超宽带碳纳米管热电成像扫描仪在线多波长无损药品质量监测。

IF 23.4 Q1 OPTICS
Miki Kubota,Yuya Kinoshita,Sayaka Hirokawa,Daiki Shikichi,Noa Izumi,Naoko Hagiwara,Daiki Sakai,Yuto Matsuzaki,Minami Yamamoto,Leo Takai,Yukito Kon,Yuto Aoshima,Raito Ota,Mitsuki Kosaka,Meiling Sun,Yukio Kawano,Kou Li
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引用次数: 0

摘要

虽然生产现场的非破坏性在线监测对于药品的安全分发周期至关重要,但开发用于详细动态可视化目标药片中异物和物质组成的分析系统的努力仍然不足。虽然光谱学有望用于制药测试,但在大型设备外壳的在线设置中面临技术挑战,但这项工作通过有选择性地从目标药片的综合光学参考中提取信息辐射波长,展示了紧凑的动态光监测系统。本研究利用碳纳米管(CNT)光热电成像仪和相关的超宽带亚太赫兹(THz)-红外(IR)多波长监测,开发了一种药物制剂药丸无损在线动态检测系统。所提出的系统中的碳纳米管成像仪在现有传感器的超宽带区域工作,促进对外部亚太赫兹红外辐射的多波长光监测。在功能光学材料(如砷化镓、氧化钒、石墨烯、聚合物、过渡金属二硫化物)研究的最新进展中,碳纳米管在共同满足信息高效光吸收和溶液可加工配置方面发挥着有利的主导作用,这些配置可用于制药监测场所的可自由连接的薄膜成像仪的可打印设备制造。上述非破坏性动态监测系统通过集成功能性薄膜成像仪片和紧凑的多个光源来维持在线实验设置。此外,可渗透的亚太赫兹-红外辐射,为每个波长或组成的非金属材料提供不同的透射率值,以非接触的方式识别药物本身的成分材料和隐藏的外来物质。本工作最后通过结合碳纳米管成像仪和紧凑型光学装置的性能,使用非破坏性在线动态光监测系统检查药品的不可见细节特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
In-line multi-wavelength non-destructive pharma quality monitoring with ultrabroadband carbon nanotubes photo-thermoelectric imaging scanners.
While non-destructive in-line monitoring at manufacturing sites is essential for safe distribution cycles of pharmaceuticals, efforts are still insufficient to develop analytical systems for detailed dynamic visualisation of foreign substances and material composition in target pills. Although spectroscopies, expected towards pharma testing, have faced technical challenges in in-line setups for bulky equipment housing, this work demonstrates compact dynamic photo-monitoring systems by selectively extracting informative irradiation-wavelengths from comprehensive optical references of target pills. This work develops a non-destructive in-line dynamic inspection system for pharma agent pills with carbon nanotube (CNT) photo-thermoelectric imagers and the associated ultrabroadband sub-terahertz (THz)-infrared (IR) multi-wavelength monitoring. The CNT imager in the proposed system functions in ultrabroadband regions over existing sensors, facilitating multi-wavelength photo-monitoring against external sub-THz-IR-irradiation. Under recent advances in the investigation of functional optical materials (e.g., gallium arsenide, vanadium oxide, graphene, polymers, transition metal dichalcogenides), CNTs play advantageous leading roles in collectively satisfying informative efficient photo-absorption and solution-processable configurations for printable device fabrication into freely attachable thin-film imagers in pharma monitoring sites. The above non-destructive dynamic monitoring system maintains in-line experimental setups by integrating the functional thin-film imager sheets and compact multiple photo-sources. Furthermore, permeable sub-THz-IR-irradiation, which provides different transmittance values specific to non-metallic materials per wavelength or composition, identifies constituent materials for pharma agents themselves and concealed foreign substances in a non-contact manner. This work finally inspects invisible detailed features of pharma pills with the non-destructive in-line dynamic photo-monitoring system by incorporating performances of CNT imagers and compact optical setups.
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来源期刊
Light-Science & Applications
Light-Science & Applications 数理科学, 物理学I, 光学, 凝聚态物性 II :电子结构、电学、磁学和光学性质, 无机非金属材料, 无机非金属类光电信息与功能材料, 工程与材料, 信息科学, 光学和光电子学, 光学和光电子材料, 非线性光学与量子光学
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