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Practical and Scalable Manufacturing Process for Vilazodone

有机合成与工艺文献分享 2025-09-17 06:09
文章摘要
背景：Vilazodone是一种兼具选择性血清素再摄取抑制剂和5-HT1A受体部分激动剂活性的药物。研究目的：开发一种以低成本ε-己内酯为原料，通过四步反应合成Vilazodone的新工艺路线。结论：通过将羟基转化为在Fischer吲哚合成反应中稳定的官能团，成功将总收率提高至14.2%，解决了反应过程中固体堵塞管道及收率低的问题。
Practical and Scalable Manufacturing Process for Vilazodone
查看文献： Practical and Scalable Manufacturing Process for a Novel Dual-Acting Serotonergic Antidepressant Vilazodone
查看期刊： Organic Process Research & Development
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