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{"title":"Adaptation and validation of the Persian version of the foot Health Status Questionnaire in patients with plantar pain: evaluation of test-retest.","authors":"Leila Ahmadnezhad, Daniel López-López, Ricardo Becerro-de-Bengoa-Vallejo, Ana María Jiménez-Cebrián, Marta Elena Losa-Iglesias, Israel Casado-Hernández, Lisa Alves-Gomes, Emmanuel Navarro-Flores","doi":"10.1080/07853890.2025.2491665","DOIUrl":"https://doi.org/10.1080/07853890.2025.2491665","url":null,"abstract":"<p><strong>Background: </strong>The Foot Health Status Questionnaire (FHSQ) is a foot health psychometric tool for measuring foot health status that consists of eight dimensions. Currently, the FHSQ has been adapted to several languages. It was considered necessary to translate and adapt the FHSQ to the Persian language. Thus, the aim of this study was to assess the repeatability and reliability of the Foot Health Status Questionnaire (FHSQ) translated into Persian.</p><p><strong>Method: </strong>The translation into Persian and test-retest reliability methods came from the English version of the questionnaire. The questionnaire was distributed to 88 individuals diagnosed with plantar heel pain, who were recruited from a podiatry clinic in Iran. To assess test-retest reliability, the instrument was administered on two separate occasions, with a five-day interval between the initial and follow-up assessments.</p><p><strong>Results: </strong>As regards the total mark for each dimension, internal consistency and reliability were determined with the Cronbach <i>α</i> and intraclass correlation coefficient (ICC) with a confidence interval (CI) of 95%. High internal consistency was shown for the eight dimensions: (a) foot pain, with a Cronbach α of 0.773; (b) foot function and (c) general foot health with 0.788 and 0.776 respectively; (d) shoe with 0.793; (e) general health with 0.784; (f) physical function with 0.795; (g) social function with 0.801 and (h) vigour with 0.748. Excellent test-retest reliability (ICC = 0.911 [95% CI =0.844-0.949]) was shown for the total score.</p><p><strong>Conclusions: </strong>The Persian version of the FHSQ was shown to be a valid and reliable tool for acceptable use in the Iran population.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2491665"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a preliminary multivariable model predicting hamstring strain injuries during preseason screening in soccer players: a multidisciplinary approach.","authors":"Diane Baize, Stéphanie Mériaux-Scoffier, Anasthase Massamba, Thomas Hureau, Nicolas Reneaud, Yoann Garcia-Gimenez, Florian Marchand, Bastien Bontemps, Baptiste Corcelle, Vincent Maléjac, Amyn Jaafar, Emiliano Ippoliti, Florian Payet, Iliès Ajarai, Fabienne d'Arripe-Longueville, Enzo Piponnier","doi":"10.1080/07853890.2025.2494683","DOIUrl":"https://doi.org/10.1080/07853890.2025.2494683","url":null,"abstract":"<p><strong>Objective: </strong>Reducing the incidence of hamstring strain injuries (HSIs) is a priority for soccer clubs. However, robust multifactorial predictive models are lacking and potential predictors such as sprint kinematics, performance fatigability, and psychological variables have been overlooked. Thus, the aim of this study was to develop a preliminary parsimonious multifactorial model to predict players at risk of HSI through preseason screening.</p><p><strong>Materials and method: </strong>Psychological, physiological, kinematic, performance fatigability and health-related variables were collected for 120 regional and national soccer players during the 2022 preseason. HSIs were prospectively recorded over the entire soccer season. After variable selection, logistic regressions with the Wald backward stepwise method were used to refine the model. The predictive abilities of the model and of the individual variables were determined using the area under the receiver operating characteristic curve (AUC).</p><p><strong>Results: </strong>Twenty-nine players sustained an HSI during the follow-up period. The final model included eight variables: age, sex, HSI history, knee flexor performance fatigability, sprint performance (best sprint time and maximal theoretical velocity V₀), perceived vulnerability to injury, and subjective norms in soccer. While its model was preliminary, it showed good fit indices and strong predictive performance (true positive rate: 79%, AUC = .82). None of the variables evaluated independently demonstrated satisfactory performance in predicting HSI (AUC≤.65).</p><p><strong>Conclusion: </strong>Using a multidisciplinary approach and measurements of only a few variables during preseason screening, the current model tends to demonstrate high accuracy in identifying soccer players at risk of HSI.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2494683"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saddle pressures distribution at different pedaling intensities in young off-road cyclists: focus on sex.","authors":"Domenico Savio Salvatore Vicari, Antonino Patti, Valerio Giustino, Flavia Figlioli, Daniele Zangla, Nemanja Maksimovic, Patrik Drid, Antonio Palma, Antonino Bianco","doi":"10.1080/07853890.2025.2495764","DOIUrl":"https://doi.org/10.1080/07853890.2025.2495764","url":null,"abstract":"<p><strong>Background: </strong>The pressures on the saddle depend on several factors and can compress specific neurovascular tissues, leading to acute and chronic genital pathologies. Based on the pelvic differences between males and females, the aim of this study was to explore any differences on saddle pressures distribution according to sex.</p><p><strong>Methods: </strong>Twenty young off-road cyclists (10 m, 10 f) were recruited. Each participant was evaluated on own bike installed on a specific bike roller with a magnetic resistance. Firstly, each participant was asked to warm-up for 10 min at a self-selected cadence and intensity. Then, saddle pressures distribution was measured at three different pedaling intensities (100, 140, 180 W) with a pedaling cadence of 90 rpm, using a device equipped with sensors capable of acquiring pressures.</p><p><strong>Results: </strong>A significant difference in the ischial distance was found between males and females (<i>p</i> = 0.007). As pedaling intensity increased, results showed a significant higher pressure in the pubic region (<i>p</i> = 0.004) in males and a significant higher pressure in the posterior region in females (<i>p</i> = 0.034). <i>Post hoc</i> multiple comparisons test revealed a significant increase from 100 to 180 W (<i>p</i> = 0.003) in the pubic region pressure in males, while no significant differences were detected in the posterior region pressure in females.</p><p><strong>Conclusions: </strong>In male off-road cyclists, the pressure in the pubic region is higher with increasing pedaling intensity. Hence, to prevent acute and chronic genital pathologies, it would be advisable to fix the saddle in the best possible way during the bike fitting.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2495764"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular targets and mechanisms of traditional Chinese medicine combined with chemotherapy for gastric cancer: a meta-analysis and multi-omics approach.","authors":"Jie Lin, Jincheng Wang, Kai Zhao, Yongzhi Li, Xuewen Zhang, Jiyao Sheng","doi":"10.1080/07853890.2025.2494671","DOIUrl":"https://doi.org/10.1080/07853890.2025.2494671","url":null,"abstract":"<p><strong>Background: </strong>The combination of traditional Chinese medicine (TCM) with chemotherapy has been widely applied in the treatment of gastric cancer (GC). However, previous clinical studies have been constrained by small sample sizes and a lack of investigation into the molecular mechanisms of TCM. This study aims to assess the efficacy of TCM in treating GC by leveraging the strengths of meta-analysis and multi-omics approaches while also summarizing the underlying pharmacological mechanisms.</p><p><strong>Methods: </strong>A systematic literature review and meta-analysis were conducted using online databases to collect data before May 2024. This was to investigate the association between TCM combined with chemotherapy and the prognosis in GC. The molecular targets between the high-frequency TCMs and GC were identified through network pharmacology. The underlying mechanisms were investigated using multi-omics.</p><p><strong>Results: </strong>9 studies with 2,158 patients were included. The meta-analysis results demonstrated that the combination of TCM and chemotherapy significantly improved the overall survival (OS) of GC patients (OR = 2.91; 95% CI: 2.70-3.12, <i>p</i> < 0.00001) and enhanced their quality of life (OR = 4.00; 95% CI: 1.99-8.03, <i>p</i> < 0.0001). Network pharmacology analysis identified 13 potential molecular targets of TCM in GC; additionally, multi-omics analysis highlighted the significant roles of MK, MIF, GALECTIN, and CypA signaling pathways in GC.</p><p><strong>Conclusion: </strong>The combination of TCM with chemotherapy significantly improves the prognosis of GC; future research can focus on these key molecular targets and signaling pathways. This supports the application of precision medicine in cancer treatment and suggests the rational use of TCM in managing GC.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2494671"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between preoperative thyroid parameters, aggressive clinicopathological features and risk of recurrence in differentiated thyroid cancer.","authors":"Lu Yu, Xiao Chen, Jiaqi Liu, Hanyu Wang, Hui Sun","doi":"10.1080/07853890.2025.2491153","DOIUrl":"https://doi.org/10.1080/07853890.2025.2491153","url":null,"abstract":"<p><strong>Objective: </strong>The study aimed (1) to investigate the association between aggressive clinicopathological characteristics and the American Thyroid Association (ATA) recurrence risk classification in differentiated thyroid cancer (DTC) patients, and (2) to investigate the prognostic value of preoperative thyroid parameters.</p><p><strong>Methods: </strong>A total of 3833 patients histologically confirmed DTC were recruited. Preoperative clinical and postoperative pathologic data were retrospectively collected. Participants were stratified into low recurrence risk and intermediate-to-high recurrence risk groups based on the ATA risk stratification system.</p><p><strong>Results: </strong>The study cohort had a mean age of 48.87 ± 8.08 years, and 1,465 (76.82%) were female. Male (OR = 1.37, <i>p</i> = .024), aged 52 years and older (OR = 2.01, <i>p</i> < .001), larger tumor size (OR = 3.71, <i>p</i> = 0.011), nerve invasion (OR = 6.69, <i>p</i> = .004), margin involvement (OR = 5.46, <i>p</i> < .001), multifocality (OR = 3.71, <i>p</i> < .001), and bilaterality (OR = 3.95, <i>p</i> < .001) were identified as risk factors for a higher ATA recurrence risk classification, in addition to established factors such as lymph node metastasis and angioinvasion, after adjusting for potential confounding variables. Higher preoperative levels of free triiodothyronine (FT3), FT3 to free thyroxine (FT3/FT4), and lower thyroid feedback quantile-based index (TFQI) levels were associated with a higher ATA recurrence risk classification. The comprehensive predictive model incorporating these variables demonstrated excellent discrimination (AUC = 0.836). Furthermore, higher FT3/FT4 levels and lower TFQI levels were associated with higher risk of lymph node metastases and angioinvasion.</p><p><strong>Conclusions: </strong>Factors such as male sex, older age, multifocality, bilaterality, margin involvement, nerve invasion, larger tumor size, and preoperative thyroid parameters serve as complementary predictors for higher ATA recurrence risk in DTC, in addition to conventional risk factors. These insights contribute to a more nuanced understanding and optimization of current risk stratification methodologies.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2491153"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive circRNA expression profile and hub genes screening during human liver development.","authors":"Si Ying Li, Shu Ting Liu, Chen Yi Wang, Yu Zuo Bai, Zheng Wei Yuan, Xiao Bing Tang","doi":"10.1080/07853890.2025.2497111","DOIUrl":"https://doi.org/10.1080/07853890.2025.2497111","url":null,"abstract":"<p><strong>Background: </strong>Understanding the expression of non-coding RNA in the liver during embryonic development provides important insights into liver diseases. Therefore, we investigated circular RNA (circRNA) roles in human liver development, an unexplored research domain.</p><p><strong>Methods: </strong>Using high-throughput sequencing and bioinformatics, we analysed foetal liver samples across developmental stages (7-20 weeks post-conception). Differentially expressed (DE) genes were identified and subjected to enrichment analysis using Gene Ontology (GO), Kyoto Encyclopaedia of Genes and Genomes (KEGG), and Disease Ontology (DO). Modular analysis was performed using the Search Tool for Retrieval of Interacting Genes (STRING), followed by construction of a protein-protein interaction (PPI) network using Cytoscape software. The key genes were screened using Molecular Complex Detection (MCODE). The mRNA levels of hub genes were validated using quantitative reverse transcription polymerase chain reaction (qRT-PCR).</p><p><strong>Results: </strong>There were 645 DE circRNAs and 5,145 DE mRNAs between human livers at the three growth stages (HB, EH, and LH). It was found that the activity of circRNAs was boosted remarkably in the hepatoblastic stage. Enrichment analysis found they mainly involved in nervous system regulation of liver function, embryonic organ development and digestive system development. In addition, DE circRNAs were primarily involved in the PI3K-AKT, MAPK and calcium pathways, potentially contributing to adult liver diseases. Notably, only hsa_circ_001471 and novel_circ_017382 were simultaneously identified at all stages and were persistently downregulated. A co-expression regulatory network involving these circRNAs was established. Three hub genes (LGR5, FOXL1 and RSPO3) were identified from the PPI network of 167 genes and may play key roles in human liver development. The RT-qPCR validation results were in agreement with the sequencing data.</p><p><strong>Conclusions: </strong>Our findings provide the first insights into the roles and regulatory networks of circRNAs in human liver development, laying the groundwork for further investigations of molecular and signalling networks.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2497111"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for periprosthetic femoral fractures following hip arthroplasty: a systematic review and meta-analysis.","authors":"Wei-Qiang Zhao, Ke-Qin Yu, Rong-Zhen Xie, Yu-Feng Liang, Jie-Feng Huang","doi":"10.1080/07853890.2025.2494679","DOIUrl":"https://doi.org/10.1080/07853890.2025.2494679","url":null,"abstract":"<p><strong>Introduction: </strong>Periprosthetic femoral fracture (PPFF) is a serious complication following hip arthroplasty. The objective of this study was to determine the risk factors for PPFF following hip arthroplasty from existing studies.</p><p><strong>Methods: </strong>A comprehensive systematic search was performed in 4 databases: Pubmed, Embase, Web of Science, and Cochrane Library. The last search was carried out on 26th July 2024. We focused on identifying risk factors for PPFF following hip arthroplasty. Study eligibility required PPFF as an outcome and reporting of associated risk factors. Quality assessment was performed using the Newcastle-Ottawa Scale (NOS), with evidence certainty evaluated via Grading of Recommendations, Assessment, Development, and Evaluations (GRADE). Meta-analyses employed both fixed-effect and random-effects models to pool odds ratios for identified risk factors.</p><p><strong>Results: </strong>Out of 1553 articles, 36 studies published between 2006 and 2024 were included. Risk factors associated with increased incidence of PPFF ranges from very Low to High. High-quality evidence supported the use of uncemented stems (Odds Ratio [OR]: 3.36, 95% Confidence Interval [95% CI]: 3.02-3.74), major teaching hospital (OR: 2.04, 95% CI: 1.37-3.05). Moderate-quality evidence: female gender (OR: 1.60, 95% CI: 1.43-1.78), morbid obesity (OR: 1.44, 95% CI: 1.01-2.16), higher Deyo-Charlson index (OR: 1.44, 95% CI: 1.18-1.77), rheumatoid arthritis (OR: 1.89, 95% CI: 1.16-3.06), femoral Dorr type C (OR: 4.23, 95% CI: 2.82-6.33). Low evidence: age > 70 years (OR: 1.67, 95% CI: 1.19-2.34), revision hip arthroplasty (OR: 2.60, 95% CI: 1.59-4.27). BMI > 30 and history of hip surgery are not the risk (very low). Diagonized as osteoarthritis before surgery is a protective factor (OR:0.51, 95%CI: 0.40-0.65, quality = High).</p><p><strong>Conclusion: </strong>This meta-analysis provided some low-to-high evidence about the risk of PPFF following hip arthroplasty. It's recommended that clinicians consider these risk factors when evaluating patients for hip arthroplasty and take steps to mitigate their impact, like optimizing patients health preoperatively, using cemented stems, and monitoring high-risk patients closely.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2494679"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of amniotic fluid on hair follicle growth.","authors":"Gamze Tumentemur, Elif Ganime Aygun, Bulut Yurtsever, Didem Cakirsoy, Ercument Ovali","doi":"10.1080/09546634.2025.2451389","DOIUrl":"10.1080/09546634.2025.2451389","url":null,"abstract":"<p><p><b>Purpose:</b> Human amniotic fluid stem cells (hAFSCs) have shown significant regenerative potential in treating hair loss, wound healing, and tissue repair. This study aims to evaluate the effects of human amniotic fluid (hAF) on hair follicle (HF) regeneration and immune system modulation.</p><p><p><b>Materials and Methods:</b> The hAF used was pooled, acellular, and gamma-irradiated to standardize its contents and enhance its stability. Both irradiated (FAFI) and non-irradiated (FAF) hAF were assessed for their efficacy and safety in promoting hair growth and modulating immune responses in a rat model of hair loss. The study examined HF regeneration, transition to the anagen phase, and macrophage polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype.</p><p><p><b>Results:</b> Both FAF and FAFI treatments significantly increased HF density, with FAFI exhibiting enhanced effects. Histological analysis demonstrated improved HF regeneration, increased M2 macrophages, and reduced collagen fiber deposition in treated areas. Gamma irradiation likely improved the efficacy of FAFI by stabilizing active components and inhibiting protease activity.</p><p><p><b>Conclusions:</b> Irradiated hAF is a safe and effective therapeutic candidate for alopecia and HF growth disorders. These findings support further evaluation of hAF in clinical trials to validate its potential for hair regeneration therapies.</p>","PeriodicalId":94235,"journal":{"name":"The Journal of dermatological treatment","volume":"36 1","pages":"2451389"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for delayed gastric emptying after pancreatoduodenectomy: a 10-year retrospective study.","authors":"Carlos Jiménez-Romero, Agustín de Juan Lerma, Alberto Marcacuzco Quinto, Oscar Caso Maestro, Laura Alonso Murillo, Paula Rioja Conde, Iago Justo Alonso","doi":"10.1080/07853890.2025.2453076","DOIUrl":"10.1080/07853890.2025.2453076","url":null,"abstract":"<p><strong>Background: </strong>Delayed gastric emptying (DGE) is a frequent complication of pancreatoduodenectomy (PD) and is associated with prolonged hospital stay, readmission, increased hospital costs and decreased quality of life. However, the pathophysiology of DGE remains unclear.</p><p><strong>Methods: </strong>This is a retrospective study of patients who underwent PD for pancreatic or periampullary tumours. All these patients were operated between January 2012 and February 2023. The patients were divided into four groups according to the development of DGE after PD: No DGE, DGE grade A, DGE grade B and DGE grade C. The groups were compared in terms of outcomes and complications. We also analysed the preoperative and perioperative risk factors for DGE development.</p><p><strong>Results: </strong>Between January 2012 and February 2023, a total of 250 patients underwent PD. These patients were divided into four groups: No DGE (<i>n</i> = 152); DGE grade A (<i>n</i> = 42); DGE grade B (<i>n</i> = 45); and DGE grade C (<i>n</i> = 11). The incidence of the postoperative pancreatic fistulas (POPFs) grade B/C was significantly higher in the DGE grade C group (<i>p</i> < .001), and the rates of post-pancreatectomy haemorrhage (<i>p</i> = .004) and reoperation (<i>p</i> < .001) were significantly higher in the DGE grade B/C groups. A significantly higher rate of grade III-IV Clavien-Dindo complications (<i>p</i> < .001), longer intensive care unit (<i>p</i> < .001) and longer hospital stays (<i>p</i> < .001) were observed in the DGE grade C group; and 90-day mortality (<i>p</i> < .001) and morbidity (<i>p</i> < .001) were significantly higher in the DGE grade B/C groups. Multivariate analysis demonstrated that the POPF grade B/C was a risk factor of DGE grade B/C (OR: 9.147; 95%CI: 4.125-20.281; <i>p</i> < .001).</p><p><strong>Conclusions: </strong>POPF B/C is a risk factor for grade B/C DGE. Prevention of surgical complications and early treatment could contribute to the decreased incidence of DGE.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2453076"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Portuguese consensus on first line treatment of moderate-to-severe psoriasis with a non-TNF inhibitor therapy - a delphi methodology.","authors":"Tiago Torres, Sofia Magina, Maria João Paiva Lopes","doi":"10.1080/09546634.2025.2453601","DOIUrl":"10.1080/09546634.2025.2453601","url":null,"abstract":"<p><strong>Introduction: </strong>Psoriasis (PsO) is a common chronic, inflammatory, immune-mediated disease. In 2023, a 4.4% prevalence of PsO was reported in Portugal. Currently, Tumor Necrosis Factor inhibitors (TNFi) are the recommended first-line (1 L) biologic agents in Portugal given their lower cost. However, TNFi may not be suitable for several patients. In these patients, interleukin inhibitors (ILi) should be considered as they provide more effective outcomes and a better safety profile.</p><p><strong>Methods: </strong>Qualitative interviews with PsO experts were conducted to identify PsO biologic treatment needs, resulting in an online survey to explore clinical cases focused on subpopulations of PsO. A delphi study evaluated consensus on clinical criteria to initiate non-TNFi therapy in seven predefined subpopulations of patients.</p><p><strong>Results: </strong>This study highlights the benefit of starting non-TNFi therapy in all PsO predefined subpopulations. Patients with infection risk, mild heart failure and associated comorbidities, autoimmune diseases and family history of demyelinating disease consensually benefit from starting non-TNFi therapy in 1 L. Several risks associated with latent tuberculosis, advanced age and oncological disease were also evaluated.</p><p><strong>Conclusion: </strong>Given the existence of various risks associated with TNFi usage, this clinical perspective overview of Portuguese experts in PsO treatment emphasizes the need for a tailored therapeutic framework in the management of PsO.</p>","PeriodicalId":94235,"journal":{"name":"The Journal of dermatological treatment","volume":"36 1","pages":"2453601"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}