IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-01-31 DOI: 10.1080/20565623.2025.2458434

Doha El-Sayed Ellakwa, Laila Ahmed Rashed, Ola Sayed Ali, Noha Amr El-Sabbagh

{"title":"A study to determine the effect of nano-selenium and thymoquinone on the Nrf2 gene expression in Alzheimer's disease.","authors":"Doha El-Sayed Ellakwa, Laila Ahmed Rashed, Ola Sayed Ali, Noha Amr El-Sabbagh","doi":"10.1080/20565623.2025.2458434","DOIUrl":"10.1080/20565623.2025.2458434","url":null,"abstract":"Introduction: Alzheimer's disease is a developing public health concern in aging communities that affects a sizable section of the global population. The risk of Alzheimer's disease increases with age; it affects one-third of males and two-thirds of women. This research attempts to assess the effect of nano-selenium and thymoquinone on Nrf2 gene expression levels in Alzheimer's disease (AD).Methods: There were five identical groups of 50 albino male rats: a control group that was healthy; an AD positive control group; an AD group that received nano-selenium (5 mg/kg); an AD group that received thymoquinone (2 mg/kg); and an AD group that received both. The duration of treatment was 4 weeks. The levels of Nrf2 in brain tissues were evaluated using real-time PCR.Results: Nrf2 mean expression levels in the nano-selenium-treated rats, the thymoquinone-treated rats, and the rats that were given both treatments all increased significantly compared to AD rats with no treatment.Conclusions: This study showed that nano-selenium and thymoquinone elevated Nrf2 gene expression levels in AD.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2458434"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reporting and representation of participant race and ethnicity in phase III clinical trials for solid tumors. 实体瘤III期临床试验中参与者种族和民族的报告和代表性。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-01-30 DOI: 10.1080/20565623.2025.2458415

Tianyi Wang, Dinorah J Villanueva, Ambily Banerjee, Dina Gifkins

{"title":"Reporting and representation of participant race and ethnicity in phase III clinical trials for solid tumors.","authors":"Tianyi Wang, Dinorah J Villanueva, Ambily Banerjee, Dina Gifkins","doi":"10.1080/20565623.2025.2458415","DOIUrl":"10.1080/20565623.2025.2458415","url":null,"abstract":"Background: Including racial and ethnic minorities in clinical trials is essential for advancing health equity. Despite progress, trials often do not mirror patient population demographics.Methods: The National Library of Medicine's Clinical Trials database was queried for phase III trials of lung, colorectal, breast, and prostate cancers. A reference population was identified from the Surveillance, Epidemiology, and End Result (SEER) database, covering 48% of the US population.Results: Among 181 trials, race and ethnicity data were included in 86.7% and 60.2% of trials, respectively, with improving reporting over time. Participants were predominantly White (76.3%), followed by Asian/Pacific Islander (14.1%), Black/African American (4.5%), and American Indian/Alaska Native (0.6%). Hispanic/Latino constituted 6.4% of participants. The proportion of non-White groups increased from 19.4% in trials started before 2011 to 26.2% after 2015. Compared with SEER data, the percentages were lower for Asian/Pacific Islander across all cancers, Black/African American in breast and prostate cancers, American Indian or Alaska Native in colorectal, breast, and prostate cancers in US solely trials.Conclusions: Reporting and enrollment of racial and ethnic minorities in trials remain inadequate but improving. To enhance diversity, real-world data are warranted to identify recruitment goals by better assessing the geographic distribution within the patient population.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2458415"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantum leadership: new approach in managing shoulder dystocia in simulation-based training. 量子领导力：模拟训练中处理肩难产的新方法。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-01-30 DOI: 10.1080/20565623.2025.2458427

Georges Yared, Christopher Massaad, Kariman Ghazal

{"title":"Quantum leadership: new approach in managing shoulder dystocia in simulation-based training.","authors":"Georges Yared, Christopher Massaad, Kariman Ghazal","doi":"10.1080/20565623.2025.2458427","DOIUrl":"10.1080/20565623.2025.2458427","url":null,"abstract":"Background: Shoulder dystocia, a challenging condition for obstetricians, poses significant risks to both maternal and neonatal health, including maternal postpartum hemorrhage, neonatal hypoxia, and brachial plexus injury. Despite being unpredictable and unpreventable, effective management can mitigate these risks. Miscommunication and poor leadership are responsible for 72% of medical errors, which further highlights the importance of robust leadership skills in obstetric emergencies.Research design and methods: A qualitative study involving 20 participants through structured interviews assessed preferred leadership styles in managing shoulder dystocia.Results: Findings revealed that 55% of participants favored quantum leadership. Other preferences included laissez-faire by one anesthesiologist and democratic by two midwives. However, all participants acknowledged the efficacy of the seven quantum leadership skills in managing shoulder dystocia. Discussion emphasized that traditional leadership styles are less effective compared to quantum leadership in managing the complexities of shoulder dystocia. The quantum Ob-Wheel, consisting of 12 milestones, integrates these seven interdependent skills to guide the management process.Conclusions: Despite the limited sample size of this study, it is worth noting that, given the unpredictable nature of shoulder dystocia, clinicians should be prepared for its occurrence during any birth, with quantum leadership providing a strategic advantage in such scenarios.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2458427"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to letter regarding 'demographic and clinical Features of rosacea in North Jordan: a 10-year University Hospital Retrospective study'. 对“北约旦酒渣鼻的人口学和临床特征：一项10年大学医院回顾性研究”的回复。

Annals of medicine Pub Date : 2025-12-01 Epub Date: 2025-03-20 DOI: 10.1080/07853890.2025.2482861

Diala Alshiyab, Saleh A Ba-Shammakh

引用次数: 0

Elevated expression of ANAPC1 in lung squamous cell carcinoma: clinical implications and mechanisms. ANAPC1在肺鳞状细胞癌中的表达升高：临床意义和机制

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-03-26 DOI: 10.1080/20565623.2025.2482487

Xiao-Song Chen, Feng Chen, Shu-Jia He, Yi-Yang Chen, Bang-Teng Chi, Wan-Ying Huang, Yue Wei, Chun-Yan Zhao, Chang Song, Rong-Quan He, Gang Chen, Jin-Liang Kong, Hui-Ping Lu

{"title":"Elevated expression of ANAPC1 in lung squamous cell carcinoma: clinical implications and mechanisms.","authors":"Xiao-Song Chen, Feng Chen, Shu-Jia He, Yi-Yang Chen, Bang-Teng Chi, Wan-Ying Huang, Yue Wei, Chun-Yan Zhao, Chang Song, Rong-Quan He, Gang Chen, Jin-Liang Kong, Hui-Ping Lu","doi":"10.1080/20565623.2025.2482487","DOIUrl":"10.1080/20565623.2025.2482487","url":null,"abstract":"Aim: To investigate the comprehensive expression levels and possible molecular mechanisms of Anaphase Promoting Complex Subunit 1 (ANAPC1) in lung squamous cell carcinoma (LUSC).Methods: Data from 2,031 samples were combined to evaluate ANAPC1 mRNA levels, and 118 samples were collected for immunohistochemical (IHC) analysis. High-expression co-expressed genes (HECEGs) associated with ANAPC1 were analyzed for signaling pathways. Clinical significance, immune computations, and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) validation of ANAPC1's role in LUSC were assessed. Molecular docking evaluated binding affinity with potential therapeutics.Results: ANAPC1 mRNA was significantly upregulated in LUSC (SMD = 1.97, 95% CI [1.26-2.67]). Protein-level analysis confirmed this upregulation (p < 0.001). Most HECEGs associated with ANAPC1 were enriched in cell cycle pathways. Higher ANAPC1 expression correlated with poorer survival in LUSC patients (HR = 1.11, 95% CI: 1-1.49). ANAPC1 expression was higher in males and N1-stage vs. females and N0-stage; lower in grade I vs. II/III. Overexpression reduces immune cell infiltration and immunotherapy effectiveness, while knockdown inhibits cell proliferation. Drug sensitivity and docking analyses identified tenovin-1, carboxyatractyloside, and phycocyanobilin as potential antitumor agents targeting ANAPC1.Conclusion: The elevated expression of ANAPC1 might play a role in LUSC advancement and progression through its participation in cell growth-related pathways.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2482487"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modifiable risk factors of dementia in the Indian scenario. 在印度的情况下，痴呆的可改变的危险因素。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-03-24 DOI: 10.1080/20565623.2025.2483132

Ankul Singh S, Lakshmi Chandran, Chitra Vellapandian

引用次数: 0

Reply to the letter to the editor: previous immunological disease can promote neurological complications of SARS-CoV-2 infection, such as VST or GBS. 回复编辑来信：既往免疫性疾病可促进SARS-CoV-2感染的神经系统并发症，如VST或GBS。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-02-17 DOI: 10.1080/20565623.2025.2463851

Shema Ayadi, Hela Jamoussi

引用次数: 0

The association between whole blood viscosity and CHA2DS2-VASc/CHA2DS2-VA scores in patients with atrial fibrillation. 房颤患者全血粘度与CHA2DS2-VASc/CHA2DS2-VA评分的关系

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-02-18 DOI: 10.1080/20565623.2025.2467607

Erkan Kahraman, Koray Kalenderoglu

{"title":"The association between whole blood viscosity and CHA2DS2-VASc/CHA2DS2-VA scores in patients with atrial fibrillation.","authors":"Erkan Kahraman, Koray Kalenderoglu","doi":"10.1080/20565623.2025.2467607","DOIUrl":"10.1080/20565623.2025.2467607","url":null,"abstract":"Introduction: CHA2DS2-VASc and CHA2DS2-VA scores are often used to demonstrate thromboembolic risk in nonvalvular atrial fibrillation. Elevated whole blood viscosity is an independent risk factor for ischemic stroke.Objective: This study aimed to ascertain the correlation between whole blood viscosity and CHA2DS2-VASc/CHA2DS2-VA scores.Methods: This study was performed retrospectively in a tertiary cardiac facility, encompassing 150 patients.Results: The study's results demonstrate that whole blood viscosity, concerning both high shear rate and low shear rate variables, are statistically significant in forecasting the likelihood of elevated CHA2DS2-VA and CHA2DS2-VASc scores. (AUC: 0.690, 0.693; p: <0.001; 0.647, 0.665; p: <0.05).Conclusion: Whole blood viscosity had a substantial correlation with the CHA2DS2-VASc/CHA2DS2-VA scores in patients with atrial fibrillation and may be used to evaluate thromboembolism risk, akin to these scores.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2467607"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regarding 'long-term cognitive and autonomic effects of COVID-19 in young adults: a cross-sectional study at 28 months'. 关于“COVID-19对年轻人的长期认知和自主神经影响：一项28个月的横断面研究”。

Annals of medicine Pub Date : 2025-12-01 Epub Date: 2025-02-27 DOI: 10.1080/07853890.2025.2464940

Lien-Chung Wei, Chun-Hung Lee

引用次数: 0

Underdosing and response to pharmacotherapy in patients with status epilepticus: a retrospective study from Saudi Arabia. 癫痫持续状态患者的剂量不足和药物治疗反应：一项来自沙特阿拉伯的回顾性研究。

Annals of medicine Pub Date : 2025-12-01 Epub Date: 2025-05-03 DOI: 10.1080/07853890.2025.2496797

Sultan M Alghadeer, Aseel Alsuwayegh, Hessa AlMuqati, Maha A Alammari, Omar A Almohammed

{"title":"Underdosing and response to pharmacotherapy in patients with status epilepticus: a retrospective study from Saudi Arabia.","authors":"Sultan M Alghadeer, Aseel Alsuwayegh, Hessa AlMuqati, Maha A Alammari, Omar A Almohammed","doi":"10.1080/07853890.2025.2496797","DOIUrl":"https://doi.org/10.1080/07853890.2025.2496797","url":null,"abstract":"Background: Despite the essential of understanding patterns of status epilepticus (SE) and investigating appropriate therapy for these patients, such data are limited in the Saudi population.Methods: A retrospective study including adult patients who were admitted to emergency departments (EDs) in two hospitals due to SE was conducted between May 2015 and July 2021. We aimed to describe the characteristics for patients who were admitted to ED with SE, describe the pattern of pharmacotherapy used in these patients, assess patients' response to these pharmacotherapy agents in different stages and investigate reasons for treatment failure.Results: A total of 420 SE episodes that received at least one dose of benzodiazepines (BDZs) or anti-seizure medications (ASMs) in ED were included. The mean age for them was 38.7 ±19.1 years and 89.0% had a history of epilepsy . BDZs or ASMs were used on first trial in 60.0% and 40.0% of episodes; and 20.6% and 84.5% (p < 0.0001) of these cases responded, respectively. The overall response to BDZs in all trials was 24.8% while it was 79.1% for the ASMs. The issue of under-dosing was more prevalent in BDZs' compared to ASMs trials (63.4% vs. 19.6%) and was significantly associated with lack of response to therapy (86.6% vs. 0.0%; p < 0.0001).Conclusions: There is an immanent need for educational, drug regulation awareness programs, and protocols enforcement policies that aims to optimize patient care by improving physicians' adherence to clinical guidelines' recommendations to improve the status of managing patients with SE in Saudi Arabia.","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2496797"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

其他最新文献