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Atroposelective Negishi Coupling Optimization

有机合成与工艺文献分享 2025-11-12 08:11
文章摘要
本文背景涉及联芳基C-C键受阻旋转产生的轴手性化合物在药物开发中的重要性。研究目的是通过高通量实验和数据科学方法优化轴手性Negishi偶联反应，以合成KRAS G12C抑制剂的关键中间体。研究结论表明，通过多元线性回归模型筛选出的Walphos配体可实现92:8选择性和85%收率，成功以40%总收率获得目标药物分子，但该方法在扩展至其他杂环体系时仍存在局限性。
Atroposelective Negishi Coupling Optimization
查看文献： Atroposelective Negishi Coupling Optimization Guided by Multivariate Linear Regression Analysis: Asymmetric Synthesis of KRAS G12C Covalent Inhibitor GDC-6036
查看期刊： Journal of the American Chemical Society
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