理学最新文献_第8页

Three-color single-molecule localization microscopy in chromatin

Light-Science & Applications Pub Date : 2025-03-17 DOI: 10.1038/s41377-025-01786-1

Nicolas Acosta, Ruyi Gong, Yuanzhe Su, Jane Frederick, Karla I. Medina, Wing Shun Li, Kiana Mohammadian, Luay Almassalha, Geng Wang, Vadim Backman

{"title":"Three-color single-molecule localization microscopy in chromatin","authors":"Nicolas Acosta, Ruyi Gong, Yuanzhe Su, Jane Frederick, Karla I. Medina, Wing Shun Li, Kiana Mohammadian, Luay Almassalha, Geng Wang, Vadim Backman","doi":"10.1038/s41377-025-01786-1","DOIUrl":"https://doi.org/10.1038/s41377-025-01786-1","url":null,"abstract":"Super-resolution microscopy has revolutionized our ability to visualize structures below the diffraction limit of conventional optical microscopy and is particularly useful for investigating complex biological targets like chromatin. Chromatin exhibits a hierarchical organization with structural compartments and domains at different length scales, from nanometers to micrometers. Single molecule localization microscopy (SMLM) methods, such as STORM, are essential for studying chromatin at the supra-nucleosome level due to their ability to target epigenetic marks that determine chromatin organization. Multi-label imaging of chromatin is necessary to unpack its structural complexity. However, these efforts are challenged by the high-density nuclear environment, which can affect antibody binding affinities, diffusivity and non-specific interactions. Optimizing buffer conditions, fluorophore stability, and antibody specificity is crucial for achieving effective antibody conjugates. Here, we demonstrate a sequential immunolabeling protocol that reliably enables three-color studies within the dense nuclear environment. This protocol couples multiplexed localization datasets with a robust analysis algorithm, which utilizes localizations from one target as seed points for distance, density and multi-label joint affinity measurements to explore complex organization of all three targets. Applying this multiplexed algorithm to analyze distance and joint density reveals that heterochromatin and euchromatin are not-distinct territories, but that localization of transcription and euchromatin couple with the periphery of heterochromatic clusters. This work is a crucial step in molecular imaging of the dense nuclear environment as multi-label capacity enables for investigation of complex multi-component systems like chromatin with enhanced accuracy.","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"183 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physisorption-assistant optoelectronic synaptic transistors based on Ta2NiSe5/SnS2 heterojunction from ultraviolet to near-infrared

Light-Science & Applications Pub Date : 2025-03-17 DOI: 10.1038/s41377-025-01792-3

Fan Tan, Chunlu Chang, Nan Zhang, Junru An, Mingxiu Liu, Xingyu Zhao, Mengqi Che, Zhilin Liu, Yaru Shi, Yahui Li, Yanze Feng, Chao Lin, Yuquan Zheng, Dabing Li, Mario Lanza, Shaojuan Li

{"title":"Physisorption-assistant optoelectronic synaptic transistors based on Ta2NiSe5/SnS2 heterojunction from ultraviolet to near-infrared","authors":"Fan Tan, Chunlu Chang, Nan Zhang, Junru An, Mingxiu Liu, Xingyu Zhao, Mengqi Che, Zhilin Liu, Yaru Shi, Yahui Li, Yanze Feng, Chao Lin, Yuquan Zheng, Dabing Li, Mario Lanza, Shaojuan Li","doi":"10.1038/s41377-025-01792-3","DOIUrl":"https://doi.org/10.1038/s41377-025-01792-3","url":null,"abstract":"Neuromorphic computing vision is the most promising technological solution to overcome the arithmetic bottleneck in machine vision applications. All-in-one neuromorphic sensors have been attracting increased attention because they can integrate visual perception, processing, and memory functionalities into one single device. However, the limited responsivity and data retention time of all-in-one neuromorphic sensors usually hinder their potential in multispectral machine vision, especially in the near-infrared (NIR) band which contains critical information for pattern recognition. Here, we demonstrate physisorption-assistant optoelectronic synaptic transistors based on Ta2NiSe5/SnS2 heterojunction, which present tunable synaptic functionality in broadband (375–1310 nm). We propose a strategy about the physisorption-assistant persistent photoconductivity (PAPPC) effect to effectively solve the problem in detecting and storing the NIR light information. Under this strategy, the responsivity and data retention time of our devices were significantly enhanced and prolonged in broadband from 375 to 1310 nm. Further, the devices realize multilevel non-volatile optoelectronic memory through the modulation of several optical and back-gate signals to simulate emotion-controlled learning and memory processes, optical writing-electric erasing, and associative learning. Moreover, we developed a simplified human visual system to simulate color-cognitive perception and memory functions. Our approach offers a route for creating advanced all-in-one neuromorphic sensors and developing neuromorphic computing vision.","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"214 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topological beaming of light: proof-of-concept experiment

Light-Science & Applications Pub Date : 2025-03-13 DOI: 10.1038/s41377-025-01799-w

Yu Sung Choi, Ki Young Lee, Soo-Chan An, Minchul Jang, Youngjae Kim, Seungjin Yoon, Seung Han Shin, Jae Woong Yoon

引用次数: 0

Non-aqueous electrowetting liquid lens with centimeter-level large aperture based on dielectric failure suppression principle

Light-Science & Applications Pub Date : 2025-03-12 DOI: 10.1038/s41377-025-01777-2

You-Ran Zhao, Zhao-Song Li, Yi Zheng, Di Wang, Xiao-Ke Lu, Yu-Cheng Lin, Hao-Ran Zhang, Chao Liu, Qiong-Hua Wang

{"title":"Non-aqueous electrowetting liquid lens with centimeter-level large aperture based on dielectric failure suppression principle","authors":"You-Ran Zhao, Zhao-Song Li, Yi Zheng, Di Wang, Xiao-Ke Lu, Yu-Cheng Lin, Hao-Ran Zhang, Chao Liu, Qiong-Hua Wang","doi":"10.1038/s41377-025-01777-2","DOIUrl":"https://doi.org/10.1038/s41377-025-01777-2","url":null,"abstract":"Liquid lens offers a novel approach to achieving large depth of field, wide viewing angle, high speed, and high-quality imaging in zoom optical systems. However, the aperture and reliability limit the lens’s performance in various optical applications. The liquid material is crucial for the reliability of the large-aperture liquid lens. To solve the dielectric failure problem associated with the large aperture, we first reveal the mechanism of dielectric failure based on the transport properties of electrolyte solutions and the impact of electrochemical reaction rates from physical chemistry so as to propose a theoretical method to suppress dielectric failure fundamentally. Based on this theory, we develop a series of non-aqueous organic solutions to suppress high-voltage dielectric failure. Next, we identify the optimal formulation for comprehensive optical performance and fabricate a centimeter-level large-aperture electrowetting liquid lens. This lens features an optical power variation range of −11.98 m−1 to 12.93 m−1, with clear and high-quality imaging function, which can enlarge the field of view and depth adjustment range of holographic reconstructions while maintaining excellent edge clarity of the reconstructed images. The proposed centimeter-level large-aperture non-aqueous electrowetting liquid lens effectively suppresses dielectric failure under high voltage, demonstrates excellent optical performance, and holds exciting potential for applications in 3D display, precision measurement, biomedical observation, and more.","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143599006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Airborne optical imaging technology: a road map in CIOMP

Light-Science & Applications Pub Date : 2025-03-10 DOI: 10.1038/s41377-025-01776-3

Ping Jia, Dapeng Tian, Yutang Wang, Dong Yao, Rui Xu, Jianwei Sun, Hui Sun, Bao Zhang

{"title":"Airborne optical imaging technology: a road map in CIOMP","authors":"Ping Jia, Dapeng Tian, Yutang Wang, Dong Yao, Rui Xu, Jianwei Sun, Hui Sun, Bao Zhang","doi":"10.1038/s41377-025-01776-3","DOIUrl":"https://doi.org/10.1038/s41377-025-01776-3","url":null,"abstract":"Airborne optical imaging can flexibly obtain the intuitive information of the observed scene from the air, which plays an important role of modern optical remote sensing technology. Higher resolution, longer imaging distance, and broader coverage are the unwavering pursuits in this research field. Nevertheless, the imaging environment during aerial flights brings about multi-source dynamic interferences such as temperature, air pressure, and complex movements, which forms a serious contradiction with the requirements of precision and relative staticity in optical imaging. As the birthplace of Chinese optical industry, the Changchun Institute of Optics, Fine Mechanics and Physics (CIOMP) has conducted the research on airborne optical imaging for decades, resulting in rich innovative achievements, completed research conditions, and exploring a feasible development path. This article provides an overview of the innovative work of CIOMP in the field of airborne optical imaging, sorts out the milestone nodes, and predicts the future development direction of this discipline, with the aim of providing inspiration for related research.","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"91 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OFC: Outside Front Cover

IF 9.1

Green Chemical Engineering Pub Date : 2025-03-10 DOI: 10.1016/S2666-9528(25)00006-8

引用次数: 0

Outside Back Cover

IF 9.1

Green Chemical Engineering Pub Date : 2025-03-10 DOI: 10.1016/S2666-9528(25)00015-9

引用次数: 0

Fluorine-modified passivator for efficient vacuum-deposited pure-red perovskite light-emitting diodes

Light-Science & Applications Pub Date : 2025-03-10 DOI: 10.1038/s41377-025-01740-1

Nian Liu, Zhengzheng Liu, Yuanlong Huang, Peipei Du, Xiang Zhang, Yuxin Leng, Jiajun Luo, Juan Du, Jiang Tang

引用次数: 0

Relay-projection microscopic telescopy

Light-Science & Applications Pub Date : 2025-03-07 DOI: 10.1038/s41377-025-01800-6

Wenjun Yi, Shuyue Zhu, Meicheng Fu, Nan Gu, Junli Qi, Siyu Liu, Mengjun Zhu, Ping Wang, Xin Chen, Yi Zhang, Hongyu Zhang, Yao Xu, Junyi Du, Peng Xiong, Zhaohua Dong, Luobing Dong, Qiong Liu, Xiujian Li

{"title":"Relay-projection microscopic telescopy","authors":"Wenjun Yi, Shuyue Zhu, Meicheng Fu, Nan Gu, Junli Qi, Siyu Liu, Mengjun Zhu, Ping Wang, Xin Chen, Yi Zhang, Hongyu Zhang, Yao Xu, Junyi Du, Peng Xiong, Zhaohua Dong, Luobing Dong, Qiong Liu, Xiujian Li","doi":"10.1038/s41377-025-01800-6","DOIUrl":"https://doi.org/10.1038/s41377-025-01800-6","url":null,"abstract":"The fundamental trade-off between spatial resolution and imaging distance poses a significant challenge for current imaging techniques, such as those used in modern biomedical diagnosis and remote sensing. Here, we introduce a new conceptual method for imaging dynamic amplitude-phase-mixed objects, termed relay-projection microscopic telescopy (rPMT), which fundamentally challenges conventional light collection techniques by employing non-line-of-sight light collection through square-law relay-projection mechanisms. We successfully resolved tiny features measuring 2.76 μm, 22.10 μm, and 35.08 μm for objects positioned at distances of 1019.0 mm, 26.4 m, and 96.0 m, respectively, from single-shot spatial power spectrum images captured on the relay screen; these results demonstrate that the resolution capabilities of rPMT significantly surpass the Abbe diffraction limit of the 25 mm-aperture camera lens at the respective distances, achieving resolution improvement factors of 7.9, 25.4, and 58.2. The rPMT exhibits long-distance, wide-range, high-resolution imaging capabilities that exceed the diffraction limit of the camera lens and the focusing range limit, even when the objects are obscured by a scattering medium. The rPMT enables telescopic imaging from centimeters to beyond hundreds of meters with micrometer-scale resolution using simple devices, including a laser diode, a portable camera, and a diffusely reflecting whiteboard. Unlike contemporary high-resolution imaging techniques, our method does not require labeling reagents, wavefront modulation, synthetic receive aperture, or ptychography scanning, which significantly reduce the complexity of the imaging system and enhance the application practicality. This method holds particular promise for in-vivo label-free dynamic biomedical microscopic imaging diagnosis and remote surveillance of small objects.","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dimensionality-enhanced mid-infrared light vortex detection based on multilayer graphene

Light-Science & Applications Pub Date : 2025-03-06 DOI: 10.1038/s41377-024-01735-4

Dehong Yang, Jiawei Lai, Zipu Fan, Shiyu Wang, Kainan Chang, Lili Meng, Jinluo Cheng, Dong Sun

{"title":"Dimensionality-enhanced mid-infrared light vortex detection based on multilayer graphene","authors":"Dehong Yang, Jiawei Lai, Zipu Fan, Shiyu Wang, Kainan Chang, Lili Meng, Jinluo Cheng, Dong Sun","doi":"10.1038/s41377-024-01735-4","DOIUrl":"https://doi.org/10.1038/s41377-024-01735-4","url":null,"abstract":"Recent conceptual demonstrations of direct photocurrent readout of light vortices have enabled the development of light orbital angular momentum-sensitive focal plane arrays and on-chip integration of orbital angular momentum detection. However, known orbital angular momentum-sensitive materials are limited to two topological Weyl Semimetals belonging to the C2v point group, namely, WTe2 and TaIrTe4. Both are fragile under ambient conditions and challenging for large-scale epitaxial growth. In this work, we demonstrate that multilayer graphene, which is complementary metal–oxide–semiconductor compatible and epitaxially growable at the wafer scale, is applicable for orbital angular momentum detection in the mid-infrared region. Using a multilayer graphene photodetector with a designed U-shaped electrode geometry, we demonstrate that the topological charge of orbital angular momentum can be detected directly through the orbital photogalvanic effect and that the orbital angular momentum recognition capability of multilayer graphene is an order of magnitude greater than that of TaIrTe4. We found that the detection capability of multilayer graphene is enabled by the enhanced orbital photogalvanic effect response due to the reduced dimensionality and scattering rate. Our work opens a new technical route to improve orbital angular momentum recognition capability and is immediately applicable for large-scale integration of ambient stable, mid-infrared direct orbital angular momentum photodetection devices.","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0