生物医学工程学杂志 Pub Date : 2025-08-25 DOI: 10.7507/1001-5515.202407055

Yueyang Yuan, Zhongping Zhang, Lixin Xie, Haoxuan Huang, Wei Liu

{"title":"[A signal sensing system for monitoring the movement of human respiratory muscle based on the thin-film varistor].","authors":"Yueyang Yuan, Zhongping Zhang, Lixin Xie, Haoxuan Huang, Wei Liu","doi":"10.7507/1001-5515.202407055","DOIUrl":"10.7507/1001-5515.202407055","url":null,"abstract":"In order to accurately capture the respiratory muscle movement and extract the synchronization signals corresponding to the breathing phases, a comprehensive signal sensing system for sensing the movement of the respiratory muscle was developed with applying the thin-film varistor FSR402 IMS-C07A in this paper. The system integrated a sensor, a signal processing circuit, and an application program to collect, amplify and denoise electronic signals. Based on the respiratory muscle movement sensor and a STM32F107 development board, an experimental platform was designed to conduct experiments. The respiratory muscle movement data and respiratory airflow data were collected from 3 healthy adults for comparative analysis. In this paper, the results demonstrated that the method for determining respiratory phase based on the sensing the respiratory muscle movement exhibited strong real-time performance. Compared to traditional airflow-based respiratory phase detection, the proposed method showed a lead times ranging from 33 to 210 ms [(88.3 ± 47.9) ms] for expiration switched into inspiration and 17 to 222 ms [(92.9 ± 63.8) ms] for inspiration switched into expiration, respectively. When this system is applied to trigger the output of the ventilator, it will effectively improve the patient-ventilator synchrony and facilitate the ventilation treatment for patients with respiratory diseases.","PeriodicalId":39324,"journal":{"name":"生物医学工程学杂志","volume":"42 4","pages":"733-738"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Circadian and non-circadian regulation of the male reproductive system and reproductive damage: advances in the role and mechanisms of clock genes]. [男性生殖系统的昼夜节律和非昼夜节律调节与生殖损伤：生物钟基因的作用和机制研究进展]。

生理学报 Pub Date : 2025-08-25 DOI: 10.13294/j.aps.2025.0060

Meng-Chao He, Ying-Zhong Dai, Yi-Meng Wang, Qin-Ru Li, Si-Wen Luo, Xi Ling, Tong Wang, Jia Cao, Qing Chen

{"title":"[Circadian and non-circadian regulation of the male reproductive system and reproductive damage: advances in the role and mechanisms of clock genes].","authors":"Meng-Chao He, Ying-Zhong Dai, Yi-Meng Wang, Qin-Ru Li, Si-Wen Luo, Xi Ling, Tong Wang, Jia Cao, Qing Chen","doi":"10.13294/j.aps.2025.0060","DOIUrl":"https://doi.org/10.13294/j.aps.2025.0060","url":null,"abstract":"Recently, male reproductive health has attracted extensive attention, with the adverse effects of circadian disruption on male fertility gradually gaining recognition. However, the mechanism by which circadian disruption leads to damage to male reproductive system remains unclear. In this review, we first summarized the dual regulatory roles of circadian clock genes on the male reproductive system: (1) circadian regulation of testosterone synthesis via the hypothalamic-pituitary-testicular (HPT) and hypothalamic-pituitary-adrenal (HPA) axes; (2) non-circadian regulation of spermatogenesis. Next, we further listed the possible mechanisms by which circadian disruption impairs male fertility, including interference with the oscillatory function of the reproductive system, i.e., synchronization of the HPT axis, crosstalk between the HPT axis and the HPA axis, as well as direct damage to germ cells by disturbing the non-oscillatory function of the reproductive system. Future research using spatiotemporal omics, epigenomic assays, and neural circuit mapping in studying the male reproductive system may provide new clues to systematically unravel the mechanisms by which circadian disruption affects male reproductive system through circadian clock genes.","PeriodicalId":7134,"journal":{"name":"生理学报","volume":"77 4","pages":"712-720"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Technical maturity and bubble risks of brain-computer interface (BCI): Considerations from research to industrial translation]. [脑机接口技术成熟度与泡沫风险：从研究到产业转化的思考]。

生物医学工程学杂志 Pub Date : 2025-08-25 DOI: 10.7507/1001-5515.202507053

Yunfa Fu, Haichen Lu

{"title":"[Technical maturity and bubble risks of brain-computer interface (BCI): Considerations from research to industrial translation].","authors":"Yunfa Fu, Haichen Lu","doi":"10.7507/1001-5515.202507053","DOIUrl":"10.7507/1001-5515.202507053","url":null,"abstract":"Brain-computer interface (BCI) technology faces structural risks due to a misalignment between its technological maturity and industrialization expectations. This study used the Technology Readiness Level (TRL) framework to assess the status of major BCI paradigms-such as steady-state visual evoked potential (SSVEP), motor imagery, and P300-and found that they predominantly remained at TRL4 to TRL6, with few stable applications reaching TRL9. The analysis identified four interrelated sources of bubble risk: overly broad definitions of BCI, excessive focus on decoding performance, asynchronous translational progress, and imprecise terminology usage. These distortions have contributed to the misallocation of research resources and public misunderstanding. To foster the sustainable development of BCI, this paper advocated the establishment of a standardized TRL evaluation system, clearer terminological boundaries, stronger support for fundamental research, enhanced ethical oversight, and the implementation of inclusive and diversified governance mechanisms.","PeriodicalId":39324,"journal":{"name":"生物医学工程学杂志","volume":"42 4","pages":"651-659"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Research on fatigue recognition based on graph convolutional neural network and electroencephalogram signals]. 基于图卷积神经网络和脑电图信号的疲劳识别研究

生物医学工程学杂志 Pub Date : 2025-08-25 DOI: 10.7507/1001-5515.202410003

Song Li, Yunfa Fu, Yan Zhang, Gong Lu

{"title":"[Research on fatigue recognition based on graph convolutional neural network and electroencephalogram signals].","authors":"Song Li, Yunfa Fu, Yan Zhang, Gong Lu","doi":"10.7507/1001-5515.202410003","DOIUrl":"10.7507/1001-5515.202410003","url":null,"abstract":"Electroencephalogram (EEG) serves as an effective indicator of detecting fatigue driving. Utilizing the open accessible Shanghai Jiao Tong University Emotion Electroencephalography Dataset (SEED-VIG), driving states are divided into three categories including awake, tired and drowsy for investigation. Given the characteristics of mutual influence and interdependence among EEG channels, as well as the consistency of the graph convolutional neural network (GCNN) structure, we designed an adjacency matrix based on the Pearson correlation coefficients of EEG signals among channels and their positional relationships. Subsequently, we developed a GCNN for recognition. The experimental results show that the average classification accuracy of driving state categories for 20 subjects, from the SEED-VIG dataset under the smooth feature of differential entropy (DE) linear dynamic system is 91.66%. Moreover, the highest classification accuracy can reach 98.87%, and the average Kappa coefficient is 0.83. This work demonstrates the reliability of this method and provides a guideline for the research field of safe driving brain computer interface.","PeriodicalId":39324,"journal":{"name":"生物医学工程学杂志","volume":"42 4","pages":"686-692"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Advances in multimodal biomedical imaging of small animals]. [小动物多模态生物医学成像研究进展]。

生物医学工程学杂志 Pub Date : 2025-08-25 DOI: 10.7507/1001-5515.202406024

Zhengyan Deng, Peng Xi, Juan Tang, Qiushi Ren, Yuanjun Yu

{"title":"[Advances in multimodal biomedical imaging of small animals].","authors":"Zhengyan Deng, Peng Xi, Juan Tang, Qiushi Ren, Yuanjun Yu","doi":"10.7507/1001-5515.202406024","DOIUrl":"10.7507/1001-5515.202406024","url":null,"abstract":"Small animal multimodal biomedical imaging refers to the integration of multiple imaging techniques within the same system or device to acquire comprehensive physiological and pathological information of small animals, such as mice and rats. With the continuous advancement of biomedical research, this cutting-edge technology has attracted extensive attention. Multimodal imaging techniques, based on diverse imaging principles, overcome the limitations of single-modal imaging through information fusion, significantly enhancing the overall system's sensitivity, temporal/spatial resolution, and quantitative accuracy. In the future, the integration of new materials and artificial intelligence will further boost its sensitivity and resolution. Through interdisciplinary innovation, this technology is expected to become the core technology of personalized medicine and expand its applications to drug development, environmental monitoring, and other fields, thus reshaping the landscape of biomedical research and clinical practice. This review summarized the progress on the application and investigation of multimodal biomedical imaging techniques, and discussed its development in the future.","PeriodicalId":39324,"journal":{"name":"生物医学工程学杂志","volume":"42 4","pages":"841-846"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Research progress in electroencephalogram-based brain age prediction]. [基于脑电图的脑年龄预测研究进展]。

生物医学工程学杂志 Pub Date : 2025-08-25 DOI: 10.7507/1001-5515.202503043

Hongyue Zu, Ping Zhan, Hui Yu, Weidong Wang, Hongyun Liu

引用次数: 0

[Space magnetic environment and circadian rhythm]. [空间磁环境与昼夜节律]。

生理学报 Pub Date : 2025-08-25 DOI: 10.13294/j.aps.2025.0072

Bing-Xin Gao, Cao Wang, Rui-Xian Jiang, Wei-Ming Tian

{"title":"[Space magnetic environment and circadian rhythm].","authors":"Bing-Xin Gao, Cao Wang, Rui-Xian Jiang, Wei-Ming Tian","doi":"10.13294/j.aps.2025.0072","DOIUrl":"https://doi.org/10.13294/j.aps.2025.0072","url":null,"abstract":"In recent years, China's manned space program has advanced rapidly, with deep space exploration missions such as manned lunar landing steadily progressing, leading to a significant extension of astronauts' duration in outer space. In this context, the impact of the space magnetic field environment on astronaut health has become increasingly conspicuous. Characterized by its complexity, the spatial magnetic field indirectly regulates the circadian rhythm system by interfering with mitochondrial functions, such as electron transport chain activity, ATP synthesis efficiency, and reactive oxygen species (ROS) balance. This disruption can lead to circadian misalignment, sleep disorders, metabolic dysregulation, and other issues, severely compromising astronauts' physical and mental well-being, as well as mission performance. Currently, researchers have carried out extensive investigations into the influence of the space magnetic environment on circadian rhythms. Nevertheless, due to disparities in magnetic field parameters, exposure durations, and the model organisms employed in experiments, the results have been inconsistent. This review systematically elaborates on ground-based simulation technologies for spatial magnetic field environments and their applications, summarizes the effects of magnetic fields with varying intensities and types on core circadian rhythm biomarkers in model organisms and humans, and explores the underlying molecular and physiological mechanisms of magnetic field-induced circadian rhythm perturbation. This work aims to deepen the understanding of the mechanisms of the space magnetic environment on biological rhythms, and establish a scientific basis for formulating adaptive protective strategies centered on circadian regulation for astronauts, thereby ensuring the successful implementation of long-term deep-space missions.","PeriodicalId":7134,"journal":{"name":"生理学报","volume":"77 4","pages":"721-730"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Evaluation method and system for aging effects of autonomic nervous system based on cross-wavelet transform cardiopulmonary coupling]. [基于交叉小波变换心肺耦合的自主神经系统衰老效应评价方法与体系]。

生物医学工程学杂志 Pub Date : 2025-08-25 DOI: 10.7507/1001-5515.202410050

Juntong Lyu, Yining Wang, Wenbin Shi, Pengyan Tao, Jianhong Ye

{"title":"[Evaluation method and system for aging effects of autonomic nervous system based on cross-wavelet transform cardiopulmonary coupling].","authors":"Juntong Lyu, Yining Wang, Wenbin Shi, Pengyan Tao, Jianhong Ye","doi":"10.7507/1001-5515.202410050","DOIUrl":"10.7507/1001-5515.202410050","url":null,"abstract":"Heart rate variability time and frequency indices are widely used in functional assessment for autonomic nervous system (ANS). However, this method merely analyzes the effect of cardiac dynamics, overlooking the effect of cardio-pulmonary interplays. Given this, the present study proposes a novel cardiopulmonary coupling (CPC) algorithm based on cross-wavelet transform to quantify cardio-pulmonary interactions, and establish an assessment system for ANS aging effects using wearable electrocardiogram (ECG) and respiratory monitoring devices. To validate the superiority of the proposed method under nonstationary and low signal-to-noise ratio conditions, simulations were first conducted to demonstrate the performance strength of the proposed method to the traditional one. Next, the proposed CPC algorithm was applied to analyze cardiac and respiratory data from both elderly and young populations, revealing that young populations exhibited significantly stronger couplings in the high-frequency band compared with their elderly counterparts. Finally, a CPC assessment system was constructed by integrating wearable devices, and additional recordings from both elderly and young populations were collected by using the system, completing the validation and application of the aging effect assessment algorithm and the wearable system. In conclusion, this study may offers methodological and system support for assessing the aging effects on the ANS.","PeriodicalId":39324,"journal":{"name":"生物医学工程学杂志","volume":"42 4","pages":"748-756"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Research on hybrid brain-computer interface based on imperceptible visual and auditory stimulation responses]. 基于难以察觉的视觉和听觉刺激反应的脑机混合接口研究

生物医学工程学杂志 Pub Date : 2025-08-25 DOI: 10.7507/1001-5515.202504033

Zexin Pang, Yijun Wang, Qingpeng Dong, Zijian Cheng, Zhaohui Li, Ruoqing Zhang, Hongyan Cui, Xiaogang Chen

{"title":"[Research on hybrid brain-computer interface based on imperceptible visual and auditory stimulation responses].","authors":"Zexin Pang, Yijun Wang, Qingpeng Dong, Zijian Cheng, Zhaohui Li, Ruoqing Zhang, Hongyan Cui, Xiaogang Chen","doi":"10.7507/1001-5515.202504033","DOIUrl":"10.7507/1001-5515.202504033","url":null,"abstract":"In recent years, hybrid brain-computer interfaces (BCIs) have gained significant attention due to their demonstrated advantages in increasing the number of targets and enhancing robustness of the systems. However, Existing studies usually construct BCI systems using intense auditory stimulation and strong central visual stimulation, which lead to poor user experience and indicate a need for improving system comfort. Studies have proved that the use of peripheral visual stimulation and lower intensity of auditory stimulation can effectively boost the user's comfort. Therefore, this study used high-frequency peripheral visual stimulation and 40-dB weak auditory stimulation to elicit steady-state visual evoked potential (SSVEP) and auditory steady-state response (ASSR) signals, building a high-comfort hybrid BCI based on weak audio-visual evoked responses. This system coded 40 targets via 20 high-frequency visual stimulation frequencies and two auditory stimulation frequencies, improving the coding efficiency of BCI systems. Results showed that the hybrid system's averaged classification accuracy was (78.00 ± 12.18) %, and the information transfer rate (ITR) could reached 27.47 bits/min. This study offers new ideas for the design of hybrid BCI paradigm based on imperceptible stimulation.","PeriodicalId":39324,"journal":{"name":"生物医学工程学杂志","volume":"42 4","pages":"660-667"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Circadian rhythm disturbances and neurodevelopmental disorders]. [昼夜节律紊乱和神经发育障碍]。

生理学报 Pub Date : 2025-08-25 DOI: 10.13294/j.aps.2025.0065

Deng-Feng Liu, Yi-Chun Zhang, Jia-Da Li

引用次数: 0

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