化学•材料最新文献

{"title":"Influence of Crowding Agents on the Small GTPase Rab2B: Stability Consideration and Intermediate Formation.","authors":"Jyoti Rani Nath, Zahoor Ahmad Parray, Pramit K Chowdhury","doi":"10.1021/acs.jpcb.5c02668","DOIUrl":"https://doi.org/10.1021/acs.jpcb.5c02668","url":null,"abstract":"<p><p>This work investigates the thermal and chemical denaturation of recombinant Rab2B in the absence and presence of varying concentrations of denaturant (urea) under crowded environments using the synthetic crowders PEG 8 (polyethylene glycol, MW of 8 kDa) and Ficoll 70 (MW of 70 kDa). Rab2B plays an important role in vesicle trafficking, and more specifically, it is crucial in maintaining the integrity of the Golgi morphology. Our findings demonstrate that increasing concentrations of urea lead to a decrease in both the thermal and chemical stability of Rab2B in a crowder-dependent manner. A distinct formation of intermediate was induced by the crowders in the presence of 2 M urea having greater structural content as realized from CD and fluorescence studies. Furthermore, ANS fluorescence assays allowed us to monitor the changes in hydrophobicity of the protein under different conditions, while time-resolved fluorescence studies were carried out to gain information on the accessibility of the tryptophan residues. Taken in the context of the function of Rab2B, these findings contribute to a better understanding of the effect of macromolecular crowding on the stability and conformation of the protein. Since Rab2B is known to undergo a switch in conformation between GDP- and GTP-bound states and shows subsequent interaction with binding partner(s), the underlying flexibility of Rab2B and the possibility of formation of functional intermediates underscore the importance of the crowded medium in assisting the protein to execute its role in the physiological interior.</p>","PeriodicalId":60,"journal":{"name":"The Journal of Physical Chemistry B","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144853951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic mechanism, preparation and application of noise reduction polymer-based composites for aviation noise: A mini-review","authors":"Zheng Liu ,&nbsp;Ruihan Zhang","doi":"10.1016/j.compositesa.2025.109246","DOIUrl":"10.1016/j.compositesa.2025.109246","url":null,"abstract":"<div><div>With the development of the aviation industry, noise levels have become a key factor affecting aircraft comfort. Aircraft noise mainly consists of aerodynamic, structural vibration, and engine noise, each with unique intensity and frequency characteristics that differ from those in traditional building and rail transit. Thus, common noise-reduction materials like foams and fiber felts are no longer sufficient for future civil aircraft and propulsion systems. A major research direction in polymer-based composites focuses on designing material structures and understanding how microstructural features influence macroscopic noise-reduction performance. Moreover, applying advanced polymer composites to aircraft panels, engine nacelle liners, and other critical parts offers a promising way to reduce noise at the source, supporting overall noise control in next-generation aircraft, which is a central goal in current civil aviation research. This review first discusses the sources, hazards, and mechanisms of aviation noise, then introduces the classification and evaluation methods of s noise reduction polymer-based composites. It also summarizes recent global progress and trends in sound-insulation and sound-absorbing composites. Finally, it highlights advances in high-performance, multifunctional noise-reduction polymer-based composites and outlines future directions for aerospace acoustic materials.</div></div>","PeriodicalId":282,"journal":{"name":"Composites Part A: Applied Science and Manufacturing","volume":"199 ","pages":"Article 109246"},"PeriodicalIF":8.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solvent Transport in Disordered and Dynamic Membrane Pores: Implications for Reverse Osmosis and Nanofiltration Membranes.","authors":"Hanqing Fan,Menachem Elimelech","doi":"10.1021/acs.est.5c07128","DOIUrl":"https://doi.org/10.1021/acs.est.5c07128","url":null,"abstract":"Pressure-driven separations with nanoporous membranes, such as reverse osmosis and nanofiltration, play a vital role in addressing water scarcity and enabling resource recovery. Understanding water or solvent transport in membrane pores is essential for advancing membrane separation technologies. A key question in transport modeling is to establish a relationship between solvent permeability and membrane porous structure properties, such as porosity or pore size. The nano- and subnanometer pores in polymeric membranes such as reverse osmosis and nanofiltration membranes are highly tortuous and dynamically connected, which challenges the conventional methods of transport modeling. This study addresses this challenge by developing a theoretical framework to describe solvent transport through membranes with dynamic and disordered porous structure. Specifically, we propose a lattice model to describe the pore network, while preserving the viscous nature of solvent permeation. We further establish a relationship between solvent permeability and membrane porosity or pore size, which is validated by molecular dynamics simulations and experimental data. By integrating this relationship into the solution-friction model, we define pore connectivity and local friction coefficient to quantify the impact of pore structure on solvent permeability. Our analysis highlights the dominant influence of pore connectivity on the permeability of reverse osmosis and nanofiltration membranes, particularly when the pore size approaches the dimensions of solvent molecules. Overall, this study provides critical insights into water and solvent transport mechanisms in nanoporous membranes, opening the door for strategies to substantially enhance membrane performance.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"19 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microstructural alteration and its impact on the effective stiffness of short carbon fiber-reinforced PLA in fused deposition modeling","authors":"Adarsh Kumar Shah ,&nbsp;Arnab Palit ,&nbsp;Mark A. Williams ,&nbsp;Paul F. Wilson ,&nbsp;Atul Jain","doi":"10.1016/j.compositesa.2025.109229","DOIUrl":"10.1016/j.compositesa.2025.109229","url":null,"abstract":"<div><div>This study investigates the change in microstructure of short carbon fiber-reinforced polylactic acid (CF-PLA) filaments during fused deposition modeling (FDM) printing and its impact on the effective elastic modulus of printed parts. A comprehensive experimental protocol is employed, including thermogravimetric analysis (TGA), photomicrography, and micro-computed tomography (µ-CT) to characterize key microstructural parameters such as fiber volume fraction, aspect ratio, and fiber orientation distribution. Additionally, uniaxial tensile tests are performed on specimens printed in three raster orientations (<em>0°</em>, <em>±45°</em>, and <em>90°</em>) to characterize mechanical response. The experiments reveal significant fiber misalignment, fiber breakage, and matrix degradation during FDM printing, all contributing to a substantial reduction in Young’s modulus.</div><div>To interpret the experimental observations, two novel tri-scale homogenization models (Mori-Tanaka-Finite Element and Fully Finite Element) were developed, integrating micro-, meso-, and macro-scale data to predict effective stiffness with errors below 5% and 7%, respectively, across various raster orientations. A key innovation in this framework is the introduction of a degradation parameter to account for matrix deterioration during printing. Parametric studies identified fiber breakage as the most significant factor, causing a 27.15% stiffness loss, followed by misalignment (15.54%) and matrix degradation (10.74%). This holistic framework, combining experimental and computational approaches, elucidates process-structure–property relationships, offering a new insights about FDM-printed short fiber-reinforced composites for structural applications.</div></div>","PeriodicalId":282,"journal":{"name":"Composites Part A: Applied Science and Manufacturing","volume":"199 ","pages":"Article 109229"},"PeriodicalIF":8.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Velocity of Climate Change and the Vulnerability of Mountain Lake Landscapes.","authors":"Christine A Parisek,Jonathan A Walter,Steve Sadro,Andrew L Rypel","doi":"10.1021/acs.est.5c03154","DOIUrl":"https://doi.org/10.1021/acs.est.5c03154","url":null,"abstract":"Freshwater ecosystems in mountain landscapes are threatened by climate change. Accumulated heat can result in lethal short-term heat exposure, while velocity of change governs severity and rates of long-term heat exposure. Here, we novelly integrate heat accumulation and velocity of change approaches to classify climate-vulnerable USA mountain watersheds. We combine watershed position and air temperature data to calculate degree-days. We then calculate the current velocity of this change and used discriminant function analyses to classify watershed vulnerability through 2100. Our results demonstrate how rates of heat accumulation are increasing across mountain landscapes. We estimate 19% of watersheds are at greatest vulnerability to accumulated heat, and this will increase to 33% by 2100. Further, mean killing degree days (i.e., region-specific mean number of days above 90th temperature percentile) are projected to increase 215-254% (mean = 236%) over this same time frame. Together, results indicate heat accumulation will increase substantially over the next 75 years; changes are projected to be most severe in lower elevation landscapes and those with greatest historical velocity of change. These changes will likely restructure species' distributions. Decision-makers can use these classifications to better understand landscapes, species' needs, and ecosystem services, thereby enabling effective allocation of conservation resources.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"49 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Cu/Ag Dual Regioselective Cyclization Catalysis to Access Functionalized 3-Amido and 3-Indolyl Phthalides.","authors":"Anindya S Manna,Tanmoy Ghosh,Rajesh Nandi,Subhasis Pal,Sandip Das,Prakash K Mandal,Narendra Nath Ghosh,Dilip K Maiti","doi":"10.1021/acs.joc.5c01066","DOIUrl":"https://doi.org/10.1021/acs.joc.5c01066","url":null,"abstract":"To address the increasing demands for selectivity and sustainability in modern synthesis, integrated multicatalytic strategies such as synergistic dual catalysis, regioselective cyclization, and combo catalysis have emerged as powerful tools for accessing complex, highly functionalized, and valuable molecules. In this study, we first report a unique, straightforward, and practicable domino Cu/Ag synergistic-cooperative cyclization catalysis for the efficient derivatization of variably functionalized 3-amido phthalides and 3-indolyl phthalides in good to excellent yields through regioselective C-C/C-N/C-O bond formation. These pharmaceutically relevant and important scaffolds are widely recognized for their diverse therapeutic potential, ranging from cardiovascular to Alzheimer's disease applications. The developed protocol utilizes readily producible, inexpensive precursors and proceeds under robust, moisture-insensitive, and step-economic conditions, avoiding expensive catalytic systems, harsh reaction conditions, or hazardous chemicals. Plausible mechanistic insights are proposed and supported by literature surveys, control experiments, and DFT computations for this easily practicable protocol. Furthermore, the scale-up to gram-scale production with good yields and postmodifications of the core 3-substituted phthalide products demonstrates the practical potency and versatility of this synergistic multicatalytic strategy.","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"295 1","pages":""},"PeriodicalIF":4.354,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Conventional Views on Iodine Vacancies: Spin-Orbit Coupling-Mediated Structural Dynamics and Photophysical Implications in Bulk Perovskites.","authors":"Zhen-Bo Guo,Xiang-Mei Duan,Jing Wang","doi":"10.1021/acs.jpclett.5c02152","DOIUrl":"https://doi.org/10.1021/acs.jpclett.5c02152","url":null,"abstract":"Iodine vacancies (VI) are widely regarded as the dominant recombination centers, limiting the photovoltaic performance of halide perovskites. However, most studies neglect the influence of spin-orbit coupling (SOC) on the stability of defect configurations during structural modeling. Here, we investigate the impact of SOC on the structure and carrier dynamics of the VI- in the CsPbI3 system by using ab initio nonadiabatic molecular dynamics with time-dependent density functional theory. Our study demonstrates that SOC significantly alters the stable configuration of VI-, allowing the nondimer to replace the conventional Pb dimer as the lower-energy defect structure. Such a transition, governed by the competition between the electronic energy and lattice strain energy, leads to an effective suppression of nonadiabatic electron-phonon coupling and mitigates sublattice distortions, thereby extending the lifetime by approximately 4 times, which approaches that of the defect-free system. These findings reveal that the role of bulk VI may not be as detrimental as previously thought and offer new guidance for defect engineering in perovskites.","PeriodicalId":62,"journal":{"name":"The Journal of Physical Chemistry Letters","volume":"27 1","pages":"8657-8665"},"PeriodicalIF":6.475,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational and Experimental Studies into Photoenamination/Diels-Alder Reactions.","authors":"James Deng,Domenic Kronenberg,Jiao Yu J Wang,Asja A Kroeger,Michael S Sherburn,Michelle L Coote","doi":"10.1021/acs.joc.5c01614","DOIUrl":"https://doi.org/10.1021/acs.joc.5c01614","url":null,"abstract":"The scope of the photoenolization/Diels-Alder (oxa-PEDA) process is wide, whereas the corresponding aza-variant (photoenamination/Diels-Alder, aza-PEDA) is currently limited to N-silylimines. This work uses computational and experimental studies to better understand the challenges of the aza-PEDA reaction and hence expand its narrow scope. Prompted by a recent report that discussed a triplet mechanism, we reevaluate the mechanism of the aza-PEDA process on the singlet manifold. Several significant hurdles are presented upon switching from O to N: the 1,5-hydrogen atom transfer reaction that converts the triplet imine to the enamine is less energetically favored than the corresponding reaction in triplet ketones, the conformation required for this reaction is significantly less populated, and the photoexcited state can undergo radiationless decay. An otherwise promising N-tosylimine precursor was shown to favor an alternative pathway involving photochemical N-S bond cleavage. Aza-PEDA reactions were finally extended beyond N-silylimines by way of an N-methanesulfonylimine derivative.","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"1 1","pages":""},"PeriodicalIF":4.354,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phthalate and Nonphthalate Plasticizer Exposure among Children of Korea, Thailand, Indonesia, and Bangladesh: Occurrences and Risk Comparison.","authors":"Joeun Jung,Ah-Reum Jo,Yuna Kim,Eun-Ah Park,Jin-Yeong Heo,Na-Youn Park,Sonja A Wrobel,Holger M Koch,Jeongim Park,Aram Lee,Kraichat Tantrakarnapa,Wissanupong Kliengchuay,Sarima Niampradit,Ramadhan Tosepu,Ani Umar,Khaled Hossain,Osman Goni,Hyunwoong Park,Younglim Kho,Kyungho Choi","doi":"10.1021/acs.est.5c04600","DOIUrl":"https://doi.org/10.1021/acs.est.5c04600","url":null,"abstract":"Children are considered vulnerable to plasticizer exposure and related adverse health effects. In many Asian countries, however, the extent of plasticizer exposure among children is poorly understood despite the increasing use of plasticizers. This study compared plasticizer exposure levels and risks among children in four Asian countries and investigated the major risk drivers. Children aged 6-14 years old were recruited between 2022 and 2023 from Korea (n = 89), Thailand (n = 111), Indonesia (n = 100), and Bangladesh (n = 100). They were measured for major metabolites of phthalates and nonphthalate plasticizers in the first morning void urine. Indonesian and Bangladeshi children showed higher exposure to phthalates but lower exposure to nonphthalate alternatives. At the same time, children from Thailand and Korea exhibited a greater transition to the alternatives. In all countries, DEHA contributed to over 80% of the total estimated daily intake (EDI) for all plasticizers. Bangladeshi children exhibited 1.5-2 times greater total plasticizer exposure than the children of the other countries across all EDI quartiles. Among the high-risk subgroup (within the top 25th percentile of the hazard index), DEHP accounted for 62 and 52% of the cumulative risk in Indonesia and Bangladesh, while DnBP contributed to 63 and 54% in Thailand and Korea, respectively. Our observations reveal critical disparities in plasticizer exposure among Asian children, highlighting an urgent need for follow-up investigations on the exposure sources of major risk drivers and region-specific interventions.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"27 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144851229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Click Chemistry Linkages on the Biological Behavior of Albumin-Binding ¹⁷⁷Lu-DOTAGA-pIBA-LLP2A Analogues Targeting Melanoma.","authors":"Longbo Li, Aidan Wirrick, Michael D Pun, Christine L Lovingier, Fabio Gallazzi, Cyril O Y Fong, Lisa Watkinson, Terry L Carmack, Mikayla Rodgers, Katherine Tucker, Khanh-Van Ho, Carolyn J Anderson","doi":"10.1021/acs.bioconjchem.5c00277","DOIUrl":"https://doi.org/10.1021/acs.bioconjchem.5c00277","url":null,"abstract":"<p><p>The transmembrane integrin, very late antigen-4 (VLA-4), which is a critical integrin involved in promoting tumor progression, angiogenesis, and metastasis, is overexpressed in metastatic melanoma. The peptidomimetic LLP2A has a high binding affinity to VLA-4 and is used as a radiopharmaceutical targeting agent for imaging and therapy. Previous studies demonstrated that the albumin-binding compound, [¹⁷⁷Lu]Lu-DOTAGA-pIBA-PEG₄-LLP2A, significantly improved tumor retention and blood circulation time but resulted in lower tumor-to-nontumor tissue ratios compared to the nonalbumin-binding compound, [¹⁷⁷Lu]Lu-DOTAGA-PEG₄-LLP2A. To streamline the synthesis of VLA-4 targeting molecules as therapeutic agents and allow a modular approach, we investigated three click chemistry linkers for preparing DOTAGA-pIBA-PEG₄-LLP2A analogues: [¹⁷⁷Lu]Lu-DOTAGA-pIBA-TCO-tetrazine-PEG₄-LLP2A ([¹⁷⁷Lu]Lu-<b>1</b>), [¹⁷⁷Lu]Lu-DOTAGA-pIBA-BCN-azide-PEG₄-LLP2A ([¹⁷⁷Lu]Lu-<b>2</b>), and [¹⁷⁷Lu]Lu-DOTAGA-pIBA-DBCO-azide-PEG₄-LLP2A ([¹⁷⁷Lu]Lu-<b>3</b>). Determining the click linkage that provides optimal synthesis ease and pharmacokinetics will allow us to readily produce additional VLA-4 targeting radiopharmaceuticals. Saturation binding assays demonstrated high binding affinity of [¹⁷⁷Lu]Lu-<b>1</b>, [¹⁷⁷Lu]Lu-<b>2</b>, and [¹⁷⁷Lu]Lu-<b>3</b> to VLA-4 in B16F10 cells, with <i>K</i>_d = 1.2 ± 0.2, 0.8 ± 0.4, and 1.6 ± 0.5 nM, respectively. Biodistribution of [¹⁷⁷Lu]Lu-<b>1</b> showed peak tumor uptake at 24 h (12.2 ± 0.7%IA/g) and retention to 96 h (9.5 ± 1.7%IA/g), while [¹⁷⁷Lu]Lu-<b>2</b> peaked at 48 h (13.5 ± 2.2%IA/g) and gradually decreased (9.93 ± 3.3%IA/g at 96 h). [¹⁷⁷Lu]Lu-<b>3</b> peaked at 48 h (16.9 ± 3.9%IA/g) and was retained to 96 h (14.8 ± 3.8%IA/g). Compared with [¹⁷⁷Lu]Lu-<b>1</b> and [¹⁷⁷Lu]Lu-<b>3</b>, [¹⁷⁷Lu]Lu-<b>2</b> cleared more rapidly from normal tissues. [¹⁷⁷Lu]Lu-<b>2</b> showed higher tumor-to-kidney ratios compared to [¹⁷⁷Lu]Lu-<b>1</b> at all time points and higher tumor-to-liver ratios up to 96 h. [¹⁷⁷Lu]Lu-<b>2</b> also showed higher tumor-to-liver ratios compared to [¹⁷⁷Lu]Lu-<b>3</b> up to 48 h. The tumor can be clearly visualized with all compounds using SPECT/CT. The BCN click linkage ([¹⁷⁷Lu]Lu-<b>2</b>) will be applied in future compounds with other targeting ligands, radionuclides, albumin binders, and chelators.</p>","PeriodicalId":29,"journal":{"name":"Bioconjugate Chemistry","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}