理学最新文献

{"title":"Time-dependent physical unclonable functions by long-lived triplet excitons in carbon dots","authors":"Yan-Wei Hu, Qing Cao, Shi-Yu Song, Yuan Sun, Ya-Chuan Liang, Wen-Bo Zhao, Chao-Fan Lv, Chong-Xin Shan, Kai-Kai Liu","doi":"10.1038/s41377-025-01940-9","DOIUrl":"https://doi.org/10.1038/s41377-025-01940-9","url":null,"abstract":"<p>Physical unclonable functions (PUFs), relying extensively on the random spatial distribution of block elements, are promising technology for generating unclonable cryptograph. Herein, we demonstrate time-dependent PUFs (TD-PUFs) by introducing carbon dots (CDs) with bright and long-lived triplet excitons as block elements. The constructed TD-PUFs evolve into multiple unclonable PUFs over time, effectively breaking the spatial limitation of transitional PUFs and increasing the complexity, making them much more difficult to be attacked. This temporal evolution introduces an additional layer of security, as the dynamic nature of TD-PUFs makes it increasingly challenging for adversaries to predict or replicate their states. We have developed pixel matrix function (PMF) to describe the evolution process of the TD-PUFs, enabling a detailed analysis of the dynamic behavior and unique security features. In addition, we exhibit a TD-PUFs painting (30 × 40 cm²) by an etching technology where the primary structures of the panting undergo a transformation over time, driven by the varying triplet exciton lifetimes of the CDs. The proposed concept of TD-PUFs overcome their spatial limitations and increase the complexity, making the PUF labels more difficulty to be cracked.</p>","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144898178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incorporating information of causal variants in genomic prediction using GBLUP or machine learning models in a simulated livestock population.","authors":"Jifan Yang, Mario P L Calus, Yvonne C J Wientjes, Theo H E Meuwissen, Pascal Duenk","doi":"10.1186/s40104-025-01250-5","DOIUrl":"10.1186/s40104-025-01250-5","url":null,"abstract":"<p><strong>Background: </strong>Genomic prediction has revolutionized animal breeding, with GBLUP being the most widely used prediction model. In theory, the accuracy of genomic prediction could be improved by incorporating information from QTL. This strategy could be especially beneficial for machine learning models that are able to distinguish informative from uninformative features. The objective of this study was to assess the benefit of incorporating QTL genotypes in GBLUP and machine learning models. This study simulated a selected livestock population where QTL and their effects were known. We used four genomic prediction models, GBLUP, (weighted) 2GBLUP, random forest (RF), and support vector regression (SVR) to predict breeding values of young animals, and considered different scenarios that varied in the proportion of genetic variance explained by the included QTL.</p><p><strong>Results: </strong>2GBLUP resulted in the highest accuracy. Its accuracy increased when the included QTL explained up to 80% of the genetic variance, after which the accuracy dropped. With a weighted 2GBLUP model, the accuracy always increased when more QTL were included. Prediction accuracy of GBLUP was consistently higher than SVR, and the accuracy for both models slightly increased with more QTL information included. The RF model resulted in the lowest prediction accuracy, and did not improve by including QTL information.</p><p><strong>Conclusions: </strong>Our results show that incorporating QTL information in GBLUP and SVR can improve prediction accuracy, but the extent of improvement varies across models. RF had a much lower prediction accuracy than the other models and did not show improvements when QTL information was added. Two possible reasons for this result are that the data structure in our data does not allow RF to fully realize its potential and that RF is not designed well for this particular prediction problem. Our study highlighted the importance of selecting appropriate models for genomic prediction and underscored the potential limitations of machine learning models when applied to genomic prediction in livestock.</p>","PeriodicalId":64067,"journal":{"name":"Journal of Animal Science and Biotechnology","volume":"16 1","pages":"118"},"PeriodicalIF":6.5,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taurine alleviated paraquat-induced oxidative stress and gut-liver axis damage in weaned piglets by regulating the Nrf2/Keap1 and TLR4/NF-κB signaling pathways.","authors":"Chen Chen, Min Qi, Weilong Zhang, Fanxing Chen, Zhihong Sun, Weizhong Sun, Wenjie Tang, Zhenguo Yang, Xuan Zhao, Zhiru Tang","doi":"10.1186/s40104-025-01244-3","DOIUrl":"10.1186/s40104-025-01244-3","url":null,"abstract":"<p><strong>Background: </strong>Oxidative stress can impair intestinal barrier function and cause liver damage, resulting in reduced animal productivity. Paraquat (PQ) induces significant oxidative stress in weaned piglets. The antioxidant, anti-inflammatory, and metabolic regulatory functions of taurine (Tau), a free amino acid that is widely distributed in the body, have been extensively studied. However, the mechanisms by which dietary Tau alleviates oxidative stress and gut-liver axis damage in weaned piglets remain unclear.</p><p><strong>Methods: </strong>Forty weaned piglets (20 males and 20 females; 6.41 ± 0.11 kg; 25 days old; Duroc × Landrace × Yorkshire) were used in a 2 × 2 factorial design to investigate the mechanism by which dietary Tau (0% or 0.4%) alleviates PQ-induced oxidative stress and gut-liver axis damage. We analyzed key biomarkers related to gut barrier function, mucosal damage repair, liver damage, gut-liver immunity, antioxidant capacity, systemic immune homeostasis, antioxidant levels, and gut microbiota diversity in piglets under normal and acute oxidative stress. In particular, we evaluated the coordinated regulation of gut-liver axis function mediated by Tau through the Nrf2/Keap1 (antioxidant) and TLR4/NF-κB (immune modulation) signaling pathways. Partial least squares path modeling and molecular docking were used to explore the intrinsic relationship between PQ, Tau, and the gut-liver axis.</p><p><strong>Results: </strong>PQ exposure impaired gut barrier function, increased the liver fibrosis area, and markedly affected gut microbial diversity (P < 0.05). Tau effectively alleviated PQ-induced oxidative stress by activating the Nrf2/Keap1 pathway and inhibiting the TLR4/NF-κB pathway. This enhanced gut barrier function, promoted mucosal repair, and significantly suppressed the concentration and circulation of lipopolysaccharides in the blood, consequently reducing liver damage (P < 0.05). This further facilitated the optimization of gut microbiota composition, thereby supporting the positive regulation of the gut-liver axis and improving systemic immune and antioxidant functions.</p><p><strong>Conclusions: </strong>Tau improved the health status of weaned piglets under both normal and stressed conditions by modulating the Nrf2/Keap1 and TLR4/NF-κB pathways, offering a potential new nutritional strategy for alleviating gut-liver damage.</p>","PeriodicalId":64067,"journal":{"name":"Journal of Animal Science and Biotechnology","volume":"16 1","pages":"117"},"PeriodicalIF":6.5,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12359926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of quantum key distribution and high-throughput classical communications in field-deployed multi-core fibers","authors":"Qi Wu, Domenico Ribezzo, Giammarco Di Sciullo, Sebastiano Cocchi, Divya Ann Shaji, Lucas Alves Zischler, Ruben Luis, Paolo Serena, Chiara Lasagni, Alberto Bononi, Tetsuya Hayashi, Alessandro Gagliano, Paolo Martelli, Alberto Gatto, Paola Parolari, Pierpaolo Boffi, Davide Bacco, Alessandro Zavatta, Yixiao Zhu, Weisheng Hu, Zhaopeng Xu, Mark Shtaif, Andrea Marotta, Fabio Graziosi, Antonio Mecozzi, Cristian Antonelli","doi":"10.1038/s41377-025-01982-z","DOIUrl":"https://doi.org/10.1038/s41377-025-01982-z","url":null,"abstract":"<p>Quantum key distribution (QKD) is a secure communication method for sharing symmetric cryptographic keys based on the principles of quantum physics. Its integration into the fiber-optic network infrastructure is important for ensuring privacy in optical communications. Multi-core fibers (MCFs), the likely building blocks of future high-capacity optical networks, offer new opportunities for such integration. Here, we experimentally demonstrate, for the first time, the coexistence of discrete-variable QKD and high-throughput classical communication in the C-band over a field-deployed MCF with industry standard cladding diameter of 125 μm. Specifically, we demonstrate successful secure-key establishment in one core of a 25.2-km uncoupled-core MCF, while simultaneously loading the remaining three cores with full C-band counter-propagating classical traffic at an aggregate net rate of 110.8 Tb/s. By proposing and experimentally validating an improved analytical model for inter-core spontaneous Raman scattering noise, we find that this configuration is optimal for our deployed MCF link as it is immune to four-wave mixing, that becomes relevant when the quantum and classical signals are propagating in the same direction. Our findings make an important step forward in demonstrating the integration of QKD and classical transmission in uncoupled-core multi-core fibers for next-generation optical communication networks.</p>","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"750 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid Kerr-electro-optic frequency combs on thin-film lithium niobate","authors":"Yunxiang Song, Yaowen Hu, Marko Lončar, Kiyoul Yang","doi":"10.1038/s41377-025-01906-x","DOIUrl":"https://doi.org/10.1038/s41377-025-01906-x","url":null,"abstract":"<p>Optical frequency combs are indispensable links between the optical and microwave domains. Chip-scale integration promises compact, scalable, and power-efficient frequency comb sources, enabled by the resonantly-enhanced Kerr effect or the electro-optic effect. While combs utilizing the former can reach octave-spanning bandwidths, and combs based on the latter can feature microwave-rate spacings, achieving both features at the same time has been challenging. Here, we simultaneously leverage the strong Kerr and electro-optic effects on thin-film lithium niobate, where dissipative Kerr soliton generation is followed by electro-optic phase modulation, to realize an integrated frequency comb reference with 2,589 lines spaced by 29.308 GHz and spanning 75.9 THz (588 nm). Further, we demonstrate electronic stabilization and control of the comb spacing, naturally facilitated by this approach. The broadband, microwave-rate frequency comb in our work overcomes the spacing-span tradeoff that exists in nonlinear integrated frequency comb sources, paving the way towards chip-scale solutions for next-generation laser spectroscopy, microwave and millimeter wave synthesis, as well as optical communications.</p>","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"109 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144819934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A dual-mode transparent device for 360° quasi-omnidirectional self-driven photodetection and efficient ultralow-power neuromorphic computing","authors":"Min Jiang, Yukun Zhao, Tong Liu, Yanyan Chang, Yuan Tang, Min Zhou, Yiping Shi, Jianya Zhang, Lifeng Bian, Shulong Lu","doi":"10.1038/s41377-025-01991-y","DOIUrl":"https://doi.org/10.1038/s41377-025-01991-y","url":null,"abstract":"<p>Due to the extremely high manufacturing standards, the integration of quasi-omnidirectional photodetectors and synaptic devices within a single device remains a long-standing challenge. In this work, we have designed a graphene/(Al,Ga)N nanowire heterojunction, demonstrating the monolithic integration of self-driven 360° photodetectors and artificial synapses in a dual-mode transparent device successfully. By manipulating the carrier transport dynamics through controlling the bias voltage, the degree of oxygen vacancy ionization can be precisely regulated, ultimately realizing the monolithic dual-mode device. At 0 V bias, the device functions as a fast-response self-driven photodetector with stable optical communication capabilities, achieving 360° quasi-omnidirectional photodetection. Upon applying a bias voltage, the operating mode switches to a synaptic device, which successfully simulates brain-like paired-pulse facilitation, short-/long-term plasticity processes, and learning/forgetting behaviors. The device demonstrates an exceptionally high UV/visible rejection ratio of 1.29 × 10⁴, coupled with an ultra-low dark current of less than 1 pA. Furthermore, this device has a low power consumption of 2.5 × 10⁻¹⁴ J per synaptic event, indicating an energy efficiency comparable to synaptic processes in the human brain. Moreover, nonlinear photoconductivity lets the device become a neuromorphic sensor for preprocessing images, enhancing recognition accuracy. Importantly, by leveraging the long-memory characteristic of the devices in open-circuit voltage mode, the devices have been successfully applied to guide humanoid robots in performing direction distinguishing and motion learning. This work provides new insights into the integrated manufacturing of multifunctional monolithic devices and foresees their immense potential in upcoming advanced, low-power neuromorphic computing systems.</p>","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144819326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A facile photonics reconfigurable memristor with dynamically allocated neurons and synapses functions","authors":"Zhenyu Zhou, Lulu Wang, Gongjie Liu, Yuchen Li, Zhiyuan Guan, Zixuan Zhang, Pengfei Li, Yifei Pei, Jianhui Zhao, Jiameng Sun, Yahong Wang, Yiduo Shao, Xiaobing Yan","doi":"10.1038/s41377-025-01928-5","DOIUrl":"https://doi.org/10.1038/s41377-025-01928-5","url":null,"abstract":"<p>The dynamic neural network function realized by reconfigurable memristors to implement artificial neurons and synapses is an effective method to complete the next generation of neuromorphic computing. However, due to the limitation of reconfiguration conditions, there are inconsistencies in the turn-on voltage and operating current before and after the reconfiguration of neuromorphic devices, which leads to huge difficulties in hardware application development and is an urgent problem to be solved. In this work, we introduced light as a regulatory means in the memristor and achieved the reconfiguration of volatile (endurance ~10⁶ cycles) and non-volatile (retention ~10⁴ s) characteristics with a unified working parameter through the photoelectric coupling mode. The switching voltage of the device can be controlled 100% by this method without any limiting current. This will allow neurons and synapses to be dynamically allocated on demand. We completed the verification such as Morse code decoding, Poisson coded image recognition, denoising in the image recognition process, and intelligent traffic signal recognition hardware system under different work modes. It is verified that the device can dynamically adjust the neuromorphic according to needs, providing a new idea for the further integration of neuromorphic computing in the future.</p>","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144819937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"15-Fold increase in solar thermoelectric generator performance through femtosecond-laser spectral engineering and thermal management","authors":"Tianshu Xu, Ran Wei, Subhash C. Singh, Chunlei Guo","doi":"10.1038/s41377-025-01916-9","DOIUrl":"https://doi.org/10.1038/s41377-025-01916-9","url":null,"abstract":"<p>Solar thermoelectric generators (STEGs) have recently gained increasing attention. However, their widespread adoption has been limited due to the lack of high-efficiency thermoelectric materials and compact heat sinks for effective heat dissipation. To address these issues, we develop a spectral engineering and thermal management strategy that significantly increases STEG power generation by 15 times with only a 25% increase in weight. At the hot side, we transform a regular tungsten (W) to a selective solar absorber (W-SSA) through a femtosecond (fs)-laser processing technique, which enhances the solar absorption while minimizing the IR emissivity, obtaining &gt;80% absorption efficiency at elevated temperatures. We also design a greenhouse chamber for W-SSA and achieved &gt;40% reduction in convective heat loss. At the cold side, we apply the fs laser processing to transform a regular aluminum (Al) to a super-high-capacity micro-structured heat dissipator (μ-dissipator), which improves the cold-side heat dissipation through both radiation and convection, achieving twice the cooling performance of a regular Al heat dissipator. These spectral engineering and thermal management increase the temperature difference across the STEG, resulting in a substantial increase in output power. The high-efficiency STEG can find a wide range of applications, such as wireless sensor networks, wearable electronics, and medical sensors.</p>","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144819321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visualizing the internalization and biological impact of nanoplastics in live intestinal organoids by Fluorescence Lifetime Imaging Microscopy (FLIM)","authors":"Irina A. Okkelman, Hang Zhou, Sergey M. Borisov, Angela C. Debruyne, Austin E. Y. T. Lefebvre, Marcelo Leomil Zoccoler, Linglong Chen, Bert Devriendt, Ruslan I. Dmitriev","doi":"10.1038/s41377-025-01949-0","DOIUrl":"https://doi.org/10.1038/s41377-025-01949-0","url":null,"abstract":"<p>Increased micro- and nanoplastic (MNP) pollution poses significant health risks, yet the mechanisms of their accumulation and effects on absorptive tissues remain poorly understood. Addressing this knowledge gap requires tractable models coupled to dynamic live cell imaging methods, enabling multi-parameter single cell analysis. We report a new method combining adult stem cell-derived small intestinal organoid cultures with live fluorescence lifetime imaging microscopy (FLIM) to study MNP interactions with gut epithelium. To facilitate this, we optimized live imaging of porcine and mouse small intestinal organoids with an ‘apical-out’ topology. Subsequently, we produced a set of pristine MNPs based on PMMA and PS (&lt;200 nm, doped with deep-red fluorescent dye) and evaluated their interaction with organoids displaying controlled epithelial polarity. We found that nanoparticles interacted differently with apical and basal membranes of the organoids and showed a species-specific pattern of cellular uptake. Using a phasor analysis approach, we demonstrate improved sensitivity of FLIM over conventional intensity-based microscopy. The resulting ‘fluorescence lifetime barcoding’ enabled distinguishing of different types of MNP and their interaction sites within organoids. Finally, we studied short (1 day)- and long (3 day)-term exposure effects of PMMA and PS-based MNPs on mitochondrial function, total cell energy budget and epithelial inflammation. We found that even pristine MNPs could disrupt chemokine production and mitochondrial membrane potential in intestinal epithelial cells. The presented FLIM approach will advance the study of MNP toxicity, their biological impacts on gastrointestinal tissue and enable the tracing of other fluorescent nanoparticles in live organoid and 3D ex vivo systems.</p>","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144819323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Yb-doped fiber with a bat-type refractive index distribution for beyond kilowatt all-fiber single-frequency laser amplification","authors":"Wei Li, Wei Liu, Yu Deng, Yisha Chen, Huan Yang, Qi Chen, Junjie Zheng, Hu Xiao, Zilun Chen, Zhiyong Pan, Pengfei Ma, Zefeng Wang, Lei Si, Shanhui Xu, Jinbao Chen","doi":"10.1038/s41377-025-01956-1","DOIUrl":"https://doi.org/10.1038/s41377-025-01956-1","url":null,"abstract":"<p>High-power single-frequency fiber lasers with diffraction-limited spots are indispensable for a wide range of photonic applications and are particularly in advanced detection and sensing technologies. However, the simultaneous achievement of kilowatt-level output power and diffraction-limited beam quality has remained elusive in all reported single-frequency fiber laser systems to date, primarily due to limitations imposed by the stimulated Brillouin scattering (SBS) effect and transverse mode instability (TMI) effect. In this study, we demonstrate the design and manufacturing of an ultra-low numerical aperture (NA) functional Yb-doped fiber featuring a bat-type refractive index distribution, specifically engineered for single-frequency laser amplification. In the fabrication, we implemented multiple chelate gas filling and particle deposition iterations, leading to an active fiber with a bat-type refractive index distribution. The unique capabilities of this large mode area and high-order modes leakage fiber (HOMLF) were demonstrated by stably amplifying the single-frequency laser with more than one kilowatt output power and near single mode beam quality (M_x² = 1.10, M_x² = 1.18) for the first time. This fiber design advances the leap forward in single-frequency fiber lasers, which could contribute as a novel and efficient laser amplification technique for the next generation of gravitational wave detection systems.</p>","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144819324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}