理学最新文献

{"title":"Diagnosis of West Nile virus infections: Evaluation of different laboratory methods.","authors":"Tatjana Vilibic-Cavlek, Maja Bogdanic, Vladimir Savic, Zeljka Hruskar, Ljubo Barbic, Vladimir Stevanovic, Ljiljana Antolasic, Ljiljana Milasincic, Dario Sabadi, Gorana Miletic, Ivona Coric, Anna Mrzljak, Eddy Listes, Giovanni Savini","doi":"10.5501/wjv.v13.i4.95986","DOIUrl":"10.5501/wjv.v13.i4.95986","url":null,"abstract":"<p><strong>Background: </strong>The diagnosis of West Nile virus (WNV) is challenging due to short-term and low-level viremia, flavivirus cross-reactivity, and long immunoglobulin M (IgM) persistence.</p><p><strong>Aim: </strong>To evaluate different methods for WNV detection [reverse transcription-polymerase chain reaction (RT-PCR), IgM/IgG antibodies, IgG avidity] in serum, cerebrospinal fluid (CSF), and urine samples of patients with confirmed WNV infection.</p><p><strong>Methods: </strong>The study included patients with confirmed WNV neuroinvasive infection (<i>n</i> = 62), asymptomatic WNV seropositive individuals (<i>n</i> = 22), and individuals with false-positive WNV IgM antibodies (<i>n</i> = 30). WNV RNA was detected using RT-PCR. A commercial ELISA was used to detect WNV IgM/IgG antibodies with confirmation of cross-reactive samples using a virus neutralization test (VNT). IgG-positive samples were tested for IgG avidity.</p><p><strong>Results: </strong>The WNV-RNA detection rates were significantly higher in the urine (54.5%)/serum (46.4%) than in CSF (32.2%). According to the sampling time, the WNV-RNA detection rates in urine collected within 7 days/8-14/≥ 15 days were 29.4/66.6/62.5% (<i>P</i> = 0.042). However, these differences were not observed in the CSF. The median RT-PCR cycle threshold values were significantly lower in urine (32.5, IQR = 28-34) than in CSF (34.5, IQR = 33-36). The frequency of positive WNV IgM and IgG significantly differed according to the sampling time in serum but not in CSF. Positive IgM/IgG antibodies were detected in 84.3/9.3% of serum samples collected within 7 days, 100/71.1% of samples collected 8-14, and 100% samples collected after ≥ 15 days. Recent WNV infection was confirmed by low/borderline avidity index (AI) in 13.6% of asymptomatic individuals. A correlation between ELISA and AI was strong negative for IgM and strong positive for IgG. No significant correlation between ELISA IgG and VNT was found.</p><p><strong>Conclusion: </strong>The frequency of WNV RNA and antibody detection depends on the sampling time and type of clinical samples. IgG avidity could differentiate recent WNV infections from long-persisting IgM antibodies.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"13 4","pages":"95986"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 in pregnancy: Perinatal outcomes and complications.","authors":"Karolina Akinosoglou, Georgios Schinas, Evangelia Papageorgiou, Theodoros Karampitsakos, Vasiliki Dimakopoulou, Eleni Polyzou, Argyrios Tzouvelekis, Markos Marangos, Despoina Papageorgiou, Nikolaos Spernovasilis, George Adonakis","doi":"10.5501/wjv.v13.i4.96573","DOIUrl":"10.5501/wjv.v13.i4.96573","url":null,"abstract":"<p><strong>Background: </strong>The risk of severe coronavirus disease 2019 (COVID-19) in pregnant women is elevated.</p><p><strong>Aim: </strong>To examine the outcomes of pregnant women with COVID-19 and report perinatal outcomes and complications, while providing a brief review of current literature.</p><p><strong>Methods: </strong>The study included pregnant women presenting from April 2020 to February 2022 to the emergency department (ED) of a tertiary hospital. We retrospectively recorded the maternal and perinatal files, including patient epidemiological and clinical characteristics, laboratory values, outcomes, treatment modalities and associations were explored.</p><p><strong>Results: </strong>Among the 60 pregnant women, 25% required hospitalization, all of whom were symptomatic. Preterm delivery occurred in 30% of cases. Ten percent of neonates required admission to the neonatal intensive care unit, and 5% were classified as small for their gestational age. All mothers survived COVID-19 and pregnancy, with 6.6% requiring invasive mechanical ventilation. Preterm delivery rates did not differ between hospitalized and non-hospitalized pregnant women; composite unfavorable perinatal outcomes, including stillbirth, small for gestational age, or neonatal intensive care unit (ICU) admission, did not significantly increase in the cases hospitalized for COVID-19 (<i>P</i> = 0.09). The odds of hospitalization increased 2.3-fold for each day of delayed ED presentation [adj. OR (95%CI: 1.46-3.624), <i>P</i> < 0.001]. Comorbidity status was an independent predictor of hospitalization, albeit with marginal significance [adj. OR = 16.13 (95%CI: 1.021-255.146), <i>P</i> = 0.048]. No independent predictors of adverse fetal outcome (composite) were identified, and eventual hospitalization failed to reach statistical significance by a slight margin (<i>P</i> = 0.054).</p><p><strong>Conclusion: </strong>Delayed ED presentation and comorbidities increase hospitalization odds. This study highlights the importance of continuous and specific guidance for managing pregnant COVID-19 patients, including timely and appropriate interventions to minimize maternal and perinatal morbidity and mortality.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"13 4","pages":"96573"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding rhabdomyolysis induced acute kidney injury in patients with COVID-19.","authors":"Alexander Ikanović, Karan Varshney","doi":"10.5501/wjv.v13.i4.101065","DOIUrl":"10.5501/wjv.v13.i4.101065","url":null,"abstract":"<p><p>This work comments on an article published in the recent issue of the <i>World Journal of Virology</i>. Rhabdomyolysis is a complex condition with symptoms such as myalgia, changes to urination, and weakness. With the potential for substantial kidney impairment, it has also been shown to be a severe complication of coronavirus disease 2019 (COVID-19). To date, various theoretical explanations exist for the development of rhabdomyolysis induced acute kidney injury (RIAKI) in COVID-19 infection, including the accumulation of released striated muscle myoglobin in the urine (myoglobinuria). In their article, they (2024) demonstrate in a retrospective study that RIAKI in COVID-19 patients tended to have elevated levels of C-reactive protein, ferritin, and procalcitonin. These patients also had poorer overall prognoses when compared to COVID-19 patients who have acute kidney injury (AKI) due to other causes. It is clear from these findings that clinicians must closely monitor and assess for the presence of rhabdomyolysis in COVID-19 patients who have developed AKIs. Moreover, additional research is required to further understand the mechanisms behind the development of RIAKI in COVID-19 patients in order to better inform treatment guidelines and protocols.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"13 4","pages":"101065"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptance of COVID-19 vaccine and its related determinants in Nigeria: An online survey.","authors":"Eyiuche D Ezigbo, Seyi S Enitan, Esther N Adejumo, Abiodun E Durosinmi, Richard Y Akele, Michael O Dada, Grace E Itodo, Abah M Idoko, Okeoghene M Edafetanure-Ibeh, Edwin N Okafor, Adedeji A Abdulsalam, Oyekan I Oyedoyin, Polit U Yelpoji, Ogunwola O Opeyemi, Ogbuji S Nmesomachi, Adesola O Oyekale, Chisom B Onyeji","doi":"10.5501/wjv.v13.i4.98551","DOIUrl":"10.5501/wjv.v13.i4.98551","url":null,"abstract":"<p><strong>Background: </strong>Vaccine hesitancy is a major challenge in the fight against the coronavirus disease 2019 (COVID-19) pandemic. Identifying the sociodemographic factors associated with vaccine acceptance among Nigerians is crucial for improving vaccine uptake.</p><p><strong>Aim: </strong>To assess the acceptance rate of COVID-19 vaccine and its related determinants among Nigerians.</p><p><strong>Methods: </strong>An online cross-sectional survey (observational study) was conducted between February 2021 and May 2021, using a questionnaire hosted on SurveyMonkey. The invitation to take part in the poll was sent out to participants through social networking platforms. A logistic regression was used to determine which sociodemographic factors were associated with vaccine acceptance constructs.</p><p><strong>Results: </strong>A total of 1800 persons responded to the survey, a larger proportion of whom were males (53.9%) and within the age group of 21-30 years (29.4%) and earned an average income of less than $500 per month (43.3%). Only 0.56% of participants had a high perceived risk of COVID-19 infection, while only 1.11% had a perceived risk of dying from COVID-19. The perception rate of the COVID-19 vaccine among participants was 51.1%, while the acceptance rate was 63.9%. There was no significant association between the COVID-19 vaccine acceptance rate and related determinants assessed, particularly age (<i>χ</i>² = 3.049, <i>P</i> = 0.550), sex (<i>χ</i>² = 0.102, <i>P</i> = 0.749), average income (<i>χ</i>² = 3.802, <i>P</i> = 0.875), and religion (<i>χ</i>² = 2.819, <i>P</i> = 0.420). Participants with chronic conditions demonstrated a higher acceptance rate compared to the general population.</p><p><strong>Conclusion: </strong>Despite the positive perception observed and substantial vaccine acceptance rate among the study participants, more public health interventions are still needed to enhance vaccine acceptability in Nigeria.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"13 4","pages":"98551"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Candidemia chronicles: Retrospective analysis of candidemia epidemiology, species distribution, and antifungal susceptibility patterns in Bahrain.","authors":"Nermin Kamal Saeed, Safiya Almusawi, Mohammed Al-Beltagi","doi":"10.5501/wjv.v13.i4.98839","DOIUrl":"10.5501/wjv.v13.i4.98839","url":null,"abstract":"<p><strong>Background: </strong>Invasive fungal infections, particularly candidemia, pose significant clinical challenges globally. Understanding local epidemiology, species distribution, and antifungal susceptibility patterns is crucial for effective management despite regional variations.</p><p><strong>Aim: </strong>To investigate the epidemiology, species distribution, antifungal susceptibility patterns, and associated risk factors of candidemia among patients in Bahrain from 2021 to 2023.</p><p><strong>Methods: </strong>This retrospective study analyzed demographic data, <i>Candida</i> species distribution, antifungal susceptibility profiles, and risk factors among candidemia patients treated at a tertiary care hospital in Bahrain over three years. Data was collected from medical records and analyzed using descriptive statistics.</p><p><strong>Results: </strong>A total of 430 candidemia cases were identified. The mean age of patients was 65.7 years, with a mortality rate of 85.5%. <i>Candida albicans</i> (<i>C. albicans</i>) was the most common species, followed by <i>Candida parapsilosis</i>, <i>Candida tropicalis (C. tropicalis)</i>, and emerging multidrug-resistant <i>Candida auris</i> (<i>C. auris</i>). Antifungal susceptibility varied across species, with declining susceptibility to azoles observed, particularly among <i>C. albicans</i> and <i>C. tropicalis</i>. Major risk factors included central venous catheters, broad-spectrum antibiotics, and surgical procedures.</p><p><strong>Conclusion: </strong>This study highlights the substantial burden of candidemia among older adults in Bahrain, characterized by diverse <i>Candida</i> species. It also concerns levels of antifungal resistance, notably in <i>C. auris</i>. The findings underscore the importance of local epidemiological surveillance and tailored treatment strategies to improve outcomes and mitigate the spread of multidrug-resistant <i>Candida</i> species. Future research should focus on molecular resistance mechanisms and optimizing therapeutic approaches to address this growing public health concern.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"13 4","pages":"98839"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights from respiratory virus co-infections.","authors":"Vasiliki E Georgakopoulou","doi":"10.5501/wjv.v13.i4.98600","DOIUrl":"10.5501/wjv.v13.i4.98600","url":null,"abstract":"<p><p>Respiratory viral co-infections present significant challenges in clinical settings due to their impact on disease severity and patient outcomes. Current diagnostic methods often miss these co-infections, complicating the epidemiology and management of these cases. Research, primarily conducted <i>in vitro</i> and <i>in vivo</i>, suggests that co-infections can lead to more severe illnesses, increased hospitalization rates, and greater healthcare utilization, especially in high-risk groups such as children, the elderly, and immunocompromised individuals. Common co-infection patterns, risk factors, and their impact on disease dynamics highlight the need for advanced diagnostic techniques and tailored therapeutic strategies. Understanding the virological interactions and immune response modulation during co-infections is crucial for developing effective public health interventions and improving patient outcomes. Future research should focus on the molecular mechanisms of co-infection and the development of specific therapies to mitigate the adverse effects of these complex infections.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"13 4","pages":"98600"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of vitamin D on COVID-19 and other viral diseases.","authors":"Basavraj S Nagoba, Ajay M Gavkare, Abhijit S Rayate, Neeta Nanaware, Sachin Bhavthankar","doi":"10.5501/wjv.v13.i4.100356","DOIUrl":"10.5501/wjv.v13.i4.100356","url":null,"abstract":"<p><p>This editorial aims to elucidate the intricate relationship between vitamin D and viral pathogenesis. It explores the anticipated role of vitamin D as a modulator in the immune response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other viral pathogens. The editorial comments are based on the review article by Engin <i>et al</i>. The potential role of vitamin D in modulating immune responses has been highlighted by several studies, suggesting that it may influence both the risk and severity of infections. Vitamin D receptors are present in immunocompetent cells, which indicates that vitamin D can potentially modulate innate and adaptive immune responses. This context is relevant in the pathophysiology of coronavirus disease 2019 (COVID-19), where the immune response to the virus can significantly impact the disease progression and outcome. The immunomodulatory effects of vitamin D can protect against SARS-CoV-2 infection by enhancing innate and adaptive immune responses. It also maintains the integrity of the body's physical barriers and modulates inflammatory responses, thereby preventing entry and replication of the virus. Many studies have suggested that adequate vitamin D levels help alleviate morbidity and mortality associated with COVID-19. Furthermore, vitamin D supplementation has been linked with a lower risk of severe disease and mortality in COVID-19 patients, particularly in those with a deficiency during seasons with less sunlight exposure.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"13 4","pages":"100356"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compositional engineering of phase-stable and highly efficient deep-red emitting phosphor for advanced plant lighting systems","authors":"Jianwei Qiao, Dehong Li, Qiufeng Shi, Haijie Guo, Ping Huang, Lei Wang","doi":"10.1038/s41377-024-01679-9","DOIUrl":"https://doi.org/10.1038/s41377-024-01679-9","url":null,"abstract":"<p>Inorganic luminescent materials hold great promise for optoelectronic device applications, yet the limited efficiency and poor thermal stability of oxide-based deep-red emitting phosphors hinder the advancement of plant lighting technologies. Herein, a simple compositional engineering strategy is proposed to stabilize the phase, boost external quantum efficiency (EQE) and enhance thermal stability. The chemical modification of the PO₄ tetrahedron in NaMgPO₄:Eu by incorporating SiO₄ lowers the formation energy, leading to the generation of pure olivine phase and increasing the EQE from 27% to 52%, setting a record for oxide deep-red phosphors. In parallel, the introduced deep defect level improves thermal stability at 150 °C from 62.5% to 85.4%. Besides, the excitation and emission peaks shifted to 440 nm and 675 nm, respectively, aligning precisely with the specific spectral absorption requirements of plant phytochromes. Moreover, the luminescent intensity showed nearly no decay after being exposed to 80% relative humidity and 80 ^oC for 6 h, and the pc-LED utilizing Na_1.06MgP_0.94Si_0.06O₄:Eu achieves a high output power of 780 mW at 300 mA. Our research demonstrates a facile method for optimizing the performance of inorganic luminescent materials and provides alternative solutions for low-cost plant lighting.</p>","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking high-performance near-infrared photodetection: polaron-assisted organic integer charge transfer hybrids","authors":"Muhammad Ahsan Iqbal, Xueqian Fang, Yasir Abbas, Xiaoliang Weng, Tingchao He, Yu-Jia Zeng","doi":"10.1038/s41377-024-01695-9","DOIUrl":"https://doi.org/10.1038/s41377-024-01695-9","url":null,"abstract":"<p>Room temperature femtowatt sensitivity remains a sought-after attribute, even among commercial inorganic infrared (IR) photodetectors (PDs). While organic IR PDs are poised to emerge as a pivotal sensor technology in the forthcoming Fourth-Generation Industrial Era, their performance lags behind that of their inorganic counterparts. This discrepancy primarily stems from poor external quantum efficiencies (<i>EQE</i>), driven by inadequate exciton dissociation (high exciton binding energy) within organic IR materials, exacerbated by pronounced non-radiative recombination at narrow bandgaps. Here, we unveil a high-performance organic Near-IR (NIR) PD via integer charge transfer between Poly[2,5-bis(3-tetradecylthiophen-2-yl)thieno[3,2-b]thiophene] (C-14PBTTT) donor (D) and Tetrafluorotetracyanoquinodimethane (TCNQF4) acceptor (A) molecules, showcasing strong low-energy subgap absorptions up to 2.5 µm. We observe that specifically, polaron excitation in these radical and neutral D-A blended molecules enables bound charges to exceed the Coulombic attraction to their counterions, leading to an elevated <i>EQE</i> (polaron absorption region) compared to Frenkel excitons. As a result, our devices achieve a high <i>EQE</i> of <span>∼</span>10⁷%, femtowatt sensitivity (<i>NEP)</i> of ~0.12 fW Hz^-1/2 along a response time of ~81 ms, at room temperature for a wavelength of 1.0 µm. Our innovative utilization of polarons highlights their potential as alternatives to Frenkel excitons in high-performance organic IR PDs.</p>","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bright future for micro-LED displays","authors":"Vineeth K. Bandari, Oliver G. Schmidt","doi":"10.1038/s41377-024-01683-z","DOIUrl":"https://doi.org/10.1038/s41377-024-01683-z","url":null,"abstract":"<p>The development of GaN-based Micro-LED arrays achieving brightnesses exceeding 10⁷ nits and high-density micro-displays with up to 1080×780 pixels marks a true breakthrough in the field. This breakthrough is a result of mastering a combination of long-standing challenges comprising wafer-scale high-quality epitaxial growth, sidewall passivation, efficient photon extraction, and elegant bonding technologies, and promises significant advantages for augmented and virtual reality devices, wearables, and next-generation consumer electronics.</p>","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142782497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}