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Application of Vinamidinium Salt Chemistry for MMV048

有机合成与工艺文献分享 2024-11-14 06:22

文章摘要

本文探讨了Vinamidinium盐化学在MMV048有机合成中的应用。通过逆合成分析，文章指出可以通过一系列钯催化的交叉偶联反应来组装三芳香核。研究还探讨了通过电亲核试剂与硝基化合物的反应来避免钯交叉偶联，因为起始材料中已经存在联苯键。研究始于寻找经济构建5-溴-2-三氟甲基吡啶12的方法，以合成硝基9。最终，研究测试了关键假设：两个末端芳香子单元可以在不需要钯催化的情况下同时构建中心氨基吡啶环。

Application of Vinamidinium Salt Chemistry for MMV048

查看文献： Application of Vinamidinium Salt Chemistry for a Palladium Free Synthesis of Anti-Malarial MMV048: A “Bottom-Up” Approach
查看期刊： Organic Letters

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