一个健康方法克服真菌疾病和抗真菌耐药性。

IF 4.6 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Michael Woods, Jason A McAlister, Jennifer Geddes-McAlister
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引用次数: 3

摘要

真菌疾病的全球负担对人类、动物和环境健康构成重大威胁,危及人类和牲畜种群,并造成世界范围内粮食供应的脆弱性。抗真菌药物为人类和动物提供抗感染的基本疗法,而杀菌剂则为农业提供保护。然而,有限的抗真菌药物导致农业和健康之间的交叉使用,促进了耐药性的发展,并大大降低了我们对疾病的防御能力。至关重要的是,在自然环境中普遍存在的抗真菌耐药菌株对用于治疗人类和动物感染的同一类抗真菌药物表现出耐药性,阻碍了临床有效治疗。这种相互联系支持了“同一个健康”方法的必要性,以对抗真菌疾病和克服抗真菌药物耐药性,确保对特定群体的治疗和保护不会无意中危及或牺牲其他植物、动物或人类。在这篇综述中,我们介绍了抗真菌耐药性的来源,并讨论了环境和临床资源的整合来管理疾病。此外,我们还探索了药物协同作用和重新利用策略的机会,突出了正在研究的克服耐药性的真菌靶点,并提出了发现新真菌靶点的技术。本文分类为:感染性疾病>分子与细胞生理学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A One Health approach to overcoming fungal disease and antifungal resistance.

The global burden of fungal disease poses a substantial threat to human, animal, and environmental health, endangering both human and livestock populations and creating vulnerabilities to food supplies world-wide. Antifungal drugs provide essential therapies to humans and animals against infections, while fungicides provide protection in agriculture. However, a limited arsenal of antifungal agents results in cross-use between agriculture and health, promoting the development of resistance, and drastically reducing our defenses against disease. Critically, antifungal resistant strains found ubiquitously within the natural environment demonstrate resistance to the same classes of antifungals used to treat human and animal infections, hindering effective treatment within the clinic. This interconnectivity supports the need for a One Health approach to combat fungal diseases and overcome antifungal resistance, ensuring that treatment and protection of a defined group does not inadvertently endanger or sacrifice other plants, animals, or humans. In this review, we present sources of antifungal resistance and discuss the integration of environmental and clinical resources to manage disease. Moreover, we explore opportunities for drug synergy and repurposing strategies, highlight fungal targets being investigated to overcome resistance, and propose technologies for the discovery of novel fungal targets. This article is categorized under: Infectious Diseases > Molecular and Cellular Physiology.

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来源期刊
WIREs Mechanisms of Disease
WIREs Mechanisms of Disease MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
11.40
自引率
0.00%
发文量
45
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