工业工程最新文献

{"title":"PPARα-dependent lipid metabolic disruption mediates triphenyl phosphate–induced hepato- and neurotoxicity in zebrafish","authors":"Congying Luo ,&nbsp;Qiong Zhang ,&nbsp;Han Xie ,&nbsp;Dinghui Wang ,&nbsp;Xiaoling Shi ,&nbsp;Yanhong Huang ,&nbsp;Yimin Zhang ,&nbsp;Kusheng Wu","doi":"10.1016/j.emcon.2025.100561","DOIUrl":"10.1016/j.emcon.2025.100561","url":null,"abstract":"<div><div>The extensive use of triphenyl phosphate (TPhP) has resulted in its ubiquity in aquatic ecosystems, raising significant concerns about its escalating risks to aquatic organisms. In this study, we employed adult and larval zebrafish (<em>Danio rerio</em>) as model organisms to assess the adverse effects of TPhP exposure on aquatic life. The objectives were to evaluate TPhP-induced hepatotoxicity and neurotoxicity and the role of lipid metabolism in mediating these toxic effects. The results demonstrated that TPhP exposure led to alterations in body weight, length, and body mass index (BMI), along with changes in brain and liver somatic indices in zebrafish. Through comprehensive analyses of histopathological changes, transcriptional profiles, biochemical markers, and neurobehavioral assays, TPhP was shown to induce both morphological and functional impairments in the brain and liver. In TPhP-exposed larvae, reduced tissue integrity and altered spatial distribution of brain and hepatic tissues were observed. Notably, changes in the expression of neurodevelopmental and lipid metabolism-related genes in larvae mirrored those detected in adult zebrafish, indicating conserved toxic mechanisms across life stages. Mechanistically, TPhP exposure induced oxidative stress in both brain and liver tissues and suppressed the expression of PPARα, as well as its downstream genes involved in fatty acid β-oxidation and lipid homeostasis. Consequently, hepatic triglyceride (TG) and total cholesterol (T-CHO) levels were significantly decreased, whereas free fatty acid (FFA) content was elevated. Thus, TPhP inhibits PPARα signaling via oxidative stress, leading to lipid metabolic dysfunction and subsequent damage to neural and hepatic tissues. This study provides robust evidence of TPhP-induced hepatotoxicity and neurotoxicity in zebrafish, and elucidates the critical role of PPARα-mediated disruption of lipid metabolism in these toxic pathways, thereby enhancing our understanding of the ecological risks posed by organophosphate flame retardants.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 4","pages":"Article 100561"},"PeriodicalIF":6.9,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144921673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Misaligned light entrainment causes metabolic disorders in <i>Chrono</i> knockout mice].","authors":"Ruo-Han Wang, Shao-Ying Lan, Bo-Yuan Cao, Xi-Ming Qin","doi":"10.13294/j.aps.2025.0061","DOIUrl":"https://doi.org/10.13294/j.aps.2025.0061","url":null,"abstract":"<p><p>Most of the life forms on Earth have gradually evolved an endogenous biological clock under the long-term influence of periodic daily light-dark cycles. This biological clock system plays a crucial role in the orderly progression of life activities. In mammals, central circadian clock is located in the suprachiasmatic nucleus of the hypothalamus and the function of the biological clock relies on a transcription-translation negative feedback loop. As a negative regulator in this loop, the function of CHRONO is less known. To deeply explore the role of the <i>Chrono</i> gene in rhythm entrainment and physiology, we constructed a <i>Chrono</i> gene knockout mouse strain using the CRISPR/Cas9 technology and analyzed its entrainment ability under different T cycles. Running wheel tests and glucose tolerance tests were also performed. The results showed that the period of the endogenous biological clock of <i>Chrono</i> knockout mice was prolonged, and the entrainment rate under the T21 cycle was decreased. In addition, metabolic abnormalities, including weight gain and impaired glucose tolerance, were observed in the non-entrained mice. Overall, this study reveals a crucial role of the <i>Chrono</i> gene in maintaining circadian rhythms and metabolic balance, providing a new perspective for understanding the relationship between the biological clock and metabolism. Further research is needed to fully understand the underlying molecular mechanisms.</p>","PeriodicalId":7134,"journal":{"name":"生理学报","volume":"77 4","pages":"731-740"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Simulation analysis of adaptability of large airborne negative pressure isolation cabin to aviation conditions].","authors":"Lei Guo, Falin Li, Lang Jiang, Haibo Du, Bingjie Xue, Wei Yong, Yuanyuan Jiang, Muzhe Zhang","doi":"10.7507/1001-5515.202403011","DOIUrl":"10.7507/1001-5515.202403011","url":null,"abstract":"<p><p>In order to solve the problems of difficult test, high cost and long cycle in the development of large-scale airborne negative pressure isolation system, the simulation analysis of negative pressure response characteristics is carried out around various aviation conditions such as aircraft ascending, leveling and descending, especially rapid decompression, based on the computational fluid dynamics (CFD) method. The results showed that the isolation cabin could achieve -50 Pa pressure difference environment and form a certain pressure gradient. The exhaust air volume reached the maximum value in the early stage of the aircraft's ascent, and gradually decreased with the increase of altitude until it was level flying. In the process of aircraft descent, the exhaust fan could theoretically maintain a pressure difference far below -50 Pa without working; Under the special condition of rapid pressure loss, it was difficult to deal with the rapid change of low pressure only by the exhaust fan, so it was necessary to design safety valve and other anti-leakage measures in the isolation cabin structure. Therefore, the initial stage of aircraft ascent is the key stage for the adjustment and control of the negative pressure isolation system. By controlling the exhaust air volume and adjusting parameters, it can adapt to the change of low pressure under normal flight conditions, form a relatively stable negative pressure environment, and meet the needs of biological control, isolation and transport.</p>","PeriodicalId":39324,"journal":{"name":"生物医学工程学杂志","volume":"42 4","pages":"775-781"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Finite element modeling and simulation study of solid-liquid biphase fiber-reinforced lumbar intervertebral disc].","authors":"Yongchang Gao, Yantao Fu, Qingfeng Cui, Shibin Chen, Peng Liu, Xifang Liu","doi":"10.7507/1001-5515.202310021","DOIUrl":"10.7507/1001-5515.202310021","url":null,"abstract":"<p><p>The lumbar intervertebral disc exhibits a complex physiological structure with interactions between various segments, and its components are extremely complex. The material properties of different components in the lumbar intervertebral disc, especially the water content (undergoing dynamic change as influenced by age, degeneration, mechanical loading, and proteoglycan content) - critically determine its mechanical properties. When the lumbar intervertebral disc is under continuous pressure, water seeps out, and after the pressure is removed, water re-infiltrates. This dynamic fluid exchange process directly affects the mechanical properties of the lumbar intervertebral disc, while previous isotropic modeling methods have been unable to accurately reflect such solid-liquid phase behaviors. To explore the load-bearing mechanism of the lumbar intervertebral disc and establish a more realistic mechanical model of the lumbar intervertebral disc, this study developed a solid-liquid biphasic, fiber-reinforced finite element model. This model was used to simulate the four movements of the human lumbar spine in daily life, namely flexion, extension, axial rotation, and lateral bending. The fluid pressure, effective solid stress, and liquid pressure-bearing ratio of the annulus fibrosus and nucleus pulposus of different lumbar intervertebral discs were compared and analyzed under the movements. Under all the movements, the fluid pressure distribution was closer to the nucleus pulposus, while the effective solid stress distribution was more concentrated in the outer annulus fibrosus. In terms of fluid pressure, the maximum fluid pressure of the lumbar intervertebral disc during lateral bending was 1.95 MPa, significantly higher than the maximum fluid pressure under other movements. Meanwhile, the maximum effective solid stress of the lumbar intervertebral disc during flexion was 2.43 MPa, markedly higher than the maximum effective solid stress under other movements. Overall, the liquid pressure-bearing ratio under axial rotation was smaller than that under other movements. Based on the solid-liquid biphasic modeling method, this study more accurately revealed the dominant role of the liquid phase in the daily load-bearing process of the lumbar intervertebral disc and the solid-phase mechanical mechanism of the annulus fibrosus load-bearing, and more effectively predicted the solid-liquid phase co-load-bearing mechanism of the lumbar intervertebral disc in daily life.</p>","PeriodicalId":39324,"journal":{"name":"生物医学工程学杂志","volume":"42 4","pages":"799-807"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Brain midline segmentation method based on prior knowledge and path optimization].","authors":"Shuai Geng, Yonghui Li, Yu Ao, Weili Shi, Yu Miao, Shuhan Wang, Zhengang Jiang","doi":"10.7507/1001-5515.202412032","DOIUrl":"10.7507/1001-5515.202412032","url":null,"abstract":"<p><p>To address the challenges faced by current brain midline segmentation techniques, such as insufficient accuracy and poor segmentation continuity, this paper proposes a deep learning network model based on a two-stage framework. On the first stage of the model, prior knowledge of the feature consistency of adjacent brain midline slices under normal and pathological conditions is utilized. Associated midline slices are selected through slice similarity analysis, and a novel feature weighting strategy is adopted to collaboratively fuse the overall change characteristics and spatial information of these associated slices, thereby enhancing the feature representation of the brain midline in the intracranial region. On the second stage, the optimal path search strategy for the brain midline is employed based on the network output probability map, which effectively addresses the problem of discontinuous midline segmentation. The method proposed in this paper achieved satisfactory results on the CQ500 dataset provided by the Center for Advanced Research in Imaging, Neurosciences and Genomics, New Delhi, India. The Dice similarity coefficient (DSC), Hausdorff distance (HD), average symmetric surface distance (ASSD), and normalized surface Dice (NSD) were 67.38 ± 10.49, 24.22 ± 24.84, 1.33 ± 1.83, and 0.82 ± 0.09, respectively. The experimental results demonstrate that the proposed method can fully utilize the prior knowledge of medical images to effectively achieve accurate segmentation of the brain midline, providing valuable assistance for subsequent identification of the brain midline by clinicians.</p>","PeriodicalId":39324,"journal":{"name":"生物医学工程学杂志","volume":"42 4","pages":"766-774"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Target marker deployment strategies for Hayabusa2 extended mission to fast rotator 1998 KY26","authors":"Anivid Pedros-Faura,&nbsp;Mirko Trisolini,&nbsp;Yuichi Tsuda,&nbsp;Daniel J. Scheeres,&nbsp;Shota Kikuchi,&nbsp;Jay W. McMahon","doi":"10.1007/s42064-024-0229-1","DOIUrl":"10.1007/s42064-024-0229-1","url":null,"abstract":"<div><p>The Hayabusa2 extended mission, named Hayabusa2# (SHARP: Small Hazardous Asteroid Reconnaissance Probe), is planned to rendezvous with the fast-rotating asteroid 1998 KY26 in 2031. Hayabusa2# will be the first ever mission to rendezvous with such a rapidly rotating small asteroid, posing significant challenges because of its distinctive dynamical environment. In this paper, we investigate potential target marker (TM) deployment strategies, for both landing and orbiting scenarios, to maximize science acquisition. In particular, we model the surface and orbital environments to identify feasible target market operations and present landing site selection strategies and candidate insertion orbits considering realistic deployment errors. The TM is one of the only two remaining deployable payloads, and therefore, can play a critical role during the extended mission phase. Our results show that surface operations can be extremely challenging whereas orbit operations could help us gain valuable information on the asteroid’s gravity field. Overall, this research contributes to the exploration and characterization of extremely small bodies specifically through the use of artificial objects, in this case the target marker.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":52291,"journal":{"name":"Astrodynamics","volume":"9 4","pages":"517 - 536"},"PeriodicalIF":6.5,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42064-024-0229-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-vitro metabolites characterization of 1,3-diphenylguanidine and 1,3-di-o-tolylguanidine by high-resolution mass spectrometry and urinary profiling","authors":"Andrea Estévez-Danta,&nbsp;Iago Riveiro,&nbsp;María Lage-Díaz,&nbsp;José Benito Quintana,&nbsp;Rosa Montes,&nbsp;Rosario Rodil","doi":"10.1016/j.emcon.2025.100551","DOIUrl":"10.1016/j.emcon.2025.100551","url":null,"abstract":"<div><div>The discovery of the hazardous effects associated with the polymer additives 1,3-diphenyl guanidine (DPG) and 1,3-di-o-tolylguanidine (DTG) has prompted the need for biomonitoring studies to detect human exposure. However, limited information is available about their metabolism. To address this gap, this study investigates the Phase I and II <em>in-vitro</em> biotransformation of both chemicals using human liver microsomes and cytosol. The samples were analyzed using liquid chromatography coupled to high resolution-(tandem) mass spectrometry through suspect (of <em>in-silico</em> predicted metabolites) and non-target screening. The analysis revealed four Phase I and two Phase II metabolic products for both DPG and DTG. Hydroxylation of the benzene ring led to the tentative identification of mono- and di-hydroxylated metabolites. Subsequent Phase I deamination followed by oxidation resulted in the formation of hydroxy-phenylurea and an intramolecular cyclization resulted in the formation of hydroxy-cyclic products. Furthermore, N-glucuronidation and O-glucuronidation products were identified for the first time. After performing urinalysis, DPG and DTG could be quantified in the 0.02–0.23 μg L⁻¹ range, and DPG-227 (mono-hydroxylated DPG) was estimated to be present at ca. 0.01–0.10 μg L⁻¹ range, using DPG response as quantification surrogate. Finally, toxicity assessment using an <em>in-silico</em> tool indicated the need to consider these human metabolites in (eco)toxicological assessments, as they may have the same or even greater effects on humans and the environment.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 4","pages":"Article 100551"},"PeriodicalIF":6.9,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the greenhouse: The spread of plastic pollution from an intensively cultivated agricultural area","authors":"Marina Nuñez-Rubio ,&nbsp;Carlos Edo ,&nbsp;Virginia Gálvez-Blanca ,&nbsp;Juan Manuel Valenzuela-Lázaro ,&nbsp;Gerardo Pulido-Reyes ,&nbsp;Miguel González-Pleiter ,&nbsp;Luis Fernández-García-del-Rincón ,&nbsp;Francisco Leganés ,&nbsp;Francisca Fernández-Piñas ,&nbsp;Roberto Rosal","doi":"10.1016/j.emcon.2025.100560","DOIUrl":"10.1016/j.emcon.2025.100560","url":null,"abstract":"<div><div>Among the many sources of plastic contamination, greenhouse agriculture is a major contributor due to its intensive use of plastic materials. This study examines plastic waste in one of the world's leading greenhouse farming regions. The research included both abiotic (soil, freshwater, seawater, and air) and biotic compartments (invertebrates, herbivores, fish and predators) as well as the presence of bacterial and fungal pathogens colonizing agricultural plastics. Plastics were identified in all sampled compartments, including the nearshore seawater. The highest concentrations were recorded along the coastline, where 1397 plastic items representing 15 different polymers were found with a median concentration of 1.92 (1.73–2.13) items/m² or 3.05 (2.29–3.81) g/m², the boundaries representing interquartile ranges. Most of the polymers identified across all compartments matched those found in agricultural operations in terms of morphology, type, and colour. Notably, high plastic concentration appeared in protected areas, indicating that legal protection alone does not prevent pollution. Greenhouse plastics were especially prevalent in the protected zones near the greenhouse area, rather than in the nearby urban zones, which can be explained by the proximity of agricultural exploitations. We estimated that approximately 290 kg of plastic, including 80 kg of polyethylene, were dispersed along the coast, a figure representing about one-tenth of the plastic waste generated annually in the production zone. Our results also revealed that agricultural plastic waste may act as vector and reservoir of bacterial and fungal pathogens, promoting their spread even into protected environments.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 4","pages":"Article 100560"},"PeriodicalIF":6.9,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microfiber release during apparel manufacturing process – A greater concern than domestic laundering","authors":"S. Raja Balasaraswathi,&nbsp;R. Rathinamoorthy","doi":"10.1016/j.emcon.2025.100559","DOIUrl":"10.1016/j.emcon.2025.100559","url":null,"abstract":"<div><div>Microfibers released from textile materials have recently become a pressing concern as one of the most significant anthropogenic pollutants in recent times. Although domestic laundry has been reported as a major source of microfiber release, researchers stress the potential of manufacturing stage to contribute equally. However, limited research has been conducted on the manufacturing stage. To bridge this gap, the current study aimed to analyze microfiber release from different knitted fabrics during the cutting process in the apparel manufacturing industry. Microfibers released during cutting were collected using the atmospheric deposition method both inside and outside the industry. The findings revealed that the cutting process caused an average microfiber deposition of 2.86 × 10⁶ ± 6.02 × 10⁵ microfibers per square meter of cutting floor per day. A strong linear relationship was observed between the length of the fabric been cut and microfiber deposition (r = 0.96). Regarding fabric properties, strong positive correlations (r = 0.80 to 0.99) were noted with stitch density, thickness, areal density, and yarn count, indicating that increase in these parameters led to increased microfiber emissions. Conversely, a negative correlation was reported for loop length (r = −0.79), and an insignificant correlation was found with the tightness factor (r = 0.49). The majority of the released fibers (55.84 %) measured between 300 and 800 μm in length. The results showed that fabrics with compact structures released more short microfibers than those with loose structures. The study's findings indicated that cutting a medium-sized T-shirt can release up to 1.09 × 10⁶ microfibers, which is approximately 50 times higher than that released during laundry, with 40–70 % of the fibers transported outside the factory. With this alarming quantity, future research should focus on understanding the occupational hazards of cutting operators exposed to large quantities of microfibers. Moreover, studies should focus on developing cost-effective alternative cutting methods and microfiber-capturing systems that can be implemented in the industry to control the release of microfibers into the external environment.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 4","pages":"Article 100559"},"PeriodicalIF":6.9,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating contaminants of emerging concern (CECs) in the Venice Lagoon: A suspect screening approach for the analysis of water and sediment contamination","authors":"P.P. Guolo ,&nbsp;L. Calgaro ,&nbsp;A. Bonetto ,&nbsp;Q. Xu ,&nbsp;J. Lu ,&nbsp;A. Marcomini","doi":"10.1016/j.emcon.2025.100557","DOIUrl":"10.1016/j.emcon.2025.100557","url":null,"abstract":"<div><div>The presence of Contaminants of Emerging Concern (CECs) in the environment poses significant concern, yet their occurrence, sources, and fate remain not fully understood. This study provides the first investigation of a broad range of CECs, including active pharmaceutical ingredients (APIs), plant protection products (PPPs), and personal care products (PCPs), across raw and treated wastewater, surface water, and sediment in the Venice Lagoon and selected tributaries. Using a suspect screening analysis methodology based on high-resolution mass spectrometry (HRMS), 14 sampling stations were selected to identify contamination patterns and potential emission sources. APIs were the most frequently detected class of compounds (150 compounds), with flecainide, harman, carbamazepine, and venlafaxine found in more than 80 % of sampling stations. Analgesics were the dominant therapeutic class, followed by antidepressants and cardiovascular drugs. Among PCPs (17 compounds), icaridin, and climbazole were the most prevalent, detected at 11 and 9 sampling stations, respectively. PPPs (26 compounds) were also detected, with diuron being the most widespread as it was found at 10 sampling stations. To the best of the authors' knowledge, 92 compounds (68 APIs, 17 PCPs, and 7 PPPs) were qualitatively identified for the first time in the Venice Lagoon, although many of them are known to occur in natural waters worldwide.</div><div>The results highlight rivers and treated wastewater as major contributors to CEC emissions in the lagoon. These findings offer valuable insights for future research and targeted monitoring strategies, advancing the understanding of unmonitored contaminants in vulnerable aquatic environments.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 4","pages":"Article 100557"},"PeriodicalIF":6.9,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}