利用人类供体眼和高分辨率临床成像研究视网膜微循环:获得指导糖尿病视网膜病变未来研究的见解

IF 18.6 1区 医学 Q1 OPHTHALMOLOGY
Chandrakumar Balaratnasingam , Dong An , Martin Hein , Paula Yu , Dao-Yi Yu
{"title":"利用人类供体眼和高分辨率临床成像研究视网膜微循环:获得指导糖尿病视网膜病变未来研究的见解","authors":"Chandrakumar Balaratnasingam ,&nbsp;Dong An ,&nbsp;Martin Hein ,&nbsp;Paula Yu ,&nbsp;Dao-Yi Yu","doi":"10.1016/j.preteyeres.2022.101134","DOIUrl":null,"url":null,"abstract":"<div><p><span><span><span>The microcirculation plays a key role in delivering oxygen to and removing </span>metabolic wastes<span><span><span> from energy-intensive retinal neurons. Microvascular changes are a hallmark feature of </span>diabetic retinopathy (DR), a major cause of irreversible </span>vision loss globally. Early investigators have performed landmark studies characterising the pathologic manifestations of DR. Previous works have collectively informed us of the clinical stages of DR and the retinal manifestations associated with devastating vision loss. Since these reports, major advancements in histologic techniques coupled with three-dimensional image processing has facilitated a deeper understanding of the structural characteristics in the healthy and diseased </span></span>retinal circulation<span><span>. Furthermore, breakthroughs in high-resolution retinal imaging have facilitated clinical translation of histologic knowledge to detect and monitor progression of microcirculatory disturbances with greater precision. </span>Isolated perfusion<span> techniques have been applied to human donor eyes to further our understanding of the cytoarchitectural characteristics of the normal human retinal circulation as well as provide novel insights into the pathophysiology of DR. Histology has been used to validate emerging </span></span></span><em>in vivo</em><span><span><span> retinal imaging techniques<span> such as optical coherence tomography angiography. This report provides an overview of our research on the human retinal microcirculation in the context of the current </span></span>ophthalmic literature. We commence by proposing a standardised histologic lexicon for characterising the human retinal microcirculation and subsequently discuss the pathophysiologic mechanisms underlying key manifestations of DR, with a focus on </span>microaneurysms<span> and retinal ischaemia. The advantages and limitations of current retinal imaging modalities as determined using histologic validation are also presented. We conclude with an overview of the implications of our research and provide a perspective on future directions in DR research.</span></span></p></div>","PeriodicalId":21159,"journal":{"name":"Progress in Retinal and Eye Research","volume":null,"pages":null},"PeriodicalIF":18.6000,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Studies of the retinal microcirculation using human donor eyes and high-resolution clinical imaging: Insights gained to guide future research in diabetic retinopathy\",\"authors\":\"Chandrakumar Balaratnasingam ,&nbsp;Dong An ,&nbsp;Martin Hein ,&nbsp;Paula Yu ,&nbsp;Dao-Yi Yu\",\"doi\":\"10.1016/j.preteyeres.2022.101134\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span><span>The microcirculation plays a key role in delivering oxygen to and removing </span>metabolic wastes<span><span><span> from energy-intensive retinal neurons. Microvascular changes are a hallmark feature of </span>diabetic retinopathy (DR), a major cause of irreversible </span>vision loss globally. Early investigators have performed landmark studies characterising the pathologic manifestations of DR. Previous works have collectively informed us of the clinical stages of DR and the retinal manifestations associated with devastating vision loss. Since these reports, major advancements in histologic techniques coupled with three-dimensional image processing has facilitated a deeper understanding of the structural characteristics in the healthy and diseased </span></span>retinal circulation<span><span>. Furthermore, breakthroughs in high-resolution retinal imaging have facilitated clinical translation of histologic knowledge to detect and monitor progression of microcirculatory disturbances with greater precision. </span>Isolated perfusion<span> techniques have been applied to human donor eyes to further our understanding of the cytoarchitectural characteristics of the normal human retinal circulation as well as provide novel insights into the pathophysiology of DR. Histology has been used to validate emerging </span></span></span><em>in vivo</em><span><span><span> retinal imaging techniques<span> such as optical coherence tomography angiography. This report provides an overview of our research on the human retinal microcirculation in the context of the current </span></span>ophthalmic literature. We commence by proposing a standardised histologic lexicon for characterising the human retinal microcirculation and subsequently discuss the pathophysiologic mechanisms underlying key manifestations of DR, with a focus on </span>microaneurysms<span> and retinal ischaemia. The advantages and limitations of current retinal imaging modalities as determined using histologic validation are also presented. We conclude with an overview of the implications of our research and provide a perspective on future directions in DR research.</span></span></p></div>\",\"PeriodicalId\":21159,\"journal\":{\"name\":\"Progress in Retinal and Eye Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":18.6000,\"publicationDate\":\"2023-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in Retinal and Eye Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1350946222000945\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in Retinal and Eye Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1350946222000945","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 3

摘要

微循环在向能量密集型视网膜神经元输送氧气和清除代谢废物方面发挥着关键作用。微血管变化是糖尿病视网膜病变(DR)的标志性特征,是全球不可逆视力丧失的主要原因。早期研究人员对DR的病理表现进行了具有里程碑意义的研究。先前的工作共同为我们提供了DR的临床阶段和与毁灭性视力丧失相关的视网膜表现。自这些报告以来,组织学技术的重大进步加上三维图像处理,有助于更深入地了解健康和患病视网膜循环的结构特征。此外,高分辨率视网膜成像的突破促进了组织学知识的临床转化,以更精确地检测和监测微循环障碍的进展。独立灌注技术已应用于人类供眼,以进一步了解正常人类视网膜循环的细胞结构特征,并为DR的病理生理学提供新的见解。组织学已用于验证新兴的体内视网膜成像技术,如光学相干断层摄影血管造影。本报告概述了我们在当前眼科文献背景下对人类视网膜微循环的研究。我们首先提出了一个标准化的组织学词汇来描述人类视网膜微循环,随后讨论了DR关键表现的病理生理机制,重点是微动脉瘤和视网膜缺血。还介绍了使用组织学验证确定的当前视网膜成像模式的优点和局限性。最后,我们概述了我们研究的意义,并对DR研究的未来方向提供了展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Studies of the retinal microcirculation using human donor eyes and high-resolution clinical imaging: Insights gained to guide future research in diabetic retinopathy

The microcirculation plays a key role in delivering oxygen to and removing metabolic wastes from energy-intensive retinal neurons. Microvascular changes are a hallmark feature of diabetic retinopathy (DR), a major cause of irreversible vision loss globally. Early investigators have performed landmark studies characterising the pathologic manifestations of DR. Previous works have collectively informed us of the clinical stages of DR and the retinal manifestations associated with devastating vision loss. Since these reports, major advancements in histologic techniques coupled with three-dimensional image processing has facilitated a deeper understanding of the structural characteristics in the healthy and diseased retinal circulation. Furthermore, breakthroughs in high-resolution retinal imaging have facilitated clinical translation of histologic knowledge to detect and monitor progression of microcirculatory disturbances with greater precision. Isolated perfusion techniques have been applied to human donor eyes to further our understanding of the cytoarchitectural characteristics of the normal human retinal circulation as well as provide novel insights into the pathophysiology of DR. Histology has been used to validate emerging in vivo retinal imaging techniques such as optical coherence tomography angiography. This report provides an overview of our research on the human retinal microcirculation in the context of the current ophthalmic literature. We commence by proposing a standardised histologic lexicon for characterising the human retinal microcirculation and subsequently discuss the pathophysiologic mechanisms underlying key manifestations of DR, with a focus on microaneurysms and retinal ischaemia. The advantages and limitations of current retinal imaging modalities as determined using histologic validation are also presented. We conclude with an overview of the implications of our research and provide a perspective on future directions in DR research.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
34.10
自引率
5.10%
发文量
78
期刊介绍: Progress in Retinal and Eye Research is a Reviews-only journal. By invitation, leading experts write on basic and clinical aspects of the eye in a style appealing to molecular biologists, neuroscientists and physiologists, as well as to vision researchers and ophthalmologists. The journal covers all aspects of eye research, including topics pertaining to the retina and pigment epithelial layer, cornea, tears, lacrimal glands, aqueous humour, iris, ciliary body, trabeculum, lens, vitreous humour and diseases such as dry-eye, inflammation, keratoconus, corneal dystrophy, glaucoma and cataract.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信