发布求助
文献互助 智能选刊 最新文献

Commercial Manufacturing Process for Sotorasib (3)

有机合成与工艺文献分享 2025-10-02 06:55
文章摘要
本文背景为Sotorasib的商业化生产工艺开发，研究目的是解决反应过程中因iPr2NEt·HCl盐结晶导致的产物晶体尺寸分布不均和过滤速率慢的问题。通过实验发现，在步骤1b反应前添加二氯甲烷可溶解iPr2NEt·HCl盐，从而实现对产物3的受控结晶。最终结论表明，优化二氯甲烷用量可建立稳定的结晶工艺，在提高过滤速率的同时减少产物在母液中的损失。
Commercial Manufacturing Process for Sotorasib (3)
查看文献： Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRASG12C Inhibitor
查看期刊： Organic Process Research & Development
阅读全文
本站注明稿件来源为其他媒体的文/图等稿件均为转载稿，本站转载出于非商业性的教育和科研之目的，并不意味着赞同其观点或证实其内容的真实性。如转载稿涉及版权等问题，请作者速来电或来函联系。
推荐文献
ACS Applied Polymer Materials ACS Applied Polymer Materials
Issue Editorial Masthead
DOI: 10.1021/apv007i018_1988184 Pub Date : 2025-09-26
IF 4.7 2区 化学 Q2 ACS Applied Polymer Materials
Organic Process Research & Development Organic Process Research & Development
Lessons Learned in Organic Process Chemistry
DOI: 10.1021/acs.oprd.5c00353 Pub Date : 2025-09-26
IF 3.4 3区 化学 Q2 Organic Process Research & Development
Accounts of Chemical Research Accounts of Chemical Research
Precision Phototherapy Enabled by Decoding Complex Microenvironments.
DOI: 10.1021/acs.accounts.5c00488 Pub Date : 2025-10-02
IF 18.3 1区 化学 Q1 Accounts of Chemical Research
有机合成与工艺文献分享
Commercial Manufacturing Process for Sotorasib (4)
Commercial Manufacturing Process for Sotorasib (4). 13小时前
Commercial Manufacturing Process for Sotorasib (2)
Commercial Manufacturing Process for Sotorasib (2). 2025-09-29
Commercial Manufacturing Process for Sotorasib (1)
Commercial Manufacturing Process for Sotorasib (1). 2025-09-29
Improved Process To Sotorasib Intermediate (3)
Improved Process To Sotorasib Intermediate (3). 2025-09-27
Underappreciated Hydrolytic Instability of DBU
Underappreciated Hydrolytic Instability of DBU. 2025-09-25
最新文章
Commercial Manufacturing Process for Sotorasib (4)
Commercial Manufacturing Process for Sotorasib (4) 13小时前
Commercial Manufacturing Process for Sotorasib (3)
Commercial Manufacturing Process for Sotorasib (3) 2025-10-01
Commercial Manufacturing Process for Sotorasib (2)
Commercial Manufacturing Process for Sotorasib (2) 2025-09-29
Commercial Manufacturing Process for Sotorasib (1)
Commercial Manufacturing Process for Sotorasib (1) 2025-09-29
热门类别
综合性期刊 物理 法学 地球科学 历史学
相关文章
Commercial Manufacturing Process for Sotorasib (4) Commercial Manufacturing Process for Sotorasib (3) J. Am. Chem. Soc. | MALDI-TOF筛选揭示3-氯戊酰胺亲电体实现RNA特异性共价修饰 吃土豆会招糖尿病？The BMJ：每周 3 份炸薯条风险升 20%，换种吃法能救命！ Commercial Manufacturing Process for Sotorasib (2)
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信