Fei Zhang, Xueke Yan, Xiaoxiao Wu, Kunwei Ma, Jiong Li, Jiaxin Kang, Baolei Fan, Baoqing Zhao, Huifang Su, Min Li
{"title":"精细结构调控下细胞器靶向行为和PDT效率的工程策略。","authors":"Fei Zhang, Xueke Yan, Xiaoxiao Wu, Kunwei Ma, Jiong Li, Jiaxin Kang, Baolei Fan, Baoqing Zhao, Huifang Su, Min Li","doi":"10.1016/j.saa.2025.126777","DOIUrl":null,"url":null,"abstract":"<p><p>Organic photosensitizers (PSs) with organelle targeting and photodynamic therapy (PDT) performance have received extensive attention from scientific researchers. In this study, diphenylamine-xanthene compounds with aggregation-induced emission (AIE) properties were designed and synthesized. The different organelle-targeting performance of the photosensitizer was achieved by subtly regulating the functional group connected to the aldehyde group. These aggregation-induced emission luminogens (AIEgens) can not only specifically target organelles, but also effectively produce reactive oxygen species (ROS) under visible light irradiation. Mitochondria-targeting AIE compounds with cationic groups (OCH<sub>3</sub>-AP) have better ROS generation capacity and cell phototoxicity than compound (OCH<sub>3</sub>-AM) targeting lipid droplets (LDs). Through in vivo experiments, it was found that OCH<sub>3</sub>-AP has a long retention ability in live tumor tissues and have potential application value in photodynamic cancer therapy.</p>","PeriodicalId":94213,"journal":{"name":"Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy","volume":"345 ","pages":"126777"},"PeriodicalIF":4.6000,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Engineering tactics for organelle targeting behavior and PDT efficiency by fine structural regulation.\",\"authors\":\"Fei Zhang, Xueke Yan, Xiaoxiao Wu, Kunwei Ma, Jiong Li, Jiaxin Kang, Baolei Fan, Baoqing Zhao, Huifang Su, Min Li\",\"doi\":\"10.1016/j.saa.2025.126777\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Organic photosensitizers (PSs) with organelle targeting and photodynamic therapy (PDT) performance have received extensive attention from scientific researchers. In this study, diphenylamine-xanthene compounds with aggregation-induced emission (AIE) properties were designed and synthesized. The different organelle-targeting performance of the photosensitizer was achieved by subtly regulating the functional group connected to the aldehyde group. These aggregation-induced emission luminogens (AIEgens) can not only specifically target organelles, but also effectively produce reactive oxygen species (ROS) under visible light irradiation. Mitochondria-targeting AIE compounds with cationic groups (OCH<sub>3</sub>-AP) have better ROS generation capacity and cell phototoxicity than compound (OCH<sub>3</sub>-AM) targeting lipid droplets (LDs). Through in vivo experiments, it was found that OCH<sub>3</sub>-AP has a long retention ability in live tumor tissues and have potential application value in photodynamic cancer therapy.</p>\",\"PeriodicalId\":94213,\"journal\":{\"name\":\"Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy\",\"volume\":\"345 \",\"pages\":\"126777\"},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2026-01-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.saa.2025.126777\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/6 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.saa.2025.126777","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/6 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Engineering tactics for organelle targeting behavior and PDT efficiency by fine structural regulation.
Organic photosensitizers (PSs) with organelle targeting and photodynamic therapy (PDT) performance have received extensive attention from scientific researchers. In this study, diphenylamine-xanthene compounds with aggregation-induced emission (AIE) properties were designed and synthesized. The different organelle-targeting performance of the photosensitizer was achieved by subtly regulating the functional group connected to the aldehyde group. These aggregation-induced emission luminogens (AIEgens) can not only specifically target organelles, but also effectively produce reactive oxygen species (ROS) under visible light irradiation. Mitochondria-targeting AIE compounds with cationic groups (OCH3-AP) have better ROS generation capacity and cell phototoxicity than compound (OCH3-AM) targeting lipid droplets (LDs). Through in vivo experiments, it was found that OCH3-AP has a long retention ability in live tumor tissues and have potential application value in photodynamic cancer therapy.
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