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Methyl Cuprate Process Development

有机合成与工艺文献分享 2025-09-05 07:47
文章摘要
本文背景为有机合成工艺开发中甲基铜酸盐加成反应面临的选择性控制挑战。研究目的是通过改进反应条件解决非均相体系敏感性和副产物生成问题，并提高反应的对映选择性。结论表明添加TMS-Cl可抑制副反应但降低反式选择性，而引入DPPP配体能在保持反应活性的同时显著改善立体选择性，最终实现在-40°C条件下将顺式异构体控制在2%以下。
Methyl Cuprate Process Development
查看文献： A Scalable Synthesis of (R,R)-2,6-Dimethyldihydro-2H-pyran-4(3H)-one
查看期刊： Organic Process Research & Development
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