IF 10.3

Physiology (Bethesda, Md.) Pub Date : 2027-01-01 Epub Date: 2026-04-19 DOI: 10.1152/physiol.00008.2026

Shuqin Liu, Meiyu Hu, Xinpeng Li, Guoping Li, Dragos Cretoiu, T Scott Bowen, Joost P G Sluijter, Yihua Bei, Junjie Xiao

{"title":"Optimized Cardiac Health by Exercise: Cardiomyocytes and Immune Microenvironment.","authors":"Shuqin Liu, Meiyu Hu, Xinpeng Li, Guoping Li, Dragos Cretoiu, T Scott Bowen, Joost P G Sluijter, Yihua Bei, Junjie Xiao","doi":"10.1152/physiol.00008.2026","DOIUrl":"10.1152/physiol.00008.2026","url":null,"abstract":"Exercise is a highly cost-effective and nonpharmacological intervention for maintaining cardiovascular health and treating heart disease. Exercise can protect the heart through multiple effects, including the regulation of cardiomyocytes and noncardiomyocytes. Immune cells can be regulated upon exercise under both physiological and pathological conditions. The present review presents the current knowledge and research advances about how exercise protects the heart, especially deciphering the regulation of cardiomyocytes and the immune microenvironment by exercise. This review introduces the effect of exercise on the infiltration, phenotypic plasticity, and activation of innate and adaptive immune cells, alongside their interactions with other cellular components within the cardiac immune microenvironment. Moreover, we address the role of lymphatic vessels in regulating immune cell trafficking and activation, as well as the effects of exercise on cardiac lymphangiogenesis. It further discusses the application of multiomics approaches in investigating exercise-induced cardiac adaptations, explores potential therapeutic strategies targeting the cardiac immune microenvironment, and highlights the cardiotoxicity risks associated with excessive exercise. A deep understanding of the effects of exercise on cardiomyocytes and cardiac immune microenvironment will pave the way to promote exercise interventions and the development of exercise mimetics in the treatment of heart diseases.","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"0"},"PeriodicalIF":10.3,"publicationDate":"2027-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Screening of Alzheimer's Disease, Lewy Body Dementia, and Frontotemporal Dementia Using miRNA and Machine Learning. 使用miRNA和机器学习对阿尔茨海默病、路易体痴呆和额颞叶痴呆进行比较筛查。

IF 6.4

International journal of neural systems Pub Date : 2027-01-01 Epub Date: 2026-07-27 DOI: 10.1142/S012906572750002X

Benjamin Luo, Valentina L Kouznetsova, Igor F Tsigelny

{"title":"Comparative Screening of Alzheimer's Disease, Lewy Body Dementia, and Frontotemporal Dementia Using miRNA and Machine Learning.","authors":"Benjamin Luo, Valentina L Kouznetsova, Igor F Tsigelny","doi":"10.1142/S012906572750002X","DOIUrl":"10.1142/S012906572750002X","url":null,"abstract":"Current dementia diagnostic methods can be costly, invasive, or limited in their ability to distinguish between disorders with overlapping clinical symptoms. Dysregulated microRNAs (miRNAs) have emerged as promising noninvasive biomarkers for neurodegenerative disease, but individual miRNA changes alone may not capture the complex molecular patterns needed for accurate disease classification. Machine learning provides a way to integrate multiple layers of miRNA-derived information and identify disease-specific biomarker signatures. In this study, we developed machine learning models to classify dysregulated miRNAs associated with Alzheimer's disease dementia (AD), Lewy body dementia (LBD), and frontotemporal dementia (FTD). Each miRNA was represented using sequence-derived descriptors, predicted gene targets, and KEGG pathway features. The highest-performing models trained on AD, LBD, and FTD achieved 10-fold cross-validation accuracies of 90.6%, 92.9%, and 100%, respectively. When evaluated on independent datasets, the AD, LBD, and FTD models achieved accuracies of 88.9%, 77.8%, and 90.9%, respectively. Cross-disease testing showed reduced performance when models were applied across dementia types, suggesting partially disease-specific miRNA patterns while also indicating overlap among the molecular signatures of AD, LBD, and FTD. These results suggest that machine learning-based integration of miRNA sequence, target-gene, and pathway information can improve the identification of dementia-associated biomarker signatures and may support the future development of noninvasive diagnostic tools for dementia.","PeriodicalId":94052,"journal":{"name":"International journal of neural systems","volume":" ","pages":"2750002"},"PeriodicalIF":6.4,"publicationDate":"2027-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148595362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental evidence for the beneficial effects of low-concentration ozone. 低浓度臭氧有益作用的实验证据。

IF 4.2

Medical Gas Research Pub Date : 2027-01-01 Epub Date: 2026-09-12 DOI: 10.4103/mgr.MEDGASRES-D-25-00198

Flavia Carton, Carlo Pellicciari, Gabriele Tabaracci, Manuela Malatesta

{"title":"Experimental evidence for the beneficial effects of low-concentration ozone.","authors":"Flavia Carton, Carlo Pellicciari, Gabriele Tabaracci, Manuela Malatesta","doi":"10.4103/mgr.MEDGASRES-D-25-00198","DOIUrl":"10.4103/mgr.MEDGASRES-D-25-00198","url":null,"abstract":"Ozone (O3), a molecule consisting of three oxygen atoms, is an unstable compound whose clinical application as a complementary therapy continues to expand. Although numerous clinical studies support its therapeutic potential, the molecular basis of its effects has remained poorly understood. This review summarizes the current knowledge on the cellular and molecular mechanisms activated by low-concentration O3. Central to its action is the induction of mild oxidative stress by low concentrations of O3, which triggers an antioxidant response mediated through nuclear factor erythroid 2-related factor 2, enhancing cell survival. Additionally, low-concentration O3 exhibits antiinflammatory properties by modulating cytokine expression, inhibiting metalloproteinases, and activating macrophages. The regenerative potential of low-concentration O3 may be attributed to the stimulation of fibroblasts, chondrocytes, and osteoblasts. Moreover, the antitumor effects of low-concentration O3 in cancer cell lines and animal models appear to be linked to the inhibition of cell proliferation and migration, as well as proapoptotic activity. More research is needed to determine the best treatment methods, long-term effectiveness, and standardized clinical procedures for ozone therapy in specific diseases. This review provides a detailed reference for understanding how O3 therapy works.","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"17 1","pages":"177-187"},"PeriodicalIF":4.2,"publicationDate":"2027-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13667353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HydroMg attenuates doxorubicin-induced myocardial injury via promoting mitochondrial function. 氢镁通过促进线粒体功能减轻阿霉素诱导的心肌损伤。

IF 4.2

Medical Gas Research Pub Date : 2027-01-01 Epub Date: 2026-09-12 DOI: 10.4103/mgr.MEDGASRES-D-25-00179

Lu Zhang, Yawei Jin, Yuning Zhang, Mohan Li, Xiong Gao, Bin Ma, Xiaonan Ning, Aijun Sun, Wenjiang Ding, Zhiguang Ding, Xiurui Ma, Xiaolei Sun, Jian An

{"title":"HydroMg attenuates doxorubicin-induced myocardial injury via promoting mitochondrial function.","authors":"Lu Zhang, Yawei Jin, Yuning Zhang, Mohan Li, Xiong Gao, Bin Ma, Xiaonan Ning, Aijun Sun, Wenjiang Ding, Zhiguang Ding, Xiurui Ma, Xiaolei Sun, Jian An","doi":"10.4103/mgr.MEDGASRES-D-25-00179","DOIUrl":"10.4103/mgr.MEDGASRES-D-25-00179","url":null,"abstract":"In contrast to molecular hydrogen's intrinsic limitations, HydroMg's structural optimization shortens gastrointestinal transit, reducing hydrogen dissipation while enhancing cellular bioavailability. However, it remains unclear whether it also provides protection against cardiac injury. Here, we investigated the cardioprotective effect of HydroMg, a sustained-release hydrogen donor, against doxorubicin-induced cardiac injury. In vitro studies showed that 1 μg/mL HydroMg treatment attenuated doxorubicin-induced cardiomyocyte death by inhibiting apoptosis, reducing reactive oxygen species production, and restoring mitochondrial membrane potential. The cardioprotective effect of HydroMg (20, 100, 500, and 1000 mg/kg) was further validated in doxorubicin-induced mice. The 100 mg/kg HydroMg group exhibited 35.7% lower mortality than doxorubicin-treated controls. Additionally, HydroMg treatment significantly improved cardiac function and increased left ventricular ejection fraction by 12.44% compared with the doxorubicin-only group. Mechanistically, HydroMg treatment alleviated mitochondrial dysfunction in the doxorubicin-induced cardiotoxicity mouse model by scavenging reactive oxygen species to dually suppress ferroptosis (via solute carrier family 7 member 11/glutathione peroxidase 4 axis upregulation) and apoptosis (characterized by caspase-3 downregulation and Bcl-2 upregulation). Overall, HydroMg treatment inhibits doxorubicin-induced mitochondrial dysfunction by attenuating reactive oxygen species overproduction, thereby suppressing ferroptosis and apoptosis.","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"17 1","pages":"30-39"},"PeriodicalIF":4.2,"publicationDate":"2027-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13667355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perioperative hyperbaric oxygen therapy: mechanisms, evidence, and clinical application. 围手术期高压氧治疗：机制、证据和临床应用。

IF 4.2

Medical Gas Research Pub Date : 2027-01-01 Epub Date: 2026-09-12 DOI: 10.4103/mgr.MEDGASRES-D-25-00318

Takudzwa Gavaza, Nathanael Matei

{"title":"Perioperative hyperbaric oxygen therapy: mechanisms, evidence, and clinical application.","authors":"Takudzwa Gavaza, Nathanael Matei","doi":"10.4103/mgr.MEDGASRES-D-25-00318","DOIUrl":"10.4103/mgr.MEDGASRES-D-25-00318","url":null,"abstract":"Hyperbaric oxygen therapy delivers 100% oxygen at supra-atmospheric pressures, elevating plasma oxygen content and tissue oxygenation above normoxic levels. Once limited to decompression illness, hyperbaric oxygen therapy is gaining recognition as a perioperative adjunct with potential to mitigate complications through supra-physiologic tissue oxygenation. This review summarizes current evidence on the biological mechanisms, clinical applications, and considerations of perioperative hyperbaric oxygen therapy. Mechanistically, hyperbaric oxygen therapy has been shown to promote angiogenesis through redox-sensitive upregulation of hypoxia-inducible factor-1α and vascular endothelial growth factor, accelerate fibroblast proliferation and collagen synthesis, mobilize CD34-positive progenitor cells, and mitigate ischemia-reperfusion injury via antioxidant and anti-inflammatory pathways. Clinically, hyperbaric oxygen therapy has demonstrated improved graft uptake, flap salvage, and muscle recovery across trauma, reconstructive, and orthopedic contexts, and has shown promise in cardiac surgery preconditioning. The safety of hyperbaric oxygen therapy is favorable, with serious complications occurring in fewer than 0.5% of treatments. Despite accumulating evidence of its biological effect, widespread perioperative adoption remains constrained by cost, coverage limitations, and protocol heterogeneity. Higher-quality studies, including standardized dosing parameters and multicenter randomized trials, are needed to define optimal timing and patient selection. As health systems move toward precision perioperative optimization, hyperbaric oxygen appears to be gaining ground as a compelling, evidence-supported tool to improve surgical outcomes while aligning with the broader goals of restorative and regenerative medicine.","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"17 1","pages":"306-313"},"PeriodicalIF":4.2,"publicationDate":"2027-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13667376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is Insulin Resistance an Adaptive Response? Clues from Nature. 胰岛素抵抗是一种适应性反应吗？来自大自然的线索。

IF 10.3

Physiology (Bethesda, Md.) Pub Date : 2027-01-01 Epub Date: 2026-06-02 DOI: 10.1152/physiol.00059.2025

Karen L Sweazea

{"title":"Is Insulin Resistance an Adaptive Response? Clues from Nature.","authors":"Karen L Sweazea","doi":"10.1152/physiol.00059.2025","DOIUrl":"10.1152/physiol.00059.2025","url":null,"abstract":"Insulin is an evolutionarily conserved peptide hormone best known for regulating glucose homeostasis, yet its physiological roles extend well beyond glucose regulation. Across the animal kingdom, insulin signaling influences such diverse physiological processes as growth and development, stress responses, cognition, learning, memory formation, sodium balance, thermoregulation, reproduction, and vision. Although traditional laboratory models have advanced our understanding of insulin signaling and diabetes pathophysiology, they represent a relatively narrow perspective on the diversity of glucose regulation strategies and roles of insulin observed in the animal kingdom. Examination of insulin resistance through a comparative physiology lens provides a broader evolutionary framework for understanding how insulin signaling pathways and nutrient regulation have been conserved or modified across species in response to various environmental pressures. Evidence from this approach demonstrates diverse glucose regulation strategies noting that insulin resistance can at times function as an adaptive response to various stressors, even in humans. Several recent reviews have explored the evolution of insulin resistance and adaptive insulin resistance, although most have focused on a limited subset of vertebrates. Therefore, the intent of the present review is not to reproduce these efforts but to synthesize evidence across taxa, highlighting the diversity of strategies for glucose regulation and adaptive insulin resistance in vertebrates through the lens of comparative physiology. By examining insulin signaling within an evolutionary context, this review aims to identify unifying principles that challenge conventional paradigms of insulin resistance as solely pathological and instead position it as a context-dependent physiological adaptation across species.","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"0"},"PeriodicalIF":10.3,"publicationDate":"2027-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148146037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multicellular Cross Talk and Therapeutic Vaccines in Heart Failure. 心力衰竭的多细胞串扰和治疗性疫苗

IF 10.3

Physiology (Bethesda, Md.) Pub Date : 2027-01-01 Epub Date: 2026-04-29 DOI: 10.1152/physiol.00007.2026

Manami Katoh, Seitaro Nomura, Toshiyuki Ko, Jin Komuro, Hiroki Hayashi, Hironori Nakagami, Issei Komuro

{"title":"Multicellular Cross Talk and Therapeutic Vaccines in Heart Failure.","authors":"Manami Katoh, Seitaro Nomura, Toshiyuki Ko, Jin Komuro, Hiroki Hayashi, Hironori Nakagami, Issei Komuro","doi":"10.1152/physiol.00007.2026","DOIUrl":"10.1152/physiol.00007.2026","url":null,"abstract":"Heart failure (HF) remains a leading cause of morbidity and mortality worldwide despite major advances in pharmacological and device-based therapies. A central limitation of current treatments is their predominant focus on neurohumoral modulation rather than the intrinsic biological processes driving cardiac remodeling. Recent progress in genetics, single-cell and spatial omics, and systems biology has fundamentally reshaped our understanding of HF, revealing it as a heterogeneous, multicellular syndrome characterized by disrupted intercellular communication within the cardiac cellular ecosystem. Endothelial cells, fibroblasts, immune cells, and cardiomyocytes engage in dynamic signaling networks that coordinate myocardial structure, metabolism, and function; pathological remodeling emerges when these networks become maladaptive. Circulating biomarkers increasingly serve as readouts of these intercellular interactions, reflecting senescence, inflammation, fibrosis, and metabolic stress. Among them, insulin-like growth factor-binding protein 7 (IGFBP7) has emerged as a key mediator linking endothelial cell senescence to cardiomyocyte metabolic dysfunction. In parallel, stress-activated fibroblast subpopulations drive HF progression through paracrine signaling pathways such as the MYC-CXCL1-CXCR2 axis. These insights open new therapeutic opportunities beyond conventional pharmacology. Immunization-based strategies targeting pathological intercellular communication represent a novel paradigm for disease-modifying HF therapy. Peptide-based vaccines that neutralize circulating mediators or eliminate pathogenic cell populations have demonstrated efficacy in preclinical models and early clinical studies. In this review, we integrate emerging trends in HF research with recent advances in multicellular biology and therapeutic vaccination, proposing immunization as a unifying strategy to target cardiac remodeling at its roots.","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"0"},"PeriodicalIF":10.3,"publicationDate":"2027-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147795784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lymphatic Matters in Heart Disease: Systemic and Cardiac Perspectives. 心脏病中的淋巴问题：系统和心脏的观点。

IF 10.3

Physiology (Bethesda, Md.) Pub Date : 2027-01-01 Epub Date: 2026-05-13 DOI: 10.1152/physiol.00057.2025

Benjamin Kelly, Tobias Wang, Vibeke E Hjortdal, Donna M B Boedtkjer

{"title":"Lymphatic Matters in Heart Disease: Systemic and Cardiac Perspectives.","authors":"Benjamin Kelly, Tobias Wang, Vibeke E Hjortdal, Donna M B Boedtkjer","doi":"10.1152/physiol.00057.2025","DOIUrl":"10.1152/physiol.00057.2025","url":null,"abstract":"The lymphatic system plays a fundamental role in cardiovascular physiology by maintaining whole body fluid balance, facilitating immune trafficking, and enabling lipid transport. Through these functions, lymphatic performance is tightly coupled to cardiovascular health, and disturbances in lymphatic flow, pumping, or lympho-venous return can directly influence the development and progression of heart disease. This review examines the relationship between the lymphatic and cardiovascular systems with an emphasis on systemic lymphatic function and its relevance to cardiovascular pathology. We describe the structure and physiology of the human lymphatic vasculature, including mechanisms governing lymph formation, transport, and return to the venous circulation, and discuss how these processes are challenged in conditions such as heart failure, venous congestion, and altered hemodynamics. Clinical and experimental evidence linking lymphatic dysfunction to edema, inflammation, and impaired organ function across multiple cardiovascular disease states, including heart failure, atherosclerosis, congenital heart disease, and heart transplantation, is considered. In addition, comparative and translational perspectives are presented, illustrating how diverse vertebrate lymphatic strategies inform fundamental principles of lymphatic regulation and translational cardiovascular research. Finally, emerging imaging modalities and therapeutic approaches targeting lymphatic structure and function are discussed as potential avenues for improving the diagnosis and treatment of cardiovascular disease. Together, this review positions the lymphatic system as an integral, system-level contributor to cardiovascular physiology and disease, underscoring the need to consider lymphatic function alongside the blood circulation in both research and clinical practice.","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"0"},"PeriodicalIF":10.3,"publicationDate":"2027-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147937259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural bioactive gases: immunomodulatory properties and effects on human physiology of plant-derived biogenic volatile organic compounds and phytoncides. 天然生物活性气体：植物源性挥发性有机化合物和植物杀菌剂的免疫调节特性及其对人体生理的影响。

IF 4.2

Medical Gas Research Pub Date : 2027-01-01 Epub Date: 2026-06-17 DOI: 10.4103/mgr.MEDGASRES-D-26-00076

Mohammad Mahdi Asaadi, Giovanni N Roviello

引用次数: 0

Hydrogen therapy and cardiovascular diseases: a visualization analysis of research hotspots and application prospects. 氢疗法与心血管疾病：研究热点与应用前景可视化分析。

IF 4.2

Medical Gas Research Pub Date : 2027-01-01 Epub Date: 2026-09-12 DOI: 10.4103/mgr.MEDGASRES-D-25-00165

Yi Qian, Mingfei Shi, Yan Yang, Wei Qian, Ziyun Li, Jingqing Hu

{"title":"Hydrogen therapy and cardiovascular diseases: a visualization analysis of research hotspots and application prospects.","authors":"Yi Qian, Mingfei Shi, Yan Yang, Wei Qian, Ziyun Li, Jingqing Hu","doi":"10.4103/mgr.MEDGASRES-D-25-00165","DOIUrl":"10.4103/mgr.MEDGASRES-D-25-00165","url":null,"abstract":"Hydrogen, an emerging medical gas, has demonstrated diverse biological effects, including anti-oxidant, anti-inflammatory, and anti-apoptotic activities, offering significant therapeutic potential in cardiovascular diseases. This study aimed to explore the applications of hydrogen therapy in cardiovascular diseases and to illustrate both the current research status and future trends. 162 publications (129 original articles and 33 reviews) on hydrogen therapy in cardiovascular diseases were retrieved from the Web of Science Core Collection database up to April 9, 2025. The information was analyzed using Excel 2019, OriginPro 2024, VOSviewer 1.6.20 and CiteSpace 6.2. The number of publications on hydrogen therapy for cardiovascular diseases has shown a significant increase, with China, Japan, and the United States of America being the leading contributors. Keio University published the largest number of articles, and Sano Motoaki, the most prolific author (n = 14), is also from Keio University. Keyword clustering analysis shows that current research hotspots include \"ischemia-reperfusion injury,\" \"cardiac arrest,\" \"oxidative stress,\" \"inflammation,\" and \"apoptosis,\" while emerging directions may focus on the \"NLRP3 inflammasome,\" \"pyroptosis,\" and \"micro/nanomaterials.\" The underlying mechanisms of hydrogen therapy and its delivery approaches remain key research hotspots of hydrogen therapy for cardiovascular diseases; however, further high-quality clinical studies are needed to strengthen the evidence base and support its wider clinical application.","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"17 1","pages":"40-45"},"PeriodicalIF":4.2,"publicationDate":"2027-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13667371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

其他最新文献