Daphnipaxinin[7-5-7-6]四环核心的合成策略

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-10-19 DOI:10.1021/acs.joc.5c01906

Long Min,Lilin Zhao,Zhaoqi Li,Zichun Zhang

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引用次数: 0

摘要

本文报道了一种直接合成daphnipaxinin[7-5-7-6]四环框架的有效方法，该框架包含两个具有合成挑战性的中型环。以酸促I型[5 + 2]环加成反应为关键步骤，直接构建了具有合成挑战性的[7-7]熔合a /D环体系和期望的全碳季位中心非对映选择性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Strategy for the Synthesis of the [7-5-7-6] Tetracyclic Core of Daphnipaxinin.

Herein, we report an efficient approach for the direct synthesis of the [7-5-7-6] tetracyclic framework of daphnipaxinin, which contains two synthetically challenging medium-sized rings. The acid-promoted type I [5 + 2] cycloaddition reaction was used as the key step, which directly constructed a synthetically challenging [7-7] fused A/D ring system and the desired all-carbon quaternary stereocenter diastereoselectively.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.