工业工程最新文献

{"title":"Study on interaction, feedback, and response between perfluorinated compounds and soil environments","authors":"Jinhang Song ,&nbsp;Jing Song ,&nbsp;Rui Zhang ,&nbsp;Chang Che ,&nbsp;Ying Yuan ,&nbsp;Wenbing Tan ,&nbsp;Beidou Xi ,&nbsp;Kunlong Hui ,&nbsp;Juntao Zhang","doi":"10.1016/j.emcon.2024.100428","DOIUrl":"10.1016/j.emcon.2024.100428","url":null,"abstract":"<div><div>The soil environment plays a crucial role in agricultural production, safeguarding water resources, and maintaining ecological balance. Additionally, the soil environment can regulate climate through carbon cycling and serves as an essential habitat for the survival of animals and humans. Therefore, a green and healthy soil environment forms the bedrock of sustainable development of biological systems and serves as the basic support for socio-economic progress, thereby affecting the survival of every organism. However, with the advancement of human society and technology, numerous emerging pollutants have gradually been identified. Among these pollutants, perfluorinated compounds (PFASs) are known for their high thermal stability, bioaccumulation potential, and strong biological toxicity. PFASs are complex persistent pollutants that infiltrate soil ecosystems through industrial emissions, agricultural practices, and household waste, posing a significant threat to soil environments as well as human health and receiving considerable attention. However, current research mainly focuses on PFASs pollution in water media, with few reports on its interaction with soil environments. Moreover, due to the diversity and heterogeneity of soil environmental factors, the species diversity of PFASs may affect the different responses between different PFASs (short and long chain types) and soil factors. Elucidating these complex relationships is crucial for developing future treatment technologies to remediate PFASs pollution. Therefore, this paper reviews the impacts of PFASs pollution on soil properties and preliminarily compares the response and effect of various environmental factors, such as pH, organic matter, and microbial communities, to PFASs stress. Furthermore, the paper provides a scientific basis and theoretical insights into the processes, transformation mechanisms, and remediation methods related to soil PFASs pollution.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial Cell Factories in the Bioeconomy Era: From Discovery to Creation.","authors":"Xiongying Yan, Qiaoning He, Binan Geng, Shihui Yang","doi":"10.34133/bdr.0052","DOIUrl":"10.34133/bdr.0052","url":null,"abstract":"<p><p>Microbial cell factories (MCFs) are extensively used to produce a wide array of bioproducts, such as bioenergy, biochemical, food, nutrients, and pharmaceuticals, and have been regarded as the \"chips\" of biomanufacturing that will fuel the emerging bioeconomy era. Biotechnology advances have led to the screening, investigation, and engineering of an increasing number of microorganisms as diverse MCFs, which are the workhorses of biomanufacturing and help develop the bioeconomy. This review briefly summarizes the progress and strategies in the development of robust and efficient MCFs for sustainable and economic biomanufacturing. First, a comprehensive understanding of microbial chassis cells, including accurate genome sequences and corresponding annotations; metabolic and regulatory networks governing substances, energy, physiology, and information; and their similarity and uniqueness compared with those of other microorganisms, is needed. Moreover, the development and application of effective and efficient tools is crucial for engineering both model and nonmodel microbial chassis cells into efficient MCFs, including the identification and characterization of biological parts, as well as the design, synthesis, assembly, editing, and regulation of genes, circuits, and pathways. This review also highlights the necessity of integrating automation and artificial intelligence (AI) with biotechnology to facilitate the development of future customized artificial synthetic MCFs to expedite the industrialization process of biomanufacturing and the bioeconomy.</p>","PeriodicalId":56832,"journal":{"name":"生物设计研究(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11491672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triclosan induces pyroptosis by activation of the caspase-9/3/gasdermin E axis","authors":"Shiqi Wu ,&nbsp;Lei You ,&nbsp;Shan He ,&nbsp;Wenqaing Liu ,&nbsp;Jinlin Lei ,&nbsp;Jiahui Yang ,&nbsp;Xiangyin Luo ,&nbsp;Zhenxiu Ye ,&nbsp;Yonghong Zhang ,&nbsp;Jing Wang ,&nbsp;Huailan Guo ,&nbsp;Yan Zheng ,&nbsp;Lanlan Zheng ,&nbsp;Chen Li","doi":"10.1016/j.emcon.2024.100425","DOIUrl":"10.1016/j.emcon.2024.100425","url":null,"abstract":"<div><div>The high concentrations of TCS in personal care products, and the potential for even greater exposure in occupational settings, raise significant concerns about its cytotoxic effects. Numorous studies highlight the importance of understanding the molecular mechanisms of pyroptosis in toxicological research on environmental pollutants. However, it remains unclear whether TCS exposure could induce GSDME-mediated pyroptosis. In this study, we aimed to investigate the cytotoxic effects of 200 μM TCS on L02 cells and elucidate the molecular mechanisms involved in TCS-induced pyroptosis, a novel form of cell death. Our results demonstrate that TCS inhibits the proliferation of L02 cells in a dose-dependent manner and triggers caspase-dependent cell death, leading to mitochondrial dysfunction and subsequent pyroptosis through the activation of the caspase-9/3/GSDME axis. Furthermore, through transcriptional and metabolomic analyses, we identified alterations in the PI3K-Akt and MAPK cellular signaling pathways, as well as changes in carbon and nitrogen metabolism. Our data provide valuable insights into the biotoxicity of high TCS concentrations and establish a theoretical basis for future studies on its impact and risk.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142536166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global review of PCBs and chemical flame retardants in e-waste recycling sites: Addressing geographic imbalances","authors":"Moyofoluwa O. Ogunyemi ,&nbsp;Temilola O. Oluseyi ,&nbsp;Aderonke O. Oyeyiola ,&nbsp;Mohamed Abou-Elwafa Abdallah ,&nbsp;Stuart Harrad","doi":"10.1016/j.emcon.2024.100426","DOIUrl":"10.1016/j.emcon.2024.100426","url":null,"abstract":"<div><div>Informal e-waste recycling poses substantial environmental and human health risks due to contamination by flame retardants (FRs) and related chemical additives. This study systematically reviews the status of research on polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and organophosphate esters (OPEs) in e-waste recycling sites, with a particular focus on concentration levels and geographic disparities in data availability. Only a few studies have been conducted in Africa and South America and there are significant gaps. This geographic imbalance and other factors impede accurate assessment and comprehensive understanding of global e-waste pollution and associated risks. In examining the concentrations of PCBs and FRs, the study finds notable variations across different countries. For instance, high levels of these toxic chemicals were reported in China and India, which are major hubs for e-waste recycling in Asia. Concentrations in these regions often exceed international safety standards, posing severe risks for workers and local communities. Conversely, data from Africa and South America are sparse, despite the growing presence of informal e-waste recycling activities in these continents. Factors driving these differences include the prevalence of informal recycling practices, variations in waste import volumes, regulatory gaps, and disparities in technological capacity for safe waste management. In developing countries, weaker enforcement of environmental laws and reliance on rudimentary recycling methods lead to higher levels of contamination. However, developed nations with stricter regulations and advanced technologies exhibit lower concentrations of these pollutants. While high concentrations of FRs are documented in environmental matrices, human biomonitoring and epidemiological studies are needed to correlate environmental concentrations with health outcomes, particularly for workers at e-waste sites. In summary, this review emphasizes the critical need for broader geographical coverage, standardized methodologies, and robust regulatory frameworks to mitigate the significant health and environmental risks associated with FRs and PCBs in e-waste recycling sites.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142573434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of PBAT/lignin composite foam materials with excellent foaming performance and mechanical properties via grafting esterification and twin-screw melting free radical polymerization","authors":"Hongsen Xu,&nbsp;Jingwen Shaoyu,&nbsp;Junyang Jin,&nbsp;Ming Li,&nbsp;Lei Ji,&nbsp;Wei Zhuang,&nbsp;Chenglun Tang,&nbsp;Zhiwei Chang,&nbsp;Hanjie Ying,&nbsp;Chenjie Zhu","doi":"10.1186/s42825-024-00177-3","DOIUrl":"10.1186/s42825-024-00177-3","url":null,"abstract":"<div><p>As one of the mainstream biodegradable materials, poly(butylene adipate-co-terephthalate) (PBAT) foams offer a sustainable alternative to traditional plastic foams, effectively reducing environmental pollution. However, the high cost and poor mechanical performance of PBAT foams impede their practical application. Herein, the glycidyl methacrylate-grafted biomass lignin (GML) was used to produce a PBAT/GML composite foam with good foaming performance and mechanical properties at high lignin-filling amounts by twin-screw melting free radical polymerization and supercritical CO₂ foaming process. The compatibility of GML in the PBAT matrix was improved due to the formation of ester bonds in modified lignin, endowing the PBAT/GML (PGML) composite foam with exceptional foaming performance. Additionally, the mechanical properties of PGML composite foam were remarkably enhanced due to the introduction of the abundant aromatic structures of GML and the construction of a stable covalent crosslinking network. The compressive strengths and compression modulus of the PGML foam were improved by 2.53 times and 2.47 times, while its bending strength and bending modulus were improved by 1.27 times and 3.92 times compared to the neat PBAT. This research affords a new strategy for developing low-cost biodegradable biomass PBAT/lignin composite foam materials with good foaming performance and mechanical properties.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-024-00177-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of external quality inspection for fruit grading using CNN models","authors":"Luis E. Chuquimarca ,&nbsp;Boris X. Vintimilla ,&nbsp;Sergio A. Velastin","doi":"10.1016/j.aiia.2024.10.002","DOIUrl":"10.1016/j.aiia.2024.10.002","url":null,"abstract":"<div><div>This article reviews the state of the art of recent CNN models used for external quality inspection of fruits, considering parameters such as color, shape, size, and defects, used to categorize fruits according to international marketing levels of agricultural products. The literature review considers the number of fruit images in different datasets, the type of images used by the CNN models, the performance results obtained by each CNNs, the optimizers that help increase the accuracy of these, and the use of pre-trained CNN models used for transfer learning. CNN models have used various types of images in the visible, infrared, hyperspectral, and multispectral bands. Furthermore, the fruit image datasets used are either real or synthetic. Finally, several tables summarize the articles reviewed, which are prioritized according to inspection parameters, facilitating a critical comparison of each work.</div></div>","PeriodicalId":52814,"journal":{"name":"Artificial Intelligence in Agriculture","volume":null,"pages":null},"PeriodicalIF":8.2,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142533851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sewage sludge as soil amendment in arid soils - A trace metal, nutrient and trace organics perspective","authors":"Saif Uddin ,&nbsp;Mohammad Zaman ,&nbsp;Karell Martínez-Guijarro ,&nbsp;Mohammad Al-Murad ,&nbsp;Montaha Behbehani ,&nbsp;Nazima Habibi ,&nbsp;Ahmed Al-Mutairi","doi":"10.1016/j.emcon.2024.100420","DOIUrl":"10.1016/j.emcon.2024.100420","url":null,"abstract":"<div><div>Sewage sludge management has emerged as a critical environmental challenge due to the large volumes generated globally. Valorization techniques, including energy production and agricultural applications, offer sustainable solutions, particularly in regions with low soil fertility. The sewage sludge utilization in the Middle East region is low. This paper presents a pragmatic risk-based assessment using the risk-based corrective action approach to evaluate sludge application in desert soils. This methodology focuses on the source-pathway-receptor interaction and assesses the likelihood of contaminants posing a real threat. In arid desert regions like Kuwait, where soil organic content and moisture are extremely low, the application of sewage sludge presents a feasible option to enhance soil quality and valorize unutilized sludge dumps which pose significant environmental concerns but are left to desiccate in the absence of any environmental regulation towards its utilization and due to religious apprehensions. Since the sludge characterization is not well detailed a brief review of the available data was included to establish the bounds of various organic, metal and nutrients that were used for generating the model. This study examines the changes in the physico-chemical properties of desert soils following sludge application, focusing on the likely fate of trace metals and organic contaminants. The alkaline desert soils of Kuwait, with a pH range of 7.7–8.9, are particularly suitable for sludge application due to the low mobility of metals in alkaline conditions. Additionally, sludge application lowers soil pH, improving conditions for plant growth. The region's deeper water table and scant annual precipitation (&lt;0.15 m) further reduce the risk of groundwater contamination and deeper soil profile contamination. The presence of organic content, nitrates, Zn, and Cu in sludge can promote native vegetation growth. However, trace organic contaminants, including PAHs, PCBs, and pharmaceuticals, pose a potential risk to soil contamination, but since the geological section shows intervening impervious layers the contamination is going to be localized, even if there is sufficient leachable fraction. Given the minimal risk of contamination under the unique conditions of arid regions, this approach highlights the potential for eco-friendly sludge valorization, that will improve vegetation cover and arrest the suspended particulate suspension. However, before the large-scale implementation of this modelled concept, a detailed experimental study on the pilot scale or lysimeters is recommended to assess the long-term impacts of sludge application and to obtain data that can inform policy guidelines for sustainable sludge management in desert environments.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142536164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodegradation of polycyclic aromatic hydrocarbons: The role of ligninolytic enzymes and advances of biosensors for in-situ monitoring","authors":"Eshet Lakew Tesfaye ,&nbsp;Fekadu Mazengiaw Bogale ,&nbsp;Tadele Assefa Aragaw","doi":"10.1016/j.emcon.2024.100424","DOIUrl":"10.1016/j.emcon.2024.100424","url":null,"abstract":"<div><div>Polycyclic aromatic hydrocarbons (PAHs) and their derivatives are common pollutants that require effective remediation techniques. PAH biodegradation using bacterial and fungal enzymes has gained popularity because it effectively removes these contaminants. Ligninolytic enzymes (LEs), such as laccase (Lac), lignin peroxidase (LiP), manganese peroxidase (MnP), and versatile peroxidases (VPs), have been studied for their role in PAHs biodegradation. These enzymes, produced by different living organisms, have demonstrated significant potential in degrading complex PAH structures, contributing to cleaner and more sustainable remediation techniques. This review evaluates the biodegradation capacity of PAHs using different strains and/or their LEs and provides an in-depth analysis of their mechanisms and removal efficiencies. In addition, the fundamental catalytic mechanisms governing the biodegradation of PAHs and factors that must be optimized to promote effective breakdown and detoxification are highlighted. This review also highlights recent biosensor developments that provide enhanced sensitivity and specificity for PAH detection. Although some LE-producing strains are efficient in completely biodegrading certain PAH types, further research is needed to explore the complete biodegradation of PAHs with higher molecular structures using genetically modified strains or their LEs. Despite progress, challenges remain in optimizing enzyme activity and integrating biosensors into large-scale use. Future research should focus on enhancing stability and improving field deployment for better environmental monitoring.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive inventory of imports of electrical and electronic equipment and related plastics and POPs plastic additives into Nigeria in the past 32 years (1990–2022)","authors":"Joshua O. Babayemi ,&nbsp;Innocent C. Nnorom ,&nbsp;Roland Weber","doi":"10.1016/j.emcon.2024.100423","DOIUrl":"10.1016/j.emcon.2024.100423","url":null,"abstract":"<div><div>The global management of electrical and electronic equipment (EEE) and related plastics, and the persistent organic pollutants (POPs) contained in it constitute a global challenge in particular for low-income countries in Africa where monitoring capacity and waste management infrastructure are lacking. While plastic recycling is highlighted as an important part of the solution to plastic pollution, such recycling is threatened by the presence of POPs. Overall, there is a lack of data on POPs in (W)EEE plastics with the exception of PBDEs. The objective of this study was to analyse the overall imports of (W)EEE into Nigeria and estimate the associated amount of plastics and POPs for better planning and management of WEEE plastics. This study assessed all EEE importation categories and compiled the importations of 28 EEE product groups with the highest importation, covering more than 98 % of officially imported EEE based on the United Nations Comtrade Database using harmonized system (HS) codes. The impact factors of POPs and plastic from the UNEP inventory guidance were used for the estimates. Overall, 4568 kilo-tonnes (kt) of EEE were officialy imported between 1990 and 2022 containing 1337 kt of plastic. If considering also the estimated imported WEEE and EEE not covered in the Comtrade statistics, the total imported (W)EEE is estimated to 12,259 kt including 3644 kt of plastics and an estimated 1043 t of hexaBDE/heptaBDE and 8511 t of DecaBDE as major POP additives, and lower levels of 154 t of HBCD, 91 t of SCCPs, 364 t of MCCP, and 146 t of Dechlorane Plus. The study is the first estimate of all major POPs in (W)EEE plastics in a low-income country and provides important information for their management.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142536165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Research on Application of Quantitative CT in Clinical Diagnosis and Treatment of Osteoporosis.","authors":"Ning Xia, Dong-Fa Liao, Xiang-Wei Li, Da Liu","doi":"10.3881/j.issn.1000-503X.16035","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16035","url":null,"abstract":"<p><p>Quantitative CT (QCT) is a method of measuring bone mineral density (BMD) of human based on a CT machine,calibrated by QCT body model and analyzed by professional software.Compared with dual-energy X-ray absorptiometry,QCT can not only assess the cortical and cancellous BMD but also exclude the influences of osteophytes and aortic/vascular calcification,thus being capable of accurately reflecting patients' bone mass.In recent years,increasing studies on QCT and osteoporosis (OP) have been carried out,and the application of QCT in the diagnosis of OP,evaluation of vertebral bone conditions,prediction of fracture risks,and assessment of anti-OP treatment is garnering increasing attention from researchers at home and abroad.This article reviews the research progress in this field,aiming to provide a reference for the research on QCT in the diagnosis and treatment of OP.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}