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Cinchona Alkaloid-Catalysis for an Efficient Thiophosphorylation

有机合成与工艺文献分享 2025-08-25 07:02

文章摘要

背景：研究聚焦于未保护核苷的硫代磷酸化反应，使用PSCl3作为硫代磷酸化试剂，吡啶作为碱基在不同溶剂中进行。研究目的：探索吡啶添加剂对反应的影响，并通过DFT计算和实验筛选，发现奎宁等金鸡纳生物碱能有效催化反应，提高选择性和产率。结论：奎宁衍生物作为相转移催化剂显著增强反应速率，机理研究表明反离子氯可能通过去质子化激活核苷，最终实现2.5 kg规模的放大应用。

Cinchona Alkaloid-Catalysis for an Efficient Thiophosphorylation

查看文献： New Mechanism for Cinchona Alkaloid-Catalysis Allows for an Efficient Thiophosphorylation Reaction
查看期刊： Journal of the American Chemical Society

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Cinchona Alkaloid-Catalysis for an Efficient Thiophosphorylation

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