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Corrigendum to "Probiotic bacterial adsorption coupled with CRISPR/Cas12a system for mercury (II) ions detection" [Biosens. Bioelectron. 263 (2024) 116627]. 对 "结合 CRISPR/Cas12a 系统的益生菌吸附与汞 (II) 离子检测 "的更正 [Biosens.
IF 10.7 1区 生物学
Biosensors and Bioelectronics Pub Date : 2025-01-01 Epub Date: 2024-10-03 DOI: 10.1016/j.bios.2024.116831
Ying Yu, Yuan Zhang, Yining Zhao, Kangzheng Lv, Lianzhong Ai, Zhengjun Wu, Zibo Song, Juan Zhang
{"title":"Corrigendum to \"Probiotic bacterial adsorption coupled with CRISPR/Cas12a system for mercury (II) ions detection\" [Biosens. Bioelectron. 263 (2024) 116627].","authors":"Ying Yu, Yuan Zhang, Yining Zhao, Kangzheng Lv, Lianzhong Ai, Zhengjun Wu, Zibo Song, Juan Zhang","doi":"10.1016/j.bios.2024.116831","DOIUrl":"10.1016/j.bios.2024.116831","url":null,"abstract":"","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":" ","pages":"116831"},"PeriodicalIF":10.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142374695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The value of electrochemical ratiometry in immunosensing: A systematic study. 电化学比率法在免疫传感中的价值:系统研究。
IF 10.7 1区 生物学
Biosensors and Bioelectronics Pub Date : 2025-01-01 Epub Date: 2024-10-05 DOI: 10.1016/j.bios.2024.116817
Jin Song, Rui Gong, Shibo Song, Ghulam Abbas, Yaohong Ma, Yiwei Li
{"title":"The value of electrochemical ratiometry in immunosensing: A systematic study.","authors":"Jin Song, Rui Gong, Shibo Song, Ghulam Abbas, Yaohong Ma, Yiwei Li","doi":"10.1016/j.bios.2024.116817","DOIUrl":"10.1016/j.bios.2024.116817","url":null,"abstract":"<p><p>Reluctant reproducibility and accuracy make electrochemical immunosensors suffering from high possibility of false negative/positive results, and it is the main obstacle that hinders them into an eligible alternative technology to the gold-standard method. It has been demonstrated sporadically previously that ratiometry helps deal with this issue but to what extent this could be beneficial and why it could fulfill is yet to be explored. In this study, to the best of our knowledge, for the first time, we have attempted to answer these questions through comprehensive experiments. For this purpose, labeled and label-free electrochemical immunosensors for SARS-CoV-2 pseudovirus quantification are constructed as a model electrochemical immunosensor. Conventional and ratiometric immunosensors are prepared by using electrochemically synthesized graphene modified electrodes coupled with various electrochemical probe pairs. It was found that the electrocatalyst modification at the electrode interface makes the predominant contribution to immunosensor sensitivity, while appropriate ratiometry provided electrochemical immunosensors with significantly enhanced reproducibility, accuracy, as well as sensing stability. Further, the experiments confirmed that the improvement in sensor performance achieved by ratiometry is primarily through overcoming the inherent errors and dynamic variations of the base electrode. It is also demonstrated electrochemical immunosensors made thereof could easily rival the performances of the gold-standard PCR method, in the view of immunoassay diagnosis. Therefore, it is of great promise to evolve electrochemical immunosensors into an eligible substitute technique towards the prevalent nucleic acid detection method in point-of-care testing (POCT), with the aid of electrochemical ratiometry.</p>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":" ","pages":"116817"},"PeriodicalIF":10.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing oxygen vacancy-rich CuMn2O4/carbon dots dual-function nanozymes via Chan-Lam coupling reaction for the colorimetric/fluorescent determination of D-penicillamine. 通过 Chan-Lam 偶联反应开发富氧空位铜锰氧化物/碳点双功能纳米酶,用于 D-青霉胺的比色/荧光测定。
IF 10.7 1区 生物学
Biosensors and Bioelectronics Pub Date : 2025-01-01 Epub Date: 2024-10-19 DOI: 10.1016/j.bios.2024.116864
Min Feng, Xiaodan Zhang, Yuming Huang
{"title":"Developing oxygen vacancy-rich CuMn<sub>2</sub>O<sub>4</sub>/carbon dots dual-function nanozymes via Chan-Lam coupling reaction for the colorimetric/fluorescent determination of D-penicillamine.","authors":"Min Feng, Xiaodan Zhang, Yuming Huang","doi":"10.1016/j.bios.2024.116864","DOIUrl":"10.1016/j.bios.2024.116864","url":null,"abstract":"<p><p>Defect engineering is a promising approach to construct high performance nanozymes due to its ability to regulate their physical and chemical properties. However, how to construct defects to improve the activity of nanozymes remains a challenge. Herein, for the first time, the Chan-Lam coupling reaction is used to construct the oxygen vacancy (O<sub>V</sub>)-rich CuMn<sub>2</sub>O<sub>4</sub>/carbon dots (CDs) (O<sub>V</sub>-CuMn<sub>2</sub>O<sub>4</sub>/CDs) dual-function nanozymes with fluorescent (FL) and oxidase-like properties, via regulating the low-valent metal ions (Cu<sup>+</sup> and Mn<sup>2+</sup>) and O<sub>v</sub> contents in the spinel CuMn<sub>2</sub>O<sub>4</sub> and in-situ growth of β-cyclodextrin (β-CD)-derived CDs. Expectedly, relative to CuMn<sub>2</sub>O<sub>4</sub>, the O<sub>V</sub>-CuMn<sub>2</sub>O<sub>4</sub>/CDs exhibited 35.8%, 8.5%, and 14.6% rise in the contents of Cu<sup>+</sup>, Mn<sup>2+</sup> and O<sub>v</sub>, respectively. Abundant O<sub>v</sub> provides more O<sub>2</sub> adsorption/activation sites, and the charge transfer between O<sub>v</sub> and metal atoms increases the charge density around metal atoms. This produces more low-valent metals (like Cu<sup>+</sup> and Mn<sup>2+</sup>) to promote the electron transfer from metal to O atoms and O-O bond cleavage. Thus, the oxidase-like activity of O<sub>V</sub>-CuMn<sub>2</sub>O<sub>4</sub>/CDs is 4.1 times that of CuMn<sub>2</sub>O<sub>4</sub>. Also, the in-situ growth of β-CD-derived carbon dots on CuMn<sub>2</sub>O<sub>4</sub> endows O<sub>V</sub>-CuMn<sub>2</sub>O<sub>4</sub>/CDs selective target recognition. Thus, a sensitive and selective colorimetric and fluorescence dual-mode method was established for determining D-penicillamine (D-PA), with the limit of detection of 0.25 and 0.048 μM, respectively. The method was applied to D-PA determination in real samples. This work demonstrates the Chan-Lam coupling reaction can be used to construct high performance nanozymes for developing dual-mode sensor for the detection of targets.</p>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":"267 ","pages":"116864"},"PeriodicalIF":10.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142491903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel multifunctional PEEK internal fixation plate regulated by Gentamicin/chitosan coating. 由庆大霉素/壳聚糖涂层调节的新型多功能 PEEK 内固定板。
IF 5.4 2区 医学
Colloids and Surfaces B: Biointerfaces Pub Date : 2025-01-01 Epub Date: 2024-10-12 DOI: 10.1016/j.colsurfb.2024.114316
Jingfeng Sun, Jinying Li, Aiting Shan, Lijuan Wang, Jiaming Ye, Shaochuan Li, Wuyi Zhou
{"title":"A novel multifunctional PEEK internal fixation plate regulated by Gentamicin/chitosan coating.","authors":"Jingfeng Sun, Jinying Li, Aiting Shan, Lijuan Wang, Jiaming Ye, Shaochuan Li, Wuyi Zhou","doi":"10.1016/j.colsurfb.2024.114316","DOIUrl":"10.1016/j.colsurfb.2024.114316","url":null,"abstract":"<p><p>Polyetheretherketone (PEEK) has been broadly used in orthopedic implant devices. Nevertheless, the bioinert tended to cause implant loosening and bacterial infection in orthopedic and trauma surgery. In this study, a drug-laden chitosan coating (CS) was constructed and deposited on the porous surface of PEEK (CG-SPEEK) internal fixation plate for multi-functionalization. The physical characterizations of CG-SPEEK were further investigated in the morphology, hydrophilicity, surface energy, roughness, drug release and mechanical properties. CG-SPEEK exhibited excellent antibacterial capabilities in both Staphylococcus aureus and Escherichia coli compared to other groups. Besides, BMSCs cells showed better biocompatibility and certain osteogenic activity on composite coating in vitro. Furthermore, CG-SPEEK promoted bone regeneration to some extent and express certain effect against infections in vivo study. Overall, combining personalized design and modification is an innovative strategy to realized functionalization, which may have a strong potential in clinical application.</p>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"245 ","pages":"114316"},"PeriodicalIF":5.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142454498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multienzyme-like active MnO2 nanozyme with ROS scavenging for inflammatory injury therapy induced by avian flavivirus through antiviral function. 具有清除 ROS 功能的多酶活性 MnO2 纳米酶,通过抗病毒功能治疗禽黄病毒诱发的炎症损伤。
IF 5.4 2区 医学
Colloids and Surfaces B: Biointerfaces Pub Date : 2025-01-01 Epub Date: 2024-10-09 DOI: 10.1016/j.colsurfb.2024.114302
Linhua Xu, Wei Fan, Ming Han, Wei Li, Yu He, Zhen Wu, Aimin Wu, Yue Xie, Huaiyong Gao, Shun Chen, Xianxiang Wang
{"title":"Multienzyme-like active MnO<sub>2</sub> nanozyme with ROS scavenging for inflammatory injury therapy induced by avian flavivirus through antiviral function.","authors":"Linhua Xu, Wei Fan, Ming Han, Wei Li, Yu He, Zhen Wu, Aimin Wu, Yue Xie, Huaiyong Gao, Shun Chen, Xianxiang Wang","doi":"10.1016/j.colsurfb.2024.114302","DOIUrl":"10.1016/j.colsurfb.2024.114302","url":null,"abstract":"<p><p>Duck Tembusu virus (DTMUV) is an acute avian flavivirus that primarily infects poultry, mosquitoes, and some mammals including humans. The viral infection triggers reactive oxygen species (ROS) and inflammatory response that are crucial in mediating injury. Crafting multifunctional nanozymes that possess both ROS scavenging and anti-inflammatory activities presents formidable challenges. The study synthesized manganese dioxide cauliflowers (MnO<sub>2</sub> Cfs) endowed with multiple enzyme-like activities (analogous to SOD, CAT, and GPX) that effectively alleviated the injury induced by DTMUV both in vitro and in vivo. Remarkably, MnO<sub>2</sub> Cfs efficiently neutralized various ROS, encompassing hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), superoxide anion (O<sub>2</sub><sup>·-</sup>) and hydroxyl radical (·OH). Our in vitro assessments showed that MnO<sub>2</sub> Cfs could alleviate cytopathic effects and modulate the innate immune response during DTMUV infection through their ROS scavenging and anti-inflammatory properties. In vivo experiments supported these findings, demonstrating that ducklings therapied by MnO<sub>2</sub> Cfs experienced alleviated injury during DTMUV infection. Importantly, MnO<sub>2</sub> Cfs also effectively inhibited DTMUV replication in both laboratory and field conditions. This study presents a novel strategy for nanozyme design, promising significant therapeutic potential for treating viral inflammatory diseases.</p>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"245 ","pages":"114302"},"PeriodicalIF":5.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142454510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fast tailoring the ZIF-8 surface microenvironment at ambient temperature to boost glucose oxidase-like activity of AuNPs for biosensing. 在常温下快速定制 ZIF-8 表面微环境,提高用于生物传感的 AuNPs 的葡萄糖氧化酶样活性。
IF 5.4 2区 医学
Colloids and Surfaces B: Biointerfaces Pub Date : 2025-01-01 Epub Date: 2024-10-22 DOI: 10.1016/j.colsurfb.2024.114331
Xianrui Jiang, Tao Yao, Xingxin Shi, Hongliang Han, Zhanfang Ma
{"title":"Fast tailoring the ZIF-8 surface microenvironment at ambient temperature to boost glucose oxidase-like activity of AuNPs for biosensing.","authors":"Xianrui Jiang, Tao Yao, Xingxin Shi, Hongliang Han, Zhanfang Ma","doi":"10.1016/j.colsurfb.2024.114331","DOIUrl":"10.1016/j.colsurfb.2024.114331","url":null,"abstract":"<p><p>Rational design and tailoring of the surface microenvironment surrounding the catalytic sites, such as noble metal nanoparticles, is an effective way to enhance the catalytic activity of mimicking enzymes. However, it remains on-going challenges to regulate the microenvironment of the catalytic sites due to the lack of tunable variability in structural precision of conventional solid catalysts. Herein, three types of zeolitic imidazolate framework-8 (ZIF-8) with different major crystal facet orientations, i.e., cubic with (100) facets (denoted ZIF-8<sub>c</sub>), truncated dodecahedral with (100), (110) facets (denoted ZIF-8<sub>tr</sub>), and dodecahedral with (110) facets (denoted ZIF-8<sub>r</sub>), were developed facilely using an electrochemical method by switching the potential at ambient temperature. Because the Zn<sup>2+</sup> nodes were predominantly exposed on the (100) facets of ZIF-8, while the ligands were mainly exposed on the (110) facets. Hence, gold nanoparticles (AuNPs) showed differential glucose oxidase (GOx)-like activities when anchored in situ on different crystal facets of ZIF-8 and obeyed the following order ZIF-8<sub>c</sub>/Au>ZIF-8<sub>tr</sub>/Au>ZIF-8<sub>r</sub>/Au. Notably, both the metal nodes and aromatic linkers of ZIF-8 interacted with AuNPs through coordination and π-π interactions. The Zn<sup>2+</sup> nodes facilitated the formation of the electron-deficient Au species. The electron transfer from AuNPs to Zn<sup>2+</sup> sites effectively boosted the catalytic activity. It was known that directly tailoring the microenvironment at the supporting sites of noble metal catalysts to boost catalysis through a facile electrochemical method was not reported. Based on the favorable GOx-like activity and long-term stability of ZIF-8<sub>tr</sub>/Au, a highly sensitive electrochemical biosensing platform for assaying squamous cell carcinoma antigen (SCCA) was developed. It enabled fg-level detection of cancer marker.</p>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"245 ","pages":"114331"},"PeriodicalIF":5.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Osteoblasts win the race for the surface on DNA polyelectrolyte multilayer coatings against S. epidermidis but not against S. aureus. 成骨细胞在 DNA 聚电解质多层涂层表面的抗表皮葡萄球菌竞赛中获胜,但在抗金黄色葡萄球菌竞赛中却没有获胜。
IF 5.4 2区 医学
Colloids and Surfaces B: Biointerfaces Pub Date : 2025-01-01 Epub Date: 2024-10-24 DOI: 10.1016/j.colsurfb.2024.114336
Carmelo Covato, Alina Pilipenco, Andrea Scheberl, Erik Reimhult, Guruprakash Subbiahdoss
{"title":"Osteoblasts win the race for the surface on DNA polyelectrolyte multilayer coatings against S. epidermidis but not against S. aureus.","authors":"Carmelo Covato, Alina Pilipenco, Andrea Scheberl, Erik Reimhult, Guruprakash Subbiahdoss","doi":"10.1016/j.colsurfb.2024.114336","DOIUrl":"10.1016/j.colsurfb.2024.114336","url":null,"abstract":"<p><p>Biomaterial-associated infections pose severe challenges in modern medicine. Previously, we reported that polyanionic DNA surface coatings repel bacterial adhesion and support osteoblast-like cell attachment in monoculture experiments, candidate for orthopaedic implant coatings. However, monocultures lack the influence of bacteria or bacterial toxins on osteoblast-like cell adhesion to biomaterial surfaces. In this study, co-culture of staphylococcus (S. epidermidis and S. aureus) and SaOS-2 osteosarcoma cells was studied on chitosan-DNA polyelectrolyte multilayer coated glass based on the concept of `the race for the surface`. Staphylococcus was first deposited onto the surface in a microfluidic chamber to mimic peri-operative contamination, and subsequently, SaOS-2 cells were seeded. Both staphylococcus and SaOS-2 cells were cultured together on the surfaces for 24 h under flow. The presence of S. epidermidis decreased SaOS-2 cell number on all surfaces after 24 h. However, the cells that adhered spread equally well in the presence of low virulent S. epidermidis. However, highly virulent S. aureus induced cell death of all adherent SaOS-2 cells on chitosan-DNA multilayer coated glass, a worse outcome than on uncoated glass. The outcome of our co-culture study highlights the limitations of monoculture models. It demonstrates the need for in vitro co-culture assays to meaningfully bridge the gap in lab testing of biomaterials and their clinical evaluations where bacterial infection can occur. The relative failure of cell-adhesive and bacteria-repelling DNA coatings in co-cultures also suggests the need to incorporate bactericidal in addition to non-adhesive functions to protect competitive cell spreading over a long period.</p>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"245 ","pages":"114336"},"PeriodicalIF":5.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precise photothermal treatment of bacterial infection mediated by charge-switchable nanoplatform with acylsulfonamide betaine surface. 具有酰基磺酰胺甜菜碱表面的电荷转移纳米平台介导的细菌感染精准光热疗法。
IF 5.4 2区 医学
Colloids and Surfaces B: Biointerfaces Pub Date : 2025-01-01 Epub Date: 2024-11-05 DOI: 10.1016/j.colsurfb.2024.114362
Wenyuan Sun, Shumin Hu, Binzhong Lu, Yu Bao, Mengyao Guo, Yingying Yang, Qiuli Cheng, Leitao Zhang, Wenlan Wu, Junbo Li
{"title":"Precise photothermal treatment of bacterial infection mediated by charge-switchable nanoplatform with acylsulfonamide betaine surface.","authors":"Wenyuan Sun, Shumin Hu, Binzhong Lu, Yu Bao, Mengyao Guo, Yingying Yang, Qiuli Cheng, Leitao Zhang, Wenlan Wu, Junbo Li","doi":"10.1016/j.colsurfb.2024.114362","DOIUrl":"10.1016/j.colsurfb.2024.114362","url":null,"abstract":"<p><p>Photothermal therapy (PTT) offers a promising approach for the treatment of drug-resistant bacterial-infected wounds, yet it requires precise targeting of thermal damage to bacteria rather than healthy tissues. Herein, ultrasmall CuS NPs modified with polyzwitterion containing acylsulfonamide betaine (PCBSA@CuS), which provides a sensitive and reversible charge conversion around pH 6.8, are used to enhance the healing of bacteria-infected wounds. In the acidic infection microenvironment, the majority of PCBSA@CuS can electrostatically adsorb onto bacterial cells through cationic exposure, resulting in direct damage and death of bacteria upon NIR irradiation. Additionally, the photothermal NPs rapidly return to a zwitterionic nature in normal physiological environments, ensuring lower affinity and avoiding thermal damage to healthy tissues during continuous PTT. Compared to inert photothermal systems such as PEG-modified CuS NPs, the NPs used in this study exhibited higher bactericidal and wound healing efficacy. Therefore, this nano-antibacterial agent with highly sensitive thermal-targeting function provides a novel photothermal strategy for efficient and biosafe treatment of infected wounds.</p>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"245 ","pages":"114362"},"PeriodicalIF":5.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surface-induced self-assembly of peptides turns superhydrophobic surface of electrospun fibrous into superhydrophilic one. 表面诱导的多肽自组装将电纺纤维的超疏水表面变成超亲水表面。
IF 5.4 2区 医学
Colloids and Surfaces B: Biointerfaces Pub Date : 2025-01-01 Epub Date: 2024-11-01 DOI: 10.1016/j.colsurfb.2024.114350
Xuan Sun, Han Ren, Yue-Chan Cui, Qian Liu, Jie Li, Jie Gao
{"title":"Surface-induced self-assembly of peptides turns superhydrophobic surface of electrospun fibrous into superhydrophilic one.","authors":"Xuan Sun, Han Ren, Yue-Chan Cui, Qian Liu, Jie Li, Jie Gao","doi":"10.1016/j.colsurfb.2024.114350","DOIUrl":"10.1016/j.colsurfb.2024.114350","url":null,"abstract":"<p><p>Current surface modification strategies for electrospun materials always require covalent conjugation technology, which is relatively inefficient and might damage the bioactivity and structure of peptides and proteins. Here we introduce the use of surface-induced self-assembly technology to modify electrospun materials, which is a simple but efficient noncovalent-based process. Results show that the peptide NapFFGRGD forms burr-like structures on the surface of PCL fibers, reducing the water contact angle of the fibers. Adjusting the peptide sequence and salt concentration affects the self-assembly and surface properties of modified PCL fibers. Additionally, we demonstrate the potential application of this surface modification technique for enhancing cellular responses in tissue engineering applications. The research provides valuable insights into the surface modification of PCL fibers and offers a new method for improving the biological compatibility of materials in tissue engineering.</p>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"245 ","pages":"114350"},"PeriodicalIF":5.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Curcumin-encapsulated glucan nanoparticles as an oxidative stress modulator against human hepatic cancer cells. 姜黄素包裹的葡聚糖纳米颗粒是一种抗人肝癌细胞氧化应激的调节剂。
IF 5.4 2区 医学
Colloids and Surfaces B: Biointerfaces Pub Date : 2025-01-01 Epub Date: 2024-10-19 DOI: 10.1016/j.colsurfb.2024.114326
Tiago Roquito, Mariana Colaço, João Panão Costa, Olga Borges
{"title":"Curcumin-encapsulated glucan nanoparticles as an oxidative stress modulator against human hepatic cancer cells.","authors":"Tiago Roquito, Mariana Colaço, João Panão Costa, Olga Borges","doi":"10.1016/j.colsurfb.2024.114326","DOIUrl":"10.1016/j.colsurfb.2024.114326","url":null,"abstract":"<p><p>In Hepatitis B patients, the virus targets liver cells, leading to inflammation and liver damage, which can result in severe complications such as liver failure, cirrhosis, and liver cancer. Therapeutic options for liver disease are currently limited. Curcumin, a polyphenol with potential protective effects against chronic diseases like cancer, suffers from poor water solubility, restricting its pharmacological applications. This study explores the encapsulation of curcumin in glucan nanoparticles (NPs) and its impact on oxidative stress in liver cancer cells. Two sizes of curcumin-loaded glucan NPs, GC111 (111 nm) and GC398 (398 nm), were produced with nearly 100 % encapsulation efficiency. Cytotoxicity studies revealed that particle size influences the extent of observed effects, with GC111 NPs causing a greater reduction in cell viability. Additionally, the smaller GC111 NPs demonstrated a higher capacity to induce oxidative stress in cancer cells by stimulating the production of ROS, NO, and the chemokine RANTES in a concentration-dependent manner. These findings suggest that the smaller GC111 NPs are promising candidates for future studies aimed at evaluating oxidative stress-induced tumor cell death mechanisms.</p>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"245 ","pages":"114326"},"PeriodicalIF":5.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142491921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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