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Risk of Formaldehyde Contamination in Amines from Residual DCM

有机合成与工艺文献分享 2025-09-23 07:47
文章摘要
本文研究了胺类化合物中甲醛污染的风险。背景显示在PEG-酰胺1的制造过程中发现了高水平的甲基醇杂质。研究目的是探究胺类化合物在二氯甲烷存在下产生甲醛的机制，并通过控制实验验证反应路径。研究发现伯胺和仲胺在室温下与DCM通过连续亲核取代反应生成双(烷基氨基)甲烷中间体，随后水解产生甲醛。结论表明DCM含量与时间因素共同影响甲醛生成水平，最终发现使用氢氧化铵处理可有效转化N-羟甲基杂质，且不引起相邻手性中心的外消旋化。
Risk of Formaldehyde Contamination in Amines from Residual DCM
查看文献： Risk of Formaldehyde Contamination in Amines from Residual Dichloromethane
查看期刊： Organic Process Research & Development
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