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Stereoselective Synthesis of ABBV-992

有机合成与工艺文献分享 2024-12-02 07:17
文章摘要
本文介绍了AbbVie公司在开发下一代共价BTK抑制剂过程中，发现的新型共价抑制剂ABBV-992的立体选择性合成方法。文章详细描述了通过Klingemann−Japp反应制备中间体氢脒的过程，并探讨了在流动条件下优化反应条件的方法。研究还涉及了通过调节试剂摩尔比和淬灭条件来控制反应路径，以及在不同反应条件下实现N-烷基化的挑战。最终，研究团队成功开发了一种新的半还原协议，并探讨了其在其他杂环系统中的应用潜力。
Stereoselective Synthesis of ABBV-992
查看文献： Stereoselective Synthesis of ABBV-992 Enabled by a Flow Diazotization and a Partial Reduction of a Pyridone
查看期刊： Organic Process Research & Development
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