化学•材料最新文献

{"title":"Label-free electrochemical biosensor for real-time detection of live Salmonella typhimurium in salad samples using non-Faradaic EIS","authors":"Sumana Karmakar ,&nbsp;Durgasha Poudyal ,&nbsp;Kundan Kumar Mishra ,&nbsp;Vikram Narayanan Dhamu ,&nbsp;Sriram Muthukumar ,&nbsp;Shalini Prasad","doi":"10.1016/j.bios.2025.117961","DOIUrl":"10.1016/j.bios.2025.117961","url":null,"abstract":"<div><div>Rapid detection of live <em>Salmonella typhimurium</em> in food is critical for preventing contamination and protecting public health. Traditional methods, though reliable, are slow, costly, and require centralized labs. Many existing biosensors primarily detect dead bacteria, increasing false-positive risks. To address these limitations, we report a portable biosensor that for the first time enables rapid, label-free, viability-specific detection of live <em>S. typhimurium</em> in food using non-Faradaic electrochemical impedance spectroscopy (EIS). The sensor achieves a detection limit of 9 CFU/mL within 5 min, significantly improving upon conventional techniques. Validation against ELISA confirmed its sensitivity and specificity. The platform exhibits strong analytical performance, maintaining inter- and intra-study coefficient of variation (%CV) below 20 %, confirming its reproducibility. Additionally, the biosensor demonstrates a positive predictive value (PPV) and a negative predictive value (NPV) exceeding 85 %, ensuring reliable detection accuracy. By distinguishing live bacteria, this biosensor provides more precise pathogen assessment, reducing false positives. Its rapid response time, high sensitivity, and ease of use make it an ideal tool for routine food safety testing. This study enhances biosensor technology by integrating a ZnO/Au-based non-Faradaic EIS platform offering a reliable, efficient, and field-deployable solution for bacterial detection, contributing to public health and global food security through timely intervention and contamination prevention.</div></div>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":"290 ","pages":"Article 117961"},"PeriodicalIF":10.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aerosolization of Azithromycin, Ofloxacin, and Co-occurring Antibiotic Resistance Genes during Municipal Wastewater Treatment","authors":"R. Sean Norman, Caroline O. Granger, Kristin H. Cochran, Mirza Isanovic, Stella Self, Eili Klein, Susan D. Richardson","doi":"10.1021/acs.est.5c08502","DOIUrl":"https://doi.org/10.1021/acs.est.5c08502","url":null,"abstract":"To effectively combat antibiotic resistance, it is critical to understand antibiotic usage patterns and their environmental dissemination. Wastewater treatment plants (WWTPs) are well-documented sources of antibiotics discharged into aquatic environments, but their role in releasing antibiotics via bioaerosols has not previously been investigated. In this study, seasonal air and liquid samples were collected throughout 2019 from a midsize WWTP employing both mechanical surface agitation and fine bubble aeration of activated sludge. Azithromycin and ofloxacin were detected in bioaerosols collected near aeration tanks at concentrations ranging from below detection limits up to 29 pg L^–1 air, suggesting that bioaerosols may represent a previously underappreciated route of environmental and occupational antibiotic exposure. Metagenomic analysis confirmed the co-occurrence of antibiotic resistance genes (ARGs) conferring resistance to macrolides and fluoroquinolones in both air and liquid samples. These findings highlight bioaerosols as an important yet overlooked pathway for the dissemination of antibiotics and ARGs, emphasizing the necessity of integrating airborne pathways into environmental antibiotic resistance surveillance programs, especially given the global scale of WWTP operations.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"48 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144987460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Theoretical Combustion Kinetic Study of Unsymmetrical Dimethylhydrazine: H-Atom Abstraction and Reactions on the Potential Energy Surface of C₂H₇N₂ Radicals.","authors":"Xin Bai, Xuan Ren, Ruining He, Frederick Nii Ofei Bruce, Yiheng Tong, Wei Lin, Jin Wu, Zonggang Du, Yiwen Hu, Yang Li","doi":"10.1021/acs.jpca.5c02879","DOIUrl":"https://doi.org/10.1021/acs.jpca.5c02879","url":null,"abstract":"<p><p>Unsymmetrical dimethylhydrazine (UDMH) is a widely used hypergolic rocket fuel. It is one of the most commonly used fuels for attitude control engines, such as those in missiles, satellites, spacecraft, and launch vehicles. We conducted a high-level theoretical study to develop a detailed combustion kinetic mechanism for UDMH, focusing on crucial elementary reactions. We analyzed 14 H atom abstraction reactions (HAA) of UDMH, four unimolecular reactions, and five chemical activation reactions on the potential energy surface (PES) of UDMH radicals (C₂H₇N₂). Seven reactive radicals Ḣ, ȮH, NO₂, HȮ₂, ĊH₃, CH₃Ȯ, and CH₃Ȯ₂ were involved. The M06-2X/6-311++G(d,p) method, along with the CCSD/cc-pVXZ (where X = T, Q) methods, was used for theoretical calculations. The rate coefficients and thermochemical property parameters for the 23 elementary reactions and related key species were calculated. Our results indicate that HAA by Ḣ, ȮH, and CH₃Ȯ dominate at low temperatures (300-700 K) compared to CH₃Ȯ₂, HȮ₂, and NO₂. Some of the calculated rate coefficients were compared with previous experimental and theoretical studies, and our computed values agreed well with reference data. For the reactions on the PES, the N-N breaking reaction and the CH₃NNH + ĊH₃ system show great importance in the initial reaction network. The pressure dependence of all the reactions on the PES was evaluated. Regarding the thermochemical properties of UDMH and its corresponding product radicals, our standard enthalpy values deviate by about 1 kcal·mol^-1 from database values.</p>","PeriodicalId":59,"journal":{"name":"The Journal of Physical Chemistry A","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144990989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal Nitrogen Oxide (NOx) and Its Potential Impact on Infant Metabolism during the First Month of Life: Evidence from Two Distinct Cohorts─The Atlanta African American Maternal-Child Cohort and the Southern California Mother’s Milk Study","authors":"Elizabeth A. Holzhausen, Youran Tan, Nathan Young, Roshonda B. Jones, Ziyin Tang, Jeremy A. Sarnat, Fredrick Lurmann, Howard H. Chang, ViLinh Tran, Dean P. Jones, Michael I. Goran, Anne L. Dunlop, Donghai Liang, Tanya L. Alderete","doi":"10.1021/acs.est.5c04955","DOIUrl":"https://doi.org/10.1021/acs.est.5c04955","url":null,"abstract":"Exposure to traffic-related air pollution (TRAP) during pregnancy has been linked with adverse health outcomes, yet the biological mechanisms remain poorly understood. High-resolution metabolomics offers a promising approach to examine how TRAP influences infant health. However, few studies have focused on Black and Latino populations, who are disproportionately exposed to TRAP. This study aims to assess the association between prenatal exposure to TRAP and the infant metabolome in two distinct, geographically independent populations: the prospective Atlanta African American Cohort and the Southern California Mother’s Milk Study (MMS). This study provides novel evidence that prenatal nitrogen oxides (NO_<i>x</i>), a major component of TRAP, are associated with perturbations in the infant circulating and fecal metabolome during the first month of life. We found that prenatal NO_<i>x</i> exposure was linked with the intensity of 8 and 16 level-1 metabolites in the ATL AA and MMS, respectively. Metabolites associated with NO_<i>x</i> included several involved in lipid and xenobiotic metabolism. In analyses including untargeted metabolic features, we found that prenatal NO_<i>x</i> was associated with perturbations in metabolic pathways including oxidative stress and inflammatory response. These findings provide novel insight into the biological mechanisms by which prenatal TRAP may influence infant health and development.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"114 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144987464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photochemical Production of Singlet Oxygen by Toronto Road Dust","authors":"Alexandra I. Burnett, Clare L. S. Wiseman, Sarah A. Styler","doi":"10.1021/acs.est.4c09631","DOIUrl":"https://doi.org/10.1021/acs.est.4c09631","url":null,"abstract":"Road dust, which consists of brake and tire wear, pavement particles, crustal material, semivolatile vehicle exhaust components, and natural organic matter, can contribute to both airborne particulate matter and urban runoff. To date, research has mainly focused on the health impact of road dust, but little work has been conducted to characterize its role as a reactive surface in the environment. Our group has previously shown that illuminated road dust is a source of singlet oxygen, an important environmental oxidant. Here, we report the singlet oxygen steady state concentration ([¹O₂]_ss) of illuminated aqueous suspensions and aqueous extracts of road dust samples collected from three different road types (local, arterial, and expressway) in Toronto, Canada. We find that the [¹O₂]_ss generated by aqueous extracts of road dust samples spans less than an order of magnitude and there is no clear trend in the [¹O₂]_ss with road type, but that road dust [¹O₂]_ss depends on organic content and light absorbance. The median singlet oxygen apparent quantum yield of the road dust extracts is 5.4% (UV-A), which is more than double the median reported values (UV-A) for river, lake, soil and wastewater samples. Comparisons of road dust aqueous extracts with aqueous road dust suspensions reveal that suspended road dust has a much higher [¹O₂]_ss, emphasizing the need to examine singlet oxygen production by the insoluble components in particulate matter. Overall, our results highlight the potential of road dust to transform pollutants in the atmosphere and in urban runoff.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"24 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144987466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Production of Methylmercury in Peatlands Following Permafrost Thaw Increases along a Trophic Gradient.","authors":"Lauren M Thompson,Renae Shewan,Vaughn Mangal,Lorna I Harris,Chi Him Cheng,Lucas P P Braga,Olesya Kolmakova,Andrew J Tanentzap,Klaus H Knorr,McKenzie A Kuhn,Charlotte Haugk,Alyssa Azaroff,Sofi Jonsson,Vincent L St Louis,Igor Lehnherr,William L Quinton,Oliver Sonnentag,David Olefeldt","doi":"10.1021/acs.est.5c04510","DOIUrl":"https://doi.org/10.1021/acs.est.5c04510","url":null,"abstract":"Permafrost thaw in peatlands risks increasing the production and mobilization of methylmercury (MeHg), a bioaccumulative neurotoxin that poses a health hazard to humans. We studied 12 peatlands on a trophic gradient in northwestern Canada, including permafrost peat plateaus and thawed bogs and fens, to determine the effects of thaw on MeHg production from measures of soil and porewater MeHg and in situ methylation assays. The production of MeHg was greater in thawed peatlands, especially rich fens, as indicated by higher potential rates of microbial methylation of inorganic mercury (Hg) to MeHg and higher soil %MeHg (MeHg:total Hg). Soil %MeHg was 0.1% in permafrost peat plateaus, 0.7% in bogs, and 2.0% in fens. Microbial analysis indicated three putative methylators (two methanogens and one novel bacteria) as most influential to the community composition, although their abundances were not consistently highest in fens. Fens had a greater range of porewater MeHg concentrations than bogs, potentially due to hydrological flushing, controls on MeHg solubility, or redox disequilibria in fens. MeHg in porewater was strongly associated with dissolved organic matter that had a low aromaticity and a low oxygen-to-carbon ratio. Regionally upscaling our results suggested that the expansion of bogs and fens due to thawing may increase the landscape-scale potential for MeHg production by 65% by 2100, representing a substantial risk to downstream aquatic ecosystems.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"303 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144960227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solidified natural gas (SNG) technology for biogas/biomethane storage: Current status and future outlook","authors":"Viphada Yodpetch ,&nbsp;Kan Jeenmuang ,&nbsp;Chakorn Viriyakul ,&nbsp;Santi Kulprathipanja ,&nbsp;Pramoch Rangsunvigit","doi":"10.1016/j.rser.2025.116233","DOIUrl":"10.1016/j.rser.2025.116233","url":null,"abstract":"<div><div>Biogas or biomethane is considered a promising renewable and clean energy source. Efficient storage of biomethane is essential for its widespread applications across different energy sectors. This review offers an overview of biomethane storage methods, focusing particularly on solidified natural gas (SNG) technology for biomethane or solidified biomethane (SBM). In SBM, biomethane gas is stored in the form of hydrates, with the gas enclosed within the lattice formed by water molecules, thereby forming solid hydrate crystals. This provides a safe, eco-friendly, and compact storage and transportation solution. The review investigates approaches to enhance SBM technology viability, including the use of different promoters to improve kinetics and thermodynamics during hydrate formation, both individually and in combination, as well as the effect of trace gas on the biomethane hydrate formation. Additionally, the review evaluates technology feasibility through various perspectives such as the stability of solid biomethane hydrates, the reusability of hydrate former solutions, and economic factors, ultimately contributing to the development of a sustainable global energy future.</div></div>","PeriodicalId":418,"journal":{"name":"Renewable and Sustainable Energy Reviews","volume":"226 ","pages":"Article 116233"},"PeriodicalIF":16.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144996750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A S/N co-doped carbon-based peroxidase-like nanozyme for the detection of AChE and organophosphorus pesticides","authors":"Zhixuan Han,&nbsp;Chenyu Zhou,&nbsp;Yuntai Lv,&nbsp;Xingguang Su","doi":"10.1016/j.colsurfb.2025.115121","DOIUrl":"10.1016/j.colsurfb.2025.115121","url":null,"abstract":"<div><div>Herein, a novel S/N co-doped carbon-based nanozyme （S/N-Fe₈₀₀） with peroxidase-like properties was synthesized by doping thiourea into Fe MOF and introducing g-C₃N₄ for pyrolysis. Generated by enzymatic cascade with acetylcholinesterase (AChE) involved, H₂O₂ could react with S/N-Fe₈₀₀ to generate reactive oxygen species (ROS). O-Phenylenediamine (OPD) could be catalyzed by ROS, resulting in the production of 2,3-diaminophenazine (DAP) with a fluorescent emission at 564 nm. The organophosphorus pesticides (OPs), including triazophos (Taz) and phosmet (Pho), have the capacity to impede the enzymic catalytic reaction of AChE, thus affect the fluorescence of DAP. A rapid and sensitive sensing platform that allows for the simultaneous determination of AChE, Taz and Pho was successfully established through monitoring the fluorescence at 564 nm. The limit of detection (LOD) for AChE, Taz and Pho were determined to be 0.035 U/L, 0.047 ng/mL and 0.072 ng/mL, respectively. This method achieved satisfactory results in the human serum and common agricultural products.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"257 ","pages":"Article 115121"},"PeriodicalIF":5.6,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotics Sources, Concentrations, and Risk of Antimicrobial Resistance Selection in the Three Gorges Reservoir Basin, China.","authors":"Shiyang Li,Qi Zhang,Meijun Chen,Maryna Strokal,Carolien Kroeze,Lin Ma,Fusuo Zhang,Xuanjing Chen,Xinping Chen,Nynke Hofstra","doi":"10.1021/acs.est.5c00740","DOIUrl":"https://doi.org/10.1021/acs.est.5c00740","url":null,"abstract":"The widespread use of antibiotics in humans and animals raises significant environmental concerns. However, few approaches can simultaneously quantify their transfer from humans and animals and track their fate in soils and rivers. In this study, we developed the MARINA-Antibiotics model (Model to Assess River Inputs of pollutaNts to seAs for Antibiotics) to quantify the sources and concentrations of 30 widely used antibiotics, as well as assess their associated environmental risks, and implemented this model in the Three Gorges Reservoir Area in 2020. The risk of antimicrobial resistance was evaluated by calculating the risk quotient based on the minimum selective concentration. Our findings revealed that 11 tons of antibiotics entered cropland via manure application. High and medium risk quotients indicated potential risks from ciprofloxacin, enrofloxacin, sulfapyridine, tetracycline, doxycycline, and ofloxacin in cropland. In total, 13 tons were discharged into rivers, primarily through point sources (99%). In rivers, degradation and sedimentation accounted for 90% of antibiotic removal. Tetracyclines and fluoroquinolones contributed the highest loads to the sediments. The risk of promoting AMR was low for most antibiotics except for ciprofloxacin and enrofloxacin. This study improves our understanding of antibiotic sources and spatial patterns in watershed environments, providing valuable insights for clean water management.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"38 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Toxicologically Informed Relative Potency Factors to Examine Associations between Water Disinfection Byproducts and Birth Defects","authors":"John A. Kaufman, Michael G. Narotsky, Glenn E. Rice, J. Michael Wright","doi":"10.1021/acs.est.5c05918","DOIUrl":"https://doi.org/10.1021/acs.est.5c05918","url":null,"abstract":"We used toxicologically informed relative potency factors (RPFs) to compare RPF-weighted versus unweighted epidemiologic analyses of five birth defects (atrial septal defect [ASD], ventricular septal defect [VSD], tetralogy of Fallot [TOF], cleft palate without cleft lip, and obstructive genitourinary defects [OGD]) and various disinfection byproduct (DBP) mixtures in drinking water. We derived RPFs for four trihalomethanes (THMs) and nine haloacetic acids (HAAs) from published animal developmental bioassays using benchmark dose models at 10% responses, estimated adjusted odds ratios (aORs) for RPF-weighted quintile 5 (vs 1) DBP mixture sums, and compared the RPF-weighted and unweighted aORs. RPFs were generally higher for brominated DBP species (e.g., HAA RPF10s from mouse whole embryo culture dysmorphogenesis data: monobromoacetic acid [MBAA] = 1.00, trichloroacetic acid [TCAA] = 0.0011, and dichloroacetic acid [DCAA] = 0.0005), which occurred at lower concentrations than chlorinated species. For THM mixtures, aORs changed &lt;10% with RPF weighting, except for TOF (+19%) for the sum of brominated THMs (tribromomethane + bromodichloromethane + dibromochloromethane). We detected &gt;10% aOR changes for HAA3 (TCAA + DCAA + dibromoacetic acid) with TOF and OGD; HAA5 (HAA3 + monochloroacetic acid + MBAA) with ASD, TOF, and OGD; HAA6 (all brominated HAAs) with TOF; and HAA9 (HAA5 + tribromoacetic acid + bromochloroacetic acid + bromodichloroacetic acid + dibromochloroacetic acid) with OGD. The results suggest that unweighted DBP metrics may reasonably estimate risks of regulated DBPs, but this should be examined elsewhere based on individual-level estimates, which should be prone to less exposure measurement error.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"21 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144987468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}