化学•材料最新文献

{"title":"","authors":"Hikaru Ishikura, Juan J. Rojas, Callum S. Begg, Chulho Choi and James A. Bull*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"90 29","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":3.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.joc.5c01175","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144696339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Ashok Kumar, Rohit Gupta and Ganesan Mani*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"90 29","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":3.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.joc.5c00965","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144696349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Xinkun An, Tingting Zhang, Haoyun Ma, Xie He, Yiyi Li and Mingan Wang*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"90 29","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":3.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.joc.5c00806","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144696355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Chenyi Li*, Dan Hu, Yao Wang, Heng Yin, Fuyu Li, Wen Xia, Lixia Liu and Yulong Li*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"90 29","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":3.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.joc.5c00942","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144696361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palladium-Catalyzed Silylation of 1-(2-Iodophenyl)-1H-indoles via Intramolecular C-H Activation.","authors":"Man Cao,Wenguang Li,Tongtong Zong,Heyun Sheng,Xu Zhang,Ming Chen,Wenchao Gao,Yongqi Yu,Ting Li","doi":"10.1021/acs.joc.5c00863","DOIUrl":"https://doi.org/10.1021/acs.joc.5c00863","url":null,"abstract":"An efficient palladium-catalyzed C-H silylation of 1-(2-iodophenyl)-1H-indoles has been developed. The reaction exhibits an obvious electronic effect. This protocol uses Pd(OAc)2 as a catalyst with hexamethyldisilane as the trimethylsilyl source. The reaction exhibits good functional group tolerance and provides straightforward access to diverse silicon-containing indoles under relatively mild conditions.","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"126 1","pages":""},"PeriodicalIF":4.354,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deoxygenative Route to Alkynylation of Heterocyclic N-Oxides under Ball Milling.","authors":"Ajay Kumar Dhiya,Manpreet Kaur,Anuj Sharma","doi":"10.1021/acs.joc.5c00737","DOIUrl":"https://doi.org/10.1021/acs.joc.5c00737","url":null,"abstract":"Herein, we disclose the first example of stainless-steel-induced deoxygenative C-2 alkynylation of heterocyclic N-oxides under ball milling via a radical-mediated pathway. The current approach afforded the corresponding alkynylated quinolines/pyridines through alkynylation and deoxygenation in one step. Significant tolerance of structural variations with various electron-donating (-Me, -OMe, -Et, -nBu, -OEt) and electron-withdrawing substituents (-I, -Br, -Cl, -F, -CF3, -NO2), both in the quinoline/pyridine N-oxides and in phenylacetylene derivatives, has been observed, affording 34 products in 61-94% yields. The method was successfully applied to the synthesis of two mGluR5 antagonists. Detailed mechanistic investigations based on extensive control experiments and XPS analysis corroborated the significant role of Fe(III) species present in the milling equipment (stainless steel) as well as the mechanical impact of the milling equipment (Fe/Zr-jar/balls) in facilitating the reaction via a radical pathway.","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"124 1","pages":""},"PeriodicalIF":4.354,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An injectable hydroxyapatite microsphere filler loaded with GHK-Cu tripeptide for anti-Inflammatory and antioxidant","authors":"Die Hu ,&nbsp;Xuexun Zhang ,&nbsp;Shiwen Gong ,&nbsp;Wentao Ma ,&nbsp;Bo Cheng ,&nbsp;Jing Yang ,&nbsp;Lesan Yan ,&nbsp;Binbin Li ,&nbsp;Tong Qiu ,&nbsp;Xinyu Wang","doi":"10.1016/j.colsurfb.2025.114982","DOIUrl":"10.1016/j.colsurfb.2025.114982","url":null,"abstract":"<div><div>With the wide application of soft tissue fillers, implant material-induced inflammatory reactions have become a key factor affecting the therapeutic efficacy. This study developed an injectable filler with enhanced anti-inflammatory and antioxidant effects by adsorbing glycyl-L-histidyl-L-lysine copper complex (GHK-Cu) onto hydroxyapatite microspheres (HAPs), marking the first combination of HAPs and GHK-Cu to address inflammation caused by soft tissue fillers. GHK-Cu was successfully loaded onto HAPs by electrostatic adsorption. HAPs were then mixed with carboxymethyl cellulose (CMC), glycerol (GLY), and water to form GHK-Cu@CMHA gel. The study focus on the effective combination of HAPs as a carrier for sustained GHK-Cu delivery and the anti-inflammatory properties of GHK-Cu. GHK-Cu@CMHA exhibits sustained release properties for 7 days, which ensures prolonged therapeutic effects, minimizes peptide waste and reduces injection frequency, with good flowability and injectability. In the model of LPS-induced inflammation model in vivo and in vitro, GHK-Cu@CMHA gel reduced levels of inflammatory factors and Reactive oxygen species (ROS) levels decreased, while superoxide dismutase (SOD) activity was enhanced. In this process, H&amp;E staining and Masson staining revealed significant collagen deposition. These findings further confirm that GHK-Cu@CMHA is a novel injectable soft tissue filler with good anti-inflammatory and antioxidant properties, which holds well potential for inflammation inhibition.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"256 ","pages":"Article 114982"},"PeriodicalIF":5.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144711149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Luka Dockx,&nbsp;Bálint Sztáray* and Anthony D. Dutoi*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":59,"journal":{"name":"The Journal of Physical Chemistry A","volume":"129 29","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":2.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.jpca.5c03431","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Madhusmita Devi,&nbsp;Palak Mandal,&nbsp;Aditya N. Panda and Sandip Paul*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":60,"journal":{"name":"The Journal of Physical Chemistry B","volume":"129 29","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":2.8,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.jpcb.5c00836","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Yao Jie,&nbsp;Jing-Yi Guo,&nbsp;Hao Lu,&nbsp;Tian-Yao Shen,&nbsp;Yi-Fan Zhang,&nbsp;Jia Zhao,&nbsp;Chen-Xu Hu,&nbsp;Min Pu and Hong Yan*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":61,"journal":{"name":"The Journal of Physical Chemistry C","volume":"129 29","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":3.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.jpcc.5c02690","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}