Annals of medicine Pub Date : 2025-12-01 Epub Date: 2024-12-21 DOI: 10.1080/07853890.2024.2445186

Yi-Peng He, Ping Zhou, Li-Mei Guan, San-Gang Wu

{"title":"Clinical and dosimetric feasibility of sparing submandibular gland in patients with oral cavity squamous cell carcinoma.","authors":"Yi-Peng He, Ping Zhou, Li-Mei Guan, San-Gang Wu","doi":"10.1080/07853890.2024.2445186","DOIUrl":"https://doi.org/10.1080/07853890.2024.2445186","url":null,"abstract":"Background: To investigate the incidence of submandibular gland (SMG) involvement and explore the feasibility of sparing SMG in the oral cavity squamous cell carcinoma (OSCC).Methods: This study retrospectively analyzed patients between January 2018 to October 2022. Ten patients with tongue squamous cell carcinoma receiving postoperative radiotherapy were replanned to investigate the feasibility of sparing SMG. The dose constraint for the SMG was a mean dose (Dmean) <39 grey (Gy).Results: A total of 238 patients were identified and 105 had metastatic neck lymph nodes. Level II was the most common site of metastasis (n = 94, 89.5%), followed by level IB (n = 37, 35.2%), level III (n = 26, 24.8%), level IA (n = 3, 2.6%), and level IV (n = 2, 1.9%). A total of 50 metastatic lymph nodes were located at the level IB, of which 18 (36.0%), 29 (58.0%), and 3 (6%) were located in the lateral, anterior, and inferior aspect of the SMG. No metastatic lymph nodes were found within or on the medial aspect of the SMG. The Dmean of the SMG was <39 Gy in all patients with a Dmean of 38.8 Gy. The median dose of PTV54 D95% was 53.8 Gy, which met the prespecified allowable coverage goal.Conclusions: Our study suggests that SMG involvement is rare in OSCC. With strict imaging and clinical evaluation, sparing SMG during radiotherapy is feasible.","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2445186"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-Speed Three-Dimensional-Digital Image Correlation and Schlieren Imaging Integrated With Shock Tube Loading for Investigating Dynamic Response of Human Tympanic Membrane Exposed to Blasts. 高速三维数字图像相关性和 Schlieren 图像与冲击管加载相结合，用于研究暴露于爆炸物的人体鼓膜的动态响应。

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2025-11-01 Epub Date: 2024-10-23 DOI: 10.1115/1.4066622

Anahita Alipanahi, Jonathan Oliveira Luiz, John J Rosowski, Cosme Furlong, Jeffrey Tao Cheng

{"title":"High-Speed Three-Dimensional-Digital Image Correlation and Schlieren Imaging Integrated With Shock Tube Loading for Investigating Dynamic Response of Human Tympanic Membrane Exposed to Blasts.","authors":"Anahita Alipanahi, Jonathan Oliveira Luiz, John J Rosowski, Cosme Furlong, Jeffrey Tao Cheng","doi":"10.1115/1.4066622","DOIUrl":"https://doi.org/10.1115/1.4066622","url":null,"abstract":"Investigating the dynamic response of human tympanic membranes (TMs) exposed to blasts requires full-field-of-view and three-dimensional (3D) methodologies. Our paper introduces a system that combines high-speed 3D digital image correlation (HS 3D-DIC) and Schlieren imaging (HS-SI) with a custom-designed shock tube for generating blast waves. This integrated system allows us to measure TM surface motions under intense transient loading, capturing full-field-of-view shape deformations exceeding 100 μm with a temporal resolution of 10 μs. System characterization encompasses (i) measuring the shock tube's output levels and repeatability, (ii) assessment of the spatial and temporal resolutions of the imaging techniques, and (iii) identification of overall system limitations. Optimizing these factors is crucial for improving the reliability of our system to ensure the accurate measurement of deformations. To assess our shock tube's reliability in generating repeated blast waves, we instrumented it with high-pressure (HP) and high-frequency (HF) pressure sensors along the blast wave pathway to record overpressure waveforms and compared them with Schlieren imaging visualized blast waves. We validate our HS 3D-DIC measured deformations by comparing them with deformations measured using single-point laser Doppler vibrometry (LDV), establishing a comprehensive assessment of the TM's dynamic response and potential fracture mechanics under blast. Finally, we test our approach with 3D-printed TM-like samples and a real cadaveric human TM. This methodology lays the groundwork for further investigations of blast-related auditory damage and the invention of more effective protective and medical solutions.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"8 4","pages":"041101"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behind Amor Blunt Trauma Lung and Liver Strains From Indenter Loading Via Finite Element Modeling.

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2025-08-01 Epub Date: 2024-11-21 DOI: 10.1115/1.4066830

Narayan Yoganandan, Karthik Somasundaram, Balaji Harinathan, Karthik Banurekha Devaraj, Alok Shah, Jared Koser, Brian Stemper, Valeta Carol Chancey, B Joseph McEntire

{"title":"Behind Amor Blunt Trauma Lung and Liver Strains From Indenter Loading Via Finite Element Modeling.","authors":"Narayan Yoganandan, Karthik Somasundaram, Balaji Harinathan, Karthik Banurekha Devaraj, Alok Shah, Jared Koser, Brian Stemper, Valeta Carol Chancey, B Joseph McEntire","doi":"10.1115/1.4066830","DOIUrl":"10.1115/1.4066830","url":null,"abstract":"To determine behind armor blunt trauma (BABT) injury criteria, experiments have been conducted by launching blunt projectiles at live swine at velocities up to 65 meters per second (m/s) using one type of indenter design. To ensure the generalizability of the developed injury criteria, additional tests with different indenter designs are needed. The objectives of this study were to evaluate the kinematics and injury parameters from two indenter designs using human body finite element modeling. The simulation matrix consisted of chord and cylindrical shape indenter designs with two different masses of 150 and 230 grams. They were used to impact the liver and lung regions at velocities of 30 and 60 m/s using a human body model. Rib and lung strains from lung impacts and rib strain and liver strain energy densities (SED) from liver impacts were used to evaluate the design variables of mass and shape. Both designs played a role in skeletal and organ injury parameters. Analysis revealed an increased susceptibility for skeletal and organ traumas with the high mass indenter during high velocity impacts. The cylindrical indenter may be protective for organ injuries due to the larger area of loading on the ribcage compared to the chord indenter. Results from the chord indenter may serve as a conservative estimate of injury criteria.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"8 3","pages":"031009"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantifying the Fascicular Changes in Recovered Achilles Tendon Patients Using Diffusion Magnetic Resonance Imaging and Tractography. 利用弥散磁共振成像和韧带造影术量化跟腱康复患者的筋膜变化

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2025-08-01 Epub Date: 2024-10-16 DOI: 10.1115/1.4066623

Shabnam Rahimnezhad, Tanzil M Arefin, Xiaoxiao Bai, Thomas Neuberger, Daniel Cortes

{"title":"Quantifying the Fascicular Changes in Recovered Achilles Tendon Patients Using Diffusion Magnetic Resonance Imaging and Tractography.","authors":"Shabnam Rahimnezhad, Tanzil M Arefin, Xiaoxiao Bai, Thomas Neuberger, Daniel Cortes","doi":"10.1115/1.4066623","DOIUrl":"https://doi.org/10.1115/1.4066623","url":null,"abstract":"Regardless of the way of treatment, persistent deficits in calf muscles in recovered patients from Achilles tendon rupture (ATR) exist long-term postinjury. Studies on calf muscle changes mostly highlight morphological changes in the calf muscles and Achilles tendon. However, limited attention has been given to fascicular changes. Diffusion tensor imaging (DTI) can provide a better understanding of the characteristics and properties of tissues with organized microstructure. In the current study, we used DTI-derived indices (mean diffusivity (MD), fractional anisotropy (FA), and eigenvalues-λ 1, λ 2, and λ 3) and fiber tractography to better understand the soleus muscle after recovery from ATR by comparing the results of injured legs with healthy ones. Our findings suggest that the standard deviations of measured parameters (FA, MD, and eigenvalues) within the soleus muscle are better predictors of the changes associated with the ATR as compared to the control counterpart for the volumetric region of interest (ROI). Additionally, in four out of five participants, smaller tracts were observed in the injured leg compared to the healthy one, as evidenced by the fiber length distribution of the tracts. Altogether, this study demonstrates the feasibility of the DTI and fiber tractography approaches to quantify the fascicular changes in the individuals recovered from ATR.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"8 3","pages":"031006"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heme oxygenase/carbon monoxide system and development of the heart. 血红素含氧酶/一氧化碳系统与心脏的发育

IF 3

Medical Gas Research Pub Date : 2025-03-01 Epub Date: 2024-09-25 DOI: 10.4103/mgr.MEDGASRES-D-24-00031

Vicki L Mahan

{"title":"Heme oxygenase/carbon monoxide system and development of the heart.","authors":"Vicki L Mahan","doi":"10.4103/mgr.MEDGASRES-D-24-00031","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00031","url":null,"abstract":"Progressive differentiation controlled by intercellular signaling between pharyngeal mesoderm, foregut endoderm, and neural crest-derived mesenchyme is required for normal embryonic and fetal development. Gasotransmitters (criteria: 1) a small gas molecule; 2) freely permeable across membranes; 3) endogenously and enzymatically produced and its production regulated; 4) well-defined and specific functions at physiologically relevant concentrations; 5) functions can be mimicked by exogenously applied counterpart; and 6) cellular effects may or may not be second messenger-mediated, but should have specific cellular and molecular targets) are integral to gametogenesis and subsequent embryogenesis, fetal development, and normal heart maturation. Important for in utero development, the heme oxygenase/carbon monoxide system is expressed during gametogenesis, by the placenta, during embryonic development, and by the fetus. Complex sequences of biochemical pathways result in the progressive maturation of the human heart in utero . The resulting myocardial architecture, consisting of working myocardium, coronary arteries and veins, epicardium, valves and cardiac skeleton, endocardial lining, and cardiac conduction system, determines function. Oxygen metabolism in normal and maldeveloping hearts, which develop under reduced and fluctuating oxygen concentrations, is poorly understood. \"Normal\" hypoxia is critical for heart formation, but \"abnormal\" hypoxia in utero affects cardiogenesis. The heme oxygenase/carbon monoxide system is important for in utero cardiac development, and other factors also result in alterations of the heme oxygenase/carbon monoxide system during in utero cardiac development. This review will address the role of the heme oxygenase/carbon monoxide system during cardiac development in embryo and fetal development.","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":" ","pages":"10-22"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disrupting the activity of endogenous gas neurotransmitters: a therapeutic strategy using engineered metal-organic frameworks for cancer. 干扰内源性气体神经递质的活性：利用工程金属有机框架治疗癌症的策略。

IF 3

Medical Gas Research Pub Date : 2025-03-01 Epub Date: 2024-09-25 DOI: 10.4103/mgr.MEDGASRES-D-24-00046

Nan Wang, Yichao Tao, Yang Yang, Yuqin Jin, Hui Zhang, Cheng Li, Huanlong Qin, Qian Chen

引用次数: 0

Oxygen-ozone therapy for myocardial ischemic stroke and cardiovascular disorders. 氧-臭氧疗法治疗心肌缺血中风和心血管疾病。

IF 3

Medical Gas Research Pub Date : 2025-03-01 Epub Date: 2024-08-31 DOI: 10.4103/mgr.MEDGASRES-D-23-00013

Sergio Pandolfi, Salvatore Chirumbolo, Marianno Franzini, Umberto Tirelli, Luigi Valdenassi

{"title":"Oxygen-ozone therapy for myocardial ischemic stroke and cardiovascular disorders.","authors":"Sergio Pandolfi, Salvatore Chirumbolo, Marianno Franzini, Umberto Tirelli, Luigi Valdenassi","doi":"10.4103/mgr.MEDGASRES-D-23-00013","DOIUrl":"10.4103/mgr.MEDGASRES-D-23-00013","url":null,"abstract":"Cardiovascular diseases (CVDs) represent a major concern for human health worldwide. Emergencies in this field include wide repertories of studies dealing primarily with CVD prevention. In addition to dietary habits and lifestyles, medical knowledge is fully needed to improve public educational programs toward cardiovascular risk factors and to enrich the endowment of pharmaceutical options and therapies to address CVDs, particularly for ischemic damage due to an impairment in the endothelial-myocardial relationship. Because ozone is a stimulator of the endothelial nitric oxide synthase/nitric oxide pathway, ozone therapy has been widely demonstrated to have the ability to counteract endothelial-cardiac disorders, providing a novel straightforward opportunity to reduce the impact of CVDs, including atrial fibrillation. In this review, we attempt to establish a state-of-the-art method for the use of ozone in CVD, suggesting that future remarks be addressed to provide fundamental insights into this issue. The purpose of this study was to highlight the role of ozone in the adjunctive medical treatment of cardiovascular pathologies such as acute myocardial infarction due to ischemic disorders.","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":" ","pages":"36-43"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142109352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperbaric oxygen treatment promotes tendon-bone interface healing in a rabbit model of rotator cuff tears. 高压氧治疗可促进肩袖撕裂兔模型中肌腱与骨骼界面的愈合。

IF 3

Medical Gas Research Pub Date : 2025-03-01 Epub Date: 2024-08-31 DOI: 10.4103/mgr.MEDGASRES-D-24-00034

Hongqiu Li, Meiling Xiao, Feng Yang, Zhonghai Zhao, A Liang

{"title":"Hyperbaric oxygen treatment promotes tendon-bone interface healing in a rabbit model of rotator cuff tears.","authors":"Hongqiu Li, Meiling Xiao, Feng Yang, Zhonghai Zhao, A Liang","doi":"10.4103/mgr.MEDGASRES-D-24-00034","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00034","url":null,"abstract":"Due to the high-intensity pressure that the shoulder cuff endures, it is prone to traumas and tears. The main critical function of the shoulder cuff muscles is to effectively facilitate shoulder movement and securely maintain the humeral head in the precise center of the joint cavity to prevent superior migration during abduction processes. Shoulder cuff injuries typically involve the muscle-tendon-bone interface, but existing repair techniques do not always guarantee complete and secure healing, leading to retears. Hyperbaric oxygen therapy, as an auxiliary treatment, can significantly promote the muscle-tendon-bone healing process. To explore the impact of hyperbaric oxygen therapy on the bone-tendon interface healing process in a rabbit model specifically designed for shoulder cuff tears, an experiment was conducted on New Zealand white rabbits by performing a full-thickness tear of the supraspinatus tendon in the left shoulder, followed by 2 hours per day of 100% oxygen treatment at 2 absolute atmospheres for 5 days. The results indicate that hyperbaric oxygen therapy significantly enhances vascularization at the interface between the shoulder cuff and tendon-bone, promotes collagen fiber regeneration in the tendon, improves the tensile strength of the tendon-bone complex, and does not have a significant effect on biomechanical stability. This suggests that hyperbaric oxygen therapy has a significant positive impact on the histological and biomechanical healing of shoulder cuff tears in rabbits, expediting the healing process of the tendon-bone interface.","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":" ","pages":"164-170"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142109351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of lung function with brachial artery function and cardiac function in divers after hyperbaric exposure. 高压氧暴露后潜水员肺功能与肱动脉功能和心脏功能的相关性。

IF 3

Medical Gas Research Pub Date : 2025-03-01 Epub Date: 2024-07-25 DOI: 10.4103/mgr.MEDGASRES-D-24-00037

Lijun Yin, Tingting Zhang, Yukun Wen, Xuhua Yu, Jiajun Xu, Shifeng Wang, Wenwu Liu

引用次数: 0

Lenvatinib Maintenance Therapy After Complete Response to Atezolizumab Plus Bevacizumab in Hepatocellular Carcinoma and Portal Vein Tumoral Thrombosis: Alternative Strategy in a Resource-limited Setting. 肝细胞癌和门静脉瘤栓形成患者对阿特珠单抗加贝伐单抗治疗完全应答后的伦伐替尼维持治疗：在资源有限的情况下的替代策略。

IF 3.3

Journal of Clinical and Experimental Hepatology Pub Date : 2025-03-01 Epub Date: 2024-11-13 DOI: 10.1016/j.jceh.2024.102455

Pramod Kumar, Rohit Maidur, Adarsh Channagiri, Nischay, Chandrashekhar Patil, Pradeep Krishna, Suresh Raghavaiah

引用次数: 0

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