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Synergistic Effect of Cu and Ru on Regioselectivity

有机合成与工艺文献分享 2025-02-25 07:31
文章摘要
本文探讨了Cu和Ru在1,4,5-三取代三唑5的区域选择性合成中的协同效应。研究背景是基于药物化学程序中的关键中间体的合成需求。研究目的是通过实验发现Cu的添加不仅提高了反应速率，还使得反应能在较低温度下进行，从而提高了安全性。结论指出，Cu的存在对反应有积极影响，而非负面影响，这对于有机合成和工艺化学家来说是一个重要的发现。
Synergistic Effect of Cu and Ru on Regioselectivity
查看文献： Synergistic Effect of Copper and Ruthenium on Regioselectivity in the Alkyne–Azide Click Reaction of Internal Alkynes
查看期刊： Organic Process Research & Development
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