发布求助
文献互助 智能选刊 最新文献

Improved Process To Sotorasib Intermediate (1)

有机合成与工艺文献分享 2025-09-24 06:40
文章摘要
本文报道了sotorasib中间体rac-4第一代合成工艺的改进研究。背景显示三光气在乙腈溶剂中会逐渐分解为光气，而乙腈是开发多步连续流工艺的理想溶剂。研究目的是通过工艺优化控制三光气分解过程，解决反应放热剧烈和副反应问题。通过将三光气分解与异氰酸酯生成分步进行，采用-5°C低温悬浮反应体系，并优化加料方式（浸没式加料），成功抑制了副产物6的生成。结论表明1.0 mol%催化剂可实现三光气在3小时内可控转化，为规模化生产提供了安全可靠的工艺方案。
Improved Process To Sotorasib Intermediate (1)
查看文献： Development of an Improved Process To Prepare a Key Intermediate in the Manufacture of Sotorasib
查看期刊： Organic Process Research & Development
阅读全文
本站注明稿件来源为其他媒体的文/图等稿件均为转载稿，本站转载出于非商业性的教育和科研之目的，并不意味着赞同其观点或证实其内容的真实性。如转载稿涉及版权等问题，请作者速来电或来函联系。
推荐文献
Accounts of Chemical Research Accounts of Chemical Research
Mental Healthcare Providers Understanding and Experiences of Palliative Care: A Qualitative Analysis.
DOI: 10.1177/08258597221134865 Pub Date : 2025-10-01 Date: 2022/10/20 0:00:00
IF 17.7 1区 化学 Q1 Accounts of Chemical Research
ACS Applied Polymer Materials ACS Applied Polymer Materials
Issue Editorial Masthead
DOI: 10.1021/apv007i018_1988184 Pub Date : 2025-09-26
IF 4.7 2区 化学 Q2 ACS Applied Polymer Materials
Organic Process Research & Development Organic Process Research & Development
Lessons Learned in Organic Process Chemistry
DOI: 10.1021/acs.oprd.5c00353 Pub Date : 2025-09-26
IF 3.4 3区 化学 Q2 Organic Process Research & Development
有机合成与工艺文献分享
Improved Process To Sotorasib Intermediate (3)
Improved Process To Sotorasib Intermediate (3). 14小时前
Underappreciated Hydrolytic Instability of DBU
Underappreciated Hydrolytic Instability of DBU. 2025-09-25
Improved Process To Sotorasib Intermediate (2)
Improved Process To Sotorasib Intermediate (2). 2025-09-24
Risk of Formaldehyde Contamination in Amines from Residual DCM
Risk of Formaldehyde Contamination in Amines from Residual DCM. 2025-09-22
Analytical Artifact Due to Residual HCN in Acetonitrile
Analytical Artifact Due to Residual HCN in Acetonitrile. 2025-09-21
最新文章
Improved Process To Sotorasib Intermediate (3)
Improved Process To Sotorasib Intermediate (3) 14小时前
Underappreciated Hydrolytic Instability of DBU
Underappreciated Hydrolytic Instability of DBU 2025-09-25
Improved Process To Sotorasib Intermediate (2)
Improved Process To Sotorasib Intermediate (2) 2025-09-24
Improved Process To Sotorasib Intermediate (1)
Improved Process To Sotorasib Intermediate (1) 2025-09-23
热门类别
综合性期刊 物理 法学 地球科学 历史学
相关文章
里程碑！华中农业大学Cell+1 这种病毒感染率已跃居呼吸道疾病 TOP 1，无特效药，这类人需要特别注意！ Improved Process To Sotorasib Intermediate (3) 赞！西湖大学1周内集齐Cell，Nature及Science 巨噬细胞调控ILC2细胞PD-1与CTLA-4差异化表达的作用机制
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信