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{"title":"TiO₂ nanomaterial promotes plant growth and disease resistance.","authors":"Xiaotong Gai, Xiaofeng Xu, Ning Jiang, Dingli Zhang, Yongjun Zhang, YongWn Kim, YuanHu Xuan, Dandan Li","doi":"10.1080/15592324.2025.2512943","DOIUrl":"10.1080/15592324.2025.2512943","url":null,"abstract":"<p><p>TiO₂ nanomaterials can promote plant growth and enhance disease resistance. However, the underlying mechanism remains unclear. This study applied TiO₂ to promote the growth of wheat, soybean, tobacco, cucumber, and corn. Genetic analysis using macro-element transporter rice mutants in rice revealed that growth promotion induced by TiO₂ was dependent on <i>potassium transporter</i> (<i>AKT1</i>), <i>nitrate transporter 1.1B</i> (<i>NRT1.1B</i>), <i>ammonium transporter 1</i> (<i>AMT1</i>), and <i>phosphate transporter 8</i> (<i>PT8</i>). TiO₂ also enhanced chlorophyll accumulation, and growth promotion was inhibited in the chlorophyll biosynthesis rice mutants, <i>yellow-green leaf 8</i> (<i>ygl8</i>) and <i>divinyl reductase</i> (<i>dvr</i>), indicating that TiO₂ promoted growth through chlorophyll biosynthesis. In addition to photosynthesis, TiO₂ affected light signaling by inhibiting the translocation of Phytochrome B (<i>PhyB</i>) from the cytosol to the nucleus, thereby improving resistance to rice sheath blight (ShB). TiO₂ application also enhanced resistance to wheat stem rust, tobacco wildfire, angular spot disease, and rice ShB by inhibiting the growth of bacterial and fungal pathogens, suggesting that TiO₂ regulates plant defense signaling and has antibacterial and antifungal effects. Field experiments with wheat, soybeans, and rice confirmed that TiO₂ treatment significantly increased the crop yield. These findings suggest that TiO₂ is a promising nanomaterial for the simultaneous enhancement of plant growth and disease resistance.</p>","PeriodicalId":94172,"journal":{"name":"Plant signaling & behavior","volume":"20 1","pages":"2512943"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating augmented reality technology into physical therapy in the school setting: a feasibility study.","authors":"Elise Baron, Amy Pratt, Betsy Donahoe-Fillmore","doi":"10.1080/07853890.2025.2499022","DOIUrl":"10.1080/07853890.2025.2499022","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the feasibility of using an immersive augmented-reality technology (AT) in conjunction with physical therapy (PT) for in-school therapy, while determining whether this technology would be as engaging and motivating as standard PT.</p><p><strong>Methods: </strong>Participants included Fifteen students (6-8 y/o) receiving once-weekly PT. The therapist was instructed to engage students in AT and standard PT for one academic year, alternating sessions. Before each session, students were informed of therapy modality and rated their excitement using a Smiley Face Likert scale with associated text. To assess feasibility, the number and order of each session type, as well as student refusal rate, were investigated. To assess engagement, the therapist recorded time-on-task and number of times redirection was needed. Feasibility was reported as descriptive statistics, and Wilcoxon signed-rank tests were used to compare average scores on excitement and engagement between AT and standard PT.</p><p><strong>Results: </strong>60% of students (9/15) reaching the intended goal of 50% of therapy sessions as AT, as well as 60% (9/15) of students 'roughly alternating' (no more than three same session types in a row) their sessions throughout the duration of the study. The student refusal rate of AT was 0%. When using AT, students were 23% (<i>p</i>= <.0001) more excited, 4.4% (<i>p</i>=.004) more on task and needed 61% (<i>p</i>= <.0001) less refocusing compared to standard PT.</p><p><strong>Conclusion: </strong>Integrating AT alongside standard PT proved to be moderately feasible in a school setting. Additionally, students demonstrated increased excitement, increased time on tasks and decreased refocusing during a session using AT. A flexible-use approach will make AT a motivating addition to school-based therapy.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2499022"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PCSK9 is upregulated and correlated with more severe disease condition but fails to predict treatment outcomes in psoriasis patients.","authors":"Xuwen Yin, Lei Shi, Ni Zhang, Heng Li, Jianwen Long, Xinjian Yu","doi":"10.1080/09546634.2025.2482867","DOIUrl":"https://doi.org/10.1080/09546634.2025.2482867","url":null,"abstract":"<p><strong>Background: </strong>Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) not only regulates cholesterol metabolism and cardiovascular disorder but also modifies inflammatory response and autoimmunity.</p><p><strong>Objective: </strong>This study investigated the relation of PCSK9 to clinical features and treatment outcomes in psoriasis patients.</p><p><strong>Methods: </strong>One hundred and five psoriasis patients who initiated systemic treatment due to moderate-to-severe disease condition were enrolled. Baseline characteristics and treatment response after 12-week treatment were collected. Their serum samples before treatment initiation were collected and sent to PCSK9 detection by enzyme-linked immunosorbent assay. Serum PCSK9 was also detected in 30 healthy subjects.</p><p><strong>Results: </strong>PCSK9 level was 2-fold times in psoriasis patients <i>vs.</i> healthy subjects. PCSK9 could predict psoriasis risk with AUC of 0.777. By optimum cutoff value of 179 ng/ml, PCSK9 had the best predictive potential for psoriasis risk. PCSK9 quartile was positively correlated with BMI, hyperlipemia history, PASI, and sPGA. However, PCSK9 quartile was not correlated with PASI 75 response, PASI 90 response, or sPGA 0/1 response at week 12.</p><p><strong>Conclusion: </strong>PCSK9 is upregulated and correlated with severe disease condition, but fails to predict treatment outcomes in psoriasis patients.</p>","PeriodicalId":94235,"journal":{"name":"The Journal of dermatological treatment","volume":"36 1","pages":"2482867"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and epidemiological characteristics of respiratory syncytial virus, SARS-CoV-2 and influenza paediatric viral respiratory infections in southwest Saudi Arabia.","authors":"Ali Alsuheel Asseri, Saleh M Al-Qahtani, Ibrahim A Alzaydani, Ahmed Al-Jarie, Noha Saad Alyazidi, Ali A Alrmelawi, Alya Musfer Alqahtani, Rahaf S Alsulayyim, Ameerah K Alzailaie, Dhay M Abdullah, Abdelwahid S Ali","doi":"10.1080/07853890.2024.2445791","DOIUrl":"https://doi.org/10.1080/07853890.2024.2445791","url":null,"abstract":"<p><strong>Background: </strong>There is a global consensus that respiratory tract infections are the major causes of morbidity and mortality among children. In this study, we aimed to compare the clinical and epidemiological characteristics of respiratory syncytial virus (RSV), influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections among children admitted to hospital with acute respiratory infections. We also opted to identify the predictors of paediatric intensive care unit (PICU) admission.</p><p><strong>Methods: </strong>In this study, a retrospective investigation and analysis of 423 children who were admitted to Abha Maternity and Children Hospital, in the southern region of Saudi Arabia, between January and December 2022 were conducted.</p><p><strong>Results: </strong>The median age of these children was 16.5 months (Q1-Q3: 6-46.3). It was observed that the infectivity levels of RSV, SARS-CoV-2, influenza A and influenza B infections peaked in early to mid-September, mid-July, May and June, and October, respectively. There was a statistically significant difference in the total WBC counts between RSV and influenza B (<i>p</i> = 0.035) and SARS-CoV-2 and influenza B (<i>p</i> = 0.013). Moreover, there was a statistically significant difference in the absolute lymphocyte count between influenza A and RSV (<i>p</i> = 0.002). The median number of days in hospital was 6 days (Q1-Q3: 4-10). Patients with RSV infection required a significantly longer hospital stay, with a median of 8 days (Q1-Q3: 4-10). The factors associated with the likelihood of PICU admission for all study participants were congenital heart disease (odds ratio (OR) = 2.9, 95% confidence intervals (CI) [1.4-6.1]), RSV (OR = 2.3, 95% CI [1.3-4.1]) and age <6 months (OR = 2.0, 95% CI [1.2-3.4]).</p><p><strong>Conclusions: </strong>RSV was identified as the most common pathogen causing acute lower respiratory infections among the studied patients. One of the more significant findings to emerge from this study is the seasonal changes in RSV and influenza infections, which mandates further research.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2445791"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of uric acid on acute coronary syndrome prognosis in elderly patients.","authors":"Yifan Li, Tiantian Sang, Naqiang Lv, Jinxing Liu, Yingzhen Gu, Xiaorong Han, Wei Zhang, Aimin Dang","doi":"10.1080/07853890.2024.2445200","DOIUrl":"https://doi.org/10.1080/07853890.2024.2445200","url":null,"abstract":"<p><strong>Background: </strong>Uric acid (UA) plays an important role in cardiovascular diseases, yet its implications in elderly patients remains incompletely understood. This study aimed to explore the impact of UA on the prognosis in advanced-age patients with acute coronary syndrome (ACS).</p><p><strong>Methods: </strong>We included 526 patients aged 80 and older who were diagnosed with ACS. The UA levels were measured at admission, and patients were divided into four groups based on quartiles of UA levels. Major adverse cardiovascular events (MACE) during follow-up were recorded.</p><p><strong>Results: </strong>The median UA level was 344.09 μmol/L, while the median follow-up duration was 64 months. Kaplan-Meier curves demonstrated a higher cumulative incidence of MACE during long-term follow-up in the Q4 group (Log-rank <i>p</i> < 0.05). Cox regression analysis revealed an independent correlation between UA levels and an increased risk of MACE (HR 1.002, 95%CI 1.000-1.003, <i>p</i> = 0.021). The ROC curve indicated that the optimal UA value for predicting MACE was 324.25 μmol/L. After matching through PSM, the MACE-free survival rate was lower in both hyperuricemia group (UA> 420.00 μmol/L) and high UA group (324.25 μmol/L < UA≤ 420.00 μmol/L) compared to the control group. Both hyperuricemia and high UA levels were independent risk factors for long-term MACE in advanced-age ACS patients, with HR values of 1.546 (1.049-2.280, <i>p</i> = 0.028) and 1.491 (1.011-2.198, <i>p</i> = 0.044), respectively.</p><p><strong>Conclusion: </strong>Elevated UA levels were identified as independent risk factors for MACE in elderly patients with ACS. The optimal predictive value of UA for poor cardiovascular prognosis was significantly lower than the traditional definition of hyperuricemia.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2445200"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic and clinical features of rosacea in North Jordan: a 10-year university hospital retrospective study.","authors":"Diala Alshiyab, Saleh A Ba-Shammakh, Alaa Bani Bakr, Mohammad Abu-Hussein, Abdulqudos Al-Fakih, Sarah Alawneh, Leen Alhuneafat, Leen Heis, Firas Al-Qarqaz","doi":"10.1080/07853890.2024.2445775","DOIUrl":"https://doi.org/10.1080/07853890.2024.2445775","url":null,"abstract":"<p><strong>Background/objectives: </strong>This study aims to investigate the demographic and clinical characteristics of rosacea within the North Jordan population, focusing on Fitzpatrick skin types III and IV. The intent is to address gaps in dermatological research concerning ethnic and racial variations in rosacea's presentation and impact.</p><p><strong>Methods: </strong>We conducted a retrospective cohort analysis at the dermatology department of King Abdullah University Hospital, North Jordan, reviewing medical records of patients diagnosed with rosacea from January 2013 to December 2023. Data collection focused on demographics, rosacea subtypes and environmental factors exacerbating the condition. Statistical analysis utilized Jamovi and GraphPad Prism software.</p><p><strong>Results: </strong>The study included 610 patients, revealing a rosacea prevalence of 1.5% within the hospital's catchment area. Most patients were female (84.4%), with a median age of 44. The majority had Fitzpatrick skin types III and IV. The erythematotelangiectatic subtype was most common (73.6%), followed by papulopustular (23.4%) and phymatous (3%). Environmental triggers like sun exposure and temperature changes were nearly universally reported as exacerbating factors.</p><p><strong>Conclusions: </strong>Rosacea shows significant gender disparities and is influenced by environmental factors. The study underscores the need for targeted research and treatment strategies that consider ethnic and racial variations, along with gender-specific presentations of the disease.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2445775"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of curcumin on methotrexate-induced ovarian damage and follicle reserve in rats: the role of PARP-1 and P53.","authors":"Mete Keçeci, Nesibe Karaoluk","doi":"10.1080/07853890.2024.2446688","DOIUrl":"https://doi.org/10.1080/07853890.2024.2446688","url":null,"abstract":"<p><strong>Background: </strong>Methotrexate (MTX) is an agent used in the treatment of many neoplastic and non-neoplastic diseases and is known to cause oxidative damage in normal tissues. Curcumin (Cur) is a natural polyphenol compound with powerful antioxidant and antiapoptotic effects. In this study we investigate the effects of Cur on MTX-induced ovarian damage.</p><p><strong>Materials and methods: </strong>Thirty-two young adult female Wistar albino rats were divided into four groups: (1) Control (<i>n</i> = 8): only vehicle group, (2) Cur (<i>n</i> = 8): Cur-only group (200 mg/kg/day), (3) MTX (<i>n</i> = 8): MTX-only group (0.35 mg/kg/day), (4) MTX+Cur (<i>n</i> = 8): The group was given MTX (0.35 mg/kg/day) and Cur (200 mg/kg/day) for 28 days. Then, SOD, CAT, MDA, AMH levels were measured using ELISA kits. Follicle count was performed on H&E stained slides. In addition, the expressions of P53 and PARP-1 were analysed by immunohistochemistry.</p><p><strong>Results: </strong>MDA levels were seen to be higher in the MTX group than in the MTX+Cur group (<i>p</i> < 0.05). Cur treatment lowered MDA levels and increased SOD and CAT levels (<i>p</i> < 0.05 for all). In the MTX+Cur group, atretic follicle count decreased (<i>p</i> < 0,05), however, primordial follicle count increased (<i>p</i> < 0,01). Secondary follicle count and AMH levels were higher in MTX-treated groups (<i>p</i> < 0,05 and <i>p</i> < 0,01, respectively). Expressions of p53 and Poly [ADP-ribose] polymerase 1 (PARP-1) increased significantly in the MTX group compared to the other groups (<i>p</i> < 0,05).</p><p><strong>Conclusion: </strong>Cur pretreatment prior to MTX administration may be an effective option in preserving the ovarian follicle pool by regulating P53 and PARP-1 expressions with its antioxidant effect.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2446688"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of contrast-enhanced ultrasound liver imaging reporting and data system for differentiation of patients at risk of hepatocellular carcinoma and liver metastasis.","authors":"Weiqin Huang, Ruoxuan Lin, Zhongshi Du, Zhougui Wu, Xiaohui Ke, Lina Tang","doi":"10.1080/07853890.2024.2442072","DOIUrl":"10.1080/07853890.2024.2442072","url":null,"abstract":"<p><strong>Background: </strong>Hepatocellular carcinoma (HCC) and metastatic liver tumors (MLT) are the most common malignant liver lesions, each requiring distinct therapeutic approaches. Accurate differentiation between these malignancies is critical for appropriate treatment planning and prognostication. However, there is limited data on the performance of contrast-enhanced ultrasound liver imaging reporting and data system (CEUS-LI-RADS) in this differentiation.</p><p><strong>Objective: </strong>To evaluate the diagnostic efficacy of the CEUS-LI-RADS in distinguishing between HCC and MLT in an expanded population at risk for both tumors.</p><p><strong>Methods: </strong>Between June 2017 and January 2022, 108 patients with HCC and 138 patients with MLT who were pathologically diagnosed, where included in this retrospective study. Two radiologists independently reviewed the CEUS features and liver imaging reporting and data system (LI-RADS) categories of the lesions, and based on their consensus, we calculated the diagnostic performance, including the area under the receiver operating characteristic curve, sensitivity, specificity, and accuracy of the CEUS-LI-RADS criteria.</p><p><strong>Results: </strong>The sensitivity, specificity, and accuracy of CEUS LI-RADS category 5 (CEUS-LR-5) for predicting HCC were 49.1% [95% confidence interval (CI)) 39.3-58.9], 97.1% (95% CI 92.7-99.2), and 76%, respectively, whereas the corresponding values for LI-RADS category M (LR-M) for diagnosing MLT were 89.1% (95%CI 82.7-93.8), 72.2% (95%CI 62.8-80.4), and 81.7%, respectively. Based on current LR-M criteria, a small proportion of HCCs were classified as LR-M due to the presence of early cessation (45-60s). In the analysis of the MLT subgroup, we found that the tumor size affects the distribution of LI-RADS (LR) classification in the subgroup (<i>p</i> = 0.037), and LI-RADS category 3 (LR-3) classification was observed more frequently in tumors of small size (≤3cm) than those of larger size. In addition, LR-3 metastases were more frequently characterized by hypovascular supply.</p><p><strong>Conclusions: </strong>CEUS-LI-RADS demonstrates high specificity in distinguishing HCC from MLT, providing a reliable noninvasive diagnostic tool that can enhance clinical decision-making. These findings are clinically significant as they can improve patient management and treatment outcomes, and they underscore the need for future research to refine and expand the use of CEUS-LI-RADS in diverse clinical settings.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2442072"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11660419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for severe postpartum hemorrhage in placenta accreta spectrum patients undergoing prophylactic resuscitative endovascular balloon occlusion of the aorta during cesarean delivery.","authors":"Xiafei Wu, Jie He, Yuxiang Bai, Yanqiong Gan, Hongbing Xu, Hongbo Qi, Xinyang Yu","doi":"10.1080/07853890.2024.2442065","DOIUrl":"10.1080/07853890.2024.2442065","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the risk factors for severe postpartum hemorrhage (SPPH) in patients with placenta accreta spectrum (PAS) undergoing cesarean delivery, despite the prophylactic use of resuscitative endovascular balloon occlusion of the aorta (REBOA).</p><p><strong>Materials and methods: </strong>We conducted a retrospective case-control study on PAS patients who underwent cesarean delivery with prophylactic REBOA at the First Affiliated Hospital of Chongqing Medical University from January 2017 to December 2021. Prophylactic REBOA placement was determined by a prenatal ultrasound scoring system. Patients were divided into those who experienced SPPH (case group) and those who did not (control group), with SPPH defined by one or a combination of the following criteria: intraoperative blood loss ≥1500 mL, transfusion of ≥4 units of packed red blood cells, intraoperative hysterectomy, or sequential uterine artery embolization. Propensity score matching (PSM) was employed to minimize biases, and multivariate logistic regression was used to calculate adjusted odds ratios (aOR) for risk factors.</p><p><strong>Results: </strong>Of the 424 enrolled patients, 102 experienced SPPH (case group), while 322 did not (control group). After PSM, the case group comprised 79 patients, and the control group included 130. After adjusting for confounders, patients with placenta increta (aOR 3, 95% CI 1.49-6.03, <i>p</i> = 0.002), percreta (aOR 21.77, 95% CI 6.57-72.09, <i>p</i> < 0.001), lower hemoglobin levels (aOR 0.98, 95% CI 0.95-1, <i>p</i> = 0.050), and higher D-dimer levels (aOR 1.36, 95% CI 1.12-1.65, <i>p</i> = 0.002) had an elevated risk of SPPH. Threshold effect analysis indicated no significant nonlinear relationship between hemoglobin, D-dimer, and outcomes.</p><p><strong>Conclusions: </strong>PAS patients, particularly those with placenta increta and percreta, lower hemoglobin levels, and elevated D-dimer levels, are at an increased risk of SPPH during cesarean delivery, even with REBOA intervention.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2442065"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11660362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of cisplatin in modulating the tumor immune microenvironment and its combination therapy strategies: a new approach to enhance anti-tumor efficacy.","authors":"Guandu Li, Xiangyu Che, Shijin Wang, Dequan Liu, Deqian Xie, Bowen Jiang, Zunwen Zheng, Xu Zheng, Guangzhen Wu","doi":"10.1080/07853890.2024.2447403","DOIUrl":"10.1080/07853890.2024.2447403","url":null,"abstract":"<p><p>Cisplatin is a platinum-based drug that is frequently used to treat multiple tumors. The anti-tumor effect of cisplatin is closely related to the tumor immune microenvironment (TIME), which includes several immune cell types, such as the tumor-associated macrophages (TAMs), cytotoxic T-lymphocytes (CTLs), dendritic cells (DCs), myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs), and natural killer (NK) cells. The interaction between these immune cells can promote tumor survival and chemoresistance, and decrease the efficacy of cisplatin monotherapy. Therefore, various combination treatment strategies have been devised to enhance patient responsiveness to cisplatin therapy. Cisplatin can augment anti-tumor immune responses in combination with immune checkpoint blockers (such as PD-1/PD-L1 or CTLA4 inhibitors), lipid metabolism disruptors (like FASN inhibitors and SCD inhibitors) and nanoparticles (NPs), resulting in better outcomes. Exploring the interaction between cisplatin and the TIME will help identify potential therapeutic targets for improving the treatment outcomes in cancer patients.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2447403"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142934011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}