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Impurity Induced by the Degradation of HBTU in DMF

有机合成与工艺文献分享 2025-09-20 08:48
文章摘要
背景：Ferring Pharmaceuticals在肽类活性药物成分Peptide Q中发现丰度为0.09%的非肽类杂质。研究目的：通过模拟反应和参照物对比，确定杂质来源及形成机制。结论：该杂质由HBTU在DMF溶液中降解产生，被鉴定为二甲基氨基甲酰-OBt，在NMP或ACN溶剂中也能形成，提示在铀类偶联试剂介导的酰胺化/酯化反应中需关注此类杂质。
Impurity Induced by the Degradation of HBTU in DMF
查看文献： Impurity Dimethylcarbamoyl-OBt Detected in an API Induced by the Degradation of HBTU in DMF
查看期刊： Organic Process Research & Development
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