Engineering tactics for organelle targeting behavior and PDT efficiency by fine structural regulation.

IF 4.6

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Pub Date : 2026-01-15 Epub Date: 2025-08-06 DOI:10.1016/j.saa.2025.126777

Fei Zhang, Xueke Yan, Xiaoxiao Wu, Kunwei Ma, Jiong Li, Jiaxin Kang, Baolei Fan, Baoqing Zhao, Huifang Su, Min Li

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Abstract

Organic photosensitizers (PSs) with organelle targeting and photodynamic therapy (PDT) performance have received extensive attention from scientific researchers. In this study, diphenylamine-xanthene compounds with aggregation-induced emission (AIE) properties were designed and synthesized. The different organelle-targeting performance of the photosensitizer was achieved by subtly regulating the functional group connected to the aldehyde group. These aggregation-induced emission luminogens (AIEgens) can not only specifically target organelles, but also effectively produce reactive oxygen species (ROS) under visible light irradiation. Mitochondria-targeting AIE compounds with cationic groups (OCH₃-AP) have better ROS generation capacity and cell phototoxicity than compound (OCH₃-AM) targeting lipid droplets (LDs). Through in vivo experiments, it was found that OCH₃-AP has a long retention ability in live tumor tissues and have potential application value in photodynamic cancer therapy.

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精细结构调控下细胞器靶向行为和PDT效率的工程策略。

具有细胞器靶向和光动力治疗（PDT）性能的有机光敏剂（PSs）受到了科学界的广泛关注。本研究设计并合成了具有聚集诱导发射（AIE）特性的二苯胺-杂蒽化合物。光敏剂的不同细胞器靶向性能是通过微妙地调节与醛基团相连的官能团来实现的。这些聚集诱导发射发光原（AIEgens）不仅能特异性靶向细胞器，而且在可见光照射下能有效地产生活性氧（ROS）。具有阳离子基团的线粒体靶向AIE化合物（OCH3-AP）比靶向脂滴（ld）的化合物（OCH3-AM）具有更好的ROS生成能力和细胞光毒性。通过体内实验发现，OCH3-AP在活肿瘤组织中具有较长的滞留能力，在光动力癌症治疗中具有潜在的应用价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

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