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Achieving 100% amplitude modulation depth in the terahertz range with graphene-based tuneable capacitance metamaterials. 利用石墨烯基可调谐电容超材料在太赫兹范围内实现100%的调幅深度。
Light-Science & Applications Pub Date : 2025-08-04 DOI: 10.1038/s41377-025-01945-4
Ruqiao Xia,Nikita W Almond,Wadood Tadbier,Stephen J Kindness,Riccardo Degl'Innocenti,Yuezhen Lu,Abbie Lowe,Ben Ramsay,Lukas A Jakob,James Dann,Stephan Hofmann,Harvey E Beere,Sergey A Mikhailov,David A Ritchie,Wladislaw Michailow
{"title":"Achieving 100% amplitude modulation depth in the terahertz range with graphene-based tuneable capacitance metamaterials.","authors":"Ruqiao Xia,Nikita W Almond,Wadood Tadbier,Stephen J Kindness,Riccardo Degl'Innocenti,Yuezhen Lu,Abbie Lowe,Ben Ramsay,Lukas A Jakob,James Dann,Stephan Hofmann,Harvey E Beere,Sergey A Mikhailov,David A Ritchie,Wladislaw Michailow","doi":"10.1038/s41377-025-01945-4","DOIUrl":"https://doi.org/10.1038/s41377-025-01945-4","url":null,"abstract":"Effective control of terahertz radiation requires fast and efficient modulators with a large modulation depth-a challenge that is often tackled by using metamaterials. Metamaterial-based active modulators can be created by placing graphene as a tuneable element shunting regions of high electric field confinement in metamaterials. However, in this common approach, the graphene is used as a variable resistor, and the modulation is achieved by resistive damping of the resonance. In combination with the finite conductivity of graphene due to its gapless nature, achieving 100% modulation depth using this approach remains challenging. Here, we embed nanoscale graphene capacitors within the gaps of the metamaterial resonators, and thus switch from a resistive damping to a capacitive tuning of the resonance. We further expand the optical modulation range by device excitation from its substrate side. As a result, we demonstrate terahertz modulators with over four orders of magnitude modulation depth (45.7 dB at 1.68 THz and 40.1 dB at 2.15 THz), and a reconfiguration speed of 30 MHz. These tuneable capacitance modulators are electrically controlled solid-state devices enabling unity modulation with graphene conductivities below 0.7 mS. The demonstrated approach can be applied to enhance modulation performance of any metamaterial-based modulator with a 2D electron gas. Our results open up new frontiers in the area of terahertz communications, real-time imaging, and wave-optical analogue computing.","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"223 1","pages":"256"},"PeriodicalIF":0.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-fidelity tissue super-resolution imaging achieved with confocal2 spinning-disk image scanning microscopy. 用共焦旋转圆盘图像扫描显微镜实现高保真组织超分辨率成像。
Light-Science & Applications Pub Date : 2025-08-04 DOI: 10.1038/s41377-025-01930-x
Qianxi Liang,Wei Ren,Boya Jin,Liang Qiao,Xichuan Ge,Yunzhe Fu,Xiaoqi Lv,Meiqi Li,Peng Xi
{"title":"High-fidelity tissue super-resolution imaging achieved with confocal2 spinning-disk image scanning microscopy.","authors":"Qianxi Liang,Wei Ren,Boya Jin,Liang Qiao,Xichuan Ge,Yunzhe Fu,Xiaoqi Lv,Meiqi Li,Peng Xi","doi":"10.1038/s41377-025-01930-x","DOIUrl":"https://doi.org/10.1038/s41377-025-01930-x","url":null,"abstract":"Super-resolution imaging has revolutionized our ability to visualize biological structures at subcellular scales. However, deep-tissue super-resolution imaging remains constrained by background interference, which leads to limited depth penetration and compromised imaging fidelity. To overcome these challenges, we propose a novel imaging system, confocal² spinning-disk image scanning microscopy (C2SD-ISM). It integrates a spinning-disk (SD) confocal microscope, which physically eliminates out-of-focus signals, forming the first confocal level. A digital micromirror device (DMD) is employed for sparse multifocal illumination, combined with a dynamic pinhole array pixel reassignment (DPA-PR) algorithm for ISM super-resolution reconstruction, forming the second confocal level. The dual confocal configuration enhances system resolution, while effectively mitigating scattering background interference. Compared to computational out-of-focus signal removal, SD preserves the original intensity distribution as the penetration depth increases, achieving an imaging depth of up to 180 μm. Additionally, the DPA-PR algorithm effectively corrects Stokes shifts, optical aberrations, and other non-ideal conditions, achieving a lateral resolution of 144 nm and an axial resolution of 351 nm, and a linear correlation of up to 92% between the original confocal and the reconstructed image, thereby enabling high-fidelity super-resolution imaging. Moreover, the system's programmable illumination via the DMD allows for seamless realization with structured illumination microscopy modality, offering excellent scalability and ease of use. Altogether, these capabilities make the C2SD-ISM system a versatile tool, advancing cellular imaging and tissue-scale exploration for modern bioimaging needs.","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"30 1","pages":"260"},"PeriodicalIF":0.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wide-field fluorescence lifetime imaging of single molecules with a gated single-photon camera 用门控单光子相机进行单分子的宽视场荧光寿命成像
Light-Science & Applications Pub Date : 2025-08-04 DOI: 10.1038/s41377-025-01901-2
Nathan Ronceray, Salim Bennani, Marianna Fanouria Mitsioni, Nicole Siegel, Maria J. Marcaida, Claudio Bruschini, Edoardo Charbon, Rahul Roy, Matteo Dal Peraro, Guillermo P. Acuna, Aleksandra Radenovic
{"title":"Wide-field fluorescence lifetime imaging of single molecules with a gated single-photon camera","authors":"Nathan Ronceray, Salim Bennani, Marianna Fanouria Mitsioni, Nicole Siegel, Maria J. Marcaida, Claudio Bruschini, Edoardo Charbon, Rahul Roy, Matteo Dal Peraro, Guillermo P. Acuna, Aleksandra Radenovic","doi":"10.1038/s41377-025-01901-2","DOIUrl":"https://doi.org/10.1038/s41377-025-01901-2","url":null,"abstract":"<p>Fluorescence lifetime imaging microscopy (FLIM) is a powerful tool to discriminate fluorescent molecules or probe their nanoscale environment. Traditionally, FLIM uses time-correlated single-photon counting (TCSPC), which is precise but intrinsically low-throughput due to its dependence on point detectors. Although time-gated cameras have demonstrated the potential for high-throughput FLIM in bright samples with dense labeling, their use in single-molecule microscopy has not been explored extensively. Here, we report fast and accurate single-molecule FLIM with a commercial time-gated single-photon camera. Our optimized acquisition scheme achieves single-molecule lifetime measurements with a precision only about three times less than TCSPC, while imaging with a large number of pixels (512 × 512) allowing for the spatial multiplexing of over 3000 molecules. With this approach, we demonstrate parallelized lifetime measurements of large numbers of labeled pore-forming proteins on supported lipid bilayers, and temporal single-molecule Förster resonance energy transfer measurements at 5-25 Hz. This method holds considerable promise for the advancement of multi-target single-molecule localization microscopy and biopolymer sequencing.</p>","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Advancements in ultrafast photonics: confluence of nonlinear optics and intelligent strategies 作者更正:超快光子学的进展:非线性光学和智能策略的融合
Light-Science & Applications Pub Date : 2025-08-04 DOI: 10.1038/s41377-025-01868-0
Qing Wu, Liuxing Peng, Zhihao Huang, Xiaolei Liu, Meng Luo, Danheng Gao, Haoran Meng
{"title":"Author Correction: Advancements in ultrafast photonics: confluence of nonlinear optics and intelligent strategies","authors":"Qing Wu, Liuxing Peng, Zhihao Huang, Xiaolei Liu, Meng Luo, Danheng Gao, Haoran Meng","doi":"10.1038/s41377-025-01868-0","DOIUrl":"https://doi.org/10.1038/s41377-025-01868-0","url":null,"abstract":"<p>Correction to: <i>Light: Science &amp; Applications</i>,</p>","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144778571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
pH-dependent formation potential of OH∗ on Pt(111): Double layer effect on water dissociation Pt(111)上OH *的ph依赖性形成电位:水解离的双层效应
IF 17.9 2区 材料科学
Nano Materials Science Pub Date : 2025-08-01 DOI: 10.1016/j.nanoms.2024.05.009
Xue Wang , Jiaxin Zhu , Yongbo Kuang , Jun Cheng , Jiabo Le
{"title":"pH-dependent formation potential of OH∗ on Pt(111): Double layer effect on water dissociation","authors":"Xue Wang ,&nbsp;Jiaxin Zhu ,&nbsp;Yongbo Kuang ,&nbsp;Jun Cheng ,&nbsp;Jiabo Le","doi":"10.1016/j.nanoms.2024.05.009","DOIUrl":"10.1016/j.nanoms.2024.05.009","url":null,"abstract":"<div><div>The adsorption/desorption of OH∗ on electrode surfaces is pivotal in numerous electrocatalytic reactions. To understand the effect of electrolyte pH on that process, in this work, an advanced approach combining ab initio molecular dynamics (AIMD) with free energy perturbation is employed to calculate the dehydrogenation free energy of water chemisorbed at differently electrified Pt(111)/electrolyte interfaces. Our findings reveal that the onset potential for OH∗ formation shifts negatively as the pH increases at low pH condition (pH<span><math><mo>&lt;</mo></math></span>4.3), aligning with the cyclic voltammetry curves observed in experimental studies. It indicates the dissociation of chemisorbed water is the primary route for OH∗ adsorption at low pH condition. Furthermore, it is also found that the variation in dehydrogenation energy across different pH is primarily due to the local hydrogen bonding network surrounding the chemisorbed water. In addition, it is proposed that at high pH conditions OH<sup>−</sup> oxidation emerges as the primary route for OH∗ adsorption on Pt(111) constrained by the water chemisorption process. This work provides crucial insights into the pH-dependent adsorption behavior of OH∗ on the Pt(111) surface and aims to guide the optimization of electrolytes to boost the efficiency of related reactions.</div></div>","PeriodicalId":33573,"journal":{"name":"Nano Materials Science","volume":"7 4","pages":"Pages 493-499"},"PeriodicalIF":17.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In situ synthesis of oriented Zn-Mn-Co-telluride on precursor free CuO: An experimental and theoretical study of hybrid electrode paradigm for advanced supercapacitors 在无前驱体的氧化铜上原位合成定向碲化锌锰铜:先进超级电容器混合电极范例的实验和理论研究
IF 17.9 2区 材料科学
Nano Materials Science Pub Date : 2025-08-01 DOI: 10.1016/j.nanoms.2024.07.002
Muhammad Ahmad , Tehseen Nawaz , Iftikhar Hussain , Xi Chen , Shahid Ali Khan , Yassine Eddahani , B. Moses Abraham , Shafqat Ali , Ci Wang , Kaili Zhang
{"title":"In situ synthesis of oriented Zn-Mn-Co-telluride on precursor free CuO: An experimental and theoretical study of hybrid electrode paradigm for advanced supercapacitors","authors":"Muhammad Ahmad ,&nbsp;Tehseen Nawaz ,&nbsp;Iftikhar Hussain ,&nbsp;Xi Chen ,&nbsp;Shahid Ali Khan ,&nbsp;Yassine Eddahani ,&nbsp;B. Moses Abraham ,&nbsp;Shafqat Ali ,&nbsp;Ci Wang ,&nbsp;Kaili Zhang","doi":"10.1016/j.nanoms.2024.07.002","DOIUrl":"10.1016/j.nanoms.2024.07.002","url":null,"abstract":"<div><div>The evolution of energy storage technology has seen remarkable progress, with a shift from pure metals to sophisticated, tailor-made active materials. The synthesis of nanostructures with exceptional properties is crucial in the advancement of electrode materials. In this regard, our study highlights the fabrication of a novel, oriented heterostructure comprised of Zn-Mn-Co-telluride grown on a pre-oxidized copper mesh using a hydrothermal method followed by a solvothermal process. This innovative approach leads to the formation of the Zn-Mn-Co-telluride@CuO@Cu heterostructure, which demonstrates the unique oriented morphology. It outperforms both Zn-Mn-Co-telluride@Cu and CuO@Cu by exhibiting lower electrical resistivity, increased redox activity, higher specific capacity, and improved ion diffusion characteristics. The conductivity enhancements of the heterostructure are corroborated by density functional theory (DFT) calculations. When utilized in a hybrid supercapacitor (HSC) alongside activated carbon (AC) electrodes, the Zn-Mn-Co-telluride@CuO@Cu heterostructure-based HSC achieves an energy density of 75.7 ​Wh kg<sup>−1</sup>. Such findings underscore the potential of these novel electrode materials to significantly impact the design of next-generation supercapacitor devices.</div></div>","PeriodicalId":33573,"journal":{"name":"Nano Materials Science","volume":"7 4","pages":"Pages 555-563"},"PeriodicalIF":17.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141706301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A review on catalyst convergence: Unleashing the potential of MXenes for CO2 electrochemical reduction into high-value liquid product 催化剂融合综述:释放 MXenes 将二氧化碳电化学还原为高价值液体产品的潜力
IF 17.9 2区 材料科学
Nano Materials Science Pub Date : 2025-08-01 DOI: 10.1016/j.nanoms.2024.06.006
Samia , Muhammad Hasnain Jameel , Musfira Arain , Iftikhar Hussain , Muhammad Bilal Hanif , Shalu Atri , Mohd Zul Hilmi Mayzan , Haitao Dai
{"title":"A review on catalyst convergence: Unleashing the potential of MXenes for CO2 electrochemical reduction into high-value liquid product","authors":"Samia ,&nbsp;Muhammad Hasnain Jameel ,&nbsp;Musfira Arain ,&nbsp;Iftikhar Hussain ,&nbsp;Muhammad Bilal Hanif ,&nbsp;Shalu Atri ,&nbsp;Mohd Zul Hilmi Mayzan ,&nbsp;Haitao Dai","doi":"10.1016/j.nanoms.2024.06.006","DOIUrl":"10.1016/j.nanoms.2024.06.006","url":null,"abstract":"<div><div>The electrochemical reduction reaction of carbon dioxide (CO<sub>2</sub>-ERR) holds tremendous potential as a key approach for achieving carbon neutrality by harnessing renewable resources.</div><div>However, the current state of CO<sub>2</sub>-ERR encounters challenges in terms of efficiency and selectivity. Overcoming these obstacles requires the development of a robust electrocatalyst capable of enhancing process efficiency and improving selectivity towards desired products. In recent years, 2D materials have garnered significant attention as efficient catalysts. Among them, MXene stands out of high interest due to unique multilayered structure and presence of surface functional moieties. The MXene material offers high electrical conductivity, versatile surface chemistry, and tunable interface designs. This comprehensive review explores the utilization of MXene-based catalysts for CO<sub>2</sub>-ERR into valuable products. It covers fundamental aspects of electrochemical conversion, including CO<sub>2</sub> adsorption on MXene Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub>, the mechanism of CO<sub>2</sub>-ERR on MXene (Mo<sub>2</sub>CS<sub>2</sub>) single-atom catalysts, applications, synthesis methods of MXene production, and future prospects. Additionally, the review highlights the significance of modern artificial intelligence techniques, particularly machine learning, in screening and activating CO<sub>2</sub>, making it a pioneering scientific endeavor.</div></div>","PeriodicalId":33573,"journal":{"name":"Nano Materials Science","volume":"7 4","pages":"Pages 444-481"},"PeriodicalIF":17.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141699639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crystal orientation engineering toward high-performance photodetectors and their multifunctional optoelectronic applications 面向高性能光电探测器的晶体取向工程及其多功能光电应用
IF 17.9 2区 材料科学
Nano Materials Science Pub Date : 2025-08-01 DOI: 10.1016/j.nanoms.2025.05.011
Huanrong Liang , Jianing Tan , Yu Chen , Yuhang Ma , Xinyi Guan , Yichao Zou , Yuqiao Zhou , Zhaoqiang Zheng , Wenjing Huang , Chun Du , Gang Ouyang , Jiandong Yao , Guowei Yang
{"title":"Crystal orientation engineering toward high-performance photodetectors and their multifunctional optoelectronic applications","authors":"Huanrong Liang ,&nbsp;Jianing Tan ,&nbsp;Yu Chen ,&nbsp;Yuhang Ma ,&nbsp;Xinyi Guan ,&nbsp;Yichao Zou ,&nbsp;Yuqiao Zhou ,&nbsp;Zhaoqiang Zheng ,&nbsp;Wenjing Huang ,&nbsp;Chun Du ,&nbsp;Gang Ouyang ,&nbsp;Jiandong Yao ,&nbsp;Guowei Yang","doi":"10.1016/j.nanoms.2025.05.011","DOIUrl":"10.1016/j.nanoms.2025.05.011","url":null,"abstract":"<div><div>Pulsed-laser deposition has been developed to prepare large-area In<sub>2</sub>S<sub>3</sub> nanofilms and their photoelectric characteristics have been investigated. The In<sub>2</sub>S<sub>3</sub> nanofilm grown under 500 ​°C is highly oriented along the (103) direction with exceptional crystallinity. The corresponding (103)-oriented In<sub>2</sub>S<sub>3</sub> photodetectors exhibit broadband photoresponse from 370.6 ​nm to 1 064 ​nm. Under 635 ​nm illumination, the optimized responsivity, external quantum efficiency, and detectivity reach 19.8 A/W, 3 869%, and 2.59 ​× ​10<sup>12</sup> Jones, respectively. In addition, the device exhibits short rise/decay time of 3.9/3.0 ​ms. Of note, first-principles calculations have unveiled that the effective carrier mass along the (103) lattice plane is much smaller than those along the (100), (110) and (111) lattice planes, which thereby enables high-efficiency transport of photocarriers and thereby the excellent photosensitivity. Profited from the sizable bandgap, the In<sub>2</sub>S<sub>3</sub> photodetectors also showcase strong robustness against elevated operating temperature. In the end, proof-of-concept imaging application beyond human vision and under high operating temperature as well as heart rate monitoring have been achieved by using the In<sub>2</sub>S<sub>3</sub> device of the sensing component. This study introduces a novel crystal orientation engineering paradigm for the implementation of next-generation advanced optoelectronic systems.</div></div>","PeriodicalId":33573,"journal":{"name":"Nano Materials Science","volume":"7 4","pages":"Pages 522-532"},"PeriodicalIF":17.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanohydroxyapatite and liposomes-coated integral bilayer scaffold for osteochondral repair via mimicking the dual differentiation microenvironment of BMSCs 纳米羟基磷灰石和脂质体包覆整体双层支架模拟骨髓间充质干细胞双分化微环境修复骨软骨
IF 17.9 2区 材料科学
Nano Materials Science Pub Date : 2025-08-01 DOI: 10.1016/j.nanoms.2024.12.004
Weikang Zhao , Biemin Sun , Yu Song , Yuan Cao , Yichen Liu , Dandan Zhou , Qiang Zhou , Feng Xie , Wei Huang , Xiaoxiao Li , Yuling Li , Yanqin Xu , Yiyang Wang
{"title":"Nanohydroxyapatite and liposomes-coated integral bilayer scaffold for osteochondral repair via mimicking the dual differentiation microenvironment of BMSCs","authors":"Weikang Zhao ,&nbsp;Biemin Sun ,&nbsp;Yu Song ,&nbsp;Yuan Cao ,&nbsp;Yichen Liu ,&nbsp;Dandan Zhou ,&nbsp;Qiang Zhou ,&nbsp;Feng Xie ,&nbsp;Wei Huang ,&nbsp;Xiaoxiao Li ,&nbsp;Yuling Li ,&nbsp;Yanqin Xu ,&nbsp;Yiyang Wang","doi":"10.1016/j.nanoms.2024.12.004","DOIUrl":"10.1016/j.nanoms.2024.12.004","url":null,"abstract":"<div><div>Osteochondral defects pose an enormous challenge, and no satisfactory therapy is available to date due to the hierarchy of the native tissue consisting of articular cartilage and subchondral bone. Constructing a scaffold with biological function and biomimetic structure is the key to achieving a high-quality repair effect. Herein, a natural polymer-based bilayer scaffold with a porous architecture similar to that of osteochondral tissue is designed, involving the transforming growth factor-beta3-liposome-loaded upper layer for superficial cartilage regeneration and the nanohydroxyapatite-coated lower layer for subchondral bone rehabilitation. This research is conducted to evaluate the effects of nanoparticle-modified bilayer scaffold to mimic the hierarchical pro-chondrogenic and pro-osteogenic microenvironment for the recruited endogenous bone marrow mesenchymal stem cells. The fabricated composites were evaluated for mechanical, physicochemical, biological properties, in vitro and in vivo tissue regeneration potential. Overall, the current bilayer scaffold could regenerate a cartilage-bone integrated tissue with a seamless interfacial integration and exhibited superior tissue repair outcomes compared to other single layer scaffolds based on morphological, radiological and histological evaluation, verifying that this novel graft could be an effective approach to tissue-engineered analogs of cartilage-subchondral bone and offer new therapeutic opportunities for osteochondral defect-associated diseases.</div></div>","PeriodicalId":33573,"journal":{"name":"Nano Materials Science","volume":"7 4","pages":"Pages 539-554"},"PeriodicalIF":17.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantum correlation-enhanced dual-comb spectroscopy 量子相关增强双梳光谱学
Light-Science & Applications Pub Date : 2025-08-01 DOI: 10.1038/s41377-025-01891-1
Zhuoren Wan, Yuan Chen, Xiuxiu Zhang, Ming Yan, Heping Zeng
{"title":"Quantum correlation-enhanced dual-comb spectroscopy","authors":"Zhuoren Wan, Yuan Chen, Xiuxiu Zhang, Ming Yan, Heping Zeng","doi":"10.1038/s41377-025-01891-1","DOIUrl":"https://doi.org/10.1038/s41377-025-01891-1","url":null,"abstract":"<p>Dual-comb spectroscopy (DCS) is a powerful technique for spectroscopic sensing, offering exceptional spectral bandwidth, resolution, precision, and speed. However, its performance is fundamentally limited by quantum noise inherent to coherent-state optical combs. Here, we overcome this barrier by introducing quantum correlation-enhanced DCS using correlated twin combs generated via seeded four-wave mixing. One comb acts as a local oscillator to decode molecular signals, while the twin suppresses shot noise through intensity-difference squeezing, achieving a 2 dB signal-to-noise ratio improvement beyond the shot-noise limit—equivalent to a 2.6× measurement speed enhancement. Notably, when coupled with up-conversion spectroscopy, our technique records comb-line-resolved, high-resolution (7.5 pm) spectra in the critical 3 μm region for molecular fingerprinting. These results bridge quantum optics and frequency comb spectroscopy, offering great potential for trace gas detection, precision metrology, and chemical analysis. Future developments in detector efficiency and nanophotonic integration could further enhance its scalability and impact.</p>","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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