工业工程最新文献

{"title":"[Circadian rhythm disturbances and neurodevelopmental disorders].","authors":"Deng-Feng Liu, Yi-Chun Zhang, Jia-Da Li","doi":"10.13294/j.aps.2025.0065","DOIUrl":"https://doi.org/10.13294/j.aps.2025.0065","url":null,"abstract":"<p><p>Neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and intellectual developmental disorder (IDD), are highly prevalent and lack effective treatments, posing significant health challenges. These disorders are frequently comorbid with disruptions in sleep rhythms, and sleep-related indicators are often used to assess disease severity and treatment efficacy. Recent evidence has highlighted the crucial roles of circadian rhythm disturbances and circadian clock gene mutations in the pathogenesis of NDDs. This review focuses on the mechanisms by which circadian rhythm disruptions and circadian clock gene mutations contribute to cognitive, behavioral, and emotional disorders associated with NDDs, particularly through the dysregulation of dopamine system. Additionally, we discussed the potential of targeting the circadian system as novel therapeutic strategies for the treatment of NDDs.</p>","PeriodicalId":7134,"journal":{"name":"生理学报","volume":"77 4","pages":"678-688"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research advances in the mechanisms of circadian regulation in heart failure].","authors":"Qiong Wang, Jia-Yang Zhang, Le-Jia Qiu, Li-Hong Chen","doi":"10.13294/j.aps.2025.0063","DOIUrl":"https://doi.org/10.13294/j.aps.2025.0063","url":null,"abstract":"<p><p>The circadian clock is an endogenous time-keeping system that maintains physiological homeostasis by integrating environmental and genetic interactions. Heart failure is a complex clinical syndrome characterized by structural abnormalities and/or functional impairment of the heart. Growing evidence suggests that core circadian components, such as BMAL1 and REV-ERBα, play important roles in modulating myocardial energy metabolism, inflammatory responses, and oxidative stress, contributing to myocardial structural and metabolic remodeling during heart failure progression. Notably, circadian disruption is closely associated with heart failure, with aberrant blood pressure rhythms and disturbances in the sleep-wake cycle in patients. The time-dependent efficacy of heart failure medications further supports the potential of chronotherapy-based strategies to improve clinical outcomes. Here, we summarize the multifaceted regulatory roles of the circadian clock, particularly core clock genes, in heart failure pathogenesis, providing a theoretical framework for developing personalized chronotherapeutic strategies for heart failure management.</p>","PeriodicalId":7134,"journal":{"name":"生理学报","volume":"77 4","pages":"653-668"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Advances in the role of protein post-translational modifications in circadian rhythm regulation].","authors":"Zi-Di Zhao, Qi-Miao Hu, Zi-Yi Yang, Peng-Cheng Sun, Bo-Wen Jing, Rong-Xi Man, Yuan Xu, Ru-Yu Yan, Si-Yao Qu, Jian-Fei Pei","doi":"10.13294/j.aps.2024.0092","DOIUrl":"https://doi.org/10.13294/j.aps.2024.0092","url":null,"abstract":"<p><p>The circadian clock plays a critical role in regulating various physiological processes, including gene expression, metabolic regulation, immune response, and the sleep-wake cycle in living organisms. Post-translational modifications (PTMs) are crucial regulatory mechanisms to maintain the precise oscillation of the circadian clock. By modulating the stability, activity, cell localization and protein-protein interactions of core clock proteins, PTMs enable these proteins to respond dynamically to environmental and intracellular changes, thereby sustaining the periodic oscillations of the circadian clock. Different types of PTMs exert their effects through distincting molecular mechanisms, collectively ensuring the proper function of the circadian system. This review systematically summarized several major types of PTMs, including phosphorylation, acetylation, ubiquitination, SUMOylation and oxidative modification, and overviewed their roles in regulating the core clock proteins and the associated pathways, with the goals of providing a theoretical foundation for the deeper understanding of clock mechanisms and the treatment of diseases associated with circadian disruption.</p>","PeriodicalId":7134,"journal":{"name":"生理学报","volume":"77 4","pages":"605-626"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress on the early warning of heart failure based on remote dynamic monitoring technology].","authors":"Ying Shi, Mengwei Li, Lixuan Li, Wei Yan, Desen Cao, Zhengbo Zhang, Muyang Yan","doi":"10.7507/1001-5515.202406007","DOIUrl":"10.7507/1001-5515.202406007","url":null,"abstract":"<p><p>Heart failure (HF) is the end-stage of all cardiac diseases, characterized by high prevalence, high mortality, and heavy social and economic burden. Early warning of HF exacerbation is of great value for outpatient management and reducing readmission rates. Currently, remote dynamic monitoring technology, which captures changes in hemodynamic and physiological parameters of HF patients, has become the primary method for early warning and is a hot research topic in clinical studies. This paper systematically reviews the progress in this field, which was categorized into invasive monitoring based on implanted devices, non-invasive monitoring based on wearable devices, and other monitoring technologies based on audio and video. Invasive monitoring primarily involves direct hemodynamic parameters such as left atrial pressure and pulmonary artery pressure, while non-invasive monitoring covers parameters such as thoracic impedance, electrocardiogram, respiration, and activity levels. These parameters exhibit characteristic changes in the early stages of HF exacerbation. Given the clinical heterogeneity of HF patients, multi-source information fusion analysis can significantly improve the prediction accuracy of early warning models. The results of this study suggest that, compared with invasive monitoring, non-invasive monitoring technology, with its advantages of good patient compliance, ease of operation, and cost-effectiveness, combined with AI-driven multimodal data analysis methods, shows significant clinical application potential in establishing an outpatient management system for HF.</p>","PeriodicalId":39324,"journal":{"name":"生物医学工程学杂志","volume":"42 4","pages":"857-862"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Design and analysis of human arm pathological tremor simulation system].","authors":"Zixin He, Haiping Liu, Qingsheng Liu, Yu Jiang, Zhu Zhu","doi":"10.7507/1001-5515.202412025","DOIUrl":"10.7507/1001-5515.202412025","url":null,"abstract":"<p><p>In order to characterize the characteristics of pathological tremor of human upper limb, a simulation system of pathological tremor of human arm was provided and its dynamic response was analyzed. Firstly, in this study, a two-degree-of-freedom human arm dynamic model was established and linearized according to the arbitrary initial angle of joints. After solving the analytical solutions of steady-state responses of the joints, the numerical solution was used to verify it. The results of theoretical analysis show that the two natural frequencies of the developed dynamic model are 2.9 Hz and 5.4 Hz, respectively, which meet the characteristic frequency range of pathological tremors. Then, combined with the measured parameters of human arm, a tremor simulation system was built, and the measured results of joint responses are in good agreement with the theoretical and simulation analysis results, which verifies the effectiveness of the theoretical model. The results show that the human arm pathological tremor simulation system designed in this paper can characterize the frequency and response amplitude of the human upper limb pathological tremor. Moreover, the relevant research lays a theoretical foundation and experimental conditions for the subsequent development of wearable tremor suppression devices.</p>","PeriodicalId":39324,"journal":{"name":"生物医学工程学杂志","volume":"42 4","pages":"790-798"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Motor imagery classification based on dynamic multi-scale convolution and multi-head temporal attention].","authors":"Nan Xiao, Ming'ai Li","doi":"10.7507/1001-5515.202408051","DOIUrl":"10.7507/1001-5515.202408051","url":null,"abstract":"<p><p>Convolutional neural networks (CNNs) are renowned for their excellent representation learning capabilities and have become a mainstream model for motor imagery based electroencephalogram (MI-EEG) signal classification. However, MI-EEG exhibits strong inter-individual variability, which may lead to a decline in classification performance. To address this issue, this paper proposes a classification model based on dynamic multi-scale CNN and multi-head temporal attention (DMSCMHTA). The model first applies multi-band filtering to the raw MI-EEG signals and inputs the results into the feature extraction module. Then, it uses a dynamic multi-scale CNN to capture temporal features while adjusting attention weights, followed by spatial convolution to extract spatiotemporal feature sequences. Next, the model further optimizes temporal correlations through time dimensionality reduction and a multi-head attention mechanism to generate more discriminative features. Finally, MI classification is completed under the supervision of cross-entropy loss and center loss. Experiments show that the proposed model achieves average accuracies of 80.32% and 90.81% on BCI Competition IV datasets 2a and 2b, respectively. The results indicate that DMSCMHTA can adaptively extract personalized spatiotemporal features and outperforms current mainstream methods.</p>","PeriodicalId":39324,"journal":{"name":"生物医学工程学杂志","volume":"42 4","pages":"678-685"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PPARα-dependent lipid metabolic disruption mediates triphenyl phosphate–induced hepato- and neurotoxicity in zebrafish","authors":"Congying Luo ,&nbsp;Qiong Zhang ,&nbsp;Han Xie ,&nbsp;Dinghui Wang ,&nbsp;Xiaoling Shi ,&nbsp;Yanhong Huang ,&nbsp;Yimin Zhang ,&nbsp;Kusheng Wu","doi":"10.1016/j.emcon.2025.100561","DOIUrl":"10.1016/j.emcon.2025.100561","url":null,"abstract":"<div><div>The extensive use of triphenyl phosphate (TPhP) has resulted in its ubiquity in aquatic ecosystems, raising significant concerns about its escalating risks to aquatic organisms. In this study, we employed adult and larval zebrafish (<em>Danio rerio</em>) as model organisms to assess the adverse effects of TPhP exposure on aquatic life. The objectives were to evaluate TPhP-induced hepatotoxicity and neurotoxicity and the role of lipid metabolism in mediating these toxic effects. The results demonstrated that TPhP exposure led to alterations in body weight, length, and body mass index (BMI), along with changes in brain and liver somatic indices in zebrafish. Through comprehensive analyses of histopathological changes, transcriptional profiles, biochemical markers, and neurobehavioral assays, TPhP was shown to induce both morphological and functional impairments in the brain and liver. In TPhP-exposed larvae, reduced tissue integrity and altered spatial distribution of brain and hepatic tissues were observed. Notably, changes in the expression of neurodevelopmental and lipid metabolism-related genes in larvae mirrored those detected in adult zebrafish, indicating conserved toxic mechanisms across life stages. Mechanistically, TPhP exposure induced oxidative stress in both brain and liver tissues and suppressed the expression of PPARα, as well as its downstream genes involved in fatty acid β-oxidation and lipid homeostasis. Consequently, hepatic triglyceride (TG) and total cholesterol (T-CHO) levels were significantly decreased, whereas free fatty acid (FFA) content was elevated. Thus, TPhP inhibits PPARα signaling via oxidative stress, leading to lipid metabolic dysfunction and subsequent damage to neural and hepatic tissues. This study provides robust evidence of TPhP-induced hepatotoxicity and neurotoxicity in zebrafish, and elucidates the critical role of PPARα-mediated disruption of lipid metabolism in these toxic pathways, thereby enhancing our understanding of the ecological risks posed by organophosphate flame retardants.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 4","pages":"Article 100561"},"PeriodicalIF":6.9,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144921673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Misaligned light entrainment causes metabolic disorders in <i>Chrono</i> knockout mice].","authors":"Ruo-Han Wang, Shao-Ying Lan, Bo-Yuan Cao, Xi-Ming Qin","doi":"10.13294/j.aps.2025.0061","DOIUrl":"https://doi.org/10.13294/j.aps.2025.0061","url":null,"abstract":"<p><p>Most of the life forms on Earth have gradually evolved an endogenous biological clock under the long-term influence of periodic daily light-dark cycles. This biological clock system plays a crucial role in the orderly progression of life activities. In mammals, central circadian clock is located in the suprachiasmatic nucleus of the hypothalamus and the function of the biological clock relies on a transcription-translation negative feedback loop. As a negative regulator in this loop, the function of CHRONO is less known. To deeply explore the role of the <i>Chrono</i> gene in rhythm entrainment and physiology, we constructed a <i>Chrono</i> gene knockout mouse strain using the CRISPR/Cas9 technology and analyzed its entrainment ability under different T cycles. Running wheel tests and glucose tolerance tests were also performed. The results showed that the period of the endogenous biological clock of <i>Chrono</i> knockout mice was prolonged, and the entrainment rate under the T21 cycle was decreased. In addition, metabolic abnormalities, including weight gain and impaired glucose tolerance, were observed in the non-entrained mice. Overall, this study reveals a crucial role of the <i>Chrono</i> gene in maintaining circadian rhythms and metabolic balance, providing a new perspective for understanding the relationship between the biological clock and metabolism. Further research is needed to fully understand the underlying molecular mechanisms.</p>","PeriodicalId":7134,"journal":{"name":"生理学报","volume":"77 4","pages":"731-740"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Simulation analysis of adaptability of large airborne negative pressure isolation cabin to aviation conditions].","authors":"Lei Guo, Falin Li, Lang Jiang, Haibo Du, Bingjie Xue, Wei Yong, Yuanyuan Jiang, Muzhe Zhang","doi":"10.7507/1001-5515.202403011","DOIUrl":"10.7507/1001-5515.202403011","url":null,"abstract":"<p><p>In order to solve the problems of difficult test, high cost and long cycle in the development of large-scale airborne negative pressure isolation system, the simulation analysis of negative pressure response characteristics is carried out around various aviation conditions such as aircraft ascending, leveling and descending, especially rapid decompression, based on the computational fluid dynamics (CFD) method. The results showed that the isolation cabin could achieve -50 Pa pressure difference environment and form a certain pressure gradient. The exhaust air volume reached the maximum value in the early stage of the aircraft's ascent, and gradually decreased with the increase of altitude until it was level flying. In the process of aircraft descent, the exhaust fan could theoretically maintain a pressure difference far below -50 Pa without working; Under the special condition of rapid pressure loss, it was difficult to deal with the rapid change of low pressure only by the exhaust fan, so it was necessary to design safety valve and other anti-leakage measures in the isolation cabin structure. Therefore, the initial stage of aircraft ascent is the key stage for the adjustment and control of the negative pressure isolation system. By controlling the exhaust air volume and adjusting parameters, it can adapt to the change of low pressure under normal flight conditions, form a relatively stable negative pressure environment, and meet the needs of biological control, isolation and transport.</p>","PeriodicalId":39324,"journal":{"name":"生物医学工程学杂志","volume":"42 4","pages":"775-781"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Finite element modeling and simulation study of solid-liquid biphase fiber-reinforced lumbar intervertebral disc].","authors":"Yongchang Gao, Yantao Fu, Qingfeng Cui, Shibin Chen, Peng Liu, Xifang Liu","doi":"10.7507/1001-5515.202310021","DOIUrl":"10.7507/1001-5515.202310021","url":null,"abstract":"<p><p>The lumbar intervertebral disc exhibits a complex physiological structure with interactions between various segments, and its components are extremely complex. The material properties of different components in the lumbar intervertebral disc, especially the water content (undergoing dynamic change as influenced by age, degeneration, mechanical loading, and proteoglycan content) - critically determine its mechanical properties. When the lumbar intervertebral disc is under continuous pressure, water seeps out, and after the pressure is removed, water re-infiltrates. This dynamic fluid exchange process directly affects the mechanical properties of the lumbar intervertebral disc, while previous isotropic modeling methods have been unable to accurately reflect such solid-liquid phase behaviors. To explore the load-bearing mechanism of the lumbar intervertebral disc and establish a more realistic mechanical model of the lumbar intervertebral disc, this study developed a solid-liquid biphasic, fiber-reinforced finite element model. This model was used to simulate the four movements of the human lumbar spine in daily life, namely flexion, extension, axial rotation, and lateral bending. The fluid pressure, effective solid stress, and liquid pressure-bearing ratio of the annulus fibrosus and nucleus pulposus of different lumbar intervertebral discs were compared and analyzed under the movements. Under all the movements, the fluid pressure distribution was closer to the nucleus pulposus, while the effective solid stress distribution was more concentrated in the outer annulus fibrosus. In terms of fluid pressure, the maximum fluid pressure of the lumbar intervertebral disc during lateral bending was 1.95 MPa, significantly higher than the maximum fluid pressure under other movements. Meanwhile, the maximum effective solid stress of the lumbar intervertebral disc during flexion was 2.43 MPa, markedly higher than the maximum effective solid stress under other movements. Overall, the liquid pressure-bearing ratio under axial rotation was smaller than that under other movements. Based on the solid-liquid biphasic modeling method, this study more accurately revealed the dominant role of the liquid phase in the daily load-bearing process of the lumbar intervertebral disc and the solid-phase mechanical mechanism of the annulus fibrosus load-bearing, and more effectively predicted the solid-liquid phase co-load-bearing mechanism of the lumbar intervertebral disc in daily life.</p>","PeriodicalId":39324,"journal":{"name":"生物医学工程学杂志","volume":"42 4","pages":"799-807"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}