其他最新文献

{"title":"Biochemical mechanisms underpinning impaired endogenous nitric oxide formation with the use of proton pump inhibitors.","authors":"Macario A Rebelo, Carla Fiama de Azevedo Medeiros, Heitor Moreno, Jose E Tanus-Santos","doi":"10.4103/mgr.MEDGASRES-D-25-00170","DOIUrl":"10.4103/mgr.MEDGASRES-D-25-00170","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":" ","pages":"316-317"},"PeriodicalIF":4.2,"publicationDate":"2027-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13667368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147960135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breath, beyond blood: the role of gaseous biofluids in medical research.","authors":"Susmita Roy, Ronald Sroka, Kiran Sankar Maiti","doi":"10.4103/mgr.MEDGASRES-D-26-00055","DOIUrl":"10.4103/mgr.MEDGASRES-D-26-00055","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":" ","pages":"326-327"},"PeriodicalIF":4.2,"publicationDate":"2027-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13667381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148376118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High levels of nitric oxide and peroxynitrite with protein nitration: a new therapeutic target for gliomas.","authors":"Ying Yang, Qi Zhang, Yuchen Ma, Serge Yannick Ouedraogo, Liang Chen, Xianquan Zhan","doi":"10.4103/mgr.MEDGASRES-D-25-00365","DOIUrl":"10.4103/mgr.MEDGASRES-D-25-00365","url":null,"abstract":"<p><p>The gap junction signaling pathway is a core hub mediating intercellular communication, which plays a vital role in maintaining tissue homeostasis, and its dysfunction is closely related to glioma. Nitroproteomics studies have shown that protein tyrosine nitration plays an important role in the progression of glioma, and gap junction is one of the significantly enriched nitroprotein signaling pathways in glioma; proteoformics reveals that nitration can produce various proteoforms of related proteins, which have different functional states in different subtypes of glioma, suggesting that nitration may alter the functional states of related proteins in gap junction pathways. When levels of nitric oxide and peroxynitrite (ONOO-) rise, they induce the tyrosine nitration of key proteins in the gap junction pathway; this nitration not only interferes with the function of the gap junction pathway, but also affects other gap junction-linked signaling networks. Forming an attack network on the gap junction pathway through multi-pathway cross-regulation has great potential for therapeutic strategies targeting the gap junction pathway. We recommend in-depth studies of the gap junction signaling pathway and potential drugs targeting gap junction signals, including drugs that target gap junction communication activators, nitration inhibitors, and drugs that directly target specific nitroproteins, combined with conventional chemotherapy or immune checkpoint inhibitors, as well as the construction of personalized medical frameworks as important future research directions.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"17 1","pages":"117-128"},"PeriodicalIF":4.2,"publicationDate":"2027-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13667387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperbaric oxygen for the treatment of traumatic incomplete spinal cord injury: a systematic review and meta-analysis of randomized controlled trials.","authors":"Jiantao Shi, Hongfei Ge, Zhouyang Jiang, Guangjian He, Liang Tan, Rong Hu, Shengli Hu","doi":"10.4103/mgr.MEDGASRES-D-25-00250","DOIUrl":"10.4103/mgr.MEDGASRES-D-25-00250","url":null,"abstract":"<p><p>The therapeutic efficacy of hyperbaric oxygen therapy for traumatic incomplete spinal cord injury remains a subject of debate. To comprehensively evaluate the impact of hyperbaric oxygen on motor function, sensory function, and activities of daily living in patients with traumatic incomplete spinal cord injury, we conducted a systematic review and meta-analysis. We performed a comprehensive search across PubMed, Embase, the Cochrane Library, Web of Science, and major Chinese databases for randomized controlled trials published through June 2025. A total of 15 randomized controlled trials were included. The pooled results indicated that hyperbaric oxygen therapy significantly improved the American Spinal Injury Association motor score (mean difference = 10.30, 95% confidence interval: 7.70-12.90), the total American Spinal Injury Association sensory score (mean difference = 29.29, 95% confidence interval: 18.82-39.75), the American Spinal Injury Association light touch score (mean difference = 9.84, 95% confidence interval: 6.15-13.53), and the American Spinal Injury Association pinprick score (mean difference = 8.75, 95% confidence interval: 4.40-13.11). Furthermore, hyperbaric oxygen therapy was associated with significant enhancements in the Barthel Index (mean difference = 16.60, 95% confidence interval: 10.51-22.68) and the Functional Independence Measure (mean difference = 17.41, 95% confidence interval: 10.83-23.98). In conclusion, adjunctive hyperbaric oxygen therapy appears to improve motor function, sensory function, and activities of daily living in patients with traumatic incomplete spinal cord injury compared to conventional treatments alone. However, due to methodological limitations and potential publication bias in the included studies, these findings should be interpreted with caution, and further high-quality, multi-center randomized controlled trials are warranted.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"17 1","pages":"89-94"},"PeriodicalIF":4.2,"publicationDate":"2027-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13667362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Iron Lung: Ferroptosis and Iron Regulation in Aging and Lung Diseases.","authors":"Maunick Lefin Koloko Ngassie, Yamillie Ortiz, Preetham Ravi, Daniel A Pfeffer-Kleemann, Niyati A Borkar, Christina M Pabelick, Y S Prakash","doi":"10.1152/physiol.00062.2025","DOIUrl":"10.1152/physiol.00062.2025","url":null,"abstract":"<p><p>Iron is an important metal element regulating biological processes such as gene expression, electron transport, cell proliferation, differentiation and division, and cellular respiration. Regulation of iron levels is therefore critical, with excess iron accumulation leading to iron-dependent lipid peroxidation and cell death (ferroptosis). Factors such as aging and environmental exposures (e.g., high/low oxygen, particulate iron) can disrupt iron homeostasis. Iron-dependent processes influence downstream pathways such as inflammation, mitochondrial energetics, and remodeling (proliferation, fibrosis), pathways involved in lung diseases particularly at the extremes of age, from hyperoxic lung injury in neonates to chronic diseases such as asthma, chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis (PF) that increase with age. Although these diseases involve structural and functional changes in bronchial versus alveolar compartments, including airway hyperreactivity, altered mucus production, cell proliferation and migration, increased extracellular matrix (ECM) remodeling, senescence, and metabolic dysregulation, the casual or consequential links between iron dysregulation and disease pathology, particularly with aging, are still being investigated. The aim of this topical review is to <i>1</i>) highlight current knowledge regarding iron regulation in normal lung versus lung diseases, <i>2</i>) identify known roles of iron in lung homeostasis and the contribution of iron dysregulation in lung diseases with aging, and <i>3</i>) explore the potential benefit of targeting iron regulation and/or ferroptosis in lung diseases.</p>","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"0"},"PeriodicalIF":10.3,"publicationDate":"2027-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13380317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forty hyperbaric oxygen therapy sessions for traumatic brain injury: \"why?\"","authors":"Paul G Harch","doi":"10.4103/mgr.MEDGASRES-D-25-00134","DOIUrl":"10.4103/mgr.MEDGASRES-D-25-00134","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":" ","pages":"318-319"},"PeriodicalIF":4.2,"publicationDate":"2027-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13667360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146113707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical gas: dual role in ocular treatment and diagnostic applications.","authors":"Nur Syafiqah Mat Zain, Lai Kuan Lee","doi":"10.4103/mgr.MEDGASRES-D-25-00174","DOIUrl":"10.4103/mgr.MEDGASRES-D-25-00174","url":null,"abstract":"","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":" ","pages":"324-325"},"PeriodicalIF":4.2,"publicationDate":"2027-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13667365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148664078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breathing in harm: current insights into the effects of air pollution on cardiorespiratory health.","authors":"Vasiliki Michou, Dimitrios Tsamos, Aikaterini Itziou, Constantinos Tsanaktsidis","doi":"10.4103/mgr.MEDGASRES-D-25-00201","DOIUrl":"10.4103/mgr.MEDGASRES-D-25-00201","url":null,"abstract":"<p><p>Air pollution significantly contributes to cardiovascular and respiratory diseases, leading to increased morbidity and mortality. This review critically examines the mechanisms linking air pollution to higher cardiometabolic risk and cardiovascular death. It examines the impact of air pollution on respiratory health, specifically its role in exacerbating conditions such as heart failure, chronic obstructive pulmonary disease, and asthma. Special attention is given to vulnerable groups, including pregnant individuals, neonates, children, and patients with pre-existing cardiovascular or respiratory conditions, who are particularly susceptible and experience more severe health effects. Emerging evidence regarding the interactions between air pollution and coronavirus disease 2019 is also presented, showing how reductions in pollution levels during pandemic lockdowns were associated with improved cardiopulmonary health. Furthermore, the review discusses international differences in air quality standards and recent updates to exposure limits for air pollutants, as well as their implications for public health. It evaluates various mitigation strategies, including policy interventions, technological solutions, and approaches to reduce risk-based exposure. Lastly, the review emphasizes the need for comprehensive, evidence-based frameworks to minimize exposure and prevent diseases associated with pollution. Strengthening air quality management is essential for reducing the global burden of cardiovascular and respiratory diseases.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":" ","pages":"268-284"},"PeriodicalIF":4.2,"publicationDate":"2027-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13667354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anesthesia inhalation agent sevoflurane induces perioperative cognitive impairment: Apelin/early growth response 1 axis induces ferritinophagy and exacerbates ferroptosis.","authors":"Xiufeng Li, Xiaoying Zhang, Longhe Xu, Yongzhe Liu","doi":"10.4103/mgr.MEDGASRES-D-25-00173","DOIUrl":"10.4103/mgr.MEDGASRES-D-25-00173","url":null,"abstract":"<p><p>Sevoflurane is a widely used inhaled anesthetic for inducing and maintaining general anesthesia in surgical patients. After inhalation, sevoflurane crosses the alveolar capillary membrane barrier to enter the circulatory system and act on the central nervous system, producing anesthetic effects. Recent research has found that sevoflurane can induce ferroptosis and trigger neurological disorders. However, the exact process behind this is not yet understood. In this study, we used an integrated approach combining bioinformatics analysis with in vivo experiments to investigate the complex relationships between sevoflurane, ferroptosis, and ferritinophagy, along with their underlying mechanisms. By analyzing the sevoflurane anesthesia dataset (GSE139220) in the Gene Expression Omnibus database, we identified the Apelin/early growth response 1 axis as a potential ferroptosis-associated signaling pathway involved in sevoflurane-induced postoperative cognitive dysfunction. The results of in vivo experiment showed that sevoflurane could induce perioperative neurocognitive disorder by reducing the ferroptosis markers glutathione peroxidase 4, xCT, and early growth response 1, as well as increasing the ferritinophagy marker nuclear receptor coactivator 4. Importantly, Apelin-13, a subtype of apelin, reversed these effects. Therefore, we concluded that sevoflurane induces ferritinophagy by regulating the apelin/early growth response 1 axis, thereby exacerbating ferroptosis and inducing cognitive impairment. Apelin-13 may be a promising drug for inhibiting sevoflurane-induced perioperative neurocognitive disorder.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"17 1","pages":"22-29"},"PeriodicalIF":4.2,"publicationDate":"2027-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13667378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogen sulfide combined with biomaterials for wound healing: a bibliometric analysis.","authors":"Mengyue Du, Huanhuan Wang, Xiping Zhang, Shuqin Li, Sihan Cao, Chang Yao","doi":"10.4103/mgr.MEDGASRES-D-26-00152","DOIUrl":"10.4103/mgr.MEDGASRES-D-26-00152","url":null,"abstract":"<p><p>Hydrogen sulfide (H2S) is an extensively multifunctional gasotransmitter that plays a critical role in wound healing. Due to advances in biomaterials science, H2S can be incorporated into biomaterial platforms for wound healing applications. However, research in this field remains fragmented, and a systematic analysis of publication trends, collaboration networks, and thematic evolution is still lacking. In our study, we used a bibliometric approach to investigate the development and evolution of this field. A total of 116 publications from 2005 to March 31, 2026 were collected and analyzed using VOSviewer software and the Bibliometrix R package. Our findings showed that (1) the first relevant publication appeared in 2015; the number of annual publications was low at the beginning and increased gradually, with a clear acceleration after 2022; (2) China was the leading country in terms of publication output, followed by the United States, and the most productive institutions were Wenzhou Medical University and Shanghai Jiao Tong University; and (3) keyword analysis showed that \"hydrogen sulfide,\" \"wound healing,\" and \"hydrogel\" were the core research themes; current research hotspots include \"anti-inflammatory,\" \"antibacterial,\" \"pH responsive,\" \"angiogenesis,\" and \"multimodal therapy,\" while \"bacterial ferroptosis\" has emerged as a frontier topic. Overall, H2S in combination with biomaterials constitutes a rapidly developing interdisciplinary area of research. Further investigations should focus on emerging mechanisms such as bacterial ferroptosis, the development of intelligent multi-responsive biomaterials, and multimodal therapies that involve H2S together with other therapeutic modalities to facilitate the translation of laboratory findings into clinical applications.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"17 1","pages":"55-62"},"PeriodicalIF":4.2,"publicationDate":"2027-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13667350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}