{"title":"Lung function and blood gas of rats after different protocols of hypobaric exposure.","authors":"Lijun Yin, Yukun Wen, Zhixin Liang, Zhenbiao Guan, Xuhua Yu, Jiajun Xu, Shifeng Wang, Wenwu Liu","doi":"10.4103/mgr.MEDGASRES-D-24-00039","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00039","url":null,"abstract":"<p><p>High-altitude pulmonary edema (HAPE) is a common disease observed in climbers, skiers and soldiers who ascend to high altitudes without previous acclimatization. Thus, a reliable and reproducible animal model that can mimic the mechanisms of pathophysiologic response in humans is crucial for successful investigations. Our results showed that exposure to 4500 m for 2 days had little influence on lung function or blood gas, and exposure to 6000 m for 2 or 3 days could change lung function and blood gas, but most parameters returned to nearly normal levels within 48 hours. This study indicates that exposure to 6000 m for 3 days may induce evident lung edema and significantly alter lung function and blood gas, which may mimic HAPE in clinical practice. Thus, this animal model of HAPE may be used in future studies on HAPE.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"15 1","pages":"180-187"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nitric oxide-based treatments improve wound healing associated with diabetes mellitus.","authors":"Zahra Bahadoran, Parvin Mirmiran, Farhad Hosseinpanah, Khosrow Kashfi, Asghar Ghasemi","doi":"10.4103/mgr.MEDGASRES-D-24-00020","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00020","url":null,"abstract":"<p><p>Non-healing wounds are long-term complications of diabetes mellitus (DM) that increase mortality risk and amputation-related disability and decrease the quality of life. Nitric oxide (NO·)-based treatments (i.e., use of both systemic and topical NO· donors, NO· precursors, and NO· inducers) have received more attention as complementary approaches in treatments of DM wounds. Here, we aimed to highlight the potential benefits of NO·-based treatments on DM wounds through a literature review of experimental and clinical evidence. Various topical NO·-based treatments have been used. In rodents, topical NO·-based therapy facilitates wound healing, manifested as an increased healing rate and a decreased half-closure time. The wound healing effect of NO·-based treatments is attributed to increasing local blood flow, angiogenesis induction, collagen synthesis and deposition, re-epithelization, anti-inflammatory and anti-oxidative properties, and potent broad-spectrum antibacterial effects. The existing literature lacks human clinical evidence on the safety and efficacy of NO·-based treatments for DM wounds. Translating experimental favors of NO·-based treatments of DM wounds into human clinical practice needs conducting clinical trials with well-predefined effect sizes, i.e., wound reduction area, rate of wound healing, and hospital length of stay.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"15 1","pages":"23-35"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Why provide 40 sessions of hyperbaric oxygen therapy to patients with traumatic brain injury?","authors":"Cesar V Borlongan, Amir Hadanny","doi":"10.4103/mgr.MEDGASRES-D-24-00029","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00029","url":null,"abstract":"","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"15 1","pages":"132-133"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhihua Zhang, Zhenwei Li, Shuyang Li, Bing Xiong, You Zhou, Chaohong Shi
{"title":"Hyperbaric oxygen for moderate-to-severe traumatic brain injury: outcomes 5-8 years after injury.","authors":"Zhihua Zhang, Zhenwei Li, Shuyang Li, Bing Xiong, You Zhou, Chaohong Shi","doi":"10.4103/mgr.MEDGASRES-D-24-00018","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00018","url":null,"abstract":"<p><p>The use of hyperbaric oxygen (HBO 2 ) in the field of traumatic brain injury (TBI) is becoming more widespread and increasing yearly, however there are few prognostic reports on long-term functional efficacy. The aim of this study was to assess the functional prognosis of patients with moderate-to-severe TBI 5-8 years following HBO 2 treatments and to explore the optimal HBO 2 regimen associated with prognosis, using a retrospective study. Clinical data were retrospectively collected as a baseline for patients with moderate-to-severe TBI treated with HBO 2 during inpatient rehabilitation from January 2014 to December 2017. The primary outcome measure was the Disability Rating Scale (DRS) and the secondary outcome measure was the Glasgow Outcome Scale. A total of 133 patients enrolled, with 9 (6.8%) dying, 41 (30.8%) remaining moderately disabled or worse (DRS scores 4-29), 83 (62.4%) remaining partially/mildly disabled or no disability (DRS scores 0-3). Logistic regression analysis revealed that age at injury (odds ratio (OR), 0.96; 95% confidence interval (CI), 0.92-0.99), length of intensive care unit stay (OR, 0.94; 95% CI, 0.88-0.99), and HBO 2 sessions (OR, 0.97; 95% CI, 0.95-0.99) were variables that independently influenced long-term prognosis. Cubic fitting models revealed that 14 and 21.6 sessions of HBO 2 could be effective for moderate and severe TBI, respectively. This study highlighted that HBO 2 in moderate-to-severe TBI may contribute to minimize death and reduce overall disability in the long-term. However, clinicians should be cautious of the potential risk of adverse long-term prognosis from excessive HBO 2 exposure when tailoring individualized HBO 2 regimens for patients with moderate-to-severe TBI. The study was registered on ClinicalTrials.gov (NCT05387018) on March 31, 2022.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":" ","pages":"156-163"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Catarina Almeida-Ferreira, Francisca Rodrigues, Carlos Miguel Marto, Maria Filomena Botelho, Mafalda Laranjo
{"title":"Cold atmospheric plasma for breast cancer treatment: what next?","authors":"Catarina Almeida-Ferreira, Francisca Rodrigues, Carlos Miguel Marto, Maria Filomena Botelho, Mafalda Laranjo","doi":"10.4103/mgr.MEDGASRES-D-24-00043","DOIUrl":"10.4103/mgr.MEDGASRES-D-24-00043","url":null,"abstract":"","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"15 1","pages":"110-111"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sajid Farooq, Allan Bereczki, Muhammad Habib, Isolda Costa, Olavo Cardozo
{"title":"High-performance plasmonics nanostructures in gas sensing: a comprehensive review.","authors":"Sajid Farooq, Allan Bereczki, Muhammad Habib, Isolda Costa, Olavo Cardozo","doi":"10.4103/mgr.MEDGASRES-D-23-00056","DOIUrl":"10.4103/mgr.MEDGASRES-D-23-00056","url":null,"abstract":"<p><p>Plasmonic nanostructures have emerged as indispensable components in the construction of high-performance gas sensors, playing a pivotal role across diverse applications, including industrial safety, medical diagnostics, and environmental monitoring. This review paper critically examines seminal research that underscores the remarkable efficacy of plasmonic materials in achieving superior attributes such as heightened sensitivity, selectivity, and rapid response times in gas detection. Offering a synthesis of pivotal studies, this review aims to furnish a comprehensive discourse on the contemporary advancements within the burgeoning domain of plasmonic gas sensing. The featured investigations meticulously scrutinize various plasmonic structures and their applications in detecting gases like carbon monoxide, carbon dioxide, hydrogen and nitrogen dioxide. The discussed frameworks encompass cutting-edge approaches, spanning ideal absorbers, surface plasmon resonance sensors, and nanostructured materials, thereby elucidating the diverse strategies employed for advancing plasmonic gas sensing technologies.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"15 1","pages":"1-9"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}