化学•材料最新文献

{"title":"Fabrication of nanoparticle-reinforced composite hydrogel for improved durability, antifouling, and thrombosis-resistance in arteriovenous grafts.","authors":"Hewan Dawit, Shah Mehmood, Zahid Hussain, Syed Rashedul Islam, Zhili Wang, Yi Cao, Xingzhu Liu, Zixun Wang, Renjun Pei","doi":"10.1016/j.colsurfb.2024.114420","DOIUrl":"10.1016/j.colsurfb.2024.114420","url":null,"abstract":"<p><p>Arteriovenous grafts are routinely designed to provide a deliberate connection between an artery and vein in patients during hemodialysis. The commonly used grafts present significant drawbacks such as thrombosis, bacterial infection, and biofouling which prevents their functionality. To endow hydrogels with improved anti-thrombosis, stable antifouling, and strong mechanical strength, a surface-modified nanoparticle-reinforced nanohybrid hydrogel is developed. In brief, zwitterionic sulfobetaine methacrylate (SBMA) is coated on bentonite clay (BC) nanoparticles via a simple method. BC-SBMA nanoparticles were then loaded onto sodium alginate /polyvinyl alcohol hydrogel composite. Calcium chloride (Ca²⁺) crosslinking is employed to form stable network and optimize polyvinyl alcohol/sodium alginate (PS) hydrogel composite. BC-SBMA particles were dispersed into PS hydrogel and crosslinked to form nanohybrid hydrogel (PS@BC-SBMA). The nanohybrid hydrogel was characterized for its morphological, mechanical, physicochemical, antibacterial, biocompatibility, antifouling, ex-vivo anti-thrombogenic, and in-vivo anti-inflammatory properties. The results revealed that the presence ofBC-SBMA particles boosted the mechanical strength and facilitated biocompatibility. The presence of zwitterionic polymers provided excellent antifouling properties toward blood platelets, unnecessary proteins, and bacterial strains. Hence, the cooperative effects of the nanohybrid hydrogel such as biocompatibility, antifouling, and mechanical properties lead to a desirable candidate for blood-contacting implants.</p>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"247 ","pages":"114420"},"PeriodicalIF":5.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142778700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell elasticity measurement and sorting based on microfluidic techniques: Advances and applications.","authors":"Jiahuan Yang, Yong Liu, Bin Li, Jingjing Li, Sheng Yan, Huaying Chen","doi":"10.1016/j.bios.2024.116985","DOIUrl":"10.1016/j.bios.2024.116985","url":null,"abstract":"<p><p>Cell elasticity serves as a crucial physical biomarker that reflects changes in cellular structures and physiological states, providing key insights into cell behaviors. It links mechanical properties to biological function, highlighting its importance for understanding cell health and advancing biomedical research. Microfluidic technologies, with their capabilities for precise manipulation and high-throughput analysis, have significantly advanced the measurement of cell elasticity and elasticity-based cell sorting. This paper presents a comprehensive overview of advanced microsystems for assessing cell elasticity, discussing their advantages and limitations. The biomedical applications of elasticity-based sorting are highlighted, including cell classification, clinical diagnosis, drug screening, and stem cell differentiation prediction. The paper addresses the current challenges in the field, such as limited measurement efficiency and scalability, and explores future research directions, including the development of automated, high-throughput systems and the integration of elasticity measurements into practical biomedical applications. These advancements aim to deepen our understanding of cellular mechanics, improve diagnostic precision, and foster the development of novel therapeutic strategies. Ultimately, this work emphasizes the potential of cell elasticity as a key parameter in advancing disease diagnosis and therapeutic research.</p>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":"271 ","pages":"116985"},"PeriodicalIF":10.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical magneto-immunoassay based on Mycobacterium leprae mimotope for serological diagnosis of leprosy.","authors":"Sthéfane Valle de Almeida, Pablo Roberto Lins da Silva, Wilson Tiago Fonseca, Tássia Regina de Oliveira, Cristiane Zocatelli Ribeiro, Juliana de Moura, Ronaldo Censi Faria","doi":"10.1016/j.bios.2024.117022","DOIUrl":"10.1016/j.bios.2024.117022","url":null,"abstract":"<p><p>Leprosy is an infectious disease classified as Neglected Tropical Disease (NTD) by the World Health Organization (WHO). Its diagnosis is challenging, relying on clinical symptoms and invasive procedures. Delays can cause severe physical disability, including hand, foot, and eye impairments. Herein, we describe the development of a magneto-immunoassay based on an electrochemical disposable microfluidic device for the serological diagnosis of leprosy. The assay makes use of magnetic particles (MPs) modified with Mycobacterium leprae mimotope as a probe to capture and separate target-specific antibodies from serum samples. The antibody anti-M. leprae was detected using the anti-human antibody IgG conjugated with horseradish peroxidase enzyme as an electrochemical maker. The magneto-immunoassay was applied in serum samples from healthy subjects and patients diagnosed with leprosy classified as paucibacillary (PB) and multibacillary (MB). The results showed that the method could differentiate between negative and positive patients (AUC = 0.990) with high clinical sensitivity (91.2%) and specificity (100.0%). In addition, the assay showed the capability to differentiate between paucibacillary and multibacillary with sensitivities of 88.9% and 93.7%, respectively, indicating that the device can be used to guide the treatment of positive cases. Thus, magneto-immunoassay based on the use of a disposable microfluidic device demonstrated to be a valuable tool for the early diagnosis of leprosy which can help the public health system to reduce disability cases and even control and eliminate the disease by interrupting the chain of transmission.</p>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":"271 ","pages":"117022"},"PeriodicalIF":10.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid and precise treatment selection for antimicrobial-resistant infection enabled by a nano-dilution SlipChip.","authors":"Qi Wang, Xiang Li, Yan'an Ren, Qin Hu, Lei Xu, Weiling Chen, Jianfang Liu, Nannan Wu, Meifeng Tao, Jingyong Sun, Yumin Xu, Feng Shen","doi":"10.1016/j.bios.2024.117084","DOIUrl":"10.1016/j.bios.2024.117084","url":null,"abstract":"<p><p>Antimicrobial resistance (AMR) has become an increasingly severe threat to global health, and AMR-associated infection is one of the leading causes of death around the world. Due to the long turnaround time and the limited flexibility and availability of current antimicrobial susceptibility testing (AST) methods, a large portion of patients with bacterial infections are still treated empirically, increasing the risk of mistreatment. To address the demand for precision treatment of bacterial infections, we developed a nano-dilution SlipChip (nd-SlipChip)-based systematic evaluation method, which facilitates rapid, logic feedback for the assessment of antibiotics, antibiotic combinations, and phage therapy. The nd-SlipChip can conveniently generate a microdroplet array with serially diluted antibiotics and determine the minimal inhibitory concentration (MIC) within 2 h by monitoring bacterial growth profiles, facilitating timely treatment selection. We demonstrated this method for 24 clinical isolates, including gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii) and gram-positive bacteria (Staphylococcus aureus). Three clinical isolates performed the second-stage antibiotic combinations screening, and effective combination therapies were identified for two of them. The remaining isolate proceeded to third-stage phage screening, where suitable phages were successfully selected. The nd-SlipChip provides a rapid and systematic approach for the precise selection of therapies targeting bacterial infections.</p>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":"271 ","pages":"117084"},"PeriodicalIF":10.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142890803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of agarose in semi-IPN hydrogels for sustained Polymyxin B release.","authors":"David Filho, Marcelo Guerrero, Ricardo Castro, Diana Rafael, Fernanda Andrade, Adolfo Marican, Oscar Valdes, Esteban Vargas, Elisa Valenzuela, Claudia Mora, Esteban F Durán-Lara","doi":"10.1016/j.colsurfb.2024.114431","DOIUrl":"10.1016/j.colsurfb.2024.114431","url":null,"abstract":"<p><p>Hydrogels (HGs) are 3-D polymeric networks with high water content, making them appropriate for biomedical applications such as drug delivery systems. This study examines the impact of agarose in semi-interpenetrating polymer networks (Semi-IPNs) based on poly(acrylic acid) (p(AA)), N, N' Methylenebis(acrylamide) (MBA) and agarose (AGA) on the sustained release of Polymyxin B (PolB). Agarose incorporation improved the mechanical strength, swelling behavior and drug retention capacity of the HG. We synthesized the Semi-IPN HGs via free radical polymerization and characterized their structural and thermal properties using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). The features of swelling under physiological conditions were carried out. Additionally, we conducted release kinetics using the three prepared HGs, each of which had a distinct amount of AGA. The findings demonstrated that the Semi-IPN HGs with greater AGA concentrations had drug release profiles that were slower and more sustained, making them perfect for long-term therapeutic uses. We also tested the PolB-loaded HGs' antimicrobial efficacy against Pseudomonas aeruginosa, and they showed sustained antibacterial activity. Using NIH-3T3 fibroblast cells, we verified the HGs' biocompatibility, demonstrating their appropriateness for use in biomedicine. According to these findings, agarose modified Semi-IPN HGs may find application in long-term medication delivery systems that aid in the treatment of infections and promote wound healing.</p>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"247 ","pages":"114431"},"PeriodicalIF":5.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-metal MOF-on-MOF metal-organic gel-based visual sensing platform for ultrasensitive detection of chlortetracycline and D-penicillamine.","authors":"Zongwu Meng, Tao Zhang, Zerun Zhang, Xiaolong Qu, Bin Wang, Yuzhe Qiu, Pian Wu, Ping Ding","doi":"10.1016/j.bios.2024.117012","DOIUrl":"10.1016/j.bios.2024.117012","url":null,"abstract":"<p><p>The widespread presence of antibiotic residues in the environment and food represents a significant threat to human health. In this study, a novel MOF-on-MOF (FCZE) gel with excellent peroxidase activity and strong fluorescence properties successfully synthesized by using Polyvinyl pyrrolidone (PVP) as a cross-linker and H₄BTEC as a ligand. Based on the energy transfer from the FCZE ligand to Eu luminescence, an ultrasensitive fluorescence method was developed for the detection of chlortetracycline (CTC), achieving a limit of detection (LOD) as low as 0.43 nM. Furthermore, the combination of FCZE with the 3,3',5,5'-tetramethylbenzidine (TMB)-hydrogen peroxide (H₂O₂) system enabled sensitive colorimetric detection of D-penicillamine (D-PA) with an LOD of 8.66 nM. Theoretical calculations reveal that the fluorescence quenching of FCZE by CTC is attributed to the inner filter effect of CTC and its suppression of the H₄BTEC excited-state return to the ground state. Furthermore, Fukui function was employed for the first time to clarify the role of D-PA in scavenging free radicals and reducing oxidized TMB (oxTMB), providing a comprehensive understanding of the colorimetric detection mechanism. Additionally, a smartphone-assisted visual detection platform based on FCZE was developed for the detection of CTC and D-PA, with LODs of 0.71 μM and 0.13 μM, respectively. This study highlights the potential of nanomaterials for the simultaneous detection of multiple antibiotics, offering a novel strategy for the rapid and efficient monitoring of antibiotic residues in environmental samples.</p>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":"271 ","pages":"117012"},"PeriodicalIF":10.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking the use of redox probes for the detection of electroactive proteins with electrochemical sensors modified with molecularly imprinted polymers.","authors":"Amal Tlili, Ghada Attia, Sohayb Khaoulani, Chouki Zerrouki, Nourdin Yaakoubi, Ali Othmane, Najla Fourati","doi":"10.1016/j.bios.2024.117105","DOIUrl":"10.1016/j.bios.2024.117105","url":null,"abstract":"<p><p>This study aims to demonstrate that redox couples, regardless of their electrical charges, are unnecessary for detecting and quantifying electroactive proteins using an electrochemical sensor functionalized with a molecularly imprinted polymer. Our approach involved designing a polydopamine imprinted biosensor for detecting bovine serum albumin as the model protein. Electrochemical measurements were conducted in a phosphate-buffered solution (PBS) and solutions containing the negatively charged hexacyanoferrate, the neutral ferrocene, or the positively charged hexaammineruthenium (III) probes. The dissociation constants K_d (in mg.mL^-1), estimated from an extended Langmuir/one-site model, were of order of (1.0 ± 0.5)×10^-8, (4.4 ± 2.1)×10^-2, (7.6 ± 5.1)×10^-4 and in the presence of [Fe(CN)₆]^-3/-4, Fe(C₅H₅)₂, [RuN₆H₁₈]⁺³ respectively, and (8.7 ± 5.9)×10^-11 in PBS. The non-use of probes, therefore, enhances the interaction between the analytes and the imprints. To understand the origin of this finding, we investigated ultraviolet and Fourier-transform infrared spectroscopies. Results indicated that redox probes could alter the proteins' intrinsic properties and adsorb to the polydopamine polymeric matrix, thus reducing the specific interactions between the protein and the imprints. To confirm the feasibility of electrochemical quantification of electroactive proteins in PBS, we designed three polydopamine-imprinted biosensors for detecting human serum albumin, prostate-specific antigen, and immunoglobulin G. Results validated the potential for quantifying electroactive proteins in PBS without adding any probe. This pioneering study was carried out with dopamine, which is taken here as a typical example of a functional monomer. It paves the way towards the detection of electroactive proteins without adding any redox couple of any nature.</p>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":"271 ","pages":"117105"},"PeriodicalIF":10.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-resonance optical fiber lossy mode resonance immunoprobe for serum PSA detection.","authors":"Xiaoshuang Dai, Shuang Wang, Yong Wang, Xu Wang, Xupeng Wu, Xiang Liu, Junfeng Jiang, Tianhua Xu, Tiegen Liu","doi":"10.1016/j.bios.2024.117049","DOIUrl":"10.1016/j.bios.2024.117049","url":null,"abstract":"<p><p>Biomarker detection has emerged as an essential complementary approach for early-stage screening of tumors. Conventional methods are constrained by bulky systems, cumbersome operation steps, and low detection accuracy. Here, we demonstrate a dual-resonance optimally configured lossy mode resonance (LMR) immunoprobe for detecting prostate-specific antigen (PSA), a biomarker for prostate cancer (PCa). The dual-resonance structure used in this study introduces low-refractive-index magnesium fluoride (MgF₂) as a matching layer before adding indium tin oxide (ITO) as a lossy mode excitation layer to enhance the phase matching between the evanescent wave and the lossy mode to realize dual-resonance. Compared with classical optical fiber LMR, the dual-resonance effect not only improves the detection precision but also features a high accuracy of joint detection. The limit of detection (LOD) of the optical fiber immunoprobe based on dual-resonance for PSA immunoassay can reach down to 52 pg/mL, making it ideally suited for early risk management and prognostic diagnosis of PCa. In addition, the optical fiber immunoprobe is used to detect suspected PCa patients, with a successful recognition rate of 90% compared with that of standard commercially available chemiluminescent assays. This work may pave the way for promising applications of optical fiber immunoprobe for high-precision, high-accuracy, and portable early-stage screening of tumors.</p>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":"271 ","pages":"117049"},"PeriodicalIF":10.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green fluorescent FM dyes with prolonged retention for 4D tracking of plasma membrane dynamics in live plants under environmental stress.","authors":"Penglei Wu, Jiaqi Zuo, Zhengdong Han, Xin Peng, Ziqing He, Wenjing Yin, Hui Feng, Engao Zhu, Yuchun Rao, Zhaosheng Qian","doi":"10.1016/j.bios.2024.117039","DOIUrl":"10.1016/j.bios.2024.117039","url":null,"abstract":"<p><p>Macroscopic phenotypic changes in plants are frequently employed as a means of evaluating the biological response of plants to external environmental stresses. However, the lack of effective observational tools at the microscopic cellular level hinders the ability to fully comprehend the intricacies of this response. Herein, we developed a plasma membrane fluorescent dye with target-activated green emission complemented with conventional FM dyes, and established a four-dimensional (4D) imaging approach based on this dye for spatio-temporal monitoring of plasma membrane dynamics during cellular responses to external environmental stress. A green fluorescent dye, designated FMG-DBO, was constructed by modifying the bridged unit between the aniline donor and the pyridinium acceptor. Its green emission can be combined with that of conventional FM dyes, enabling high-resolution imaging of plant leaf cells containing chlorophyll. The anchoring ability of the dyes was enhanced by incorporating a rigid diaza[2.2.2]octane unit as an anti-permeability group. The long retention time of the FMG-DBO dye in the plasma membrane enables the tracking of three-dimensional dynamics of the plasma membrane of plant cells. Consequently, an FMG-DBO-based four-dimensional imaging approach was established to monitor dynamic changes of plant cells under external environmental stress at the cellular level. The biological responses of two different drought-tolerant rice root cells to drought stress were examined by this four-dimensional imaging approach. It was observed that the two types of rice root cells exhibited disparate responses to the drought environmen. This approach offers alternative cell-level visualization tools for evaluating the biological responses of plant cells under environmental stress.</p>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":"271 ","pages":"117039"},"PeriodicalIF":10.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SiO₂/Si interferometers designed for on-site botulinum neurotoxin serotypes B and C quantification and biological activity assessment.","authors":"D Nanda Kumar, Zina Baider, Shlomo E Blum, Giorgi Shtenberg","doi":"10.1016/j.bios.2024.117027","DOIUrl":"10.1016/j.bios.2024.117027","url":null,"abstract":"<p><p>Botulinum neurotoxins (BoNT), the agent causing botulism, exhibit the highest potency among bacterial toxins and pose a significant threat to both humans and animals. The current in vivo method (mouse lethality assay, MLA) is inappropriate for real-time and pen-side assessment of the occurring outbreak or case. Herein, we describe a reflective-based biosensor capable of detecting the toxin's type and activity state by competitive immunoassay and endopeptidase activity, respectively. Two serotypes (BoNT-B and BoNT-C) were assessed independently by SiO₂/Si interferometers using simulating antigens or specific peptides (i.e., synaptosomal-associated protein and vesicle-associated membrane protein). The reflective responses of both platforms were biochemically amplified using 4-chloro-1-naphthol oxidation into insoluble products. The resulting refractive index variations were observed in real-time using reflective interferometric Fourier transform spectroscopy. The portable bioassay depicted high sensitivity, selectivity, and near real-time rapid assessment (0.14 and 0.47 pg mL^-1 for BoNT-C and BoNT-B, negligible interferences with interfering serotypes, respectively). Additionally, the applicability of the bioassay for monitoring extracted toxins was tested against the in vivo method with satisfactory performance values. Overall, the presented approach can improve field assessment of new botulism incidences by acquiring epidemiological data in near real-time, thus eliminating the need for the MLA approach.</p>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":"271 ","pages":"117027"},"PeriodicalIF":10.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}