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The Clinical Outcomes of Mosaic Embryo Transfer in Preimplantation Genetic Testing Cycles 植入前基因检测周期中镶嵌胚胎移植的临床结果
Advances in Sexual Medicine Pub Date : 2023-01-01 DOI: 10.4236/asm.2023.132002
Shujing He, Linan Xu, Huiling Pan, Kuan Cheng, Zhiqiang Zhang, Cong Fang, Zi Ren
{"title":"The Clinical Outcomes of Mosaic Embryo Transfer in Preimplantation Genetic Testing Cycles","authors":"Shujing He, Linan Xu, Huiling Pan, Kuan Cheng, Zhiqiang Zhang, Cong Fang, Zi Ren","doi":"10.4236/asm.2023.132002","DOIUrl":"https://doi.org/10.4236/asm.2023.132002","url":null,"abstract":"Purpose: We aimed to analyze the pregnancy outcomes and perinatal follow-up of mosaic embryo transfer in the preimplantation genetic testing (PGT) cycles. Method: We retrospectively selected 27 mosaic embryo transfer cycles as the study group and 97 euploid embryo transfer cycles as the control group after propensity score matching, which were performed in the reproductive medicine center of the Sixth Affiliated Hospital, Sun Yat-sen University, from March 2019 to September 2023. The biopsy cells from blastocyst were undertaken next generation sequencing (NGS). Results: No significant difference in pregnancy outcomes compared between the two groups. According to the size of aneuploid, fragment the level of mosaicism or blastocyst morphological gradings, there were no significant difference in mosaic embryo transfers. Conclusion: Mosaic embryo detected in the PGT cycle can lead to clinical pregnancy and live birth of healthy offspring, which can be considerate suitable for transfer.","PeriodicalId":305034,"journal":{"name":"Advances in Sexual Medicine","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135504819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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