":"<p><strong>Background: </strong>Individuals with alcohol use disorder (AUD) often experience symptoms such as anxiety, depression, and decreased sleep quality. Although these are not diagnostic criteria, they may increase dependence risk and complicate treatment. This study aims to analyze comorbidities and their complex relationships in AUD patients through epidemiological surveys and network analysis.</p><p><strong>Materials and methods: </strong>Using multi-stage stratified cluster random sampling, we selected 27,913 individuals and identified those with AUD for the study. All screened subjects were assessed with the General Health Questionnaire, Pittsburgh Sleep Quality Index, and Simple Coping Style Questionnaire, and diagnosed according to DSM-IV criteria. Network analysis and visualization were performed in R 4.4.0. The <i>qgraph</i> and <i>bootnet</i> packages in R were used to obtain partial correlation network analysis and node centrality of mental health, sleep quality, and coping styles in individuals with AUD through the <i>estimateNetwork</i> function. The <i>bootnet</i> package was used to assess the accuracy and stability of the network. The <i>bnlearn</i> package in R was used to construct directed acyclic graph (DAG) for individuals with AUD using the Bayesian hill-climbing algorithm.</p><p><strong>Results: </strong>In the partial correlation network, among the three major comorbidity categories, 'anxiety/depression' was most strongly associated with 'sleep quality'. 'Anxiety/depression' and 'sleep quality' had the highest node centrality, with 'sleep latency' also showing notable centrality. The DAG results indicated that 'sleep latency' had the highest probability priority, directly affecting 'anxiety/depression' and key sleep quality symptoms such as 'subjective sleep quality', 'sleep disturbances', 'sleep duration', and 'sleep efficiency', while also indirectly influencing other symptoms.</p><p><strong>Conclusions: </strong>Among the comorbid symptoms of AUD, sleep latency appears to be a key factor in triggering other comorbid symptoms. This study provides a basis for interventions aimed at reducing the comorbid symptoms of AUD and promoting recovery.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2446691"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
24-month outcomes after switching to Dolutegravir/Lamivudine in people living with HIV and HBcAb positivity at the Beijing Ditan Hospital in China. 中国北京地坛医院HIV和HBcAb阳性患者改用多替格拉韦/拉米夫定治疗后24个月的疗效
Annals of medicine Pub Date : 2025-12-01 Epub Date: 2025-02-24 DOI: 10.1080/07853890.2025.2470957
Jiantao Fu, Ruojia Biao, Ying Liu, Jing Chen, Hongxin Zhao
{"title":"24-month outcomes after switching to Dolutegravir/Lamivudine in people living with HIV and HBcAb positivity at the Beijing Ditan Hospital in China.","authors":"Jiantao Fu, Ruojia Biao, Ying Liu, Jing Chen, Hongxin Zhao","doi":"10.1080/07853890.2025.2470957","DOIUrl":"10.1080/07853890.2025.2470957","url":null,"abstract":"<p><strong>Background: </strong>Dolutegravir/lamivudine (DTG/3TC) is a recommended therapy regimen for hepatitis B surface antigen (HBsAg)-negative people living with HIV (PLWH) who have achieved HIV virological suppression or are treatment-naïve. However, this may overlook the impact of occult hepatitis B infection on HIV suppression, which mainly present as hepatitis B core antibody (HBcAb) positive but HBsAg negative. We aim to assess the effect of HBcAb positivity on HIV suppression among PLWH who had switched to DTG/3TC.</p><p><strong>Methods: </strong>A retrospective study was conducted including 127 HBcAb-positive and 474 HBcAb-negative PLWH (all were HBsAg negative) who had switched to DTG/3TC at the Beijing Ditan Hospital in China. HIV-RNA suppression was compared pre-switch (not baseline), at switch, and at 12&24 months post-switch, across three categories: (1) target not detected (TND); (2) HIV RNA < 40 cp/mL; (3) blip. Virological suppression included TND and HIV RNA < 40 cp/mL. Epidemiological (gender, age) and clinical data (CD4 count, HIV viral load, etc.) were extracted from the hospital information system. A <i>p</i>-value < 0.05 was considered statistically significant.</p><p><strong>Result: </strong>HBcAb-positive PLWH were older at DTG/3TC switch (median age: 41 vs. 36 years old, <i>p</i> < 0.001) and had lower nadir CD4 counts (median nadir CD4 counts: 255 vs. 295, <i>p</i> = 0.011). No difference in TND and HIV RNA < 40 cp/mL was present in the two groups at the switch (HBcAb-positive and -negative: 86.6% vs. 88.8%, 12.6% vs. 10.5%, <i>p</i> = 0.789). Similar HBcAb-positive compared with -negative PLWH resulted in TND at 12&24 months post-switch: 91.4% vs. 91% (<i>p</i> = 0.522) and 88.4% vs. 92.7% (<i>p</i> = 0.249), respectively. Consistent result was observed in HIV RNA < 40 cp/mL.</p><p><strong>Conclusion: </strong>In the 24-month follow-up after switching to DTG/3TC, HBcAb positivity was not significantly associated with HIV virological suppression.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2470957"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11852214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraoperative hemodynamics in prediction of postoperative kidney injury after type a aortic dissection surgery: a retrospective cohort study. 术中血流动力学对 A 型主动脉夹层手术后肾损伤的预测:一项回顾性队列研究。
Annals of medicine Pub Date : 2025-12-01 Epub Date: 2025-03-05 DOI: 10.1080/07853890.2025.2474859
Lihai Chen, Yi Cheng, Xinyi Bu, Chen Zhang, Jie Sun, Xuesheng Liu, Siyu Kong, Yali Ge, Hongwei Shi, Jifang Zhou
{"title":"Intraoperative hemodynamics in prediction of postoperative kidney injury after type a aortic dissection surgery: a retrospective cohort study.","authors":"Lihai Chen, Yi Cheng, Xinyi Bu, Chen Zhang, Jie Sun, Xuesheng Liu, Siyu Kong, Yali Ge, Hongwei Shi, Jifang Zhou","doi":"10.1080/07853890.2025.2474859","DOIUrl":"10.1080/07853890.2025.2474859","url":null,"abstract":"<p><strong>Background: </strong>Type A aortic dissection (TAAD) is a severe cardiovascular condition associated with high risks for postoperative complications, particularly renal dysfunction. This study investigated whether intraoperative hypotension and venous congestion are important predictors of postoperative kidney injury and major adverse events.</p><p><strong>Methods: </strong>We retrospectively analyzed 543 adults undergoing TAAD surgery (2016-2023). Primary outcomes were acute kidney injury (AKI) and acute kidney disease (AKD). Secondary outcomes included death, stroke and composite outcome. Patients were divided into four groups: AKI only, AKD only, AKI and AKD, Non-AKI or AKD. We used restricted cubic spline and multivariate logistic regression models to adjust for confounding factors.</p><p><strong>Results: </strong>AKI or AKD was significantly associated with each 10-minute epoch of central venous pressure (CVP) ≥10, 12, 16, 20 mmHg (all <i>p</i> < 0.001), with each 60-minute epoch of CVP ≥10, 12, 16, 20 mmHg area under the curve (AUC) (all p < 0.001). Regarding death, a 6% to 13% increase rate for each 10-minute epoch of CVP ≥10, 12, 16, 20 mmHg (all <i>p</i> ≤ 0.003), a 5% to 21% increase for each 60-minute epoch of CVP ≥10, 12, 16, 20 mmHg AUC (all <i>p</i> < 0.001). In terms of stroke risk, a 5% increase rate for every 10-minute increase in the CVP AUC above 16 mmHg, and an 11% increased risk for CVP AUC above 20 mmHg (<i>p</i> = 0.039 and <i>p</i> = 0.031, respectively).</p><p><strong>Conclusion: </strong>Elevated CVP and lower MAP levels were linked to postoperative AKI and AKD risk. CVP showed stronger associations with mortality and stroke. Optimizing perioperative hemodynamic management may improve individualized interventions.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2474859"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leucine-rich alpha-2 glycoprotein in combination with C-reactive protein for predicting endoscopic activity in Crohn's disease: a single-centre, cross-sectional study. 富亮氨酸α -2糖蛋白联合c反应蛋白预测克罗恩病内窥镜活动:一项单中心横断面研究
Annals of medicine Pub Date : 2025-12-01 Epub Date: 2025-01-17 DOI: 10.1080/07853890.2025.2453083
Yoshiaki Takada, Hiroki Kiyohara, Yohei Mikami, Masataka Taguri, Ryoya Sakakibara, Yasuhiro Aoki, Kosaku Nanki, Takaaki Kawaguchi, Yusuke Yoshimatsu, Shinya Sugimoto, Tomohisa Sujino, Kaoru Takabayashi, Naoki Hosoe, Haruhiko Ogata, Motohiko Kato, Yasushi Iwao, Nobuhiro Nakamoto, Takanori Kanai
{"title":"Leucine-rich alpha-2 glycoprotein in combination with C-reactive protein for predicting endoscopic activity in Crohn's disease: a single-centre, cross-sectional study.","authors":"Yoshiaki Takada, Hiroki Kiyohara, Yohei Mikami, Masataka Taguri, Ryoya Sakakibara, Yasuhiro Aoki, Kosaku Nanki, Takaaki Kawaguchi, Yusuke Yoshimatsu, Shinya Sugimoto, Tomohisa Sujino, Kaoru Takabayashi, Naoki Hosoe, Haruhiko Ogata, Motohiko Kato, Yasushi Iwao, Nobuhiro Nakamoto, Takanori Kanai","doi":"10.1080/07853890.2025.2453083","DOIUrl":"10.1080/07853890.2025.2453083","url":null,"abstract":"<p><strong>Background and objective: </strong>Leucine-rich alpha-2 glycoprotein (LRG) is a novel biomarker for Crohn's disease (CD). The utility of combination use of LRG and C-reactive protein (CRP) has not been reported. This study aimed to investigate the diagnostic performance of LRG in combination with CRP to predict endoscopic activity.</p><p><strong>Methods: </strong>A single-centre, retrospective, cross-sectional study was conducted. Patients with CD who had serum LRG concentrations measured at least once between June 2020 and May 2021 were enrolled. Clinical activity was evaluated with the Harvey-Bradshaw Index (HBI). Spearman's rank correlation coefficient (<i>r<sub>s</sub></i>) was used to analyse the correlations between the HBI, LRG concentrations and CRP concentrations. In patients undergoing ileocolonoscopy or balloon-assisted enteroscopy within 60 days before or after LRG measurement, endoscopic activity was evaluated with the simple endoscopic score for Crohn's disease (SES-CD). The diagnostic performance of LRG and CRP for endoscopic activity was evaluated using receiver operating characteristic (ROC) analysis.</p><p><strong>Results: </strong>Four hundred and eighty-nine measurements in 343 patients were analysed. Although a strong correlation was found between LRG and CRP concentrations (<i>r<sub>s</sub></i> = 0.75), the HBI did not well correlate with LRG or CRP concentrations. Endoscopic activity was analysed in 56 patients. In diagnosing endoscopically moderate to severe activity (SES-CD > 6), the area under the ROC curve of LRG was greater than that of CRP (0.74 vs. 0.63; <i>p</i> = .037). The optimal cut-off value estimated by Youden's index was 15.5 µg/mL for LRG, and 0.13 mg/dL for CRP. LRG and CRP concentrations were considered positive when they were above these cut-off values, and the sensitivity and specificity for an SES-CD > 6 were 58.3% and 93.8%, respectively. Dual positivity of LRG and CRP showed the highest specificity.</p><p><strong>Conclusions: </strong>Combination use of dual positive LRG and CRP is useful for diagnosing endoscopically moderate to severe disease.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2453083"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of color learning protocol based on music-color association for people with visual impairment. 视障人士基于音乐-色彩关联的色彩学习方案的开发。
Annals of medicine Pub Date : 2025-12-01 Epub Date: 2025-03-10 DOI: 10.1080/07853890.2025.2476728
Hye Young Park
{"title":"Development of color learning protocol based on music-color association for people with visual impairment.","authors":"Hye Young Park","doi":"10.1080/07853890.2025.2476728","DOIUrl":"10.1080/07853890.2025.2476728","url":null,"abstract":"<p><strong>Background: </strong>This research developed and confirmed the feasibility of a color-learning mobile application for people with visual impairment based on the hypothesis that the music-color association may be synaesthetically induced through emotion.</p><p><strong>Methods: </strong>In total, 120 participants with visual impairment, comprising 60 congenital and 60 adventitious cases, were recruited. They underwent sequential procedures: Procedure 1 involved selecting color-music associations and designing tasks; Procedure 2 focused on application development with accessibility features; and Procedure 3 verified usability and effectiveness.</p><p><strong>Results: </strong>Significant improvements were observed in hue, luminance, and saturation scores following the use of the music-color association application among participants with both congenital and adventitious visual impairment. The effectiveness of the application in facilitating color learning is evident, suggesting its potential utility in enhancing color perception in this population.</p><p><strong>Conclusions: </strong>This research introduces a novel framework for color learning among visually impaired individuals using a music-based synesthetic approach. The developed mobile application offers a promising avenue for efficiently improving color perception and learning, thereby addressing the critical need for accessibility and education for this population. Further research should explore the long-term effects and broader applications of synesthetic-induced learning in diverse contexts.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2476728"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut microbiota and endometrial cancer: research progress on the pathogenesis and application. 肠道微生物群与子宫内膜癌:发病机制与应用研究进展。
Annals of medicine Pub Date : 2025-12-01 Epub Date: 2025-01-15 DOI: 10.1080/07853890.2025.2451766
Weiqin Zheng, Xiaowen Lin, Huixin Chen, Ziling Yang, Han Zhao, Shibo Li, Tao Song, Yuhui Sun
{"title":"Gut microbiota and endometrial cancer: research progress on the pathogenesis and application.","authors":"Weiqin Zheng, Xiaowen Lin, Huixin Chen, Ziling Yang, Han Zhao, Shibo Li, Tao Song, Yuhui Sun","doi":"10.1080/07853890.2025.2451766","DOIUrl":"10.1080/07853890.2025.2451766","url":null,"abstract":"<p><p>As one of the three major malignant tumors in women, the morbidity of endometrial cancer is second only to that of cervical cancer and is increasing yearly. Its etiological mechanism is not clear, and the risk factors are numerous and common and are closely related to obesity, hypertension, diabetes, etc. The gut microbiota has many strains, which play a considerable part in normal digestion and absorption in the human body and the regulation of the immune response. In the last few years, research on the gut microbiota has been unprecedentedly popular, and it has been confirmed that the gut microbiota closely correlates with the occurrence and development of all kinds of benign and malignant diseases. In this article, the effects of the gut microbiota and its metabolites on the occurrence and development of endometrial cancer is reviewed, and its application in the prevention, diagnosis and treatment of endometrial cancer is explored.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2451766"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral roflumilast for psoriasis: a real-world 24-week prospective cohort study. 口服罗氟司特治疗牛皮癣:一项现实世界24周的前瞻性队列研究
The Journal of dermatological treatment Pub Date : 2025-12-01 Epub Date: 2025-02-11 DOI: 10.1080/09546634.2025.2464107
Ana Maria Lé, Orhan Yilmaz, Martim Luz, Tiago Torres
{"title":"Oral roflumilast for psoriasis: a real-world 24-week prospective cohort study.","authors":"Ana Maria Lé, Orhan Yilmaz, Martim Luz, Tiago Torres","doi":"10.1080/09546634.2025.2464107","DOIUrl":"10.1080/09546634.2025.2464107","url":null,"abstract":"<p><strong>Objective: </strong>Psoriasis is a chronic inflammatory skin disease with significant physical and psychological burden, often associated with comorbidities such as obesity and cardiovascular disease. Current treatments include conventional systemic therapies and targeted biologic and non-biologic therapies, with several limitations related to safety, efficacy, and cost. Roflumilast, a selective PDE4 inhibitor, shows potential as an oral therapy for psoriasis due to its anti-inflammatory effects and favorable safety profile. This study aimed to evaluate the real-world effectiveness and safety of oral roflumilast in moderate-to-severe plaque psoriasis.</p><p><strong>Methods: </strong>Prospective cohort study at a single center in Portugal including adults with moderate-to-severe psoriasis treated with oral roflumilast 500 mcg once daily.</p><p><strong>Results: </strong>Among fifty-eight patients (baseline median PASI 13.7 ± 5.5), 63.0% achieved PASI < 5, 47.8% PASI < 3, and 21.7% PASI < 1 by week 24 (mNRI). Weight loss occurred in 53.4%, with a mean reduction of 6 kg ± 4.3. Mild gastrointestinal symptoms were common but rarely caused discontinuation. No serious adverse events were reported.</p><p><strong>Conclusion: </strong>Roflumilast demonstrated real-world effectiveness and a favorable safety profile in moderate-to-severe plaque psoriasis. Additional benefits, including weight loss and no need for laboratory monitoring, make it a promising treatment option, particularly for patients with comorbidities or limited access to biologic therapies.</p>","PeriodicalId":94235,"journal":{"name":"The Journal of dermatological treatment","volume":"36 1","pages":"2464107"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143401075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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