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Side Reaction Caused by Cleaning Detergents

有机合成与工艺文献分享 2025-07-24 05:30

文章摘要

本文研究了在有机合成过程中，由于清洁剂残留导致的副反应问题。背景是多次公斤级规模的5号化合物分离效果良好，但在中试阶段发现大量5号化合物在溶剂转换为甲醇结晶溶剂时完全转化为甲基酯13。研究发现，即使只有0.1 mol%的NaOH存在也会发生甲醇解反应，而大规模生产中可能是由于反应器清洁后残留的清洁剂所致。研究目的是解决这一副反应问题。结论表明，通过在浓缩过程中加入微量乙酸，可以有效避免甲醇解反应，且不影响结晶效果，内酰胺的纯度和收率与未加乙酸时相同。

Side Reaction Caused by Cleaning Detergents

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