理学最新文献

{"title":"Micro RNAs as a potential biomarker for predicting liver fibrosis severity in hepatitis C virus affected patients.","authors":"Navneet Kaur, Ravinder Garg, Chaitanya Tapasvi, Gitanjali Goyal","doi":"10.5501/wjv.v14.i2.101976","DOIUrl":"10.5501/wjv.v14.i2.101976","url":null,"abstract":"<p><strong>Background: </strong>Hepatitis C virus (HCV) infection process of progression encompasses multiple stages, commencing with inflammation and culminating in hepatocellular cancer. Numerous invasive and non-invasive procedures exist for diagnosing chronic HCV infection. Though beneficial, invasive procedures can cause morbidity and inadequate representation of the overall degree of fibrosis. Due to these reasons, non-invasive liver fibrosis biomarkers are becoming more prevalent to diagnose and track liver fibrosis without a liver biopsy. These biomarkers can detect liver fibrosis early, improving treatment and preventing cirrhosis and liver failure. Micro ribonucleic acid (MiRNA) dysregulation causes and worsens several diseases including liver disease. MiRNAs can facilitate the diagnosis of liver fibrosis and serve as a predictive tool to enhance patient care by minimizing invasive procedures and enabling more efficient and prompt therapy.</p><p><strong>Aim: </strong>To investigate the diagnostic effectiveness of several miRNAs (miRNA-122, miRNA-21, miRNA-199a, miRNA-155) in assessing the liver fibrosis severity in untreated HCV patients from the Indian Punjab population. We seek to identify the intricate diagnostic relationship of miRNAs with the extent of fibrosis among individuals with HCV.</p><p><strong>Methods: </strong>We considered 100 persons determined as HCV infected by a quantitative Real-Time Polymerase Chain Reaction examination. We employed statistical as well as probabilistic tools to ascertain the diagnostic validity of miRNAs for determining the liver fibrosis stages. We employed Bayesian Networks, to introduce a unique diagnostic paradigm for miRNAs that can be adopted as benchmark to evaluate the liver fibrosis severity in HCV cases.</p><p><strong>Results: </strong>We found that miRNAs (miR-122, miR-155 and miR-21) showed significant upregulation when compared with control and according to severity of fibrosis (<i>P</i> ≤ 0.05). The area under the curve for miR-122, miR-155, miR-21 and miR-199a in HCV group in relation to Liver Stiffness Measurement was calculated as 0.889, 0.933, 0.912 and 0.035 respectively. MiR-199a was downregulated according to degree of fibrosis.</p><p><strong>Conclusion: </strong>Depending on the diagnostic accuracy, we have concluded that miR-122, miR-155 and miR-21 are reliable markers to detect fibrosis in Hepatitis C patients.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"14 2","pages":"101976"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustained maternal human immunodeficiency virus viral load suppression and cascade of human immunodeficiency virus testing among exposed infants in Rwanda.","authors":"Hafidha Mhando Bakari, Jackson Sebeza, Haji Mbwana Ally, Hassan Fredrick Fussi, Habib Omari Ramadhani, Peter Memiah, Djemima Umutesi, Basile Ikuzo, Gallican Rwibasira","doi":"10.5501/wjv.v14.i2.107322","DOIUrl":"10.5501/wjv.v14.i2.107322","url":null,"abstract":"<p><strong>Background: </strong>To prevent mother to child transmission (MTCT) of human immunodeficiency virus (HIV), sustained maternal viral load suppression (VLS) and early HIV testing among HIV exposed infants (HEI) is critical.</p><p><strong>Aim: </strong>To investigate maternal viral load results and infant HIV testing uptake at 6-weeks, and 9-months and 18-months in Rwanda.</p><p><strong>Methods: </strong>Between 2015 and 2022, VLS (< 200 copies/mL) was measured among pregnant women living with HIV (WLHIV) from 38-healthcare facilities. Viral loads (VL) were measured at 6-months, 12-months and 24-months, respectively. For maternal VL, the unit of analysis was visit-pair, and the pairs were created to define those with VL < 200 copies/mL at two consecutive visits as having sustained VLS, persistent viremia (VL ≥ 200 copies/mL at two consecutive visits), viral rebound (VL < 200 copies/mL at prior visit only) and newly suppressed (VL < 200 copies/mL at subsequent visit only). HEI were considered to have persistent HIV testing if they had all three HIV tests. Poisson regression models with generalized estimating equations were used to estimate the adjusted incidence rate ratio (aIRR) and 95%CI for factors associated with sustained VLS and persistent HIV testing.</p><p><strong>Results: </strong>A total of 1145 mother-infant pairs were analyzed. Infant HIV testing uptake at 6- weeks, 9-months and 18-months was 1145 (100.0%), 1089 (95.1%), 1006 (87.9%) respectively. Nine hundred ninety-nine HEI (87.3%) tested for HIV persistently. At 18-months, the incidence of HIV among HEI was 8 (0.7%). Of 1145 mothers, 1076 (94.0%) had ≥ 2 VL results making a total of 2010 visit-pairs (142-single; 934-double visit-pairs). The incidence rate of sustained VLS, persistent viremia, viral rebound and new suppression were 91.0%, 1.3%, 3.6% and 4.0% respectively. Maternal disclosure of HIV status (aIRR = 1.08, 95%CI: 1.02-1.14) was associated with increased likelihood of sustained VLS. Having peer support (aIRR = 1.05 95%CI: 1.01-1.10) was associated with persistent HIV testing among HEI.</p><p><strong>Conclusion: </strong>Sustained VLS is high among pregnant WLHIV in Rwanda. The low incidence of HIV among HEI may be attributed to high VLS levels. Targeted interventions, including enhanced HIV disclosure and peer support, are crucial for improving sustained VLS and increasing infant HIV testing uptake to reduce MTCT.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"14 2","pages":"107322"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alpha to JN.1 variants: SARS-CoV-2 genomic analysis unfolding its various lineages/sublineages evolved in Chhattisgarh, India from 2020 to 2024.","authors":"Pushpendra Singh, Ruchi Khare, Kuldeep Sharma, Anudita Bhargava, Sanjay Singh Negi","doi":"10.5501/wjv.v14.i2.100001","DOIUrl":"10.5501/wjv.v14.i2.100001","url":null,"abstract":"<p><strong>Background: </strong>The evolutionary mutational changes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) since its emergence in Chhattisgarh, India in 2020 have warranted the need for the characterization of every lineage/sublineage that has evolved until February 2024.</p><p><strong>Aim: </strong>To unravel the evolutionary pathway of SARS-CoV-2 in Chhattisgarh from 2020 to February 2024.</p><p><strong>Methods: </strong>A total of 635 coronavirus disease 2019 cases obtained between 2020 and February 2024 were investigated by whole genome sequencing.</p><p><strong>Results: </strong>Whole genome sequencing analysis identified the evolution of SARS-CoV-2 into seventeen lineages from 2020 to 2024. SARS-CoV-2 initially emerged in Chhattisgarh in its Alpha (B.1.1.7) variant in 2020. Thereafter, it continuously underwent periodical mutational changes in the spike gene to further differentiate into various lineages/sublineages, viz., Kappa, Delta, BA.1, and BA.2 in 2021; the Omicron lineage (BA.5, BA.2.12.1, BA.2.75, BQ.1, and XBB) in 2022; the new Omicron lineage (XBB.1.5, XBB.1.16, XBB.1.9.1, and XBB.2.3) in 2023; and finally to JN.1 in January and February 2024. The predominant lineages over these 4 years were BA.1.1.7 (Alpha) in 2020, B.1.617.2 (Delta) in the period between 2021 and mid-2022, B.1.1.529 (Omicron) in late 2022 to 2023, and Omicron-JN.1 in early 2024. The presently circulating JN.1 lineage was observed harboring exclusive predominant mutations of E4554K, A570V, P621A, and P1143 L with 99% prevalence.</p><p><strong>Conclusion: </strong>SARS-CoV-2 from 2020 to 2024 has evolved into 17 lineages/sublineages in Chhattisgarh. The presently circulating JN.1 harbored 40 mutations, especially E554K, A570V, P621S, and P1143 L, capacitating the virus with features of host cell entry, stability, replication, rapid transmissibility, and crucial immune evasion. Therefore, earlier immunity from either vaccination or prior infection may not protect against the current lineage and increases the possibility of future outbreaks. Thus, the periodical genomic surveillance of SARS-CoV-2 is essential for the genomic blueprint of the circulating virus, which may help in updating the vaccine strain and various basic research for developing appropriate therapeutics and diagnostics.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"14 2","pages":"100001"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic diarrhoea in a human immunodeficiency virus/acquired immunodeficiency syndrome patient: A case report.","authors":"Sheetal Panjaria, Prasan Kumar Panda","doi":"10.5501/wjv.v14.i2.108412","DOIUrl":"10.5501/wjv.v14.i2.108412","url":null,"abstract":"<p><strong>Background: </strong>Chronic diarrhoea in people living with human immunodeficiency virus (PLHIV)/acquired immunodeficiency syndrome presents a diagnostic challenge, often resulting from opportunistic infections (OIs), malignancies, or disease progression itself. We present a case of an advanced human immunodeficiency virus (HIV) patient with chronic diarrhoea, significant weight loss, and antiretroviral therapy (ART) non-compliance, highlighting the diagnostic dilemma between HIV wasting syndrome, OIs, and malignancy.</p><p><strong>Case summary: </strong>A 36-year-old female, diagnosed with HIV five years ago on family screening, presented with three months of profuse watery diarrhoea, associated with crampy abdominal pain and weight loss (14 kg, 30% in 3 months). She was non-compliant with ART. There was no history of recent travel, food contamination, or tuberculosis contact. Fever episodes were mild and transient. Physical examination revealed pallor and bilateral pedal oedema without lymphadenopathy or organomegaly. Genital examination was unremarkable. Routine investigations revealed severe anaemia and confirmed PLHIV status. CD4 count was < 36 cells/µL. Empirical treatment with nitazoxanide was initiated for possible cryptosporidiosis. After ruling out OIs, ART was restarted. With treatment, her diarrhoea resolved, and she tolerated oral intake. Nutritional support was provided, and she was discharged in stable condition with ART, prophylactic antibiotics, and follow-up instructions for further evaluation.</p><p><strong>Conclusion: </strong>In ART-noncompliant PLHIV with chronic diarrhoea, distinguishing between HIV wasting syndrome, OIs (<i>Cryptosporidium</i>, <i>Mycobacterium avium</i> complex, cytomegalovirus colitis) and malignancies (non-Hodgkin lymphoma and anal carcinoma) are critical. Gradual CD4 decline, systemic inflammation, and malnutrition favour progressive HIV/acquired immunodeficiency syndrome rather than an acute OI or malignancy. Early recognition and management, including ART reinitiation and nutritional support, are crucial for prognosis.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"14 2","pages":"108412"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient on-chip terahertz generation and detection with GaN photoconductive emitters","authors":"Can B. Uzundal, Qixin Feng, Weichen Tang, Chen Hu, Collin Sanborn, Yoseob Yoon, Sudi Chen, Jiawei Ruan, Steven G. Louie, Feng Wang","doi":"10.1038/s41377-025-01870-6","DOIUrl":"https://doi.org/10.1038/s41377-025-01870-6","url":null,"abstract":"<p>Photoconductive emitters for terahertz generation hold promise for highly efficient down-conversion of optical photons because it is not constrained by the Manley-Rowe relation. Existing terahertz photoconductive devices, however, faces limits in efficiency due to the semiconductor properties of commonly used GaAs materials. Here, we demonstrate that large bandgap semiconductor GaN, characterized by its high breakdown electric field, facilitates the highly efficient generation of terahertz waves in a coplanar stripline waveguide. Towards this goal, we investigated the excitonic contribution to the electro-optic response of GaN under static electric field both through experiments and first-principles calculations, revealing a robust excitonic Stark shift. Using this electro-optic effect, we developed a novel ultraviolet pump-probe spectroscopy for in-situ characterization of the terahertz electric field strength generated by the GaN photoconductive emitter. Our findings show that terahertz power scales quadratically with optical excitation power and applied electric field over a broad parameter range. We achieved an optical-to-terahertz conversion efficiency approaching 100% within the 0.03–1 THz bandwidth at the highest bias field (116 kV/cm) in our experiment. Further optimization of GaN-based terahertz generation devices could achieve even greater optical-to-terahertz conversion efficiencies.</p>","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144479075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiome, dysbiosis and use of probiotics in various diseases.","authors":"Ece Tüsüz Önata, Öner Özdemir","doi":"10.5501/wjv.v14.i2.99574","DOIUrl":"10.5501/wjv.v14.i2.99574","url":null,"abstract":"<p><p>The community of microorganisms that colonize certain areas of the human body is called microbiota. Microorganisms such as bacteria, fungi and viruses make up the microbiota. The sum of the genomes of these microorganisms and microorganisms refers to the microbiome. It has been shown that microbiota has important effects such as protecting the organ from pathogens, contributing to metabolic functions (such as vitamin synthesis, carbohydrate digestion) and providing immunoregulation. Dysbiosis refers to compositional and functional changes in the microbiota. At the beginning of the 21^st century, numerous studies have investigated the human microbiota and its imbalance in relation to various diseases and found that dysbiosis is associated with many diseases. The aim of this mini-review article is to provide brief information about dysbiosis and its care and to raise awareness.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"14 2","pages":"99574"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marburg virus disease: Emerging threat, pathogenesis, and global public health strategies.","authors":"Praveen Kumar Uppala, Sita Kumari Karanam, Naga Vishnu Kandra, Sandhya Edhi","doi":"10.5501/wjv.v14.i2.103576","DOIUrl":"10.5501/wjv.v14.i2.103576","url":null,"abstract":"<p><p>The Marburg virus (MARV) is a dangerous infection that causes a deadly sickness known as MARV disease. This severe hemorrhagic fever is a major concern for people all over the world. Since the initial identification in 1967 during simultaneous outbreaks in Germany and Serbia, MARV has caused recurrent epidemics predominantly in sub-Saharan Africa with fatality rates ranging from 24% to 90% as a result of differences in virus strains, healthcare infrastructure, and the quality of patient treatment. Like Ebola virus, MARV causes a viral hemorrhagic fever identified in some of the same principles of clinical and epidemiological concern. However, MARV has unique biologic characteristics that require specialized research and response by public health and among researchers. Diagnosis relies on molecular tools such as real-time reverse transcriptase-polymerase chain reaction and enzyme-linked immunosorbent assay, as well as clinical and epidemiological assessments. Despite advancements in understanding MARV biology, no vaccines or antiviral therapies have been approved, with treatment limited to supportive care. Experimental therapeutics, monoclonal antibodies, RNA-based drugs, and adenovirus-based vaccines, show promise but require further validation. Current efforts in outbreak containment include surveillance, rapid diagnostics, case isolation, and safe burial practices. However, gaps in understanding MARV pathogenesis, limited diagnostic tools, and the absence of regulatory-approved vaccines underscore the urgent need for global collaboration and investment in research. Bridging these gaps is critical to mitigating the public health impact of MARV, ensuring effective response strategies for future outbreaks.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"14 2","pages":"103576"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of dispersion-engineered metasurfaces: Debye relaxation and folded path concept","authors":"Hammad Ahmed, Buxiong Qi, Xianzhong Chen","doi":"10.1038/s41377-025-01890-2","DOIUrl":"https://doi.org/10.1038/s41377-025-01890-2","url":null,"abstract":"<p>Dispersion engineering is advancing with recent breakthroughs in metasurfaces using the 2nd-order Debye relaxation and the folded-path concept, greatly improving relevant applications such as imaging, beam shaping, and cloaking.</p>","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144371051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observing half-integer topological winding numbers in non-Hermitian synthetic lattices","authors":"Mu Yang, Yu-Wei Liao, Hao-Qing Zhang, Yue Li, Zhi-He Hao, Zheng-Wei Zhou, Xi-Wang Luo, Jin-Shi Xu, Chuan-Feng Li, Guang-Can Guo","doi":"10.1038/s41377-025-01909-8","DOIUrl":"https://doi.org/10.1038/s41377-025-01909-8","url":null,"abstract":"<p>Non-Hermitian (NH) systems have revealed unique topological phenomena that are not observed in Hermitian counterparts, such as novel topology classifications and the NH skin effect. In periodic NH systems, eigenenergies become complex and exhibit windings in the complex plane, while eigenstate winding numbers, which are strictly integers in Hermitian systems, can take half-integer values. However, direct experimental observation of NH winding of both eigenenergies and eigenstates, especially the half-integer winding, remains a significant challenge. In this work, we utilize the orbital angular momentum (OAM) synthetic dimension to construct an NH topological lattice and achieve direct observation of both eigenstate and eigenenergy windings. We report the first experimental observation of a half-integer eigenstate winding number, and reveal the intrinsic relationship between the direction in the NH skin dynamics and eigenenergy windings. Furthermore, by partitioning the OAM chain into two semi-infinite chains, we observe zero boundary modes and demonstrate that their distributions are jointly determined by the winding numbers of both the eigenstates and eigenenergies. This work provides comprehensive insights into NH topologies and offers a new experimental platform for exploring NH phenomena.</p>","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144371129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Luminescence lifetime thermometers based on hybrid cuprous halides with exceptional water resistance and giant thermal expansion","authors":"Chenliang Li, Luping Wang, Datao Tu, Xiaoying Shang, Mingjie Yang, Jiacheng Gong, Fei Wen, Yun Xing, Zhi Xie, Jiaxin Jiang, Shaohua Yu, Xueyuan Chen","doi":"10.1038/s41377-025-01910-1","DOIUrl":"https://doi.org/10.1038/s41377-025-01910-1","url":null,"abstract":"<p>Optical probes hold great promise for temperature sensing owing to their attractive properties including rapid response, high spatial resolution, and remote non-invasive detection. However, the exploration of thermometric probes is hindered by their low relative sensitivity (<i>S</i>_<i>r</i>) or poor structural stability in water. Herein, we propose the first example of organic-inorganic metal halides based on TPP₃Cu₂Br₂ (TPP = triphenylphosphine) that simultaneously present excellent water resistance and sensitive temperature-dependent photoluminescence lifetime in water. Benefiting from the soft lattice induced by the organic molecule of TPP, giant thermal expansion and great lattice distortion were achieved with increasing temperature. As such, the self-trapped exciton luminescence lifetime of TPP₃Cu₂Br₂ can be shortened to 1.9% of the initial value from 280 to 380 K, resulting in the highest <i>S</i>_<i>r</i> of 12.82% K⁻¹ among the undoped metal halides based luminescent thermometers. Significantly, TPP₃Cu₂Br₂ displayed extraordinary water stability with emission intensity remaining nearly unchanged after immersing in water for 15 days. Moreover, high-precision luminescence lifetime based thermal sensing in water environment was successfully conducted, which proved to be inert to the detection depth in water with a small read-out error. This work offers new routes in the exploration of novel metal halides for highly sensitive thermometric probes toward versatile application scenarios.</p>","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144371128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}