{"title":"超宽带碳纳米管热电成像扫描仪在线多波长无损药品质量监测。","authors":"Miki Kubota,Yuya Kinoshita,Sayaka Hirokawa,Daiki Shikichi,Noa Izumi,Naoko Hagiwara,Daiki Sakai,Yuto Matsuzaki,Minami Yamamoto,Leo Takai,Yukito Kon,Yuto Aoshima,Raito Ota,Mitsuki Kosaka,Meiling Sun,Yukio Kawano,Kou Li","doi":"10.1038/s41377-025-01957-0","DOIUrl":null,"url":null,"abstract":"While non-destructive in-line monitoring at manufacturing sites is essential for safe distribution cycles of pharmaceuticals, efforts are still insufficient to develop analytical systems for detailed dynamic visualisation of foreign substances and material composition in target pills. Although spectroscopies, expected towards pharma testing, have faced technical challenges in in-line setups for bulky equipment housing, this work demonstrates compact dynamic photo-monitoring systems by selectively extracting informative irradiation-wavelengths from comprehensive optical references of target pills. This work develops a non-destructive in-line dynamic inspection system for pharma agent pills with carbon nanotube (CNT) photo-thermoelectric imagers and the associated ultrabroadband sub-terahertz (THz)-infrared (IR) multi-wavelength monitoring. The CNT imager in the proposed system functions in ultrabroadband regions over existing sensors, facilitating multi-wavelength photo-monitoring against external sub-THz-IR-irradiation. Under recent advances in the investigation of functional optical materials (e.g., gallium arsenide, vanadium oxide, graphene, polymers, transition metal dichalcogenides), CNTs play advantageous leading roles in collectively satisfying informative efficient photo-absorption and solution-processable configurations for printable device fabrication into freely attachable thin-film imagers in pharma monitoring sites. The above non-destructive dynamic monitoring system maintains in-line experimental setups by integrating the functional thin-film imager sheets and compact multiple photo-sources. Furthermore, permeable sub-THz-IR-irradiation, which provides different transmittance values specific to non-metallic materials per wavelength or composition, identifies constituent materials for pharma agents themselves and concealed foreign substances in a non-contact manner. This work finally inspects invisible detailed features of pharma pills with the non-destructive in-line dynamic photo-monitoring system by incorporating performances of CNT imagers and compact optical setups.","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"86 1","pages":"306"},"PeriodicalIF":23.4000,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"In-line multi-wavelength non-destructive pharma quality monitoring with ultrabroadband carbon nanotubes photo-thermoelectric imaging scanners.\",\"authors\":\"Miki Kubota,Yuya Kinoshita,Sayaka Hirokawa,Daiki Shikichi,Noa Izumi,Naoko Hagiwara,Daiki Sakai,Yuto Matsuzaki,Minami Yamamoto,Leo Takai,Yukito Kon,Yuto Aoshima,Raito Ota,Mitsuki Kosaka,Meiling Sun,Yukio Kawano,Kou Li\",\"doi\":\"10.1038/s41377-025-01957-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"While non-destructive in-line monitoring at manufacturing sites is essential for safe distribution cycles of pharmaceuticals, efforts are still insufficient to develop analytical systems for detailed dynamic visualisation of foreign substances and material composition in target pills. Although spectroscopies, expected towards pharma testing, have faced technical challenges in in-line setups for bulky equipment housing, this work demonstrates compact dynamic photo-monitoring systems by selectively extracting informative irradiation-wavelengths from comprehensive optical references of target pills. This work develops a non-destructive in-line dynamic inspection system for pharma agent pills with carbon nanotube (CNT) photo-thermoelectric imagers and the associated ultrabroadband sub-terahertz (THz)-infrared (IR) multi-wavelength monitoring. The CNT imager in the proposed system functions in ultrabroadband regions over existing sensors, facilitating multi-wavelength photo-monitoring against external sub-THz-IR-irradiation. Under recent advances in the investigation of functional optical materials (e.g., gallium arsenide, vanadium oxide, graphene, polymers, transition metal dichalcogenides), CNTs play advantageous leading roles in collectively satisfying informative efficient photo-absorption and solution-processable configurations for printable device fabrication into freely attachable thin-film imagers in pharma monitoring sites. The above non-destructive dynamic monitoring system maintains in-line experimental setups by integrating the functional thin-film imager sheets and compact multiple photo-sources. Furthermore, permeable sub-THz-IR-irradiation, which provides different transmittance values specific to non-metallic materials per wavelength or composition, identifies constituent materials for pharma agents themselves and concealed foreign substances in a non-contact manner. This work finally inspects invisible detailed features of pharma pills with the non-destructive in-line dynamic photo-monitoring system by incorporating performances of CNT imagers and compact optical setups.\",\"PeriodicalId\":18069,\"journal\":{\"name\":\"Light-Science & Applications\",\"volume\":\"86 1\",\"pages\":\"306\"},\"PeriodicalIF\":23.4000,\"publicationDate\":\"2025-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Light-Science & Applications\",\"FirstCategoryId\":\"1089\",\"ListUrlMain\":\"https://doi.org/10.1038/s41377-025-01957-0\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPTICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Light-Science & Applications","FirstCategoryId":"1089","ListUrlMain":"https://doi.org/10.1038/s41377-025-01957-0","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPTICS","Score":null,"Total":0}
While non-destructive in-line monitoring at manufacturing sites is essential for safe distribution cycles of pharmaceuticals, efforts are still insufficient to develop analytical systems for detailed dynamic visualisation of foreign substances and material composition in target pills. Although spectroscopies, expected towards pharma testing, have faced technical challenges in in-line setups for bulky equipment housing, this work demonstrates compact dynamic photo-monitoring systems by selectively extracting informative irradiation-wavelengths from comprehensive optical references of target pills. This work develops a non-destructive in-line dynamic inspection system for pharma agent pills with carbon nanotube (CNT) photo-thermoelectric imagers and the associated ultrabroadband sub-terahertz (THz)-infrared (IR) multi-wavelength monitoring. The CNT imager in the proposed system functions in ultrabroadband regions over existing sensors, facilitating multi-wavelength photo-monitoring against external sub-THz-IR-irradiation. Under recent advances in the investigation of functional optical materials (e.g., gallium arsenide, vanadium oxide, graphene, polymers, transition metal dichalcogenides), CNTs play advantageous leading roles in collectively satisfying informative efficient photo-absorption and solution-processable configurations for printable device fabrication into freely attachable thin-film imagers in pharma monitoring sites. The above non-destructive dynamic monitoring system maintains in-line experimental setups by integrating the functional thin-film imager sheets and compact multiple photo-sources. Furthermore, permeable sub-THz-IR-irradiation, which provides different transmittance values specific to non-metallic materials per wavelength or composition, identifies constituent materials for pharma agents themselves and concealed foreign substances in a non-contact manner. This work finally inspects invisible detailed features of pharma pills with the non-destructive in-line dynamic photo-monitoring system by incorporating performances of CNT imagers and compact optical setups.