生命科学最新文献

{"title":"Pepper RING-Type E3 Ligase, CaAIAR1, Negatively Modulates ABA Signaling and Drought Stress Response by Controlling CaADBZ1 Stability.","authors":"Jihye Choi, Woonhee Baek, Chae Woo Lim, Mirim Kim, Dae Sung Kim, Sung Chul Lee","doi":"10.1111/pce.70986","DOIUrl":"https://doi.org/10.1111/pce.70986","url":null,"abstract":"<p><p>The ubiquitin-proteasome pathway plays a crucial role in plant abiotic stress responses by regulating protein stability. Our previous work demonstrated that the pepper bZIP transcription factor CaADBZ1 regulates abscisic acid (ABA) signaling and drought stress responses. However, the regulatory factors controlling CaADBZ1 protein stability remain unknown. Here, we performed a yeast two-hybrid assay to identify the E3 ubiquitin ligase involved in regulating CaADBZ1 stability. The pepper RING-type E3 ligase CaAIAR1 (Capsicum annuum ABA-Induced Ankyrin repeat RING-type E3 ligase 1) interacts with CaADBZ1 both in vitro and in vivo. CaAIAR1 ubiquitinates CaADBZ1 and exhibits E3 ligase activity that depends on its RING domain. A cell-free degradation assay revealed that CaADBZ1 was unstable under non-stress conditions, and CaAIAR1 accelerated its degradation via the 26S proteasome pathway. CaAIAR1 expression was significantly induced by various abiotic stresses and was associated with altered phenotypic responses to drought stress and exogenous ABA treatment. Moreover, CaAIAR1-silenced pepper plants exhibited enhanced drought tolerance compared to control plants, as evidenced by reduced transpiration rates and increased ABA sensitivity in leaves. Conversely, CaAIAR1-overexpressing Arabidopsis plants showed decreased drought tolerance compared to control plants and exhibited reduced ABA sensitivity at the seedling stage. In addition, co-silencing CaAIAR1 and CaADBZ1 increased drought sensitivity, producing a phenotype opposite to that of CaAIAR1 silencing alone, indicating that CaAIAR1 functions upstream of CaADBZ1 in drought stress. Collectively, our findings suggest that CaAIAR1 negatively regulates the drought response and ABA signaling by modulating CaADBZ1 protein stability.</p>","PeriodicalId":222,"journal":{"name":"Plant, Cell & Environment","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Abiotic Stress Rewires DNA Methylation to Modulate Regulatory Potential Rather Than Transcription in Arabidopsis.","authors":"Alberto Lozano-Enguita, Adrián Morillas-Montávez, Victoria Baca-González, Jesús Pascual, Luis Valledor, Juan Carlos Del Pozo, Elena Caro","doi":"10.1111/pce.70985","DOIUrl":"https://doi.org/10.1111/pce.70985","url":null,"abstract":"<p><p>Plants are simultaneously exposed to multiple abiotic stresses, yet how opposing epigenetic signals are integrated remains unclear. Here, we investigated the combined effects of heat stress and phosphate deficiency in Arabidopsis thaliana, two conditions with antagonistic impacts on DNA methylation. Using an integrated multi-omic approach (WGBS, RNA-seq and small RNA-seq) in roots and shoots under field-mimicking conditions, we show that combined stress establishes a distinct, non-additive epigenomic state characterised by widespread CHH hypomethylation and differential engagement of RdDM and CMT2 pathways. Despite extensive methylation remodelling across transposable elements, genes and intergenic regions, we observe a genome-wide decoupling between DNA methylation dynamics and transcriptional output. Notably, differentially methylated regions are enriched in transcription factor binding sites, particularly GATA motifs, linking CHH hypomethylation to increased chromatin accessibility and activation of GATA-associated regulatory networks. In contrast, nuclear mitochondrial DNA insertions represent a notable exception, where CHH hypomethylation is directly coupled to transcriptional activation. Functional analyses reveal distinct contributions of RdDM and CMT2 to basal silencing and stress responsiveness at these loci. Overall, our results support a model that positions DNA methylation as a regulator of regulatory potential rather than a direct determinant of transcription under combined stress.</p>","PeriodicalId":222,"journal":{"name":"Plant, Cell & Environment","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disruption of MtREC8 Affects Pollen Viability and Fertility in Medicago truncatula.","authors":"Na Wang, Jinting Cao, Yan Feng, Jinyu Du, Teng Jiang, Yizhi Huang, Yanxi Pei, Jiangqi Wen, Kirankumar S Mysore, Hui Wang, Hao Lin, Lifang Niu","doi":"10.1111/pce.70980","DOIUrl":"https://doi.org/10.1111/pce.70980","url":null,"abstract":"","PeriodicalId":222,"journal":{"name":"Plant, Cell & Environment","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MeWRKY30 and MeABF3 Cooperatively Regulate Drought Tolerance in Cassava by Transcriptionally Activating MeCBF1.","authors":"Yufei Zhu, Wenjuan Wang, Xiaojie Liu, Zhibo Li, Ping Gan, Xiaoling Yu, Zhaoqin Cai, Xiuchun Zhang, Mengbin Ruan, Shuxia Li","doi":"10.1111/pce.70996","DOIUrl":"https://doi.org/10.1111/pce.70996","url":null,"abstract":"","PeriodicalId":222,"journal":{"name":"Plant, Cell & Environment","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A C-Terminus-Truncated AtHAK5 K⁺ Transporter Improves Efficiency of K⁺ Utilisation in Arabidopsis.","authors":"Manuel Nieves-Cordones, Martha Silva, Jesus Amo, Almudena Martínez-Martínez, Adrián Yáñez, Vicente Martínez, Francisco Rubio","doi":"10.1111/pce.70993","DOIUrl":"https://doi.org/10.1111/pce.70993","url":null,"abstract":"","PeriodicalId":222,"journal":{"name":"Plant, Cell & Environment","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"H⁺-Pyrophosphatase VP1 Enhances Low Phosphorus Tolerance by Interacting With the Auxin Influx Carrier AUX1 in Wheat.","authors":"Chengjie Xu, Huijuan Zhang, Jia Guo, Chunxiao Wang, Wanggao Ma, Yuqi Niu, Yongbin Zhou, Jun Chen, Zhaoshi Xu, Youzhi Ma, Yongkang Ren, Daizhen Sun, Ming Chen, Zhaohui Tang","doi":"10.1111/pce.70970","DOIUrl":"https://doi.org/10.1111/pce.70970","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Phosphorus (P) is an essential macronutrient for crop growth, and its deficiency significantly limits wheat productivity, thereby underscoring the importance of improving phosphorus use efficiency (PUE) for global food security. Although proton-pyrophosphatase (Type I H&lt;sup&gt;+&lt;/sup&gt;-pyrophosphatase, VP1, H&lt;sup&gt;+&lt;/sup&gt;-PPases) plays critical roles in plant responses to abiotic stresses, the molecular mechanisms underlying its function in wheat (Triticum aestivum L.) under low-phosphorus (LP) stress remain largely unexplored. Elymus dahuricus, a wild forage grass species, exhibits notable resistance to diverse environmental stresses. In the present study, a VP1-like gene from Elymus dahuricus (EdVP1) was introduced into wild-type (WT) wheat cultivar Shimai366 (SHI366). Two-year field trials conducted under LP conditions demonstrated that overexpression of EdVP1 significantly increased spike number per meter, grain yield, phosphorus harvest index (PHI), and phosphorus use efficiency (PUE). Specifically, transgenic lines OE13 and OE28 exhibited average yield increases of 14.25% and 15.65%, respectively, relative to WT plants over two consecutive years, accompanied by improved photosynthetic rates and chlorophyll content during the grain-filling stage. Additionally, P concentrations in the roots of transgenic lines were significantly elevated compared to SHI366. Subsequent assays under phosphorus-deficient conditions confirmed substantial improvements in both biomass accumulation and root system architecture (RSA) in the transgenic lines. Physiological analyses further demonstrated reduced accumulation of reactive oxygen species (ROS) and enhanced activities of antioxidant enzymes in these lines. Collectively, these findings indicate that the VP1 gene from Elymus dahuricus markedly enhances wheat tolerance to P deficiency. To elucidate the underlying mechanisms of VP1-like genes in wheat, the endogenous plasma membrane (PM) H&lt;sup&gt;+&lt;/sup&gt;-PPases gene TaVP1 (TraesCS7D02G507600), which exhibits the closest evolutionary relationship and highest sequence homology with EdVP1 among grass species, was identified and found to be upregulated in EdVP1 transgenic wheat. TaVP1 expression was predominantly localized in roots and was strongly induced by P-deficient and auxin (IAA) treatment. Notably, auxin levels were significantly increased in the roots of transgenic lines, concomitant with upregulated expression of the auxin influx carrier gene TaAUX1 (TraesCS3B02G401000). Both in vivo and in vitro assays demonstrated a direct interaction between TaVP1 and TaAUX1 at the plasma membrane. Furthermore, factors associated with downstream auxin transport and response, along with the key phosphate starvation transcription factor TaPHR1, exhibit an upregulated expression pattern in the transgenic lines. Taken together, these results reveal a novel mechanism by which H&lt;sup&gt;+&lt;/sup&gt;-PPase enhances tolerance to phosphorus deficiency in wheat through crosstalk with auxin","PeriodicalId":222,"journal":{"name":"Plant, Cell & Environment","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycolysis-Dependent Fatty Acid Metabolism Supports Human Tfh Cell Function.","authors":"Someshwar Nath Jha, Bhushan Nikam, Vivekananda Barik, Anuska Khatua, Deepak Jena, Shilpa Sachan, Mamuni Swain, Poonam Coshic, Sunil K Raghav, Nimesh Gupta","doi":"10.1111/imcb.70166","DOIUrl":"https://doi.org/10.1111/imcb.70166","url":null,"abstract":"<p><p>Follicular helper T (Tfh) cells orchestrate germinal center (GC) derived humoral immunity by providing essential help to B cells. Despite their key role in humoral immunity, the metabolic cues that shape Tfh cell differentiation and functions in humans remain poorly understood. Here, using a human ex vivo Tfh cell differentiation model, we investigated the metabolic requirements of Tfh cell development and function through targeted metabolic perturbation of glycolysis and fatty acid metabolism, transcriptomic analyses, and metabolic rescue experiments. Unexpectedly, early glycolytic inhibition enhanced Tfh cell differentiation but markedly impaired function, including reduced IL-21 production and diminished B-cell help. Transcriptomic and metabolic analyses revealed that glycolytic inhibition was accompanied by suppression of fatty acid metabolism. Consistently, independent inhibition of fatty acid synthesis or oxidation suppressed Tfh cell help functions, including IL-21 and IFN-γ production, as well as B-cell help potential. Interestingly, acetate supplementation partially restored IFN-γ secretion in glycolysis-inhibited conditions, but not IL-21, indicating limited metabolic compensation. Together, these findings reveal distinct metabolic requirements for Tfh cell differentiation and function and identify glycolysis-dependent fatty acid metabolism as an important determinant of human Tfh cell functional competence. This metabolic crosstalk provides new insight into the regulation of Tfh cells and Tfh-driven humoral immunity in vaccination and autoimmunity.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Out of the shadows: Phosphatase PP2A promotes shade avoidance by dephosphorylating phytochrome-interacting factor 7","authors":"Brian C. Mooney","doi":"10.1111/tpj.71158","DOIUrl":"10.1111/tpj.71158","url":null,"abstract":"&lt;p&gt;In dense vegetation, plants fiercely compete with their neighbours for sunlight. Shade-avoiding species like &lt;i&gt;Arabidopsis thaliana&lt;/i&gt; respond to vegetative shade with a series of adaptations collectively known as shade-avoidance syndrome (SAS). SAS includes the elongation of hypocotyls and stems alongside upward leaf movement and a decrease in leaf blade area. These responses enable plants to grow beyond their neighbour's shadow and regain access to light (Casal, &lt;span&gt;2013&lt;/span&gt;).&lt;/p&gt;&lt;p&gt;Leaves primarily absorb red (R) light while reflecting far-red (FR) wavelengths. Plants detect vegetative shade by monitoring the ratio of R:FR light using the photoreceptor phytochrome B (phyB) (Reed et al., &lt;span&gt;1993&lt;/span&gt;). When red light is abundant, the active ‘Pfr’ conformation of phyB translocates to the nucleus where it promotes the phosphorylation and subsequent degradation of PHYTOCHROME-INTERACTING FACTOR (PIF) transcription factors. In shade (when R:FR &lt; 1), phyB is maintained in the cytosol in an inactive ‘Pr’ state, allowing PIFs to accumulate and drive the expression of genes that promote SAS.&lt;/p&gt;&lt;p&gt;PIF7 has emerged as the central regulator of the shade avoidance response (Li et al., &lt;span&gt;2012&lt;/span&gt;). Its regulatory activity is partly controlled by reversible phosphorylation. Under white light, both phosphorylated and unphosphorylated forms co-exist. Phosphorylated PIF7 is restricted to the cytoplasm, while the unphosphorylated form accumulates in the nucleus. However, nuclear phyB sequesters PIF7 in condensates leading to the suppression of its DNA-binding activity. In shade, PIF7 is largely dephosphorylated. Coupled with the exclusion of inactive phyB from the nucleus, this enables PIF7 to activate the transcription of auxin biosynthesis and signalling genes, thereby promoting SAS-related elongation. Despite the importance of this PIF7 phosphorylation switch, the enzymes responsible for its regulation have remained unknown.&lt;/p&gt;&lt;p&gt;Professor Enamul Huq at The University of Texas at Austin investigates how plants perceive and respond to light. Considering his group's long-standing interest in phytochromes and PIFs, elucidating the regulation of PIF7 was a natural progression. In their new study, Huq's group revealed that phosphatase PP2A dephosphorylates PIF7 to promote shade avoidance (Cai et al., &lt;span&gt;2026&lt;/span&gt;). This work also included a collaboration with researchers specialising in phosphatase biology at Hebei Normal University, the previous home of first author Xingbo Cai.&lt;/p&gt;&lt;p&gt;PP2A is a heterotrimeric phosphatase comprising scaffold (A), regulatory (B) and catalytic (C) subunits. The Arabidopsis genome encodes 17 B subunit isoforms which are responsible for substrate specificity and subcellular localisation. Huq's group recently identified four PP2A B subunits that dephosphorylate another PIF family member, PIF3 (Cai et al., &lt;span&gt;2024&lt;/span&gt;). To determine whether these subunits also regulate PIF7 during shade avoidance, Ca","PeriodicalId":233,"journal":{"name":"The Plant Journal","volume":"127 6","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tpj.71158","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic diversity and fruit biometry variability of fruits of Acrocomia spp. interspecific hybrids","authors":"Paloma Vieira Brás,&nbsp;Sérgio Yoshimitsu Motoike,&nbsp;Pauliana Aparecida da Silva,&nbsp;Ana Carolina Melo Ribeiro,&nbsp;Míria Grasiele Casado da Silva,&nbsp;Kacilda Naomi Kuki,&nbsp;Evellyn Giselly de Oliveira Couto,&nbsp;Gleison Augusto dos Santos","doi":"10.1007/s00468-026-02840-0","DOIUrl":"10.1007/s00468-026-02840-0","url":null,"abstract":"<div><p>The macaw palm (<i>Acrocomia</i> spp.) stands out as a promising species for the sustainable production of vegetable oil due to its wide adaptability and potential use in multiple production chains. This study evaluated 11 genotypes, including parental genotypes and F₁ hybrids, for fruit biometric traits and mesocarp oil content, aiming to identify individuals with greater potential for genetic improvement programs. Analyses were carried out in plant material belonging to the Active Germplasm Bank of Macaw palm of the Federal University of Viçosa. The variables were subjected to analyses of variance, phenotypic correlation, and genetic diversity based on Mahalanobis generalized distance and the Tocher and UPGMA clustering methods. A broad phenotypic and genetic variability was observed among genotypes. Individual A4 exhibited larger fruits with higher mass and a greater pulp yield index, whereas the parent 47 − 1 showed the highest mesocarp oil content (55.31%). High heritability estimates (h² &gt; 50%) and genetic accuracies confirmed the predominance of genetic over environmental effects. The clustering methods revealed three major genetic groups, reflecting the existing intra- and interspecific diversity. The results indicate a high potential for selection gains and reinforce the importance of biometric characterization of fruits and characterization of oil content to identify superior macaw palm genotypes aimed at expanding cultivation and promoting sustainable agro-industrial utilization.</p></div>","PeriodicalId":805,"journal":{"name":"Trees","volume":"40 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00468-026-02840-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CsGATA5-CsTRYS/CsTDC2 module coordinates tryptophan-mediated wound healing in postharvest citrus fruit","authors":"Xiaoquan Gao,&nbsp;Xiaojiao Li,&nbsp;Jialin Chen,&nbsp;Wenjun Wang,&nbsp;Ou Chen,&nbsp;Lanhua Yi,&nbsp;Kaifang Zeng","doi":"10.1111/tpj.71170","DOIUrl":"10.1111/tpj.71170","url":null,"abstract":"<p>The wound healing process in postharvest citrus fruit represents a crucial physiological mechanism that effectively resists external stress and minimizes quality deterioration. Nevertheless, the molecular mechanisms involved in wound healing by GATA transcription factors in citrus remain largely unexplored. In this research, CsGATA5 was characterized as a newly identified transcriptional activator promoting wound healing in citrus fruit. Transient overexpression of <i>CsGATA5</i> in tobacco also confirmed its role in promoting suberin accumulation. Gene expression and metabolite profiling analyses following <i>CsGATA5</i> overexpression revealed that CsGATA5 activated pathways associated with amino acid metabolism during wound healing. DLR, EMSA, ChIP-qPCR, and Y1H assays demonstrated that CsGATA5 bound to the promoter regions of target genes in tryptophan metabolism (<i>CsTRYS</i> and <i>CsTDC2</i>), thereby activating their expression. Notably, the activation of <i>CsTRYS</i> and <i>CsTDC2</i> genes during citrus wound healing contributed to the subsequent induction of downstream suberin biosynthesis. Moreover, the exogenous treatment of key metabolites of the amino acid pathway, including tryptophan, 5-hydroxytryptamine, and phenylalanine, significantly promoted wound healing and further supported a potential regulatory cascade of tryptophan metabolism– tricarboxylic acid cycle– suberin biosynthesis. This study sheds light on the molecular regulatory network by which GATA transcription factors modulate wound healing in fruit.</p>","PeriodicalId":233,"journal":{"name":"The Plant Journal","volume":"128 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tpj.71170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}