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Analytical Artifact Due to Residual HCN in Acetonitrile

有机合成与工艺文献分享 2025-09-22 06:47
文章摘要
背景：在有机合成工艺中，定量核磁共振与计算效价间出现偏差，引发对未知色谱杂质的探究。研究目的：通过高分辨质谱和氢/氘交换实验鉴定杂质结构为氰醇衍生物，追溯其源于分析用乙腈试剂中的氢氰酸污染，并系统考察稀释剂组成、样品温度、pH值等参数对杂质形成的影响。结论：提出使用甲醇或无氢氰酸乙腈作为稀释剂、降低乙腈比例、使用新鲜配制样品等控制策略，证实含吡啶等杂环的醛类化合物更易形成此类分析假象。
Analytical Artifact Due to Residual HCN in Acetonitrile
查看文献： Analytical Artifact Due to Residual HCN in Acetonitrile: Identification and Control Strategies
查看期刊： Organic Process Research & Development
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